Gene info: ID 51206

Gene: GP6

GENE ID: 51206

Synonyms: BDPLT11|GPIV|GPVI

Description: glycoprotein VI platelet

Gene type: protein-coding

Location: 19q13.42

dbXrefs: Ensembl:ENSG00000088053 MIM:605546 Vega:OTTHUMG00000159709 UniprotKB:Q9HCN6

RefSeq: NG_031963.2

Retrived from: PubMed|SNP Mapped

SNPs: 6 ANCO-SNPs

Phenotype: CD|ND

# Publications: 9

Sherlock p-value : 5.962e-1 (AD) 5.803e-1 (ND) (Frontal_Cortex)

Pascal p-value : 2.509e-1 (AD) 1.470e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs1613662	chr19:55025227 (GRCh38.p7)	G>A	cocaine dependence	SNV(Single Nucleotide Variation)
rs2304167	chr19:55015713 (GRCh38.p7)	C>T	cocaine dependence	SNV(Single Nucleotide Variation)
rs1654413	chr19:55014991 (GRCh38.p7)	A>T	cocaine dependence	SNV(Single Nucleotide Variation)
rs1671152	chr19:55014977 (GRCh38.p7)	T>G	cocaine dependence	SNV(Single Nucleotide Variation)
rs1671151	chr19:55014526 (GRCh38.p7)	G>A	cocaine dependence	SNV(Single Nucleotide Variation)
rs1671150	chr19:55014129 (GRCh38.p7)	A>G	cocaine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg25818583	chr19:55549801	GP6		4.000e-9	Smoking	27651444
cg02462353	chr19:55549799	GP6		2.900e-8	Smoking	27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ZFR2	0.756
ITGA2B	0.743
MYO15A	0.741
RABL2A	0.739
SRRM3	0.739
BRICD5	0.737
PTCH2	0.735
VTN	0.728
SLC26A10	0.727
PKD1	0.724

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
YES1	-0.408
SLC40A1	-0.396
ASB4	-0.374
TFPI2	-0.37
C9orf135	-0.369
REST	-0.369
PHEX	-0.368
CDCA7L	-0.362
PABPC4L	-0.359
NXT2	-0.358

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
D001241	Aspirin	GP6 gene polymorphism results in decreased susceptibility to Aspirin	16493486
C006780	bisphenol A	bisphenol A results in decreased expression of GP6 mRNA	25181051
D002104	Cadmium	Cadmium results in decreased expression of GP6 mRNA	24376830
D004041	Dietary Fats	Dietary Fats results in increased expression of GP6 mRNA	25016146
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GP6 mRNA	25613284
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of GP6 mRNA	25613284
D014810	Vitamin E	Vitamin E results in decreased expression of GP6 mRNA	19244175

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004888	transmembrane signaling receptor activity	-	TAS	10822077
GO:0005515	protein binding	-	IPI	1715582 19940238
GO:0005518	collagen binding	-	TAS	11027634
GO:0038023	signaling receptor activity	-	TAS	11027634

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0007167	enzyme linked receptor protein signaling pathway	-	TAS	9153205
GO:0007596	blood coagulation	-	TAS	-
GO:0030168	platelet activation	-	NAS	11027634
GO:0030168	platelet activation	-	TAS	-
GO:0050900	leukocyte migration	-	TAS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	TAS	10822077
GO:0009986	cell surface	-	HDA	23382103
GO:0070062	extracellular exosome	-	HDA	23533145
GO:0097197	tetraspanin-enriched microdomain	-	IDA	18795891

KEGG ID	KEGG Term
hsa04512	ECM-receptor interaction

Reactome ID	Reactome Term	Evidence
R-HSA-109582	Hemostasis	TAS
R-HSA-114604	GPVI-mediated activation cascade	TAS
R-HSA-202733	Cell surface interactions at the vascular wall	TAS
R-HSA-75892	Platelet Adhesion to exposed collagen	TAS
R-HSA-76002	Platelet activation, signaling and aggregation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
25147721	Detection of human papillomavirus in chronic cervicitis, cervical adenocarcinoma, intraepithelial neoplasia and squamus cell carcinoma. (2014 May)	Mirzaie-Kashani E	Jundishapur J Microbiol
16129653	Use of fuzzy neural networks in modeling relationships of HPV infection with apoptotic and proliferation markers in potentially malignant oral lesions. (2005 Nov)	Campisi G	Oral Oncol
20695077	Human papillomavirus as an independent predictor in oral squamous cell cancer. (2009 Sep)	Zhao D	Int J Oral Sci
19654578	Differences in the risk of cervical cancer and human papillomavirus infection by education level. (2009 Sep 1)	Franceschi S	Br J Cancer
16476033	H3 and H3.3 histone mRNA amounts and ratio in oral squamous cell carcinoma and leukoplakia. (2006 Mar)	Piscopo M	Oral Dis
15583544	HPV DNA in clinically different variants of oral leukoplakia and lichen planus. (2004 Dec)	Campisi G	Oral Surg Oral Med Oral Pathol Oral Radiol Endod
15288840	Proliferative verrucous vs conventional leukoplakia: no significantly increased risk of HPV infection. (2004 Sep)	Campisi G	Oral Oncol
15729691	Expression of cell cycle markers and human papillomavirus infection in oral squamous cell carcinoma: use of fuzzy neural networks. (2005 Jul 10)	Lo Muzio L	Int J Cancer
18164962	High association of human papillomavirus infection with oral cancer: a case-control study. (2008 Feb)	Anaya-Saavedra G	Arch Med Res