Gene: PCP4

5121
PEP-19
Purkinje cell protein 4
protein-coding
21q22.2
Ensembl:ENSG00000183036 MIM:601629 Vega:OTTHUMG00000086731 UniprotKB:P48539
NC_000021.9
PubMed|SNP Mapped
1   ANCO-SNPs
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.807e-1 (AD)  1.576e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7276341chr21:39915132 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCP4L10.857
JAKMIP10.854
NNAT0.841
SUSD40.833
BEX50.825
BEX20.824
SCG50.821
OSCP10.82
PPP1R70.819
NSG20.816

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FCGR3B-0.474
CXCR2-0.467
OR4F5-0.462
CARD8-0.455
CXCR1-0.446
MAGEA12-0.444
OR4F29-0.439
REST-0.43
DISC1-0.43
KCNJ15-0.428

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PCP4 mRNA"19114083
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PCP4 mRNA"15059925
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of PCP4 mRNA25088246
C5850042-monochloropropanediol2-monochloropropanediol results in increased expression of PCP4 mRNA28522335
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PCP4 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PCP4 mRNA23630614
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCP4 mRNA16483693
C015001arsenitearsenite results in decreased expression of PCP4 mRNA18929588
C015001arseniteTRP53 protein affects the reaction [arsenite results in decreased expression of PCP4 mRNA]18929588
D001205Ascorbic AcidAscorbic Acid results in increased expression of PCP4 mRNA15372504
C547126AZM551248AZM551248 results in decreased expression of PCP4 mRNA22323515
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCP4 mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCP4 mRNA23735875
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCP4 mRNA21839799
D004958Estradiol[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCP4 mRNA19619570
D004958EstradiolEstradiol results in decreased expression of PCP4 mRNA19619570
D004958EstradiolEstradiol results in increased expression of PCP4 mRNA16474171|1916744
D004958Estradiol[bisphenol A co-treated with Estradiol] results in decreased expression of PCP4 mRNA26496021
D001622BetaineBetaine results in increased expression of PCP4 mRNA26391144
C006780bisphenol Abisphenol A results in increased expression of PCP4 mRNA16474171
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in decreased expression of PCP4 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PCP4 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PCP4 gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of PCP4 protein28903499
D003042CocaineCocaine results in decreased expression of PCP4 mRNA16076954
D003375Coumestrol[Coumestrol co-treated with resveratrol] results in increased expression of PCP4 mRNA19167446
D003375CoumestrolCoumestrol results in increased expression of PCP4 mRNA19167446
D003907DexamethasoneDexamethasone results in decreased expression of PCP4 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PCP4 mRNA]20032058
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in increased expression of PCP4 mRNA18164116
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PCP4 mRNA28943392
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PCP4 mRNA21658437
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCP4 mRNA"19480007
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PCP4 protein"19480007
D004237DiuronDiuron results in increased expression of PCP4 mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCP4 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCP4 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCP4 mRNA12655037|1557682
D005480FlurbiprofenFlurbiprofen results in decreased expression of PCP4 mRNA16949054
D019833GenisteinGenistein results in increased expression of PCP4 mRNA16474171
C098607JP8 aviation fuelJP8 aviation fuel affects the expression of PCP4 mRNA15476862
D007657Ketone BodiesKetone Bodies results in increased expression of PCP4 mRNA16807920
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCP4 mRNA23103053
D009532NickelNickel results in decreased expression of PCP4 mRNA24768652|2558310
D010656PhenylephrinePhenylephrine results in decreased expression of PCP4 mRNA18158353
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls analog results in increased expression of PCP4 mRNA16474171
D011192Potassium DichromatePotassium Dichromate results in increased expression of PCP4 mRNA11678601
D011441PropylthiouracilPropylthiouracil results in decreased expression of PCP4 mRNA24780913
C010313pseudocumenepseudocumene results in increased expression of PCP4 protein17337753
C059514resveratrol[Coumestrol co-treated with resveratrol] results in increased expression of PCP4 mRNA19167446
D012643SeleniumSelenium results in decreased expression of PCP4 mRNA19244175
C009277sodium arsenatesodium arsenate results in increased expression of PCP4 mRNA21795629
C017947sodium arsenitesodium arsenite affects the methylation of PCP4 gene28589171
D012969Sodium FluorideSodium Fluoride results in decreased expression of PCP4 mRNA27257137
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in decreased expression of PCP4 mRNA]20032058
D013749Tetrachlorodibenzodioxin[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of PCP4 mRNA19619570
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCP4 mRNA19619570
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PCP4 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCP4 mRNA15591033
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCP4 mRNA20959002
D013849ThimerosalThimerosal results in increased expression of PCP4 mRNA27188386
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in increased expression of PCP4 mRNA28943392
C009495titanium dioxidetitanium dioxide results in decreased expression of PCP4 mRNA23557971
C022884undecaneundecane results in increased expression of PCP4 protein17337753
D014635Valproic AcidValproic Acid affects the expression of PCP4 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCP4 mRNA23179753|2493525
D014635Valproic AcidValproic Acid results in increased expression of PCP4 mRNA23665938
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PCP4 gene25560391
D015032ZincZinc deficiency results in decreased expression of PCP4 mRNA18356318
D015032ZincZinc deficiency results in decreased expression of PCP4 mRNA19111725

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005509calcium ion binding-IDA23204517  
GO:0005515protein binding-IPI21044950  
GO:0005516calmodulin binding-IDA23204517  
GO:0005516calmodulin binding-IPI19106096  
GO ID GO Term Qualifier Evidence PubMed
GO:0045666positive regulation of neuron differentiation-IMP21491429  
GO:0099004calmodulin dependent kinase signaling pathway-IMP21491429  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA16780588  
GO:0005829cytosol-HDA16780588  
GO:0032991protein-containing complex-IDA19106096  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
15236863Decreased expression of NEFH and PCP4/PEP19 in the prefrontal cortex of alcoholics. (2004 Aug)Iwamoto KNeurosci Res
21671256Purkinje cell protein 4 positively regulates neurite outgrowth and neurotransmitter release. (2011 Oct)Harashima SJ Neurosci Res