Gene: PCSK1

5122
BMIQ12|NEC1|PC1|PC3|SPC3
proprotein convertase subtilisin/kexin type 1
protein-coding
5q15
Ensembl:ENSG00000175426 MIM:162150 Vega:OTTHUMG00000122089 UniprotKB:P29120
NG_021161.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.588e-2 (AD)  5.979e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DCLK10.938
GPR1580.906
MRAP20.904
CHGB0.902
TBC1D90.9
CADPS0.9
PRKCE0.9
ELAVL20.899
SNX100.892
NAP1L50.892

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RHOD-0.586
CSAG1-0.574
RNF135-0.574
PARD3B-0.564
CHST14-0.559
SYDE1-0.555
CDC14A-0.548
REST-0.545
RHOJ-0.54
CARD8-0.535

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00030Insulin HumanBiotechDrug11061-68-0Approved|InvestigationalTarget
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of PCSK1 mRNA21983209
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PCSK1 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PCSK1 mRNA21298039
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCSK1 mRNA16483693
C006632arsenic trioxidearsenic trioxide results in increased expression of PCSK1 mRNA21461292
C015001arsenitearsenite results in increased methylation of PCSK1 promoter23974009
D001241AspirinAspirin results in decreased expression of PCSK1 mRNA11906190
C547126AZM551248AZM551248 results in decreased expression of PCSK1 mRNA22323515
D001507BeclomethasoneBeclomethasone results in decreased expression of PCSK1 mRNA23656298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCSK1 mRNA26001963
D004958EstradiolEstradiol results in increased expression of PCSK1 mRNA25878060
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of PCSK1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PCSK1 mRNA25878060
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of PCSK1 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of PCSK1 mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in increased expression of PCSK1 mRNA20147733|2207961
D002104CadmiumCadmium results in decreased expression of PCSK1 mRNA23256528
D020245p-Chloromercuribenzoic Acid"[NOG protein co-treated with p-Chloromercuribenzoic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
D020245p-Chloromercuribenzoic Acidp-Chloromercuribenzoic Acid results in decreased expression of PCSK1 mRNA26272509
D002737ChloropreneChloroprene results in increased expression of PCSK1 mRNA23125180
D003042CocaineCocaine results in increased expression of PCSK1 mRNA27899881
D003471CuprizoneCuprizone results in decreased expression of PCSK1 mRNA26577399
D003471CuprizoneCuprizone results in increased expression of PCSK1 mRNA27523638
C010902decabromobiphenyl etherdecabromobiphenyl ether results in decreased expression of PCSK1 mRNA23640034
C014347decitabinedecitabine affects the expression of PCSK1 mRNA17145863
D002945CisplatinCisplatin results in decreased expression of PCSK1 mRNA22023808
C036042dicyclohexyl phthalatedicyclohexyl phthalate results in decreased expression of PCSK1 mRNA26924002
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in decreased expression of PCSK1 mRNA"27840820
C024629dimethyl phthalatedimethyl phthalate results in decreased expression of PCSK1 mRNA26924002
C104705dopamine quinonedopamine quinone results in decreased activity of PCSK1 protein21540292
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCSK1 mRNA17557909
C039281furanfuran results in decreased expression of PCSK1 mRNA26194646
C078049gatifloxacingatifloxacin results in increased expression of PCSK1 mRNA23200776
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PCSK1 mRNA24796395
C042720mercuric bromidemercuric bromide results in decreased expression of PCSK1 mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
D008694Methamphetamine[Methamphetamine co-treated with SCH 23390] results in decreased expression of PCSK1 mRNA19564919
D008694MethamphetamineMethamphetamine results in increased expression of PCSK1 mRNA19564919
C517284monomethyl phthalatemonomethyl phthalate results in decreased expression of PCSK1 mRNA26924002
D009151Mustard GasMustard Gas results in increased expression of PCSK1 mRNA15674843
D009532NickelNickel results in increased expression of PCSK1 mRNA24768652|2558310
D009638NorepinephrineNorepinephrine results in decreased activity of PCSK1 protein21540292
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PCSK1 mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in decreased expression of PCSK1 mRNA26272509
D010862PilocarpinePilocarpine results in increased expression of PCSK1 mRNA9015327
D011441PropylthiouracilPropylthiouracil results in increased expression of PCSK1 mRNA24780913
D012110ReserpineReserpine results in increased activity of PCSK1 protein21540292
C059514resveratrol[resveratrol co-treated with Streptozocin] results in increased expression of PCSK1 mRNA25905778
C534628SCH 23390[Methamphetamine co-treated with SCH 23390] results in decreased expression of PCSK1 mRNA19564919
C534628SCH 23390SCH 23390 affects the expression of PCSK1 mRNA19564919
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PCSK1 mRNA25895662
D012999SomanSoman results in increased expression of PCSK1 mRNA19281266
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in increased expression of PCSK1 mRNA25905778
D014284TriiodothyronineTriiodothyronine results in decreased expression of PCSK1 mRNA15291740
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCSK1 protein10919282
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PCSK1 gene27618143
C012589trichostatin Atrichostatin A results in increased expression of PCSK1 mRNA24935251|2670570
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PCSK1 mRNA"26179874
D014635Valproic AcidValproic Acid affects the expression of PCSK1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCSK1 mRNA23179753|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-ISS-  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0042802identical protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-TAS9207799  
GO:0007267cell-cell signaling-TAS9207799  
GO:0016486peptide hormone processing-TAS-  
GO:0043043peptide biosynthetic process-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA8397508  
GO:0030133transport vesicle-IEA-  
GO:0034774secretory granule lumen-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-209952Peptide hormone biosynthesisTAS
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismTAS
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-381771Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)IEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-392499Metabolism of proteinsIEA
R-HSA-400508Incretin synthesis, secretion, and inactivationIEA
R-HSA-400511Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)IEA
R-HSA-422085Synthesis, secretion, and deacylation of GhrelinTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24489861Genetic variants in PCSK1 gene are associated with the risk of coronary artery disease in type 2 diabetes in a Chinese Han population: a case control study. (2014)Wei XPLoS One