Gene: PCSK5

5125
PC5|PC6|PC6A|SPC6
proprotein convertase subtilisin/kexin type 5
protein-coding
9q21.13
Ensembl:ENSG00000099139 MIM:600488 Vega:OTTHUMG00000020039 UniprotKB:Q92824
NG_029445.1
SNP Mapped
3   ANCO-SNPs
ND
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.360e-1 (AD)  1.548e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7024200chr9:76078316 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs2792224chr9:76042814 (GRCh38.p7)A>Gnicotine dependenceSNV(Single Nucleotide Variation)
rs4416887chr9:75982309 (GRCh38.p7)A>G / A>Tnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg14178077chr9:78777801PCSK5Gene body9.736e-5Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ROR10.739
LTBP10.708
F2R0.706
LPP0.701
FERMT20.694
ACKR30.693
ATP10D0.692
YAP10.691
RHBDD10.687
ZNF8440.684

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRYBA2-0.319
BHLHA9-0.309
ANKRD2-0.307
C2CD4D-0.299
DLK2-0.299
RTP1-0.293
GSG1-0.293
SMIM18-0.288
ABCC12-0.284
CACNA1F-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene affects the expression of PCSK5 mRNA"18281256
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PCSK5 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PCSK5 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PCSK5 mRNA"19692669
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C0207389,10-dihydro-9,10-dihydroxybenzo(a)pyrene"9,10-dihydro-9,10-dihydroxybenzo(a)pyrene results in increased expression of PCSK5 mRNA"26238291
D000082AcetaminophenAcetaminophen results in increased expression of PCSK5 mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PCSK5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PCSK5 mRNA]17585979
D020106AcrylamideAcrylamide results in increased expression of PCSK5 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCSK5 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PCSK5 mRNA19770486
D006710HomocysteineHomocysteine results in decreased expression of PCSK5 mRNA17326132
C006632arsenic trioxidearsenic trioxide results in increased expression of PCSK5 mRNA15761015
D001280AtrazineAtrazine results in increased expression of PCSK5 mRNA25929836
C547126AZM551248AZM551248 results in increased expression of PCSK5 mRNA22323515
D001554BenzeneBenzene results in decreased expression of PCSK5 mRNA19162166
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of PCSK5 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCSK5 mRNA22316170|2623829
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased mutagenesis of PCSK5 gene25435355
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PCSK5 mRNA19770486|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PCSK5 mRNA21839799
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of PCSK5 mRNA20660070
D004958EstradiolEstradiol results in increased expression of PCSK5 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of PCSK5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PCSK5 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of PCSK5 mRNA26079696
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PCSK5 mRNA25993096
D002211CapsaicinCapsaicin results in decreased expression of PCSK5 mRNA16278290
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PCSK5 mRNA17484886
D002737ChloropreneChloroprene results in decreased expression of PCSK5 mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCSK5 mRNA20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PCSK5 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of PCSK5 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PCSK5 mRNA]17585979
D019327Copper SulfateCopper Sulfate results in increased expression of PCSK5 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of PCSK5 mRNA20106945|2556210
D003561CytarabineCytarabine results in decreased expression of PCSK5 mRNA21198554
D003976DiazinonDiazinon results in increased methylation of PCSK5 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PCSK5 mRNA17361019|2126653
D004237DiuronDiuron results in decreased expression of PCSK5 mRNA25152437
C118739entinostatentinostat results in decreased expression of PCSK5 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C024565ethylene dichlorideethylene dichloride results in increased expression of PCSK5 mRNA28189721
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of PCSK5 gene18519639
D005419FlavonoidsFlavonoids results in decreased expression of PCSK5 mRNA18035473
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCSK5 mRNA20938992
D017313FenretinideFenretinide results in decreased expression of PCSK5 mRNA28973697
D017313FenretinideFenretinide results in increased expression of PCSK5 mRNA28973697
C016517indole-3-carbinolindole-3-carbinol affects the expression of PCSK5 mRNA21396975
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of PCSK5 mRNA26752646
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PCSK5 mRNA"24972896
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased expression of PCSK5 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PCSK5 mRNA28001369
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PCSK5 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PCSK5 mRNA"25554681
C458513pafuramidinePCSK5 affects the reaction [pafuramidine results in increased expression of HAVCR1 protein]22940726
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PCSK5 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of PCSK5 mRNA23091169
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PCSK5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PCSK5 mRNA18301758|2381119
D010936Plant ExtractsPlant Extracts results in increased expression of PCSK5 mRNA23557933
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of PCSK5 mRNA20660070
C045950propiconazolepropiconazole results in decreased expression of PCSK5 mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of PCSK5 mRNA24780913
D011794QuercetinQuercetin results in increased expression of PCSK5 mRNA21632981
C059514resveratrolresveratrol results in increased expression of PCSK5 mRNA25905778
D012643SeleniumSelenium results in decreased expression of PCSK5 mRNA19244175
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PCSK5 mRNA25895662
D012999SomanSoman results in increased expression of PCSK5 mRNA19281266
D053260SootSoot results in decreased expression of PCSK5 mRNA26551751
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCSK5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCSK5 mRNA17101203|2129612
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PCSK5 mRNA19692669|2010694
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of PCSK5 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCSK5 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCSK5 mRNA22298810
D013806TheophyllineTheophylline results in increased expression of PCSK5 mRNA16083514
C009495titanium dioxidetitanium dioxide results in increased expression of PCSK5 mRNA23557971
D014212TretinoinTretinoin results in increased expression of PCSK5 mRNA21934132
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of PCSK5 mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PCSK5 mRNA24935251|2627250
C057693troglitazonetroglitazone results in decreased expression of PCSK5 mRNA28973697
D014520UrethaneUrethane results in increased expression of PCSK5 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of PCSK5 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PCSK5 mRNA23179753|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004175endopeptidase activity-EXP16109723  20581395  
GO:0004252serine-type endopeptidase activity-IDA8901832  
GO:0005515protein binding-IPI25416956  
GO:0008233peptidase activity-IDA15606899  
GO:0042277peptide binding-ISS8940009  
GO ID GO Term Qualifier Evidence PubMed
GO:0001822kidney development-IMP18519639  
GO:0001822kidney development-ISS8940009  
GO:0002001renin secretion into blood stream-IEP8901832  
GO:0003279cardiac septum development-IEA-  
GO:0006465signal peptide processing-IDA16912035  
GO:0007267cell-cell signaling-TAS8901832  
GO:0007368determination of left/right symmetry-IEA-  
GO:0007507heart development-ISS8940009  
GO:0007566embryo implantation-ISS8940009  
GO:0009952anterior/posterior pattern specification-IMP18519639  
GO:0016485protein processing-IDA8901832  15606899  
GO:0016486peptide hormone processing-IDA8901832  
GO:0019058viral life cycle-IEP8940009  
GO:0019058viral life cycle-ISS8940009  
GO:0030323respiratory tube development-ISS8940009  
GO:0035108limb morphogenesis-ISS8940009  
GO:0042089cytokine biosynthetic process-ISS8940009  
GO:0043043peptide biosynthetic process-IDA8901832  
GO:0048566embryonic digestive tract development-IMP18519639  
GO:0048566embryonic digestive tract development-ISS8940009  
GO:0048706embryonic skeletal system development-IMP18519639  
GO:0048706embryonic skeletal system development-ISS8940009  
GO:0051004regulation of lipoprotein lipase activity-TAS-  
GO:0060976coronary vasculature development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-ISS8940009  
GO:0005794Golgi apparatus-IDA-  
GO:0005794Golgi apparatus-ISS-  
GO:0005796Golgi lumen-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0030141secretory granule-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-166520Signaling by NTRKsTAS
R-HSA-167060NGF processingTAS
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceTAS
R-HSA-382551Transport of small moleculesTAS
R-HSA-8963889Assembly of active LPL and LIPC lipase complexesTAS
R-HSA-8963899Plasma lipoprotein remodelingTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS
R-HSA-9036866Expression and Processing of NeurotrophinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal