Gene: PCSK2

5126
NEC 2|NEC-2|NEC2|PC2|SPC2
proprotein convertase subtilisin/kexin type 2
protein-coding
20p12.1
Ensembl:ENSG00000125851 MIM:162151 Vega:OTTHUMG00000031941 UniprotKB:P16519
NC_000020.11
SNP Mapped
2   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.482e-1 (AD)  3.416e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1578405chr20:17248099 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs3818916chr20:17227076 (GRCh38.p7)G>A / G>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM2460.979
NELL20.978
GABRG20.975
CADPS0.974
MAP7D20.972
AMPH0.972
FAXC0.972
NSF0.972
DYNC1I10.972
GLRB0.97

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.579
YES1-0.574
HEY2-0.574
REST-0.574
CSAG1-0.572
MYL3-0.566
RAI14-0.56
CHST14-0.547
RAB13-0.543
COPZ2-0.54

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00030Insulin HumanBiotechDrug11061-68-0Approved|InvestigationalTarget
DB00071Insulin PorkBiotechDrug12584-58-6ApprovedTarget
ID Drug Name Action PubMed
C0067181,12-benzoperylene"1,12-benzoperylene results in increased expression of PCSK2 mRNA"26377693
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in decreased expression of PCSK2 mRNA12419474
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PCSK2 mRNA20146248
D000082AcetaminophenAcetaminophen affects the expression of PCSK2 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PCSK2 gene27153756
C103303alitretinoinalitretinoin results in increased expression of PCSK2 mRNA15585599
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PCSK2 mRNA16483693
C015001arsenitearsenite results in increased methylation of PCSK2 promoter23974009
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone] results in decreased expression of PCSK2 mRNA20146248
C006780bisphenol Abisphenol A results in decreased expression of PCSK2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PCSK2 gene28505145
C055494caffeic acid phenethyl estercaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of PCSK2 mRNA]20360939
D004390ChlorpyrifosChlorpyrifos results in increased expression of PCSK2 mRNA20350560
D003042CocaineCocaine results in decreased expression of PCSK2 mRNA12629581
D019327Copper SulfateCopper Sulfate results in decreased expression of PCSK2 mRNA19549813
D016578Crack CocaineCrack Cocaine results in increased expression of PCSK2 mRNA12629581
D003520CyclophosphamideCyclophosphamide results in decreased expression of PCSK2 mRNA15331540
D004041Dietary FatsDietary Fats results in increased expression of PCSK2 mRNA25016146
D004052Diethylnitrosaminecaffeic acid phenethyl ester inhibits the reaction [Diethylnitrosamine results in increased expression of PCSK2 mRNA]20360939
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PCSK2 mRNA20360939
C104705dopamine quinonedopamine quinone results in decreased activity of PCSK2 protein21540292
C118739entinostatentinostat results in decreased expression of PCSK2 mRNA27188386
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PCSK2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCSK2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PCSK2 mRNA15834898
D005557FormaldehydeFormaldehyde results in decreased expression of PCSK2 mRNA12679049
D006418HemeHeme metabolite results in increased expression of PCSK2 mRNA19191707
C515747isosteviolisosteviol results in increased expression of PCSK2 mRNA22479612
D007649KetamineKetamine results in increased expression of PCSK2 mRNA20080153
D007657Ketone BodiesKetone Bodies results in increased expression of PCSK2 mRNA16807920
D008701MethapyrileneMethapyrilene results in increased methylation of PCSK2 gene26431795
D008713MethimazoleMethimazole results in decreased expression of PCSK2 mRNA17403546
D009151Mustard GasMustard Gas results in increased expression of PCSK2 mRNA15674843|1567484
D009532NickelNickel results in decreased expression of PCSK2 mRNA25583101
D009638NorepinephrineNorepinephrine results in decreased activity of PCSK2 protein21540292
D019308Palmitic AcidPalmitic Acid results in increased expression of PCSK2 mRNA22479612
C494474perchlorateperchlorate results in decreased expression of PCSK2 mRNA17403546
D010936Plant ExtractsPlant Extracts results in decreased expression of PCSK2 mRNA23557933
D011441PropylthiouracilPropylthiouracil results in decreased expression of PCSK2 mRNA24780913
D011441PropylthiouracilPropylthiouracil results in increased expression of PCSK2 mRNA15585599
D011441PropylthiouracilPropylthiouracil results in decreased expression of PCSK2 mRNA17403546
D012110ReserpineReserpine results in increased activity of PCSK2 protein21540292
D012110ReserpineReserpine results in increased expression of PCSK2 mRNA8189248
D012969Sodium FluorideSodium Fluoride results in increased expression of PCSK2 mRNA27862939
D014284TriiodothyronineTriiodothyronine results in decreased expression of PCSK2 mRNA15585599
D013629TamoxifenTamoxifen affects the expression of PCSK2 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PCSK2 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PCSK2 protein10919282
D013849ThimerosalThimerosal results in increased expression of PCSK2 mRNA27188386
D013974ThyroxineThyroxine results in decreased expression of PCSK2 mRNA15585599
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PCSK2 gene25560391
D015034Zinc OxideZinc Oxide analog results in decreased expression of PCSK2 mRNA27215404
D019287Zinc SulfateZinc Sulfate results in decreased expression of PCSK2 mRNA27215404

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004252serine-type endopeptidase activity-IDA7626024  
GO:0004252serine-type endopeptidase activity-TAS-  
GO:0005515protein binding-IPI7913882  
GO:0044877protein-containing complex binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006508proteolysis-IDA7626024  
GO:0007399nervous system development-IEA-  
GO:0016486peptide hormone processing-IDA28719828  
GO:0016540protein autoprocessing-IEA-  
GO:0030070insulin processing-IDA7626024  
GO:0034230enkephalin processing-ISS-  
GO:0034231islet amyloid polypeptide processing-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA9020868  28719828  
GO:0005634nucleus-IDA-  
GO:0016020membrane-IDA8034613  
GO:0030133transport vesicle-IEA-  
GO:0030425dendrite-IEA-  
GO:0034774secretory granule lumen-TAS-  
GO:0043204perikaryon-IEA-  
GO:0043231intracellular membrane-bounded organelle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-264876Insulin processingIEA
R-HSA-2980736Peptide hormone metabolismIEA
R-HSA-392499Metabolism of proteinsIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal