Gene: TLR7

51284
TLR7-like
toll like receptor 7
protein-coding
Xp22.2
Ensembl:ENSG00000196664 MIM:300365 Vega:OTTHUMG00000021137 UniprotKB:Q9NYK1
NG_012569.1
PubMed
0   ANCO-SNPs
ND|AD
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SYK0.933
TLR60.931
IRF80.924
HLA-DOA0.922
TLR10.919
CD370.917
PTPRC0.916
TBXAS10.915
MILR10.914
BTK0.913

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ATP2C2-0.394
KCNIP3-0.384
HAGHL-0.376
WFDC1-0.376
C9orf24-0.375
ATOH7-0.37
KRTAP5-7-0.369
BDH1-0.368
MAGIX-0.367
TMEM179-0.367

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00724ImiquimodSmall Molecule99011-02-6Approved|InvestigationalTarget
DB01611HydroxychloroquineSmall Molecule118-42-3ApprovedTarget
DB04860IsatoribineSmall Molecule122970-40-5InvestigationalTarget
DB05127ANA971Small Molecule-InvestigationalTarget
DB05475GolotimodSmall Molecule229305-39-9InvestigationalTarget
DB06530ResiquimodSmall Molecule144875-48-9InvestigationalTarget
ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of TLR7 mRNA"23146750
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR7 mRNA23405061
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C496492abrineabrine results in increased expression of TLR7 mRNA22595364
C095512alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]"23405061
D0150752-Aminopurine2-Aminopurine inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
D000956Antigens, Viral"Antigens, Viral results in increased activity of TLR7 protein"28003376
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TLR7 mRNA24449571
D001151ArsenicArsenic results in increased expression of TLR7 mRNA27838757
D016589AstemizoleAstemizole results in decreased expression of TLR7 mRNA20221588
C000609563AZD8848AZD8848 results in increased activity of TLR7 protein29122671
C000609563AZD8848AZD8848 results in increased activity of TLR7 protein29122671
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of TLR7 mRNA20064835
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of TLR7 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of TLR7 mRNA22228805
D004958EstradiolEstradiol results in increased expression of TLR7 mRNA19484750
C006780bisphenol Abisphenol A results in decreased expression of TLR7 mRNA25181051
D000074262Canola OilCanola Oil metabolite results in decreased expression of TLR7 mRNA27363782
D002738Chloroquine[resiquimod co-treated with Chloroquine] results in increased expression of TLR7 mRNA23405061
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR7 mRNA20938992
C408982CPG-oligonucleotideCPG-oligonucleotide results in decreased expression of TLR7 mRNA23405061
C526360dechlorane plusdechlorane plus results in increased expression of TLR7 mRNA22913625
D004041Dietary FatsDietary Fats results in increased expression of TLR7 mRNA25016146
D004317DoxorubicinDoxorubicin results in increased expression of TLR7 mRNA27181935
D004317DoxorubicinFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR7 mRNA]27181935
D004726EndosulfanEndosulfan results in decreased expression of TLR7 mRNA26615145
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR7 mRNA20938992
C069837fullerene C60fullerene C60 results in decreased expression of TLR7 mRNA19167457
D062610Fungal PolysaccharidesFungal Polysaccharides inhibits the reaction [Doxorubicin results in increased expression of TLR7 mRNA]27181935
C546771gardiquimodgardiquimod results in increased activity of TLR7 protein28003376
C546771gardiquimodgardiquimod results in increased expression of TLR7 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR7 mRNA]28003376
C546771gardiquimodgardiquimod results in increased activity of TLR7 protein28003376
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]21097750
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein21097750
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein21097750
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein21097750
C056493imiquimod[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased secretion of IL6 protein21097750
C056493imiquimodTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
C056493imiquimodTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]21097750
C056493imiquimodTetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]21097750
C056493imiquimodTetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]21097750
C056493imiquimodimiquimod binds to and results in increased activity of TLR7 protein18067624|2109775
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR7 mRNA"23090859
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] results in increased expression of TLR7 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with pyrazolanthrone] results in increased expression of TLR7 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR7 mRNA23405061
D008070Lipopolysaccharides[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR7 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR7 mRNA23405061
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of TLR7 mRNA23405061
C068562loxoribineloxoribine binds to TLR7 protein15777634
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TLR7 mRNA21641980
C013592mangiferinmangiferin results in decreased expression of TLR7 mRNA15135318
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of TLR7 mRNA20938992
D015735MifepristoneMifepristone results in decreased expression of TLR7 protein17701593
C063509N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide[resiquimod co-treated with N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide] results in increased expression of TLR7 mRNA23405061
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of TLR7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of TLR7 mRNA"25554681
D009532NickelNickel results in increased expression of TLR7 mRNA24768652
C028007nickel monoxidenickel monoxide results in decreased expression of TLR7 mRNA19167457
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of TLR7 mRNA25729387
C508075Pam(3)CSK(4) peptidePam(3)CSK(4) peptide results in decreased expression of TLR7 mRNA23405061
C006253pirinixic acidpirinixic acid results in decreased expression of TLR7 mRNA20813756
D011070Poly I-CPoly I-C results in increased expression of TLR7 mRNA17669408
D011374ProgesteroneProgesterone results in increased expression of TLR7 mRNA17701593
D011374ProgesteroneProgesterone results in increased expression of TLR7 mRNA19690047
D011441PropylthiouracilPropylthiouracil results in increased expression of TLR7 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR7 mRNA]28003376
C432165pyrazolanthrone[Lipopolysaccharides co-treated with pyrazolanthrone] results in increased expression of TLR7 mRNA23405061
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein affects the localization of CD40 protein]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein affects the localization of NFE2L2 protein]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of CD40]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of HMOX]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of IL6]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of IL6 mRNA]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of TNF]26329008
D011794QuercetinQuercetin inhibits the reaction [TLR7 protein results in increased expression of TNF mRNA]26329008
D011794Quercetintin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TLR7 protein results in increased expression of IL6 mRNA]]26329008
D011794Quercetintin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TLR7 protein results in increased expression of TNF mRNA]]26329008
C402365resiquimod2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C402365resiquimod2-Aminopurine inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C402365resiquimod"alpha-cyano-(3,4-dihydroxy)-N-benzylcinnamide inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]"23405061
C402365resiquimod[resiquimod co-treated with Chloroquine] results in increased expression of TLR7 mRNA23405061
C402365resiquimod[resiquimod co-treated with N-(2-(4-bromocinnamylamino)ethyl)-5-isoquinolinesulfonamide] results in increased expression of TLR7 mRNA23405061
C402365resiquimod[resiquimod co-treated with SB 203580] results in increased expression of TLR7 mRNA23405061
C402365resiquimod[resiquimod co-treated with U 0126] results in increased expression of TLR7 mRNA23405061
C402365resiquimodresiquimod results in decreased expression of TLR7 mRNA23405061
C402365resiquimodresiquimod results in increased expression of TLR7 mRNA23405061
C402365resiquimodSB 216763 inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C402365resiquimodtripterine inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C402365resiquimodwortmannin inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C402365resiquimodresiquimod binds to TLR7 protein15851485
C402365resiquimodresiquimod results in increased activity of TLR7 protein29122671
C402365resiquimodresiquimod results in increased activity of TLR7 protein29122671
C402365resiquimodresiquimod binds to TLR7 protein15851485
C402365resiquimodresiquimod binds to and results in increased activity of TLR7 protein23405061
C099445S 28463S 28463 binds to and affects the activity of TLR7 protein16361354
C093642SB 203580[Lipopolysaccharides co-treated with SB 203580] results in increased expression of TLR7 mRNA23405061
C093642SB 203580[resiquimod co-treated with SB 203580] results in increased expression of TLR7 mRNA23405061
C417521SB 216763SB 216763 inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
D018038Sodium SeleniteSodium Selenite results in decreased expression of TLR7 mRNA18175754
D012999SomanSoman results in increased expression of TLR7 mRNA19281266
D053260SootSoot results in increased expression of TLR7 mRNA22461453
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in decreased expression of TLR7 mRNA21641980
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TLR7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] results in increased secretion of [IL12A protein binds to IL12B protein]]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ITGAX protein]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of CD86 protein]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [[imiquimod binds to and results in increased activity of TLR7 protein] which results in increased expression of ICAM1 protein]21097750
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of TLR7 mRNA26290441
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TLR7 protein results in increased expression of IL6 mRNA]]26329008
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Quercetin inhibits the reaction [TLR7 protein results in increased expression of TNF mRNA]]26329008
C009495titanium dioxidetitanium dioxide results in increased expression of TLR7 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TLR7 mRNA20133372
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of TLR7 mRNA25729387
C050414tripterinetripterine inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
C113580U 0126[Lipopolysaccharides co-treated with U 0126] results in increased expression of TLR7 mRNA23405061
C113580U 0126[resiquimod co-treated with U 0126] results in increased expression of TLR7 mRNA23405061
D001335Vehicle EmissionsVehicle Emissions affects the expression of TLR7 mRNA23940539
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of TLR7 gene25560391
C009687wortmanninwortmannin inhibits the reaction [resiquimod results in increased expression of TLR7 mRNA]23405061
D015215Zidovudine[Zidovudine co-treated with IFNA1 protein] results in increased expression of TLR7 mRNA20370541

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003725double-stranded RNA binding-IDA16111635  
GO:0003727single-stranded RNA binding-ISS-  
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0008144drug binding-IEA-  
GO:0008329signaling pattern recognition receptor activity-IBA21873635  
GO:0035197siRNA binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-IEA-  
GO:0001932regulation of protein phosphorylation-IEA-  
GO:0002224toll-like receptor signaling pathway-IBA21873635  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-IEA-  
GO:0006954inflammatory response-IEA-  
GO:0006955immune response-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0007252I-kappaB phosphorylation-IDA19740627  
GO:0032722positive regulation of chemokine production-IDA19740627  
GO:0032755positive regulation of interleukin-6 production-IBA21873635  
GO:0032755positive regulation of interleukin-6 production-IEA-  
GO:0032757positive regulation of interleukin-8 production-IDA19740627  
GO:0034154toll-like receptor 7 signaling pathway-IBA21873635  
GO:0034162toll-like receptor 9 signaling pathway-TAS-  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IBA21873635  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IDA16286015  
GO:0045087innate immune response-IEA-  
GO:0045356positive regulation of interferon-alpha biosynthetic process-IDA16286015  
GO:0045359positive regulation of interferon-beta biosynthetic process-IBA21873635  
GO:0045359positive regulation of interferon-beta biosynthetic process-IDA16286015  
GO:0045416positive regulation of interleukin-8 biosynthetic process-IBA21873635  
GO:0045416positive regulation of interleukin-8 biosynthetic process-IMP16188996  
GO:0050729positive regulation of inflammatory response-IC19740627  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IMP16188996  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:1901224positive regulation of NIK/NF-kappaB signaling-IDA19740627  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005737cytoplasm-IDA19740627  
GO:0005764lysosome-ISS-  
GO:0005768endosome-ISS-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0005886plasma membrane-IDA19740627  
GO:0010008endosome membrane-TAS-  
GO:0016021integral component of membrane-IEA-  
GO:0032009early phagosome-ISS-  
GO:0036020endolysosome membrane-TAS-  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1679131Trafficking and processing of endosomal TLRTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingTAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22103307Breastfeeding modulates neonatal innate immune responses: a prospective birth cohort study. (2012 Feb)Belderbos MEPediatr Allergy Immunol
25346143Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)Scott MEInt J Cancer
28118842Microglial-derived miRNA let-7 and HMGB1 contribute to ethanol-induced neurotoxicity via TLR7. (2017 Jan 25)Coleman LG JrJ Neuroinflammation
23497334Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. (2013 Mar 9)Todt JCRespir Res