Gene: RXFP3

51289
GPCR135|RLN3R1|RXFPR3|SALPR
relaxin family peptide receptor 3
protein-coding
5p13.2
Ensembl:ENSG00000182631 MIM:609445 Vega:OTTHUMG00000090685 UniprotKB:Q9NSD7
NC_000005.10
PubMed
0   ANCO-SNPs
AD
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.417e-1 (AD)  4.463e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NXPH20.701
MYO5B0.686
HS6ST30.678
DCC0.663
CNTNAP50.662
IGF10.662
CDKL50.658
PCDHAC10.654
SIAH30.652
ADAMTS50.648

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HEBP2-0.463
ROM1-0.444
AGTRAP-0.424
CSAG1-0.417
RARRES3-0.41
RAB13-0.405
FXYD3-0.405
STON2-0.401
HVCN1-0.4
ITPKB-0.398

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of RXFP3 mRNA22230336
D020106AcrylamideAcrylamide results in decreased expression of RXFP3 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of RXFP3 gene27153756
C015001arsenitearsenite results in increased methylation of RXFP3 promoter23974009
D001280AtrazineAtrazine results in decreased expression of RXFP3 mRNA25929836
D001280AtrazineAtrazine results in increased expression of RXFP3 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to RXFP3 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of RXFP3 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RXFP3 gene28505145
D004041Dietary FatsDietary Fats results in increased expression of RXFP3 mRNA25016146
C004312glycidolglycidol results in decreased expression of RXFP3 mRNA24915197

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004930G-protein coupled receptor activity-TAS10806363  
GO:0004966galanin receptor activity-IBA21873635  
GO:0008528G-protein coupled peptide receptor activity-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007188adenylate cyclase-modulating G-protein coupled receptor signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IBA21873635  
GO:0007218neuropeptide signaling pathway-IEA-  
GO:0032467positive regulation of cytokinesis-IMP22888021  
GO:0051482positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-TAS10806363  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-373076Class A/1 (Rhodopsin-like receptors)TAS
R-HSA-375276Peptide ligand-binding receptorsTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418594G alpha (i) signalling eventsTAS
R-HSA-444821Relaxin receptorsTAS
R-HSA-500792GPCR ligand bindingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27395787Nucleus incertus Orexin2 receptors mediate alcohol seeking in rats. (2016 Nov)Kastman HENeuropharmacology