Gene: KCNK9

51305
K2p9.1|KT3.2|TASK-3|TASK3
potassium two pore domain channel subfamily K member 9
protein-coding
8q24.3
Ensembl:ENSG00000169427 MIM:605874 Vega:OTTHUMG00000164186 UniprotKB:Q9NPC2
NG_012842.2
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.610e-1 (AD)  4.691e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2014712chr8:139628391 (GRCh38.p7)C>G / C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SSTR30.908
RTN4RL10.896
SPATS20.89
RTN4RL20.89
KCNC10.889
GFRA20.888
TNFAIP8L10.887
GABBR20.881
ELAVL40.881
KCNK10.88

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MBNL3-0.594
LRAT-0.593
HEY2-0.573
REST-0.568
COPZ2-0.562
CYP11A1-0.552
YES1-0.548
PARD3B-0.546
ASB4-0.539
NXT2-0.537

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00561DoxapramSmall Molecule309-29-5ApprovedTarget
DB01159HalothaneSmall Molecule151-67-7ApprovedTarget
ID Drug Name Action PubMed
C0209224-O-methyl-12-O-tetradecanoylphorbol 13-acetate4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction [KCNK9 protein results in increased transport of Potassium]11431495
D000643Ammonium ChlorideAmmonium Chloride affects the expression of KCNK9 mRNA16483693
D001280AtrazineAtrazine results in decreased expression of KCNK9 mRNA25929836
D001464BariumBarium inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
C006780bisphenol Abisphenol A results in decreased expression of KCNK9 mRNA25181051
D002045BupivacaineBupivacaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]11249964
C018475butyraldehydebutyraldehyde results in increased expression of KCNK9 mRNA26079696
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK9 gene20938992
D002117CalcitriolCalcitriol results in increased expression of KCNK9 mRNA16002434
D005492Folic Acid[Folic Acid co-treated with sodium arsenite] results in decreased methylation of KCNK9 mRNA22959928
D005492Folic AcidFolic Acid results in decreased methylation of KCNK9 mRNA22959928
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK9 gene20938992
D004397FonofosFonofos results in increased methylation of KCNK9 promoter22847954
D006221HalothaneHalothane promotes the reaction [KCNK9 protein results in increased transport of Potassium]11249964
C029310lardlard results in increased expression of KCNK9 mRNA26115784
D008012LidocaineLidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of KCNK9 gene20938992
D008727MethotrexateMethotrexate results in decreased expression of KCNK9 mRNA24449571
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of KCNK9 mRNA23649840
C558013NSC 689534NSC 689534 results in increased expression of KCNK9 mRNA20971185
D010278ParathionParathion results in increased methylation of KCNK9 promoter22847954
D059808PolyphenolsPolyphenols results in decreased expression of KCNK9 mRNA16293270
D011188Potassium4-O-methyl-12-O-tetradecanoylphorbol 13-acetate inhibits the reaction [KCNK9 protein results in increased transport of Potassium]11431495
D011188PotassiumBupivacaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]11249964
D011188PotassiumHalothane promotes the reaction [KCNK9 protein results in increased transport of Potassium]11249964
D011188Potassium[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium18568022
D011188PotassiumKCNK9 protein results in increased transport of Potassium11249964|1143149
D011188Potassiumsanshool inhibits the reaction [[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium]18568022
D011188Potassiumsanshool inhibits the reaction [KCNK9 protein results in increased transport of Potassium]18568022
D011188PotassiumBarium inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
D011188PotassiumKCNK9 protein results in increased transport of Potassium10734076|1578196
D011188PotassiumLidocaine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
D011188PotassiumQuinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
D011441PropylthiouracilPropylthiouracil results in decreased expression of KCNK9 mRNA24780913
D011802QuinidineQuinidine inhibits the reaction [KCNK9 protein results in increased transport of Potassium]10734076
C100574sanshoolKCNK9 protein affects the susceptibility to sanshool18568022
C100574sanshoolsanshool inhibits the reaction [[KCNK3 protein binds to KCNK9 protein] which results in increased transport of Potassium]18568022
C100574sanshoolsanshool inhibits the reaction [KCNK9 protein results in increased transport of Potassium]18568022
C100574sanshoolsanshool results in decreased activity of [KCNK3 protein binds to KCNK9 protein]18568022
C100574sanshoolsanshool results in decreased activity of KCNK9 protein18568022
C017947sodium arsenite[Folic Acid co-treated with sodium arsenite] results in decreased methylation of KCNK9 mRNA22959928
C012568terbufosterbufos results in increased methylation of KCNK9 promoter22847954
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KCNK9 mRNA"26743178
D014635Valproic AcidValproic Acid results in increased expression of KCNK9 mRNA28001369

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005249voltage-gated potassium channel activity-IEA-  
GO:0005267potassium channel activity-TAS-  
GO:0022841potassium ion leak channel activity-IBA21873635  
GO:0042803protein homodimerization activity-IEA-  
GO:0046982protein heterodimerization activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006813potassium ion transport-NAS11042359  
GO:0030322stabilization of membrane potential-IBA21873635  
GO:0071805potassium ion transmembrane transport-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0008021synaptic vesicle-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-112316Neuronal SystemTAS
R-HSA-1296071Potassium ChannelsTAS
R-HSA-1296346Tandem pore domain potassium channelsTAS
R-HSA-1299316TWIK-releated acid-sensitive K+ channel (TASK)TAS
R-HSA-397014Muscle contractionTAS
R-HSA-5576886Phase 4 - resting membrane potentialTAS
R-HSA-5576891Cardiac conductionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal