Gene: TLR8

51311
CD288
toll like receptor 8
protein-coding
Xp22.2
Ensembl:ENSG00000101916 MIM:300366 Vega:OTTHUMG00000021145 UniprotKB:Q9NR97
NG_012882.2
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
NA (AD)  NA (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CD300LF0.907
ARL110.905
SIRPB20.894
DAPP10.879
CD1D0.876
SNX200.874
TLR10.872
FPR20.867
FPR30.867
LILRB30.862

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WFDC1-0.474
KCNIP3-0.453
CHRNA4-0.45
ATP2C2-0.43
NNAT-0.426
ASPDH-0.425
WNT7A-0.425
TMEM179-0.422
NEUROD6-0.418
KCNK4-0.418

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00724ImiquimodSmall Molecule99011-02-6Approved|InvestigationalTarget
DB06530ResiquimodSmall Molecule144875-48-9InvestigationalTarget
ID Drug Name Action PubMed
D000395Air Pollutants, Occupational"Air Pollutants, Occupational results in decreased expression of TLR8 mRNA"23195993
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of TLR8 mRNA24449571
D001151ArsenicArsenic results in decreased expression of TLR8 mRNA27838757
D004958EstradiolEstradiol results in increased expression of TLR8 mRNA19484750
D003976DiazinonDiazinon results in increased methylation of TLR8 gene22964155
D004041Dietary FatsDietary Fats results in increased expression of TLR8 mRNA23409006
D004041Dietary FatsDietary Fats results in decreased expression of TLR8 mRNA21852083
D005038EthylnitrosoureaEthylnitrosourea results in increased mutagenesis of TLR8 mRNA27776689
C039281furanfuran results in increased expression of TLR8 mRNA27387713
C546771gardiquimodgardiquimod results in increased expression of TLR8 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR8 mRNA]28003376
C056493imiquimodimiquimod binds to and results in increased activity of TLR8 protein18067624|2187852
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR8 mRNA25613284
C008261lead acetatelead acetate results in increased expression of TLR8 mRNA20542052
D008043Linseed OilLinseed Oil results in increased expression of TLR8 mRNA23409006
C433788lipopolysaccharide, E. coli O26-B6"lipopolysaccharide, E. coli O26-B6 results in increased expression of TLR8 mRNA"23090859
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of TLR8 mRNA25890327
C013592mangiferinmangiferin results in decreased expression of TLR8 mRNA15135318
D009532NickelNickel results in decreased expression of TLR8 mRNA23195993
D009532NickelNickel results in increased expression of TLR8 mRNA24768652|2558310
D011192Potassium DichromatePotassium Dichromate results in decreased expression of TLR8 mRNA23608068
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of TLR8 mRNA]28003376
C037219quinolinequinoline analog results in increased phosphorylation of and results in increased activity of TLR8 protein17868034
C402365resiquimodresiquimod binds to TLR8 protein15851485
C059514resveratrolresveratrol results in decreased expression of TLR8 mRNA23419489
C017947sodium arsenitesodium arsenite results in increased expression of TLR8 mRNA17879257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of TLR8 mRNA26377647
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of TLR8 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of TLR8 mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of TLR8 mRNA23409001
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of TLR8 mRNA20133372

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IDA16123302  
GO:0003723RNA binding-TAS16123302  
GO:0003725double-stranded RNA binding-IDA16111635  
GO:0003727single-stranded RNA binding-IDA14976262  24942581  
GO:0004888transmembrane signaling receptor activity-IEA-  
GO:0008144drug binding-IEA-  
GO:0008329signaling pattern recognition receptor activity-IBA21873635  
GO:0038023signaling receptor activity-NAS12032557  
GO ID GO Term Qualifier Evidence PubMed
GO:0001774microglial cell activation-IEA-  
GO:0001932regulation of protein phosphorylation-IEA-  
GO:0002224toll-like receptor signaling pathway-IBA21873635  
GO:0002224toll-like receptor signaling pathway-TAS-  
GO:0002755MyD88-dependent toll-like receptor signaling pathway-IEA-  
GO:0006955immune response-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IBA21873635  
GO:0007249I-kappaB kinase/NF-kappaB signaling-IDA12032557  
GO:0009615response to virus-IDA12032557  
GO:0016064immunoglobulin mediated immune response-TAS16123302  
GO:0032755positive regulation of interleukin-6 production-IBA21873635  
GO:0034158toll-like receptor 8 signaling pathway-IDA24942581  
GO:0034162toll-like receptor 9 signaling pathway-TAS-  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IBA21873635  
GO:0045078positive regulation of interferon-gamma biosynthetic process-IDA16286015  
GO:0045087innate immune response-NAS12032557  
GO:0045089positive regulation of innate immune response-IDA16123302  
GO:0045356positive regulation of interferon-alpha biosynthetic process-IDA16286015  
GO:0045359positive regulation of interferon-beta biosynthetic process-IBA21873635  
GO:0045359positive regulation of interferon-beta biosynthetic process-IDA16286015  
GO:0045416positive regulation of interleukin-8 biosynthetic process-IBA21873635  
GO:0045416positive regulation of interleukin-8 biosynthetic process-IMP16188996  
GO:0050718positive regulation of interleukin-1 beta secretion-IDA24942581  
GO:0051607defense response to virus-IBA21873635  
GO:0051607defense response to virus-IMP16188996  
GO:0071260cellular response to mechanical stimulus-IEP19593445  
GO:2000778positive regulation of interleukin-6 secretion-IDA24942581  
GO:2001183negative regulation of interleukin-12 secretion-IDA24942581  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0005886plasma membrane-IBA21873635  
GO:0009897external side of plasma membrane-IDA24942581  
GO:0010008endosome membrane-TAS-  
GO:0036020endolysosome membrane-TAS-  
KEGG ID KEGG Term
hsa04620Toll-like receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1679131Trafficking and processing of endosomal TLRTAS
R-HSA-168138Toll Like Receptor 9 (TLR9) CascadeTAS
R-HSA-168181Toll Like Receptor 7/8 (TLR7/8) CascadeTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-168898Toll-Like Receptors CascadesTAS
R-HSA-975110TRAF6 mediated IRF7 activation in TLR7/8 or 9 signalingTAS
R-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activationTAS
R-HSA-975155MyD88 dependent cascade initiated on endosomeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25346143Expression of nucleic acid-sensing Toll-like receptors predicts HPV16 clearance associated with an E6-directed cell-mediated response. (2015 May 15)Scott MEInt J Cancer
23497334Smoking decreases the response of human lung macrophages to double-stranded RNA by reducing TLR3 expression. (2013 Mar 9)Todt JCRespir Res