Gene: PHF21A

51317
BHC80|BM-006
PHD finger protein 21A
protein-coding
11p11.2
Ensembl:ENSG00000135365 MIM:608325 Vega:OTTHUMG00000167038 UniprotKB:Q96BD5
NC_000011.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.379e-1 (AD)  3.327e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs11038720chr11:45947110 (GRCh38.p7)A>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PHF20.88
CASC30.873
RNF1140.869
WWC30.852
FNBP10.842
SGPL10.833
PRPF38B0.828
LSM14A0.828
ABL10.827
PGPEP10.826

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.654
OR4F5-0.611
CRH-0.331
HAPLN1-0.3
NMU-0.28
OSTN-0.277
VIP-0.267
KRT5-0.26
IGF1-0.257
PRLHR-0.257

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of PHF21A mRNA"19114083
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PHF21A mRNA19191707
D000082AcetaminophenAcetaminophen affects the expression of PHF21A mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PHF21A mRNA19770486
C006632arsenic trioxidearsenic trioxide results in increased expression of PHF21A mRNA20458559|2252195
D001280AtrazineAtrazine results in decreased expression of PHF21A mRNA22982499
C547126AZM551248AZM551248 results in decreased expression of PHF21A mRNA22323515
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PHF21A mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PHF21A mRNA27858113
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PHF21A mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PHF21A mRNA19770486
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PHF21A mRNA20504355
C006780bisphenol Abisphenol A results in increased expression of PHF21A mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of PHF21A mRNA26079696
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in decreased expression of PHF21A mRNA27858113
D002922CiguatoxinsCiguatoxins affects the expression of PHF21A mRNA18353800
C018021cobaltous chloridecobaltous chloride results in increased expression of PHF21A mRNA17553155
D019327Copper SulfateCopper Sulfate results in increased expression of PHF21A mRNA19549813
D004726EndosulfanEndosulfan results in increased expression of PHF21A mRNA26615145
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of PHF21A mRNA23649840
D008558MelphalanMelphalan results in decreased expression of PHF21A mRNA22363485
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PHF21A mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PHF21A mRNA"26251327
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of PHF21A mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PHF21A mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PHF21A mRNA"25554681
D009538NicotineNicotine results in increased expression of PHF21A mRNA16949557
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of PHF21A mRNA25729387
C045950propiconazolepropiconazole results in decreased expression of PHF21A mRNA21278054
C009277sodium arsenatesodium arsenate results in decreased expression of PHF21A mRNA21795629
C009277sodium arsenatesodium arsenate results in increased expression of PHF21A mRNA21795629
C017947sodium arsenitesodium arsenite results in decreased expression of PHF21A mRNA28595984
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF21A mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PHF21A mRNA22298810
D013849ThimerosalThimerosal results in decreased expression of PHF21A mRNA27188386
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of PHF21A mRNA25729387
D019772TopotecanTopotecan results in decreased expression of PHF21A mRNA25729387
D014212TretinoinTretinoin results in increased expression of PHF21A mRNA23724009
C057693troglitazonetroglitazone results in decreased expression of PHF21A mRNA28973697
D014520UrethaneUrethane results in increased expression of PHF21A mRNA28818685
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PHF21A gene25560391
D024483Vitamin K 3Vitamin K 3 results in decreased expression of PHF21A mRNA25270620
C111237vorinostatvorinostat results in decreased expression of PHF21A mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004407histone deacetylase activity-TAS-  
GO:0005515protein binding-IPI25416956  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006351transcription, DNA-templated-IEA-  
GO:0007596blood coagulation-TAS-  
GO:0016575histone deacetylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000118histone deacetylase complex-IBA21873635  
GO:0000118histone deacetylase complex-IDA15325272  
GO:0005654nucleoplasm-TAS-  
GO:1990391DNA repair complex-IDA24217620  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-3214815HDACs deacetylate histonesTAS
R-HSA-3247509Chromatin modifying enzymesTAS
R-HSA-4839726Chromatin organizationTAS
R-HSA-983231Factors involved in megakaryocyte development and platelet productionTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal