Gene: PDCD1

5133
CD279|PD-1|PD1|SLEB2|hPD-1|hPD-l|hSLE1
programmed cell death 1
protein-coding
2q37.3
Ensembl:ENSG00000188389 MIM:600244 Vega:OTTHUMG00000151342 UniprotKB:Q15116
NG_012110.1
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.189e-1 (AD)  1.810e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF8780.721
SLC30A20.711
MMP190.704
CCL200.7
GCH10.66
SPHK10.655
MEX3A0.654
TCF230.638
C11orf910.633
ACCSL0.631

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNA2-0.352
B3GALT2-0.322
RAB37-0.316
OMG-0.313
EXTL1-0.313
SLITRK1-0.312
PEX5L-0.31
NEUROD2-0.308
SLC24A2-0.305
EIF4E1B-0.304

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB05916CT-011BiotechDrug-InvestigationalTarget
DB09035NivolumabBiotechDrug946414-94-4ApprovedTarget
DB09037PembrolizumabBiotechDrug1374853-91-4ApprovedTarget
ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of PDCD1 mRNA"20816883
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of PDCD1 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PDCD1 mRNA]17585979
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PDCD1 mRNA21298039
D001149Arsenates[Atrazine co-treated with Arsenates] results in increased expression of PDCD1 mRNA18585445
D001280Atrazine[Atrazine co-treated with Arsenates] results in increased expression of PDCD1 mRNA18585445
C547126AZM551248AZM551248 results in decreased expression of PDCD1 mRNA22323515
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PDCD1 promoter]19654925
C006780bisphenol Abisphenol A results in decreased expression of PDCD1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDCD1 mRNA15501611
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of PDCD1 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of PDCD1 mRNA]17585979
C007262deoxynivalenoldeoxynivalenol results in increased expression of PDCD1 mRNA27757495
D064730DexrazoxaneDexrazoxane results in decreased expression of PDCD1 mRNA26873546
D064730Dexrazoxane[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of PDCD1 mRNA26873546
D003976DiazinonDiazinon affects the expression of PDCD1 mRNA22546817
D004317Doxorubicin[Doxorubicin co-treated with Dexrazoxane] results in decreased expression of PDCD1 mRNA26873546
D004317DoxorubicinDoxorubicin results in increased expression of PDCD1 mRNA26873546
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PDCD1 mRNA17555576
D015025ZearalenoneZearalenone results in increased expression of PDCD1 mRNA27757495
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDCD1 mRNA23086925|2675264
D007854LeadLead results in increased expression of PDCD1 mRNA19921347
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDCD1 mRNA10975854
D058185Magnetite Nanoparticles[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PDCD1 mRNA21641980
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PDCD1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDCD1 mRNA"25554681
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDCD1 mRNA19710929
D010936Plant ExtractsPlant Extracts results in decreased expression of PDCD1 mRNA23557933
D053260SootSoot results in increased expression of PDCD1 mRNA26551751
D004113Succimer[Succimer binds to Magnetite Nanoparticles] which results in increased expression of PDCD1 mRNA21641980
D013629TamoxifenTamoxifen affects the expression of PDCD1 mRNA17555576
C009495titanium dioxidetitanium dioxide results in increased expression of PDCD1 mRNA23557971|2776080
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of PDCD1 mRNA19042947
D014635Valproic AcidValproic Acid results in increased methylation of PDCD1 gene29154799

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15240681  17489864  21982860  26602187  28046066  
GO ID GO Term Qualifier Evidence PubMed
GO:0002644negative regulation of tolerance induction-IEA-  
GO:0006915apoptotic process-IEA-  
GO:0006959humoral immune response-TAS9332365  
GO:0007275multicellular organism development-TAS9332365  
GO:0031295T cell costimulation-TAS-  
GO:0043066negative regulation of apoptotic process-IEA-  
GO:0070234positive regulation of T cell apoptotic process-IDA25281059  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-TAS-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa04514Cell adhesion molecules (CAMs)
hsa04660T cell receptor signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-388841Costimulation by the CD28 familyTAS
R-HSA-389948PD-1 signalingTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29437869Integrative analysis of exogenous, endogenous, tumour and immune factors for precision medicine. (2018 Jun)Ogino SGut
26134222Association of PDCD1 and CTLA-4 Gene Expression with Clinicopathological Factors and Survival in Non-Small-Cell Lung Cancer: Results from a Large and Pooled Microarray Database. (2015 Jul)Deng LJ Thorac Oncol