Gene: SPTBN5

51332
BSPECV|HUBSPECV|HUSPECV
spectrin beta, non-erythrocytic 5
protein-coding
15q15.1
Ensembl:ENSG00000137877 MIM:605916 Vega:OTTHUMG00000172720 UniprotKB:Q9NRC6
NC_000015.10
PubMed|SNP Mapped
1   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.001e-2 (AD)  3.844e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1197701chr15:41895294 (GRCh38.p7)T>C / T>Gnicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF6920.659
ANKS60.657
FEZF20.654
CDH240.64
CROCC0.634
CEP1640.633
NTNG20.627
OSBPL70.626
MICAL30.626
NEIL10.625

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SLC40A1-0.343
PTGFR-0.333
NR2F2-0.32
RGS22-0.32
ACADL-0.311
THSD7A-0.306
MEI4-0.296
NDNF-0.294
GCNT2-0.29
RBMS3-0.283

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of SPTBN5 mRNA"21346803
D000082AcetaminophenAcetaminophen results in increased expression of SPTBN5 mRNA29067470
C006780bisphenol Abisphenol A results in decreased expression of SPTBN5 mRNA25181051
C018475butyraldehydebutyraldehyde results in increased expression of SPTBN5 mRNA26079696
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of SPTBN5 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of SPTBN5 mRNA27392435
C004312glycidolglycidol results in increased expression of SPTBN5 mRNA24915197
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of SPTBN5 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of SPTBN5 mRNA27392435
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of SPTBN5 mRNA22401849
D011441PropylthiouracilPropylthiouracil results in decreased expression of SPTBN5 mRNA24780913
D014635Valproic AcidValproic Acid results in increased methylation of SPTBN5 gene29154799
D014810Vitamin EVitamin E results in decreased expression of SPTBN5 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003779actin binding-NAS10764729  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0019894kinesin binding-IBA21873635  
GO:0019894kinesin binding-IDA23704327  
GO:0030507spectrin binding-IBA21873635  
GO:0030507spectrin binding-IDA23704327  
GO:0032029myosin tail binding-IBA21873635  
GO:0032029myosin tail binding-IDA23704327  
GO:0034452dynactin binding-IBA21873635  
GO:0034452dynactin binding-IDA23704327  
GO:0043621protein self-association-IDA23704327  
GO:0045505dynein intermediate chain binding-IBA21873635  
GO:0045505dynein intermediate chain binding-IDA23704327  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0006888ER to Golgi vesicle-mediated transport-TAS-  
GO:0007030Golgi organization-IBA21873635  
GO:0007030Golgi organization-IMP23704327  
GO:0007041lysosomal transport-IBA21873635  
GO:0007041lysosomal transport-IMP23704327  
GO:0007411axon guidance-TAS-  
GO:0030036actin cytoskeleton organization-IBA21873635  
GO:0030036actin cytoskeleton organization-NAS10764729  
GO:0051260protein homooligomerization-IDA23704327  
GO:0051693actin filament capping-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA23704327  
GO:0005815microtubule organizing center-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0008091spectrin-NAS10764729  
GO:0016020membrane-NAS10764729  
GO:0031941filamentous actin-IBA21873635  
GO:0032391photoreceptor connecting cilium-IBA21873635  
GO:0032391photoreceptor connecting cilium-IDA23704327  
GO:0097381photoreceptor disc membrane-IBA21873635  
GO:0097381photoreceptor disc membrane-IDA23704327  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-162582Signal TransductionTAS
R-HSA-199977ER to Golgi Anterograde TransportTAS
R-HSA-199991Membrane TraffickingTAS
R-HSA-373760L1CAM interactionsTAS
R-HSA-373760L1CAM interactionsIEA
R-HSA-375165NCAM signaling for neurite out-growthTAS
R-HSA-375165NCAM signaling for neurite out-growthIEA
R-HSA-392499Metabolism of proteinsTAS
R-HSA-422475Axon guidanceTAS
R-HSA-422475Axon guidanceIEA
R-HSA-445095Interaction between L1 and AnkyrinsTAS
R-HSA-445095Interaction between L1 and AnkyrinsIEA
R-HSA-446203Asparagine N-linked glycosylationTAS
R-HSA-5653656Vesicle-mediated transportTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-6807878COPI-mediated anterograde transportTAS
R-HSA-948021Transport to the Golgi and subsequent modificationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28559012Establishment and characterization of an oral tongue squamous cell carcinoma cell line from a never-smoking patient. (2017 Jun)Wang SJOral Oncol