Gene: PRR16

51334
DSC54|LARGEN
proline rich 16
protein-coding
5q23.1
Ensembl:ENSG00000184838 MIM:615931 Vega:OTTHUMG00000128903 UniprotKB:Q569H4
NC_000005.10
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.815e-1 (AD)  4.086e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs300974chr5:120534068 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAM0.816
TBC1D90.811
RFK0.81
ZDBF20.807
PLXNC10.803
C5orf220.802
RNF1280.798
TMX40.798
CD2000.795
SNX100.795

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.474
HIGD1B-0.45
RHOD-0.419
ACOX2-0.398
MYOM1-0.393
RIN2-0.389
SYDE1-0.389
MTRNR2L10-0.382
EYA2-0.381
CPM-0.377

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of PRR16 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PRR16 gene27153756
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of PRR16 mRNA21298039
D001151ArsenicArsenic affects the methylation of PRR16 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of PRR16 mRNA26705709
C006632arsenic trioxidearsenic trioxide results in increased expression of PRR16 mRNA15761015
C015001arsenitearsenite results in increased methylation of PRR16 promoter23974009
D004958EstradiolEstradiol affects the expression of PRR16 mRNA22574217
C044887beta-methylcholinebeta-methylcholine affects the expression of PRR16 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of PRR16 mRNA25181051
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PRR16 mRNA20971185
D016572CyclosporineCyclosporine results in increased expression of PRR16 mRNA20106945
D003907DexamethasoneDexamethasone results in increased expression of PRR16 mRNA25136773
D004041Dietary FatsDietary Fats results in decreased expression of PRR16 mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of PRR16 mRNA21592394|2648566
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of PRR16 mRNA21592394
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PRR16 mRNA"22485181
C118739entinostatentinostat results in increased expression of PRR16 mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
D005492Folic AcidFolic Acid affects the expression of PRR16 mRNA17320366
C004312glycidolglycidol results in decreased expression of PRR16 mRNA24915197
D017313FenretinideFenretinide results in decreased expression of PRR16 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRR16 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PRR16 mRNA24796395
D007649KetamineKetamine results in decreased expression of PRR16 mRNA20080153
D018021Lithium ChlorideLithium Chloride results in decreased expression of PRR16 mRNA15711924
D009532NickelNickel results in increased expression of PRR16 mRNA24768652
C029938nickel sulfatenickel sulfate results in increased expression of PRR16 mRNA22714537
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PRR16 mRNA20971185
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PRR16 mRNA26272509
D010634PhenobarbitalPhenobarbital results in increased expression of PRR16 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRR16 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PRR16 mRNA26272509
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PRR16 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of PRR16 mRNA23811191
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PRR16 mRNA22714537
D011441PropylthiouracilPropylthiouracil affects the expression of PRR16 mRNA24780913
D012822Silicon DioxideSilicon Dioxide results in decreased expression of PRR16 mRNA25351596
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of PRR16 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of PRR16 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PRR16 mRNA26377647
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in decreased expression of PRR16 mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PRR16 mRNA26290441
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRR16 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of PRR16 mRNA22378314
D014212TretinoinTretinoin results in decreased expression of PRR16 mRNA21934132|2372400
C012589trichostatin Atrichostatin A results in increased expression of PRR16 mRNA24935251
D014415TunicamycinTunicamycin results in decreased expression of PRR16 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of PRR16 mRNA23179753
D014635Valproic AcidValproic Acid results in increased expression of PRR16 mRNA24383497|2493525

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI25416956  
GO ID GO Term Qualifier Evidence PubMed
GO:0045727positive regulation of translation-IDA24656129  
GO:0045793positive regulation of cell size-IDA24656129  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal