Gene: MS4A4A

51338
4SPAN1|CD20-L1|CD20L1|HDCME31P|MS4A4|MS4A7
membrane spanning 4-domains A4A
protein-coding
11q12.2
Ensembl:ENSG00000110079 MIM:606547 Vega:OTTHUMG00000154949 UniprotKB:Q96JQ5
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.768e-1 (AD)  1.556e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
MS4A70.927
TLR10.918
LAIR10.915
GPR650.913
PTPRC0.912
SLC7A70.911
SNX200.908
MSR10.902
MS4A6A0.902
ARL110.9

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KCNIP3-0.506
ATP2C2-0.494
CPLX3-0.466
WNT7A-0.45
CHRNA4-0.449
NEUROD6-0.432
TMEM179-0.431
HAGHL-0.427
ST6GAL2-0.425
FRMPD1-0.424

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of MS4A4A mRNA"23146750
D000082AcetaminophenAcetaminophen results in decreased expression of MS4A4A mRNA21420995
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of MS4A4A mRNA24449571
C030935benz(a)anthracenebenz(a)anthracene results in increased expression of MS4A4A mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in increased expression of MS4A4A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of MS4A4A mRNA20064835
D002392Catechin[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MS4A4A mRNA24763279
D019327Copper SulfateCopper Sulfate results in decreased expression of MS4A4A mRNA19549813
D004041Dietary FatsDietary Fats results in decreased expression of MS4A4A mRNA25016146
D002117CalcitriolCalcitriol results in decreased expression of MS4A4A mRNA26485663
C511402Grape Seed Proanthocyanidins[Catechin co-treated with Grape Seed Proanthocyanidins] results in decreased expression of MS4A4A mRNA24763279
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MS4A4A mRNA25613284
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of MS4A4A mRNA25613284
C523799MRK 003MS4A4A results in increased susceptibility to MRK 00319903844
D009532NickelNickel results in increased expression of MS4A4A mRNA24768652|2558310
C017947sodium arsenitesodium arsenite affects the methylation of MS4A4A gene28589171
D053260SootSoot results in increased expression of MS4A4A mRNA26551751
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of MS4A4A mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of MS4A4A mRNA23411599

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO ID GO Term Qualifier Evidence PubMed
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28199971Association and interaction effects of Alzheimer's disease-associated genes and lifestyle on cognitive aging in older adults in a Taiwanese population. (2017 Apr 11)Lin EOncotarget