Gene: KRT76

51350
HUMCYT2A|KRT2B|KRT2P
keratin 76
protein-coding
12q13.13
Ensembl:ENSG00000185069 MIM:616671 Vega:OTTHUMG00000169797 UniprotKB:Q01546
NG_012420.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.755e-1 (AD)  5.665e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7397684chr12:52779289 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR2AP10.777
OR9G40.765
PRAMEF180.758
OR2B20.753
OR52K10.75
CSH10.744
OR5K40.743
TMCO5A0.736
OR4K170.735
OR10K20.731

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM221-0.275
MMP15-0.271
HSPB2-0.271
SLC1A4-0.27
GPT-0.263
TM7SF2-0.26
C17orf50-0.256
C9orf24-0.253
C1orf53-0.252
SORCS2-0.25

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of KRT76 gene27153756
C547126AZM551248AZM551248 results in decreased expression of KRT76 mRNA22323515
C006780bisphenol Abisphenol A results in increased methylation of KRT76 promoter27312807
C006780bisphenol Abisphenol A results in decreased expression of KRT76 mRNA25181051
D003300CopperCopper deficiency results in increased expression of KRT76 mRNA26033743
D019422Dietary SucroseDietary Sucrose results in increased expression of KRT76 mRNA26033743
C039281furanfuran results in increased expression of KRT76 mRNA25539665
C028577monobutyl phthalatemonobutyl phthalate results in decreased expression of KRT76 protein20553848
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of KRT76 protein26178269
C059514resveratrolresveratrol results in decreased expression of KRT76 protein25505154
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of KRT76 mRNA27404394

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005198structural molecule activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007010cytoskeleton organization-NAS1282112  
GO:0031424keratinization-TAS-  
GO:0043473pigmentation-IEA-  
GO:0048733sebaceous gland development-IEA-  
GO:0070268cornification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005829cytosol-TAS-  
GO:0005882intermediate filament-NAS1282112  
GO:0045095keratin filament-IEA-  
GO:0070062extracellular exosome-HDA23533145  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-6805567KeratinizationTAS
R-HSA-6809371Formation of the cornified envelopeTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

There is no Interaction data for this gene.

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal