Gene: PDE2A

5138
CGS-PDE|PDE2A1|PED2A4|cGSPDE
phosphodiesterase 2A
protein-coding
11q13.4
Ensembl:ENSG00000186642 MIM:602658 Vega:OTTHUMG00000102045 UniprotKB:O00408
NC_000011.10
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.959e-1 (AD)  1.903e-2 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg20179907chr11:72336908PDE2A6.430e-8Maternal smoking in pregnancy27040690

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAPGEFL10.951
SYT70.947
IQSEC20.947
C1orf1150.945
CAMKK20.945
ATCAY0.944
LINGO10.944
SCAMP50.941
PGBD50.94
PRRT20.939

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.596
OR4F29-0.554
SNHG18-0.481
ZNF114-0.471
HEY2-0.453
C9orf135-0.45
REST-0.447
WWTR1-0.444
DNAI2-0.443
MARCH3-0.442

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PDE2A mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PDE2A mRNA"19114083
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one results in decreased activity of PDE2A protein"22947663
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one binds to PDE2A protein"23899287
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [PDE2A protein results in increased hydrolysis of Cyclic GMP]"19684253
C5391422-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one results in decreased activity of PDE2A protein"16621444|1904934
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of PDE2A mRNA"28973690
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE2A mRNA"27188386
C0999774,5-dimethoxy-2-nitrobenzyl-8-bromo-cAMP"PDE2A protein inhibits the reaction [4,5-dimethoxy-2-nitrobenzyl-8-bromo-cAMP affects the localization of AHR protein]"17329248
C439285(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride(5-fluoro-2-methyl-1-(4-pyridyl)methylene-3-(N-benzyl)-indene)-acetamide hydrochloride binds to and results in decreased activity of PDE2A protein11602670
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE2A mRNA"27188386
C0101929-(2-hydroxy-3-nonyl)adenine9-(2-hydroxy-3-nonyl)adenine inhibits the reaction [PDE2A protein results in increased hydrolysis of Cyclic GMP]19684253
C0101929-(2-hydroxy-3-nonyl)adenine9-(2-hydroxy-3-nonyl)adenine results in decreased activity of PDE2A protein16621444|1904934
D000082AcetaminophenAcetaminophen results in decreased expression of PDE2A mRNA26690555
D020106AcrylamideAcrylamide results in decreased expression of PDE2A mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDE2A mRNA21641981|2210060
D000447AldehydesAldehydes results in increased expression of PDE2A mRNA25014914
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDE2A mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDE2A mRNA20458559
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of PDE2A mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene promotes the reaction [AHR protein binds to PDE2A promoter]19654925
C095105bexarotenebexarotene results in decreased expression of PDE2A mRNA16648578
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of PDE2A mRNA27685785
C006780bisphenol Abisphenol A results in decreased methylation of PDE2A promoter27312807
C006780bisphenol Abisphenol A results in increased methylation of PDE2A promoter27312807
C006780bisphenol Abisphenol A results in increased expression of PDE2A mRNA25181051
D0151248-Bromo Cyclic Adenosine Monophosphate8-Bromo Cyclic Adenosine Monophosphate results in decreased expression of PDE2A mRNA22079614
C018475butyraldehydebutyraldehyde results in increased expression of PDE2A mRNA26079696
D002211CapsaicinCapsaicin results in decreased expression of PDE2A mRNA20349343
D002220CarbamazepineCarbamazepine affects the expression of PDE2A mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PDE2A protein12629582
D002995Clofibric Acid[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDE2A mRNA17602206
D005576ColforsinPDE2A protein inhibits the reaction [Colforsin affects the localization of AHR protein]17329248
D019327Copper SulfateCopper Sulfate results in increased expression of PDE2A mRNA19549813
D003345CorticosteroneCorticosterone results in increased expression of PDE2A mRNA22850435
D003345CorticosteroneCorticosterone results in increased expression of PDE2A mRNA alternative form22850435
D003345CorticosteroneCorticosterone results in increased expression of PDE2A protein22850435
D003345CorticosteroneMifepristone inhibits the reaction [Corticosterone results in increased expression of PDE2A protein]22850435
D003345CorticosteroneCorticosterone results in increased expression of PDE2A protein22850435
D003345CorticosteroneMifepristone inhibits the reaction [Corticosterone results in increased expression of PDE2A protein]22850435
D016572CyclosporineCyclosporine results in increased expression of PDE2A mRNA25562108|2798913
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDE2A mRNA21266533
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Clofibric Acid] affects the expression of PDE2A mRNA17602206
D002117CalcitriolCalcitriol results in increased expression of PDE2A mRNA16002434
D004237DiuronDiuron results in increased expression of PDE2A mRNA21551480
D005047EtoposideEtoposide results in decreased expression of PDE2A mRNA25270620
C082360fipronilfipronil results in increased expression of PDE2A mRNA23962444
D005557FormaldehydeFormaldehyde results in decreased expression of PDE2A mRNA28937961
D006152Cyclic GMP"2-(3,4-dimethoxybenzyl)-7-(1-(1-hydroxyethyl)-4-phenylbutyl)-5-methylimidazo(5,1-f)(1,2,4)triazin-4 (3H)-one inhibits the reaction [PDE2A protein results in increased hydrolysis of Cyclic GMP]"19684253
D006152Cyclic GMP9-(2-hydroxy-3-nonyl)adenine inhibits the reaction [PDE2A protein results in increased hydrolysis of Cyclic GMP]19684253
D006152Cyclic GMPPDE2A protein results in increased hydrolysis of Cyclic GMP19684253
C045463leflunomideleflunomide results in increased expression of PDE2A mRNA24136188
D008694MethamphetamineMethamphetamine results in increased expression of PDE2A mRNA26307267
D008694MethamphetamineMethamphetamine results in increased methylation of PDE2A promoter26307267
D008731MethoxychlorMethoxychlor results in increased methylation of PDE2A gene23303685
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDE2A mRNA28001369
D015735MifepristoneMifepristone inhibits the reaction [Corticosterone results in increased expression of PDE2A protein]22850435
D015735MifepristoneMifepristone inhibits the reaction [Corticosterone results in increased expression of PDE2A protein]22850435
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDE2A mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDE2A mRNA"25554681
C051752nefazodonenefazodone results in decreased expression of PDE2A mRNA24136188
D009532NickelNickel results in decreased expression of PDE2A mRNA24768652|2558310
C007350nitrofennitrofen results in increased expression of PDE2A protein20196107
D005996NitroglycerinNitroglycerin results in increased expression of PDE2A mRNA12102619
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PDE2A mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PDE2A mRNA25729387
D010100OxygenOxygen deficiency results in decreased expression of PDE2A mRNA24899690
D010100OxygenOxygen deficiency results in decreased expression of PDE2A protein24899690
C046012pentanalpentanal results in increased expression of PDE2A mRNA26079696
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of PDE2A mRNA19162173
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDE2A mRNA19162173
C551178PF-04254644PF-04254644 results in decreased activity of PDE2A protein20231546
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in decreased expression of PDE2A mRNA]19482888
D010634PhenobarbitalPhenobarbital results in decreased expression of PDE2A mRNA19482888
C006253pirinixic acidpirinixic acid results in increased expression of PDE2A mRNA19162173
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PDE2A mRNA19162173
C045950propiconazolepropiconazole results in decreased expression of PDE2A mRNA21278054
C005556propionaldehydepropionaldehyde results in increased expression of PDE2A mRNA26079696
D011441PropylthiouracilPropylthiouracil results in decreased expression of PDE2A mRNA24780913
C502851quinocetonequinocetone results in increased expression of PDE2A mRNA27046791
C059514resveratrolresveratrol results in decreased expression of PDE2A mRNA12002526|1256957
C078903seocalcitolseocalcitol results in increased expression of PDE2A mRNA12040012
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of PDE2A mRNA25895662
D012834SilverSilver results in decreased expression of PDE2A mRNA27131904
C025463sulindac sulfonesulindac sulfone binds to and results in decreased activity of PDE2A protein11602670
C025463sulindac sulfonesulindac sulfone results in decreased activity of PDE2A protein10910034
D013629TamoxifenTamoxifen affects the expression of PDE2A mRNA20937368
D013749TetrachlorodibenzodioxinPDE2A protein inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of AHR protein]17329248
D013749TetrachlorodibenzodioxinPDE2A protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]17329248
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE2A mRNA21570461|2637764
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin binds to AHR protein] which results in increased expression of PDE2A mRNA16214954
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDE2A mRNA18796159
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDE2A mRNA21215274
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDE2A mRNA18796159|2121527
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDE2A mRNA28111298
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PDE2A mRNA25729387
D019772TopotecanTopotecan results in increased expression of PDE2A mRNA25729387
D014212TretinoinTretinoin results in decreased expression of PDE2A mRNA23724009
D014212TretinoinTretinoin results in increased expression of PDE2A mRNA20488242
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PDE2A mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of PDE2A mRNA28973697
D014635Valproic AcidValproic Acid affects the expression of PDE2A mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDE2A mRNA23527032
D014635Valproic AcidValproic Acid results in increased expression of PDE2A mRNA28001369
C025643vinclozolinvinclozolin results in increased expression of PDE2A mRNA23034163
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE2A mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PDE2A mRNA26272509
D015054ZymosanZymosan results in increased expression of PDE2A mRNA24758774
D015054ZymosanZymosan results in increased expression of PDE2A protein24758774

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004112cyclic-nucleotide phosphodiesterase activity-IDA15938621  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0004118cGMP-stimulated cyclic-nucleotide phosphodiesterase activity-IDA17329248  19689430  
GO:0005262calcium channel activity-TAS10375378  
GO:0005515protein binding-IPI17329248  
GO:0008144drug binding-IDA15938621  
GO:0008144drug binding-IPI15938621  
GO:0030552cAMP binding-IMP15938621  
GO:0030553cGMP binding-IDA17329248  19689430  19828435  
GO:0030553cGMP binding-IMP15938621  
GO:0030911TPR domain binding-IPI17329248  
GO:0042803protein homodimerization activity-IPI19828435  
GO:0046872metal ion binding-IEA-  
GO:00475553',5'-cyclic-GMP phosphodiesterase activity-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000122negative regulation of transcription by RNA polymerase II-IDA17329248  
GO:0006198cAMP catabolic process-IDA15938621  17704206  
GO:0006198cAMP catabolic process-IMP19252089  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0019933cAMP-mediated signaling-IMP17704206  
GO:0019934cGMP-mediated signaling-IMP17704206  
GO:0033159negative regulation of protein import into nucleus, translocation-IDA17329248  
GO:0035690cellular response to drug-IMP15938621  
GO:0036006cellular response to macrophage colony-stimulating factor stimulus-IDA14687666  
GO:0043116negative regulation of vascular permeability-IMP17704206  
GO:0043117positive regulation of vascular permeability-IMP17704206  
GO:0043951negative regulation of cAMP-mediated signaling-IDA17329248  
GO:0046069cGMP catabolic process-IDA15938621  19828435  
GO:0050729positive regulation of inflammatory response-ISS-  
GO:0061028establishment of endothelial barrier-ISS-  
GO:0070588calcium ion transmembrane transport-IEA-  
GO:0071260cellular response to mechanical stimulus-ISS-  
GO:0071320cellular response to cAMP-IDA17329248  
GO:0071321cellular response to cGMP-IDA17704206  19828435  
GO:0071560cellular response to transforming growth factor beta stimulus-IEP17704206  
GO:1904613cellular response to 2,3,7,8-tetrachlorodibenzodioxine-IDA17329248  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA10375378  
GO:0005737cytoplasm-IDA10375378  19506089  
GO:0005741mitochondrial outer membrane-IDA28463107  
GO:0005743mitochondrial inner membrane-IDA28463107  
GO:0005759mitochondrial matrix-IEA-  
GO:0005783endoplasmic reticulum-ISS-  
GO:0005794Golgi apparatus-ISS-  
GO:0005829cytosol-IDA17329248  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA19252089  
GO:0005886plasma membranecolocalizes_withIDA17329248  
GO:0042734presynaptic membrane-ISS-  
GO:0048471perinuclear region of cytoplasm-IDA10375378  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-162582Signal TransductionTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-392154Nitric oxide stimulates guanylate cyclaseTAS
R-HSA-418346Platelet homeostasisTAS
R-HSA-418457cGMP effectsTAS
R-HSA-418555G alpha (s) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23577190PADI4 and HLA-DRB1 are genetic risks for radiographic progression in RA patients, independent of ACPA status: results from the IORRA cohort study. (2013)Suzuki TPLoS One