Gene: CSAD

51380
CSD|PCAP
cysteine sulfinic acid decarboxylase
protein-coding
12q13.13
Ensembl:ENSG00000139631 MIM:616569 Vega:OTTHUMG00000048076 UniprotKB:Q9Y600
NG_030036.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.740e-2 (AD)  1.296e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RBM50.928
POGZ0.925
MAU20.915
ANKZF10.909
CCNL20.907
CLK20.906
HDAC60.903
INTS30.903
LENG80.903
PLA2G4B0.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.559
OR4F29-0.53
KLRC2-0.269
MTRNR2L9-0.259
MTRNR2L6-0.258
MTRNR2L10-0.254
TRDN-0.252
OR4F16-0.237
TTLL10-0.227
TTLL10-AS1-0.219

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00114Pyridoxal PhosphateSmall Molecule54-47-7Approved|Investigational|NutraceuticalTarget
DB00151L-CysteineSmall Molecule52-90-4Approved|NutraceuticalTarget
ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of CSAD mRNA"27413110|2890350
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CSAD mRNA"21354444
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran results in decreased expression of CSAD mRNA"25768209
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CSAD mRNA"21346803
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of CSAD mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CSAD mRNA17562736
D020106AcrylamideAcrylamide results in decreased expression of CSAD mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CSAD mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of CSAD mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin analog results in increased expression of CSAD protein26597043
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of CSAD protein26597043
D000643Ammonium ChlorideAmmonium Chloride affects the expression of CSAD mRNA16483693
D001151ArsenicArsenic affects the methylation of CSAD gene25304211
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of CSAD mRNA26377693
C022921benzo(k)fluoranthenebenzo(k)fluoranthene results in decreased expression of CSAD mRNA26377693
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of CSAD mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of CSAD mRNA19770486
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CSAD mRNA28628672
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CSAD mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of CSAD mRNA25181051
C032036bromobenzenebromobenzene results in increased expression of CSAD mRNA12628495
D002104CadmiumCadmium results in increased expression of CSAD mRNA24084258
D019256Cadmium ChlorideCadmium Chloride results in increased expression of CSAD mRNA26472689
C459604candoxincandoxin results in decreased expression of CSAD mRNA16309724
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of CSAD mRNA17484886|2733941
D002994ClofibrateClofibrate results in increased expression of CSAD mRNA23811191
D003042CocaineCocaine affects the expression of CSAD mRNA20187946
D003042CocaineCocaine results in decreased expression of CSAD protein25100957
C030123coumarincoumarin results in decreased expression of CSAD mRNA18480146
D003471CuprizoneCuprizone results in decreased expression of CSAD mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of CSAD mRNA20106945|2556210
D016572CyclosporineCyclosporine results in decreased expression of CSAD mRNA19770486
D003545CysteineCSAD protein results in increased metabolism of Cysteine23665415
D003907DexamethasoneDexamethasone results in increased expression of CSAD mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CSAD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CSAD mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CSAD mRNA28628672
D004041Dietary FatsDietary Fats affects the expression of CSAD mRNA19680557
D004041Dietary Fats[Dietary Fats co-treated with Quercetin] affects the expression of CSAD mRNA25047408
D004041Dietary FatsDietary Fats results in decreased expression of CSAD mRNA15238619|1804283
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in increased expression of CSAD mRNA19850644
D004051Diethylhexyl PhthalatePPARA protein promotes the reaction [Diethylhexyl Phthalate results in increased expression of CSAD mRNA]19850644
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CSAD mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of CSAD mRNA24535843
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of CSAD mRNA17072980
C118739entinostatentinostat results in increased expression of CSAD mRNA27188386
D018120FinasterideFinasteride results in increased expression of CSAD mRNA24136188
C039281furanfuran results in decreased expression of CSAD mRNA24183702
C039281furanfuran results in decreased expression of CSAD mRNA26194646
C039281furanfuran results in increased methylation of CSAD gene22079235
D005839GentamicinsGentamicins results in decreased expression of CSAD protein22061828
C004312glycidolglycidol results in increased expression of CSAD mRNA24915197
D017313FenretinideFenretinide results in decreased expression of CSAD mRNA28973697
D006843Hydrocarbons, Chlorinated"Hydrocarbons, Chlorinated results in decreased expression of CSAD mRNA"18077114
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CSAD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CSAD mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CSAD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of CSAD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of CSAD mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of CSAD mRNA28628672
D007854LeadLead results in increased expression of CSAD mRNA19921347
D000069349LinezolidLinezolid results in decreased expression of CSAD mRNA21296123
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CSAD mRNA27339419
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CSAD mRNA26378955
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of CSAD mRNA18077114
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of CSAD mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of CSAD mRNA"20188158
C500085muraglitazarmuraglitazar results in increased expression of CSAD mRNA21515302
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CSAD mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of CSAD mRNA"25554681|2562005
D009281NaphthalenesNaphthalenes results in decreased expression of CSAD protein17337753
D009532NickelNickel results in decreased expression of CSAD mRNA25583101
C028007nickel monoxidenickel monoxide results in decreased expression of CSAD mRNA19167457
C012655nimesulidenimesulide results in decreased expression of CSAD mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of CSAD mRNA17616710
D000073878Palm OilPalm Oil affects the expression of CSAD mRNA19680557
D000073878Palm OilPalm Oil results in decreased expression of CSAD mRNA18042831
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of CSAD mRNA25868421
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of CSAD mRNA18281256
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in increased expression of CSAD mRNA24535843
D010634PhenobarbitalPhenobarbital results in decreased expression of CSAD mRNA19270015|1948288
D010634PhenobarbitalPhenobarbital results in decreased expression of CSAD mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of CSAD mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of CSAD mRNA18445702
C006253pirinixic acidpirinixic acid results in decreased expression of CSAD protein15226431
C006253pirinixic acidpirinixic acid results in increased expression of CSAD mRNA17426115|1830175
C006253pirinixic acidpirinixic acid results in increased expression of CSAD mRNA19162173
D017035PravastatinPravastatin results in decreased expression of CSAD mRNA27225895
D017035PravastatinPravastatin results in decreased expression of CSAD mRNA27225895
C045950propiconazolepropiconazole results in decreased expression of CSAD mRNA21278054
C015586propiverinepropiverine binds to CSAD protein29273565
D011441PropylthiouracilPropylthiouracil results in decreased expression of CSAD mRNA18077114|2478091
D011794Quercetin[Dietary Fats co-treated with Quercetin] affects the expression of CSAD mRNA25047408
D015125OxyquinolineOxyquinoline results in decreased expression of CSAD mRNA21632981
D012312RitodrineRitodrine results in decreased expression of CSAD mRNA23370008
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of CSAD mRNA26378955
D014284TriiodothyronineTriiodothyronine results in increased expression of CSAD mRNA15953391
C013698tallowtallow affects the expression of CSAD mRNA19680557
D013629TamoxifenTamoxifen affects the expression of CSAD mRNA20937368
D013629TamoxifenTamoxifen results in increased expression of CSAD mRNA25123088
C030141taurine-ursodeoxycholate conjugatetaurine-ursodeoxycholate conjugate inhibits the reaction [LEP gene mutant form results in decreased expression of CSAD mRNA]21079772
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of CSAD mRNA15885361
C501413tesaglitazartesaglitazar results in increased expression of CSAD mRNA21515302
D013739TestosteroneTestosterone results in increased expression of CSAD mRNA20844152|2166921
D013739TestosteroneCSAD mutant form results in decreased secretion of Testosterone19921479
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of CSAD mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CSAD mRNA21570461|2637764
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CSAD mRNA16891777|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of CSAD mRNA21724226
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of CSAD mRNA21215274
D013853ThioacetamideThioacetamide results in decreased expression of CSAD mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of CSAD mRNA23557971
C406224valdecoxibvaldecoxib results in decreased expression of CSAD mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of CSAD mRNA17292431|1796380
D014640VancomycinVancomycin results in increased expression of CSAD mRNA18930951
D014750VincristineVincristine results in decreased expression of CSAD mRNA23649840
C029297vinylidene chloridevinylidene chloride results in decreased expression of CSAD mRNA26682919

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004782sulfinoalanine decarboxylase activity-IEA-  
GO:0030170pyridoxal phosphate binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0019752carboxylic acid metabolic process-IEA-  
GO:0042412taurine biosynthetic process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa00430Taurine and hypotaurine metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismIEA
R-HSA-1614558Degradation of cysteine and homocysteineIEA
R-HSA-1614635Sulfur amino acid metabolismIEA
R-HSA-71291Metabolism of amino acids and derivativesIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
27401490Provincial alcohol index and its relationship to alcohol-related harm in Thailand: implications for subnational alcohol policy development. (2016 Jul 11)Chaiyasong SBMC Public Health