Gene: HEMK1

51409
HEMK|MTQ1
HemK methyltransferase family member 1
protein-coding
3p21.31
Ensembl:ENSG00000114735 Vega:OTTHUMG00000156849 UniprotKB:Q9Y5R4
NC_000003.12
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.721e-1 (AD)  8.245e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2232251chr3:50577559 (GRCh38.p7)T>C / T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
AAAS0.807
MKS10.8
ATF6B0.783
SLC25A290.782
RECQL50.781
AKT20.78
POLL0.777
CCS0.777
TMEM2340.777
FUK0.771

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.485
OR4F29-0.456
MTRNR2L6-0.284
IL36B-0.278
MTRNR2L9-0.267
C17orf112-0.266
MTRNR2L10-0.264
SLC26A7-0.259
CPA3-0.256
C10orf71-0.256

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in decreased expression of HEMK1 mRNA"20816883
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of HEMK1 mRNA"18648102
C0352074-amino-2,6-dinitrotoluene"4-amino-2,6-dinitrotoluene affects the expression of HEMK1 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of HEMK1 mRNA25064622
D000082AcetaminophenAcetaminophen affects the expression of HEMK1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of HEMK1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HEMK1 mRNA21641981
D000638AmiodaroneAmiodarone affects the expression of HEMK1 mRNA25064622
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of HEMK1 mRNA24449571
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of HEMK1 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HEMK1 mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of HEMK1 mRNA22300585
C006780bisphenol Abisphenol A results in increased expression of HEMK1 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of HEMK1 mRNA26079696
D002166CamptothecinHEMK1 mRNA results in decreased susceptibility to Camptothecin25269479
D002746ChlorpromazineChlorpromazine affects the expression of HEMK1 mRNA25064622
C018021cobaltous chloridecobaltous chloride results in decreased expression of HEMK1 mRNA19376846
D016572CyclosporineCyclosporine affects the expression of HEMK1 mRNA25064622
D016572CyclosporineCyclosporine results in increased expression of HEMK1 mRNA27989131
D003976DiazinonDiazinon results in increased methylation of HEMK1 gene22964155
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of HEMK1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in increased expression of HEMK1 mRNA27392435
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HEMK1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of HEMK1 mRNA25064622
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HEMK1 mRNA17942748
C039281furanfuran results in decreased methylation of HEMK1 gene22079235
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HEMK1 protein18951874
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HEMK1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in increased expression of HEMK1 mRNA27392435
C544151jinfukangjinfukang results in increased expression of HEMK1 mRNA27392435
D007854LeadLead results in decreased expression of HEMK1 mRNA19921347
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HEMK1 mRNA"25620056
D010269ParaquatParaquat affects the expression of HEMK1 mRNA25064622
C046012pentanalpentanal results in decreased expression of HEMK1 mRNA26079696
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of HEMK1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of HEMK1 mRNA22079256
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HEMK1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of HEMK1 mRNA17942748
D013752TetracyclineTetracycline affects the expression of HEMK1 mRNA25064622
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HEMK1 mRNA25613284
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in decreased expression of HEMK1 protein18951874
D013853ThioacetamideThioacetamide affects the expression of HEMK1 mRNA25064622
D014303TrinitrotolueneTrinitrotoluene affects the expression of HEMK1 mRNA21346803
D014520UrethaneUrethane results in decreased expression of HEMK1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HEMK1 mRNA25064622
D014635Valproic AcidValproic Acid results in decreased methylation of HEMK1 gene29154799
D014810Vitamin EVitamin E results in increased expression of HEMK1 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003677DNA binding-IEA-  
GO:0005515protein binding-IPI25416956  
GO:0008170N-methyltransferase activity-IEA-  
GO:0008276protein methyltransferase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006306DNA methylation-IEA-  
GO:0006479protein methylation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
KEGG ID KEGG Term
hsa00340Histidine metabolism
hsa00350Tyrosine metabolism
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal