Gene info: ID 51422

Gene: PRKAG2

GENE ID: 51422

Synonyms: AAKG|AAKG2|CMH6|H91620p|WPWS

Description: protein kinase AMP-activated non-catalytic subunit gamma 2

Gene type: protein-coding

Location: 7q36.1

dbXrefs: Ensembl:ENSG00000106617 MIM:602743 Vega:OTTHUMG00000157324 UniprotKB:Q9UGJ0

RefSeq: NG_007486.1

Retrived from: PubMed|SNP Mapped

SNPs: 3 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 5.177e-1 (AD) 3.916e-1 (ND)

ANCO-SNPs

SNP ID	Position	Alleles	Trait	Variation Type
rs4725432	chr7:151776332 (GRCh38.p7)	C>A	nicotine dependence	SNV(Single Nucleotide Variation)
rs10224002	chr7:151717955 (GRCh38.p7)	A>G	alcohol dependence	SNV(Single Nucleotide Variation)
rs2302530	chr7:151570311 (GRCh38.p7)	G>A	nicotine dependence	SNV(Single Nucleotide Variation)

DNA Methylation

Probe	Locus(GRCh37)	Gene	Region	p-val	Trait	PubMed ID
cg01423695	chr7:151504844	PRKAG2		6.300e-10	Smoking	27651444
cg17192599	chr7:151504864	PRKAG2		9.900e-8	Smoking	27651444
cg17192599	chr7:151504864	PRKAG2		2.800e-9	Alcohol consumption der day	27843151

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
ATP6V1B2	0.931
DNM1L	0.931
RUNDC1	0.93
MEAF6	0.928
ENTPD6	0.926
NECAP1	0.926
GARS	0.925
BTBD10	0.925
VDAC1	0.924
INPP5F	0.924

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.562
OR4F29	-0.506
MTRNR2L9	-0.423
MTRNR2L10	-0.409
MTRNR2L6	-0.404
CSAG1	-0.4
RAI14	-0.394
ASB4	-0.383
MTRNR2L8	-0.378
MYOM1	-0.373

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00945	Acetylsalicylic acid	Small Molecule	50-78-2	Approved	Target

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PRKAG2 mRNA"	27291303
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PRKAG2 mRNA"	19114083
C030370	2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone	"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of PRKAG2 mRNA"	20206263
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAG2 mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAG2 mRNA"	27188386
D000082	Acetaminophen	Acetaminophen results in decreased expression of PRKAG2 mRNA	29067470
D000082	Acetaminophen	Acetaminophen results in increased expression of PRKAG2 mRNA	26690555
D000082	Acetaminophen	Acetaminophen affects the expression of PRKAG2 mRNA	17562736
D016604	Aflatoxin B1	Aflatoxin B1 affects the expression of PRKAG2 protein	20106945
D016604	Aflatoxin B1	Aflatoxin B1 results in decreased expression of PRKAG2 mRNA	22100608
D016604	Aflatoxin B1	Aflatoxin B1 results in increased expression of PRKAG2 mRNA	27153756
D018501	Antirheumatic Agents	Antirheumatic Agents results in decreased expression of PRKAG2 mRNA	24449571
D001151	Arsenic	Arsenic affects the methylation of PRKAG2 gene	25304211
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKAG2 mRNA	20106945
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PRKAG2 mRNA	19770486
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PRKAG2 mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PRKAG2 mRNA"	19150397
C543008	bis(4-hydroxyphenyl)sulfone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PRKAG2 mRNA	28628672
C006780	bisphenol A	bisphenol A results in decreased expression of PRKAG2 mRNA	22576693\|2927551
C006780	bisphenol A	bisphenol A results in increased methylation of PRKAG2 gene	22576693
C006780	bisphenol A	bisphenol A results in decreased expression of PRKAG2 mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased methylation of PRKAG2 gene	28505145
C018475	butyraldehyde	butyraldehyde results in increased expression of PRKAG2 mRNA	26079696
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of PRKAG2 mRNA	26472689
D002251	Carbon Tetrachloride	Carbon Tetrachloride affects the expression of PRKAG2 mRNA	17484886
D004390	Chlorpyrifos	Chlorpyrifos affects the expression of PRKAG2 mRNA	17452286
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAG2 gene	20938992
C018021	cobaltous chloride	cobaltous chloride results in decreased expression of PRKAG2 mRNA	19320972
D016572	Cyclosporine	Cyclosporine results in decreased expression of PRKAG2 mRNA	20106945
D016572	Cyclosporine	Cyclosporine results in increased expression of PRKAG2 mRNA	27989131
D003907	Dexamethasone	Dexamethasone results in increased expression of PRKAG2 mRNA	25047013
D003907	Dexamethasone	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PRKAG2 mRNA	28628672
D003907	Dexamethasone	Dexamethasone results in decreased expression of PRKAG2 mRNA	20032058
D003907	Dexamethasone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of PRKAG2 mRNA]	20032058
D003976	Diazinon	Diazinon results in decreased expression of PRKAG2 mRNA	17452286
D005472	Fluorouracil	TP53 protein affects the reaction [Fluorouracil results in decreased expression of PRKAG2 mRNA]	15016801
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAG2 gene	20938992
D007213	Indomethacin	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PRKAG2 mRNA	28628672
D015759	Ionomycin	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKAG2 mRNA	25613284
D015056	1-Methyl-3-isobutylxanthine	[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of PRKAG2 mRNA	28628672
D007649	Ketamine	Ketamine results in decreased expression of PRKAG2 mRNA	20080153
D007854	Lead	Lead affects the expression of PRKAG2 mRNA	28903495
D064704	Levofloxacin	Levofloxacin results in decreased expression of PRKAG2 mRNA	24136188
C482199	lipopolysaccharide, E coli O55-B5	"lipopolysaccharide, E coli O55-B5 results in decreased expression of PRKAG2 mRNA"	24972896
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PRKAG2 gene	20938992
D008727	Methotrexate	Methotrexate results in decreased expression of PRKAG2 mRNA	24449571
D008727	Methotrexate	Methotrexate results in increased expression of PRKAG2 mRNA	17400583\|2167806
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PRKAG2 mRNA	28001369
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PRKAG2 mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in decreased expression of PRKAG2 mRNA"	25554681
D010634	Phenobarbital	Phenobarbital affects the expression of PRKAG2 mRNA	19159669
D010662	Phenylmercuric Acetate	"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PRKAG2 mRNA"	27188386
D010662	Phenylmercuric Acetate	Phenylmercuric Acetate results in increased expression of PRKAG2 mRNA	26272509
C006253	pirinixic acid	pirinixic acid results in increased expression of PRKAG2 mRNA	17426115
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PRKAG2 mRNA	22714537
D011374	Progesterone	Progesterone results in increased expression of PRKAG2 mRNA	17404688
D012822	Silicon Dioxide	Silicon Dioxide analog results in increased expression of PRKAG2 mRNA	25895662
D012822	Silicon Dioxide	Silicon Dioxide results in decreased expression of PRKAG2 mRNA	19073995
D012834	Silver	Silver results in increased expression of PRKAG2 mRNA	26551752
D017673	Sodium Chloride, Dietary	"Sodium Chloride, Dietary results in decreased expression of PRKAG2 mRNA"	20349193
D013739	Testosterone	Testosterone results in increased expression of PRKAG2 mRNA	20403060
D013739	Testosterone	Testosterone inhibits the reaction [Dexamethasone results in decreased expression of PRKAG2 mRNA]	20032058
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PRKAG2 gene]	28213091
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PRKAG2 mRNA	28213091
D013752	Tetracycline	Tetracycline results in increased expression of PRKAG2 mRNA	16917069
D013755	Tetradecanoylphorbol Acetate	[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PRKAG2 mRNA	25613284
C001899	triptolide	triptolide results in decreased expression of PRKAG2 mRNA	23639586
C016805	tris(1,3-dichloro-2-propyl)phosphate	"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of PRKAG2 mRNA"	26179874
D014415	Tunicamycin	Tunicamycin results in decreased expression of PRKAG2 mRNA	17127020
D014527	Uric Acid	PRKAG2 gene SNP affects the abundance of Uric Acid	23263486
D014635	Valproic Acid	Valproic Acid affects the expression of PRKAG2 mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in increased expression of PRKAG2 mRNA	19101580\|2800136
D014638	Vanadates	Vanadates results in increased expression of PRKAG2 mRNA	22714537
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of PRKAG2 gene	25560391

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004679	AMP-activated protein kinase activity	-	IEA	-
GO:0004862	cAMP-dependent protein kinase inhibitor activity	-	IDA	17255938
GO:0005524	ATP binding	-	IDA	15877279
GO:0008603	cAMP-dependent protein kinase regulator activity	-	IMP	15877279
GO:0008607	phosphorylase kinase regulator activity	-	IMP	15877279
GO:0016208	AMP binding	-	IEA	-
GO:0019901	protein kinase binding	-	IDA	10698692
GO:0030295	protein kinase activator activity	-	IMP	15877279
GO:0043531	ADP binding	-	IDA	15877279

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005977	glycogen metabolic process	-	IMP	11827995 15877279
GO:0006110	regulation of glycolytic process	-	IMP	15877279
GO:0006468	protein phosphorylation	-	IEA	-
GO:0006469	negative regulation of protein kinase activity	-	IDA	17255938
GO:0006633	fatty acid biosynthetic process	-	IEA	-
GO:0006754	ATP biosynthetic process	-	TAS	11371514
GO:0007050	cell cycle arrest	-	TAS	-
GO:0010800	positive regulation of peptidyl-threonine phosphorylation	-	IMP	15877279
GO:0016126	sterol biosynthetic process	-	TAS	9208914
GO:0016236	macroautophagy	-	TAS	-
GO:0019217	regulation of fatty acid metabolic process	-	IMP	15877279
GO:0032147	activation of protein kinase activity	-	IEA	-
GO:0035556	intracellular signal transduction	-	IMP	15877279
GO:0042304	regulation of fatty acid biosynthetic process	-	TAS	-
GO:0045860	positive regulation of protein kinase activity	-	IMP	15877279
GO:0046320	regulation of fatty acid oxidation	-	TAS	9208914
GO:0046324	regulation of glucose import	-	TAS	11827995
GO:0071901	negative regulation of protein serine/threonine kinase activity	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005615	extracellular space	-	HDA	22664934
GO:0005654	nucleoplasm	-	TAS	-
GO:0005829	cytosol	-	TAS	-
GO:0031588	nucleotide-activated protein kinase complex	-	IDA	15877279

KEGG ID	KEGG Term
hsa04910	Insulin signaling pathway
hsa04920	Adipocytokine signaling pathway
hsa05410	Hypertrophic cardiomyopathy (HCM)

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	TAS
R-HSA-1430728	Metabolism	IEA
R-HSA-1445148	Translocation of GLUT4 to the plasma membrane	IEA
R-HSA-1592230	Mitochondrial biogenesis	IEA
R-HSA-162582	Signal Transduction	TAS
R-HSA-1632852	Macroautophagy	TAS
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	TAS
R-HSA-163680	AMPK inhibits chREBP transcriptional activation activity	IEA
R-HSA-163685	Integration of energy metabolism	TAS
R-HSA-163685	Integration of energy metabolism	IEA
R-HSA-165159	mTOR signalling	TAS
R-HSA-1852241	Organelle biogenesis and maintenance	IEA
R-HSA-199991	Membrane Trafficking	IEA
R-HSA-200425	Import of palmitoyl-CoA into the mitochondrial matrix	TAS
R-HSA-212436	Generic Transcription Pathway	TAS
R-HSA-2151209	Activation of PPARGC1A (PGC-1alpha) by phosphorylation	IEA
R-HSA-3700989	Transcriptional Regulation by TP53	TAS
R-HSA-380972	Energy dependent regulation of mTOR by LKB1-AMPK	TAS
R-HSA-556833	Metabolism of lipids	TAS
R-HSA-5628897	TP53 Regulates Metabolic Genes	TAS
R-HSA-5633007	Regulation of TP53 Activity	TAS
R-HSA-5653656	Vesicle-mediated transport	IEA
R-HSA-6804756	Regulation of TP53 Activity through Phosphorylation	TAS
R-HSA-73857	RNA Polymerase II Transcription	TAS
R-HSA-74160	Gene expression (Transcription)	TAS
R-HSA-8953897	Cellular responses to external stimuli	TAS
R-HSA-8978868	Fatty acid metabolism	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21813245	AMPK gamma2 subunit gene PRKAG2 polymorphism associated with cognitive impairment as well as diabetes in old age. (2012 Mar)	Kim E	Psychoneuroendocrinology