Gene: ANAPC7

51434
APC7
anaphase promoting complex subunit 7
protein-coding
12q24.11
Ensembl:ENSG00000196510 MIM:606949 Vega:OTTHUMG00000157009 UniprotKB:Q9UJX3
NC_000012.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.174e-1 (AD)  9.495e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PPP1R110.944
MTX20.943
RRAGA0.941
ABCF30.94
GOT20.94
SEC61A20.94
MICU10.938
PPME10.938
IDH3B0.936
RNF340.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.616
MTRNR2L6-0.411
MTRNR2L9-0.403
MTRNR2L10-0.399
IL18RAP-0.364
S100A12-0.363
KCNJ15-0.36
FCGR3B-0.357
CST7-0.352

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ANAPC7 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANAPC7 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of ANAPC7 mRNA17562736
D001151ArsenicArsenic affects the methylation of ANAPC7 gene25304211
D001280AtrazineAtrazine results in increased expression of ANAPC7 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ANAPC7 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of ANAPC7 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ANAPC7 mRNA23741332
D019327Copper SulfateCopper Sulfate affects the expression of ANAPC7 mRNA19549813
D003375CoumestrolCoumestrol results in increased expression of ANAPC7 mRNA19167446
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ANAPC7 mRNA]27941970
D004026DieldrinDieldrin results in decreased expression of ANAPC7 mRNA23041725
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ANAPC7 protein23301498
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANAPC7 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ANAPC7 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANAPC7 mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of ANAPC7 mRNA23649840
D008070LipopolysaccharidesLipopolysaccharides results in increased methylation of ANAPC7 gene21212295
C044361M-VAC protocolANAPC7 protein results in decreased susceptibility to M-VAC protocol15814643
C022838nickel chloridenickel chloride affects the expression of ANAPC7 mRNA22546817
C006253pirinixic acidpirinixic acid results in increased expression of ANAPC7 mRNA18301758
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of ANAPC7 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ANAPC7 mRNA22079256
D013629TamoxifenTamoxifen affects the expression of ANAPC7 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANAPC7 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased methylation of ANAPC7 gene21212295
D014520UrethaneUrethane results in decreased expression of ANAPC7 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of ANAPC7 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ANAPC7 mRNA23179753|2519280
C025643vinclozolinvinclozolin results in decreased expression of ANAPC7 mRNA23034163
C111237vorinostatvorinostat results in increased expression of ANAPC7 mRNA27188386

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI20360068  26496610  27173435  
GO:0019903protein phosphatase binding-IPI21241890  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0031145anaphase-promoting complex-dependent catabolic process-TAS-  
GO:0051301cell division-IEA-  
GO:0070979protein K11-linked ubiquitination-IDA18485873  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA21241890  
GO:0005654nucleoplasm-TAS-  
GO:0005680anaphase-promoting complex-IDA16364912  21926987  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
hsa04110Cell cycle
hsa04114Oocyte meiosis
hsa04120Ubiquitin mediated proteolysis
hsa04914Progesterone-mediated oocyte maturation
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-141405Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint componentsTAS
R-HSA-141430Inactivation of APC/C via direct inhibition of the APC/C complexTAS
R-HSA-1640170Cell CycleTAS
R-HSA-168256Immune SystemTAS
R-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BTAS
R-HSA-174084Autodegradation of Cdh1 by Cdh1:APC/CTAS
R-HSA-174143APC/C-mediated degradation of cell cycle proteinsTAS
R-HSA-174154APC/C:Cdc20 mediated degradation of SecurinTAS
R-HSA-174178APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1TAS
R-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin ATAS
R-HSA-176407Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphaseTAS
R-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseTAS
R-HSA-176409APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-176412Phosphorylation of the APC/CTAS
R-HSA-176814Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteinsTAS
R-HSA-179409APC-Cdc20 mediated degradation of Nek2ATAS
R-HSA-179419APC:Cdc20 mediated degradation of cell cycle proteins prior to satisfation of the cell cycle checkpointTAS
R-HSA-2262752Cellular responses to stressTAS
R-HSA-2467813Separation of Sister ChromatidsTAS
R-HSA-2555396Mitotic Metaphase and AnaphaseTAS
R-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)TAS
R-HSA-2559583Cellular SenescenceTAS
R-HSA-453276Regulation of mitotic cell cycleTAS
R-HSA-68882Mitotic AnaphaseTAS
R-HSA-68886M PhaseTAS
R-HSA-69017CDK-mediated phosphorylation and removal of Cdc6TAS
R-HSA-69052Switching of origins to a post-replicative stateTAS
R-HSA-69239Synthesis of DNATAS
R-HSA-69242S PhaseTAS
R-HSA-69278Cell Cycle, MitoticTAS
R-HSA-69306DNA ReplicationTAS
R-HSA-69618Mitotic Spindle CheckpointTAS
R-HSA-69620Cell Cycle CheckpointsTAS
R-HSA-8953897Cellular responses to external stimuliTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29328493Meta-analysis of mRNA expression profiles to identify differentially expressed genes in lung adenocarcinoma tissue from smokers and non-smokers. (2018 Mar)He XOncol Rep