Gene: SCARA3

51435
APC7|CSR|CSR1|MSLR1|MSRL1
scavenger receptor class A member 3
protein-coding
8p21.1
Ensembl:ENSG00000168077 MIM:602728 Vega:OTTHUMG00000163898 UniprotKB:Q6AZY7
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
3.593e-2 (AD)  2.217e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs12677898chr8:27655269 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRIG10.864
PLCD10.862
TUBB2B0.86
ATP1B20.845
LRP100.843
NEK60.842
PHKG10.841
GPT20.84
ALDH1L10.83
RHPN20.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.452
OR4F29-0.419
ZNF860-0.351
TYRP1-0.351
CNTN6-0.341
PPEF1-0.33
AGMAT-0.319
SAMD5-0.319
SERF1B-0.313
MYOZ3-0.309

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of SCARA3 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of SCARA3 gene27153756
C006632arsenic trioxidearsenic trioxide results in decreased expression of SCARA3 mRNA26705709
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SCARA3 mRNA26238291
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of SCARA3 mRNA"19150397
D004958EstradiolEstradiol results in increased expression of SCARA3 mRNA19484750
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SCARA3 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of SCARA3 mRNA25181051
C018475butyraldehydebutyraldehyde results in decreased expression of SCARA3 mRNA26079696
C026690cerous chloridecerous chloride results in decreased expression of SCARA3 mRNA28954213
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA3 mRNA20938992
C018021cobaltous chloridecobaltous chloride results in decreased expression of SCARA3 mRNA19320972|1937684
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of SCARA3 mRNA20971185
D003471CuprizoneCuprizone results in decreased expression of SCARA3 mRNA26577399|2752363
C014347decitabinedecitabine results in decreased methylation of SCARA3 promoter18676679
D003907DexamethasoneDexamethasone results in decreased expression of SCARA3 mRNA25047013
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SCARA3 mRNA28628672
D002945CisplatinCisplatin results in decreased expression of SCARA3 mRNA27392435
D004041Dietary FatsDietary Fats affects the expression of SCARA3 mRNA19680557
D004041Dietary FatsDietary Fats results in increased expression of SCARA3 mRNA18042831|2260994
D019422Dietary SucroseDietary Sucrose results in increased expression of SCARA3 mRNA26033743
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SCARA3 mRNA24535843
D002117CalcitriolCalcitriol results in decreased expression of SCARA3 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of SCARA3 mRNA21592394
C118739entinostatentinostat results in increased expression of SCARA3 mRNA27188386
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA3 mRNA20938992
C039281furanfuran results in increased expression of SCARA3 mRNA27387713
C004312glycidolglycidol results in decreased expression of SCARA3 mRNA24915197
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SCARA3 mRNA28628672
D007213IndomethacinIndomethacin results in decreased expression of SCARA3 mRNA28201806
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of SCARA3 mRNA28628672
C544151jinfukangjinfukang results in increased expression of SCARA3 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of SCARA3 mRNA24796395
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of SCARA3 mRNA24231268
D007649KetamineKetamine results in increased expression of SCARA3 mRNA20080153
C028521lanthanum chloridelanthanum chloride results in increased expression of SCARA3 mRNA28954213
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SCARA3 mRNA20938992
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of SCARA3 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of SCARA3 mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SCARA3 mRNA"20188158
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of SCARA3 mRNA23360888
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of SCARA3 mRNA20971185
D000073878Palm OilPalm Oil affects the expression of SCARA3 mRNA19680557
D000073878Palm OilPalm Oil results in increased expression of SCARA3 mRNA18042831
D010269ParaquatParaquat results in decreased expression of SCARA3 mRNA23315990
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of SCARA3 mRNA24535843
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of SCARA3 mRNA19710929
D011441PropylthiouracilPropylthiouracil results in decreased expression of SCARA3 mRNA24780913
D011794QuercetinQuercetin results in increased expression of SCARA3 mRNA20596804
D012822Silicon DioxideSilicon Dioxide results in decreased expression of SCARA3 mRNA22431001
D012834SilverSilver results in increased expression of SCARA3 mRNA28959546
D018038Sodium SeleniteSodium Selenite results in decreased methylation of SCARA3 promoter18676679
D018038Sodium SeleniteSodium Selenite results in increased expression of SCARA3 mRNA18676679
D012999SomanSoman results in increased expression of SCARA3 mRNA19281266
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of SCARA3 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of SCARA3 mRNA21592394
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of SCARA3 mRNA26290441
D019284ThapsigarginThapsigargin results in increased expression of SCARA3 mRNA19442820
D019284ThapsigarginThapsigargin results in decreased expression of SCARA3 protein24648495
C009495titanium dioxidetitanium dioxide results in decreased expression of SCARA3 mRNA23557971
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of SCARA3 mRNA"26179874
C057693troglitazonetroglitazone results in increased expression of SCARA3 mRNA28973697
D014520UrethaneUrethane results in decreased expression of SCARA3 mRNA28818685
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of SCARA3 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of SCARA3 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of SCARA3 mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased methylation of SCARA3 gene29154799
D014635Valproic AcidValproic Acid affects the expression of SCARA3 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of SCARA3 gene25560391
D015032ZincZinc results in decreased expression of SCARA3 mRNA16870260
C016837zinc chloridezinc chloride results in decreased expression of SCARA3 mRNA16870260

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005044scavenger receptor activity-TAS9580669  
GO:0005509calcium ion binding-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0005537mannose binding-IBA21873635  
GO:0030246carbohydrate binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0001867complement activation, lectin pathway-IBA21873635  
GO:0003429growth plate cartilage chondrocyte morphogenesis-IBA21873635  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006979response to oxidative stress-TAS9580669  
GO:0009650UV protection-TAS9580669  
GO:0034138toll-like receptor 3 signaling pathwayNOTIMP25204797  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-IEA-  
GO:0005581collagen trimer-IEA-  
GO:0005615extracellular space-IBA21873635  
GO:0005783endoplasmic reticulum-IDA-  
GO:0005789endoplasmic reticulum membrane-IEA-  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal