Gene: PDE4D

5144
ACRDYS2|DPDE3|HSPDE4D|PDE43|PDE4DN2|STRK1
phosphodiesterase 4D
protein-coding
5q11.2-q12.1
Ensembl:ENSG00000113448 MIM:600129 Vega:OTTHUMG00000162218 UniprotKB:Q08499
NG_027957.1
PubMed|SNP Mapped
ND
14   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.424e-1 (AD)  6.687e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs17780175chr5:59293960 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
XPR10.896
FBXO280.887
KPNA10.885
GFPT10.88
SHOC20.877
RLIM0.874
MOB40.874
PPP2R5E0.871
RNGTT0.868
HSPA130.868

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.48
OR4F29-0.429
TRPV5-0.386
CTNNA3-0.376
C5orf64-0.376
CSAG1-0.352
FXYD4-0.345
TNFRSF13B-0.341
SH2D1A-0.335
ANXA13-0.334

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00131Adenosine monophosphateSmall Molecule61-19-8Approved|Investigational|NutraceuticalTarget
DB00651DyphyllineSmall Molecule479-18-5ApprovedTarget
DB01088IloprostSmall Molecule78919-13-8Approved|InvestigationalTarget
DB01656RoflumilastSmall Molecule162401-32-3ApprovedTarget
DB01791PiclamilastSmall Molecule144035-83-6ExperimentalTarget
DB01954RolipramSmall Molecule61413-54-5InvestigationalTarget
DB019593,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB026762-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-DiolSmall MoleculeExperimentalTarget
DB029186-(4-Difluoromethoxy-3-Methoxy-Phenyl)-2h-Pyridazin-3-OneSmall MoleculeExperimentalTarget
DB031831-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB03606(S)-RolipramSmall Molecule85416-73-5ExperimentalTarget
DB03849CilomilastSmall Molecule153259-65-5InvestigationalTarget
DB04149(R)-RolipramSmall Molecule85416-75-7ExperimentalTarget
DB042713,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB044691-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl EsterSmall MoleculeExperimentalTarget
DB05219CrisaboroleSmall Molecule906673-24-3Approved|InvestigationalTarget
DB05266IbudilastSmall Molecule50847-11-5Approved|InvestigationalTarget
DB05298TetomilastSmall Molecule145739-56-6InvestigationalTarget
DB05676ApremilastSmall Molecule608141-41-9Approved|InvestigationalTarget
DB06246ExisulindSmall Molecule59973-80-7InvestigationalTarget
DB06842(4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-oneSmall MoleculeExperimentalTarget
DB070513,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTERSmall MoleculeExperimentalTarget
DB079543-isobutyl-1-methyl-7H-xanthineSmall Molecule28822-58-4ExperimentalTarget
DB082994-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acidSmall MoleculeExperimentalTarget
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C5544401-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester1-((5-(1-aminoethyl)-2-(8-methoxy-2-(triflurormethyl)-5-quinolinyl)-4-oxazolyl) carbonyl)-4-((cyclopropylcarbonyl)amino)proline ethyl ester results in decreased activity of PDE4D protein20621091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PDE4D mRNA"18648102
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in increased expression of PDE4D mRNA"27567155
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of PDE4D mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDE4D gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDE4D mRNA19770486
D001151ArsenicArsenic affects the methylation of PDE4D gene25304211
C006632arsenic trioxidearsenic trioxide results in increased expression of PDE4D mRNA22521957
D017638Asbestos, Crocidolite"Asbestos, Crocidolite affects the expression of PDE4D mRNA"25757056
D001280AtrazineAtrazine results in increased expression of PDE4D mRNA18461179
D001554BenzeneBenzene results in increased expression of PDE4D mRNA15929907
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDE4D mRNA22316170
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of PDE4D mRNA"19150397
D004958EstradiolEstradiol affects the expression of PDE4D mRNA23557687
D004958EstradiolEstradiol results in decreased methylation of PDE4D gene16740699
D004958EstradiolEstradiol results in increased expression of PDE4D mRNA16740699
C006780bisphenol Abisphenol A results in decreased expression of PDE4D mRNA25181051
C006780bisphenol Abisphenol A results in decreased methylation of PDE4D gene16740699
C006780bisphenol Abisphenol A results in decreased methylation of PDE4D promoter22109888
C006780bisphenol A[bisphenol A results in decreased methylation of PDE4D promoter] which results in increased expression of PDE4D22109888
C006780bisphenol Abisphenol A results in increased expression of PDE4D mRNA16740699
C006780bisphenol Abisphenol A results in increased methylation of PDE4D gene28505145
C013418bromfenacoumbromfenacoum results in decreased expression of PDE4D protein28903499
C018475butyraldehydebutyraldehyde results in decreased expression of PDE4D mRNA26079696
D000074262Canola OilCanola Oil metabolite results in decreased expression of PDE4D mRNA27363782
D002713Chlorine[Ozone co-treated with Chlorine] results in increased expression of PDE4D mRNA18636392
C074702chromium hexavalent ionchromium hexavalent ion results in decreased expression of PDE4D mRNA27793765
C418118CI 1044CI 1044 results in increased expression of PDE4D mRNA17569694
C433247CilomilastCilomilast results in decreased activity of PDE4D protein11907180
C433247CilomilastCilomilast results in decreased expression of PDE4D mRNA16956605
C433247CilomilastCilomilast results in decreased activity of PDE4D protein17155857
C018021cobaltous chloridecobaltous chloride results in increased expression of PDE4D mRNA19376846
D005576ColforsinColforsin results in increased expression of PDE4D mRNA15967414
D019327Copper SulfateCopper Sulfate results in increased expression of PDE4D mRNA19549813
D003471CuprizoneCuprizone affects the expression of PDE4D mRNA26577399
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDE4D mRNA]27941970
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PDE4D mRNA28962523
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDE4D mRNA27392435
D002945CisplatinCisplatin results in decreased expression of PDE4D mRNA27392435
C036042dicyclohexyl phthalatedicyclohexyl phthalate affects the expression of PDE4D mRNA26924002
D004041Dietary Fats[Dietary Fats co-treated with resveratrol] results in increased expression of PDE4D mRNA21852083
C024629dimethyl phthalatedimethyl phthalate affects the expression of PDE4D mRNA26924002
D004137DinitrochlorobenzeneDinitrochlorobenzene results in increased expression of PDE4D mRNA17374397
C010452estradiol-17 beta-benzoateestradiol-17 beta-benzoate results in decreased methylation of PDE4D promoter22109888
C010452estradiol-17 beta-benzoate[estradiol-17 beta-benzoate results in decreased methylation of PDE4D promoter] which results in increased expression of PDE4D22109888
D000431EthanolEthanol results in decreased expression of PDE4D mRNA20655511
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PDE4D mRNA29097150
D005473FluoxetineFluoxetine affects the expression of PDE4D mRNA alternative form12504921
D005557FormaldehydeFormaldehyde results in decreased expression of PDE4D mRNA20655997
C069837fullerene C60fullerene C60 results in decreased expression of PDE4D mRNA19167457
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in increased expression of PDE4D mRNA16206274
D017313FenretinideFenretinide results in increased expression of PDE4D mRNA28973697
D006820Hyaluronic AcidHyaluronic Acid analog results in decreased expression of PDE4D protein23178681
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PDE4D protein23178681
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDE4D mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDE4D mRNA27392435
C544151jinfukangjinfukang results in decreased expression of PDE4D mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDE4D mRNA27432991
C459562L-826,141"L-826,141 results in decreased activity of PDE4D protein"15901792
C045463leflunomideleflunomide results in increased expression of PDE4D mRNA28988120
C042720mercuric bromidemercuric bromide results in increased expression of PDE4D mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
D008694MethamphetaminePDE4D gene SNP affects the susceptibility to Methamphetamine18316681
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PDE4D mRNA28001369
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDE4D mRNA"26251327
D008942MitoxantronePDE4D protein affects the susceptibility to Mitoxantrone16217747
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in decreased expression of PDE4D mRNA22401849
C517284monomethyl phthalatemonomethyl phthalate affects the expression of PDE4D mRNA26924002
C568020moracin Mmoracin M binds to and results in decreased activity of PDE4D protein23871879
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDE4D mRNA"25511174
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDE4D mRNA"25554681
C028007nickel monoxidenickel monoxide results in increased expression of PDE4D mRNA19167457
C029938nickel sulfatenickel sulfate results in increased expression of PDE4D mRNA17374397
C451724NVP ABE171NVP ABE171 results in decreased activity of PDE4D protein11907180
D010081OxazoloneOxazolone results in increased expression of PDE4D mRNA17374397
D010126Ozone[Ozone co-treated with Chlorine] results in increased expression of PDE4D mRNA18636392
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PDE4D mRNA26272509
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of PDE4D mRNA18593933
C046012pentanalpentanal results in decreased expression of PDE4D mRNA26079696
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PDE4D mRNA26272509
D010852PicrotoxinPicrotoxin results in increased expression of PDE4D mRNA15170462
C006253pirinixic acidpirinixic acid results in increased expression of PDE4D mRNA18301758|2081375
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDE4D mRNA11678601
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of PDE4D mRNA28903501
C107773pterostilbenepterostilbene binds to PDE4D protein23871879
C034912puag-haadpuag-haad binds to PDE4D protein23871879
D011794QuercetinQuercetin results in decreased activity of PDE4D protein23873842
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride results in increased expression of PDE4D mRNA16497877
C059514resveratrol[Dietary Fats co-treated with resveratrol] results in increased expression of PDE4D mRNA21852083
C059514resveratrolresveratrol analog binds to PDE4D protein23871879
C059514resveratrolresveratrol binds to and results in decreased activity of PDE4D protein23871879
D012293RifampinRifampin results in decreased expression of PDE4D mRNA24552687
C424423RoflumilastRoflumilast results in decreased activity of PDE4D protein15901792
C424423RoflumilastRoflumilast binds to PDE4D protein23871879
D020889RolipramRolipram results in decreased activity of PDE4D protein23873842
C017947sodium arsenitesodium arsenite affects the methylation of PDE4D gene28589171
D012969Sodium FluorideSodium Fluoride results in increased expression of PDE4D mRNA21340527
C004648testosterone enanthatetestosterone enanthate results in increased expression of PDE4D mRNA25603467
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDE4D mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE4D mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE4D mRNA22298810
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of PDE4D mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of PDE4D mRNA25613284
C009495titanium dioxidetitanium dioxide results in increased expression of PDE4D mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDE4D mRNA28065790
C483909torcetrapibtorcetrapib results in increased expression of PDE4D mRNA23228038
C035964trequinsintrequinsin results in decreased activity of PDE4D protein15901792
D014212TretinoinTretinoin results in increased expression of PDE4D mRNA21934132|2372400
D014241TrichloroethyleneTrichloroethylene results in increased expression of PDE4D mRNA25549359
D014241TrichloroethyleneTrichloroethylene results in increased methylation of PDE4D gene27618143
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PDE4D mRNA24935251|2627250
D014415TunicamycinTunicamycin results in increased expression of PDE4D mRNA17127020
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDE4D mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PDE4D mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDE4D mRNA23179753|2438349
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in increased expression of PDE4D mRNA25423262
C029297vinylidene chloridevinylidene chloride results in decreased expression of PDE4D mRNA26682919
C111237vorinostatvorinostat results in increased expression of PDE4D mRNA27188386
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of PDE4D mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:00041143',5'-cyclic-nucleotide phosphodiesterase activity-NAS10913353  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-IDA9371713  17404263  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-IGI8413254  
GO:00041153',5'-cyclic-AMP phosphodiesterase activity-TAS-  
GO:0005515protein binding-IPI17620599  19955404  25416956  
GO:0008144drug binding-IPI9371713  15938621  
GO:0019899enzyme binding-ISS22975349  
GO:0030552cAMP binding-IDA9371713  15938621  
GO:0031698beta-2 adrenergic receptor binding-ISS-  
GO:0044325ion channel binding-IPI16213210  
GO:0044325ion channel binding-ISS-  
GO:0046872metal ion binding-IEA-  
GO:0051117ATPase binding-IPI21903937  
GO:0097110scaffold protein binding-IPI15182229  
GO ID GO Term Qualifier Evidence PubMed
GO:0002027regulation of heart rate-ISS16213210  
GO:0006198cAMP catabolic process-IEA-  
GO:0006198cAMP catabolic process-IMP19252089  
GO:0006939smooth muscle contraction-IEA-  
GO:0007186G-protein coupled receptor signaling pathway-TAS-  
GO:0007568aging-IEA-  
GO:0010469regulation of signaling receptor activity-ISS-  
GO:0010880regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum-ISS16213210  
GO:0019933cAMP-mediated signaling-NAS16177794  
GO:0030593neutrophil chemotaxis-IEA-  
GO:0032729positive regulation of interferon-gamma production-IMP17404263  
GO:0032743positive regulation of interleukin-2 production-IMP17404263  
GO:0032754positive regulation of interleukin-5 production-IMP17404263  
GO:0033137negative regulation of peptidyl-serine phosphorylation-ISS16213210  
GO:0035264multicellular organism growth-IEA-  
GO:0045822negative regulation of heart contraction-ISS21903937  
GO:0050852T cell receptor signaling pathway-IMP17404263  
GO:0060314regulation of ryanodine-sensitive calcium-release channel activity-ISS16213210  
GO:0061028establishment of endothelial barrier-ISS-  
GO:0071222cellular response to lipopolysaccharide-IEA-  
GO:0071872cellular response to epinephrine stimulus-IEA-  
GO:0071875adrenergic receptor signaling pathway-ISS-  
GO:0086004regulation of cardiac muscle cell contraction-ISS21903937  
GO:0086024adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate-IC-  
GO:1901844regulation of cell communication by electrical coupling involved in cardiac conduction-IC16213210  
GO:1901898negative regulation of relaxation of cardiac muscle-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005813centrosome-IEA-  
GO:0005829cytosol-IDA-  
GO:0005829cytosol-TAS-  
GO:0005886plasma membrane-IDA-  
GO:0005891voltage-gated calcium channel complex-ISS-  
GO:0016324apical plasma membrane-IEA-  
GO:0031965nuclear membrane-IDA-  
GO:0034704calcium channel complex-IDA16213210  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence
R-HSA-111885Opioid SignallingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-180024DARPP-32 eventsTAS
R-HSA-372790Signaling by GPCRTAS
R-HSA-388396GPCR downstream signallingTAS
R-HSA-418555G alpha (s) signalling eventsTAS
R-HSA-418594G alpha (i) signalling eventsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28191858Impact of the PDE4D gene polymorphism and additional SNP-SNP and gene-smoking interaction on ischemic stroke risk in Chinese Han population. (2017 Apr)Wang XNeurol Res
12791581Prenatal cigarette smoke decreases lung cAMP and increases airway hyperresponsiveness. (2003 Aug 1)Singh SPAm J Respir Crit Care Med
18398440Ischaemic stroke in hypertensive patients is associated with variations in the PDE4D genome region. (2008 Sep)Lovkvist HEur J Hum Genet
22274584A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene. (2012 Jul)Lovkvist HEur J Hum Genet
19608201Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population. (2009 Oct 15)Munshi AJ Neurol Sci
27709636PTTG1IP and MAML3, novel genomewide association study genes for severity of hyperresponsiveness in adult asthma. (2017 May)Nieuwenhuis MAAllergy
19399275Phosphodiesterase 4D gene and risk of noncardiogenic ischemic stroke in a Korean population. (2009 Apr)Kim MKJ Korean Med Sci
21989204Association of the phosphodiesterase 4D (PDE4D) gene and cardioembolic stroke in an Australian cohort. (2011 Dec)Milton AGInt J Stroke
20008879Genome-wide association studies: what do they teach us about asthma and chronic obstructive pulmonary disease? (2009 Dec)Boezen HMProc Am Thorac Soc
27058054Asthma susceptibility variants are more strongly associated with clinically similar subgroups. (2016 Nov)Lavoie-Charland EJ Asthma
16825591Polymorphisms of the phosphodiesterase 4D, cAMP-specific (PDE4D) gene and risk of ischemic stroke: a prospective, nested case-control evaluation. (2006 Aug)Zee RYStroke
23193110RGS5 gene and therapeutic response to short acting bronchodilators in paediatric asthma patients. (2013 Oct)Labuda MPediatr Pulmonol
18157711Association between inflammatory gene polymorphisms and coronary artery disease in an Indian population. (2009 Jan)Banerjee IJ Thromb Thrombolysis
28027554Features of coronary heart disease development in emergency workers of the Chornobyl accident depending on the action of radiation and non radiation risk factors and genotypes of single nucleotide polymorphism rs966221 of phosphodiesterase 4D gene. (2016 Dec)Belyi DProbl Radiac Med Radiobiol