Gene: RNF138

51444
HSD-4|NARF|STRIN|hNARF
ring finger protein 138
protein-coding
18q12.1
Ensembl:ENSG00000134758 MIM:616319 Vega:OTTHUMG00000132265 UniprotKB:Q8WVD3
NG_029944.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.605e-2 (AD)  8.949e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB33B0.869
CD1640.868
MIER30.865
TBC1D150.865
TMED70.862
RAB210.851
MBIP0.85
IKZF50.848
MIER10.844
MARCH70.844

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.552
OR4F29-0.524
HES5-0.189
SPRR2A-0.186
OR8G1-0.179
CRNN-0.172
SPRR3-0.17
CMA1-0.16
KRT6A-0.159
MUC21-0.158

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of RNF138 mRNA"21346803
D000082AcetaminophenAcetaminophen affects the expression of RNF138 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of RNF138 mRNA19770486
C000188alachloralachlor affects the expression of RNF138 mRNA19425180
D000643Ammonium ChlorideAmmonium Chloride affects the expression of RNF138 mRNA16483693
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of RNF138 mRNA24449571
D001280AtrazineAtrazine results in increased expression of RNF138 mRNA22378314
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of RNF138 mRNA"19150397|2038263
C006780bisphenol A[bisphenol A co-treated with Genistein] results in decreased methylation of RNF138 gene28505145
C006780bisphenol Abisphenol A results in decreased methylation of RNF138 gene28505145
C006780bisphenol Abisphenol A results in increased expression of RNF138 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of RNF138 gene28505145
D000069286BortezomibBortezomib results in increased expression of RNF138 mRNA20977926
C018021cobaltous chloridecobaltous chloride results in increased expression of RNF138 mRNA24386269
D016572CyclosporineCyclosporine results in increased expression of RNF138 mRNA25562108
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of RNF138 mRNA23640034
D003907DexamethasoneDexamethasone results in increased expression of RNF138 mRNA20032058
D003907DexamethasoneTestosterone inhibits the reaction [Dexamethasone results in increased expression of RNF138 mRNA]20032058
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of RNF138 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of RNF138 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of RNF138 mRNA27392435
D002117CalcitriolCalcitriol results in decreased expression of RNF138 mRNA21592394
D002117Calcitriol[Testosterone co-treated with Calcitriol] results in decreased expression of RNF138 mRNA21592394
D005485FlutamideFlutamide results in increased expression of RNF138 mRNA24793618
D019833Genistein[bisphenol A co-treated with Genistein] results in decreased methylation of RNF138 gene28505145
D006046GoldGold results in decreased expression of RNF138 mRNA25523186
C016517indole-3-carbinolindole-3-carbinol affects the expression of RNF138 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RNF138 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of RNF138 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of RNF138 mRNA27392435
D007649KetamineKetamine results in decreased expression of RNF138 mRNA20080153
C008261lead acetatelead acetate results in increased expression of RNF138 mRNA20542052
D008628MercuryMercury results in increased expression of RNF138 mRNA16823088
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of RNF138 mRNA18593933
D010634PhenobarbitalPhenobarbital affects the expression of RNF138 mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of RNF138 mRNA23091169
C018637phoronephorone affects the expression of RNF138 mRNA18198479
C006253pirinixic acidpirinixic acid results in increased expression of RNF138 mRNA21318169
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in increased expression of RNF138 mRNA]21318169
D012402RotenoneRotenone results in decreased expression of RNF138 mRNA27979718
C016104sodium bichromatesodium bichromate results in increased expression of RNF138 mRNA25993096
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in increased expression of RNF138 mRNA15885361
D013739Testosterone[Testosterone co-treated with Calcitriol] results in decreased expression of RNF138 mRNA21592394
D013739TestosteroneTestosterone results in decreased expression of RNF138 mRNA21592394
D013739TestosteroneTestosterone inhibits the reaction [Dexamethasone results in increased expression of RNF138 mRNA]20032058
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of RNF138 mRNA20106945|2163298
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of RNF138 mRNA25613284
D013792ThalidomideThalidomide results in decreased expression of RNF138 mRNA26217789
D013853ThioacetamideThioacetamide results in increased expression of RNF138 mRNA23411599|2818141
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of RNF138 mRNA"26179874
D014580Ursodeoxycholic AcidUrsodeoxycholic Acid results in increased expression of RNF138 mRNA15885361
D014635Valproic AcidValproic Acid results in decreased expression of RNF138 mRNA23179753|2718838
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of RNF138 gene25560391
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of RNF138 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003697single-stranded DNA binding-IDA26502055  
GO:0005515protein binding-IPI19549727  25416956  26502055  27173435  
GO:0019901protein kinase binding-IPI16714285  
GO:0046872metal ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IMP26502055  26502057  
GO ID GO Term Qualifier Evidence PubMed
GO:0000724double-strand break repair via homologous recombination-IMP26502055  26502057  
GO:0010792DNA double-strand break processing involved in repair via single-strand annealing-IMP26502057  
GO:0016055Wnt signaling pathway-IEA-  
GO:0016567protein ubiquitination-IMP26502055  26502057  
GO:1990830cellular response to leukemia inhibitory factor-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0035861site of double-strand break-IDA26502055  26502057  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
19603079Influence of smoking on colonic gene expression profile in Crohn's disease. (2009 Jul 15)Nielsen OHPLoS One