Gene: REV1

51455
AIBP80|REV1L
REV1, DNA directed polymerase
protein-coding
2q11.2
Ensembl:ENSG00000135945 MIM:606134 Vega:OTTHUMG00000130636 UniprotKB:Q9UBZ9
NC_000002.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
8.498e-1 (AD)  4.775e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KRIT10.928
SRSF110.927
ZNF6550.924
USP480.922
CCNT20.919
ELP20.919
TPP20.918
ZC3H140.913
ARGLU10.912
RNF1150.911

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.525
OR4F29-0.503
PLA2G5-0.318
S100A1-0.316
NKX6-1-0.285
MTRNR2L10-0.28
S100A14-0.277
MDFI-0.275
OR4F16-0.275
SLC22A6-0.275

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of REV1 mRNA"19162173
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in increased expression of REV1 mRNA16788091
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of REV1 mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REV1 mRNA"27188386
C0275764-hydroxy-2-nonenalREV1 protein affects the reaction [4-hydroxy-2-nonenal results in increased phosphorylation of H2AFX protein]22331492
C0275764-hydroxy-2-nonenalREV1 protein affects the susceptibility to 4-hydroxy-2-nonenal22331492
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REV1 mRNA"27188386
D020106AcrylamideAcrylamide results in increased expression of REV1 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of REV1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of REV1 mRNA19770486
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of REV1 mRNA24449571
D001280AtrazineAtrazine results in increased expression of REV1 mRNA25929836
C030935benz(a)anthracene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of REV1 mRNA27858113
C006703benzo(b)fluoranthene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of REV1 mRNA27858113
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of REV1 mRNA26377693
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of REV1 mRNA27858113
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of REV1 mRNA19770486
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"REV1 protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of CHEK1 protein]"22331492
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"REV1 protein affects the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased phosphorylation of H2AFX protein]"22331492
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"REV1 protein affects the susceptibility to 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"22331492
C006780bisphenol Abisphenol A results in increased expression of REV1 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of REV1 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of REV1 mRNA26079696
D002737ChloropreneChloroprene results in increased expression of REV1 mRNA23125180
C031180chrysene[Benzo(a)pyrene co-treated with benz(a)anthracene co-treated with benzo(b)fluoranthene co-treated with chrysene] results in increased expression of REV1 mRNA27858113
D003520CyclophosphamideREV1 protein results in decreased susceptibility to Cyclophosphamide21068378
D016572CyclosporineCyclosporine results in increased methylation of REV1 promoter27989131
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of REV1 mRNA23640034
D003703DemecolcineDemecolcine results in decreased expression of REV1 mRNA23649840
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of REV1 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of REV1 mRNA28302478
D004041Dietary FatsDietary Fats results in increased expression of REV1 mRNA25016146
D000431Ethanol[Fish Oils co-treated with Ethanol] results in increased expression of REV1 mRNA17347304
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REV1 mRNA17942748
D005395Fish Oils[Fish Oils co-treated with Ethanol] results in increased expression of REV1 mRNA17347304
D005472FluorouracilFluorouracil affects the expression of REV1 mRNA16584549
D005557FormaldehydeFormaldehyde results in decreased expression of REV1 mRNA20655997
D006147GuanineGuanine metabolite results in decreased activity of REV1 protein26010525
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of REV1 mRNA15458575
D007213IndomethacinIndomethacin results in decreased expression of REV1 mRNA16984733
D007649KetamineKetamine results in increased expression of REV1 mRNA20080153
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of REV1 mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of REV1 mRNA18367466
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of REV1 mRNA23649840
C005246myristicinmyristicin results in decreased expression of REV1 mRNA24792648
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of REV1 mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of REV1 mRNA23358140
D010269ParaquatParaquat results in increased expression of REV1 mRNA15458575
D010433Pentylenetetrazole[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of REV1 mRNA21503142
D010634PhenobarbitalPhenobarbital results in increased expression of REV1 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of REV1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of REV1 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of REV1 mRNA17426115
D010936Plant ExtractsPlant Extracts results in increased expression of REV1 mRNA23557933
D012834SilverSilver results in increased expression of REV1 mRNA22545559
C017947sodium arsenitesodium arsenite results in increased expression of REV1 mRNA17879257
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of REV1 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of REV1 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of REV1 mRNA21354282|2892240
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of REV1 mRNA28111298
C012589trichostatin Atrichostatin A affects the expression of REV1 mRNA28542535
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of REV1 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of REV1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of REV1 mRNA28973697
D014415TunicamycinTunicamycin results in increased expression of REV1 mRNA15458575
D014520UrethaneUrethane results in decreased expression of REV1 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of REV1 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of REV1 mRNA23179753
D014635Valproic AcidValproic Acid results in decreased methylation of REV1 gene29154799
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of REV1 gene25560391
D020888Vigabatrin[Pentylenetetrazole co-treated with Vigabatrin] affects the expression of REV1 mRNA21503142
C025643vinclozolinvinclozolin results in increased expression of REV1 mRNA23034163
D014750VincristineVincristine results in decreased expression of REV1 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003684damaged DNA binding-IEA-  
GO:0005515protein binding-IPI10906324  11485998  22266823  26318859  
GO:0017125deoxycytidyl transferase activity-TAS-  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006260DNA replication-TAS10536157  
GO:0009411response to UV-IDA11485998  
GO:0019985translesion synthesis-TAS-  
GO:0042276error-prone translesion synthesis-TAS11485998  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-110312Translesion synthesis by REV1TAS
R-HSA-110313Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA templateTAS
R-HSA-5655862Translesion synthesis by POLKTAS
R-HSA-5656121Translesion synthesis by POLITAS
R-HSA-5656169Termination of translesion DNA synthesisTAS
R-HSA-73893DNA Damage BypassTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28296937Effects of circadian clock genes and health-related behavior on metabolic syndrome in a Taiwanese population: Evidence from association and interaction analysis. (2017)Lin EPLoS One