Gene: PDE6C

5146
ACHM5|COD4|PDEA2
phosphodiesterase 6C
protein-coding
10q23.33
Ensembl:ENSG00000095464 MIM:600827 Vega:OTTHUMG00000018775 UniprotKB:P51160
NG_016752.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.177e-1 (AD)  9.320e-3 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
LRIG20.689
PAN30.687
ATP6V0A20.686
NFE2L30.686
SH3BP5-AS10.685
OVGP10.676
ZNF5460.676
NR2C10.675
UBN20.675
AMY2B0.675

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLA2G5-0.246
LYPD1-0.245
DAND5-0.24
OR4F5-0.233
TSPAN12-0.231
S100A1-0.227
C20orf141-0.226
GDF11-0.224
TNNT1-0.224
HOMER3-0.223

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00201CaffeineSmall Molecule58-08-2ApprovedTarget
DB09283TrapidilSmall Molecule15421-84-8ApprovedTarget
ID Drug Name Action PubMed
C0261373-hydroxyacetanilide3-hydroxyacetanilide results in decreased expression of PDE6C mRNA18544908
D000082AcetaminophenAcetaminophen results in decreased expression of PDE6C mRNA18544908
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of PDE6C mRNA21632981|2210060
D001280AtrazineAtrazine results in increased expression of PDE6C mRNA22378314
C030935benz(a)anthracenebenz(a)anthracene results in decreased expression of PDE6C mRNA26377693
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of PDE6C mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDE6C mRNA21632981|2187194
C006780bisphenol Abisphenol A affects the expression of PDE6C mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PDE6C mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDE6C gene28505145
C012843cinnamic aldehydecinnamic aldehyde results in decreased expression of PDE6C mRNA20008804
D004041Dietary FatsDietary Fats results in decreased expression of PDE6C mRNA25016146
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of PDE6C mRNA24535843
D005557FormaldehydeFormaldehyde results in increased expression of PDE6C mRNA23649840
C039281furanfuran results in increased expression of PDE6C mRNA25539665
D019833GenisteinGenistein results in increased methylation of PDE6C gene28505145
D006152Cyclic GMPPDE6C protein results in increased degradation of Cyclic GMP18669600
D008694MethamphetaminePDE6C gene SNP affects the susceptibility to Methamphetamine18316681
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of PDE6C mRNA23649840
C059539midostaurinmidostaurin results in decreased expression of PDE6C mRNA20980353
C016599mono-(2-ethylhexyl)phthalatemono-(2-ethylhexyl)phthalate results in increased expression of PDE6C mRNA22401849
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of PDE6C mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDE6C mRNA"25620056
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PDE6C mRNA27935865
D010634PhenobarbitalPhenobarbital results in decreased expression of PDE6C mRNA19084549
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PDE6C mRNA27935865
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDE6C mRNA25895662
D053260SootSoot results in increased expression of PDE6C mRNA26551751
D014284TriiodothyronineTriiodothyronine results in decreased expression of PDE6C mRNA22281776
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDE6C mRNA28922406
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PDE6C gene25560391
D015032ZincZinc results in decreased expression of PDE6C mRNA20932299

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0030553cGMP binding-IEA-  
GO:0046872metal ion binding-IEA-  
GO:00475553',5'-cyclic-GMP phosphodiesterase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0007601visual perception-IEA-  
GO:0007603phototransduction, visible light-IEA-  
GO:0046549retinal cone cell development-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-IEA-  
KEGG ID KEGG Term
hsa00230Purine metabolism
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22449891Prediction of susceptibility to major depression by a model of interactions of multiple functional genetic variants and environmental factors. (2012 Jun)Wong MLMol Psychiatry