Gene: DCDC2

51473
DCDC2A|DFNB66|NPHP19|NSC|RU2|RU2S
doublecortin domain containing 2
protein-coding
6p22.3
Ensembl:ENSG00000146038 MIM:605755 Vega:OTTHUMG00000016275 UniprotKB:Q9UHG0
NG_012829.2
PubMed
0   ANCO-SNPs
ND
1   
6.067e-1 (AD)  5.214e-1 (ND)   (Frontal_Cortex)
7.248e-1 (AD)  8.305e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PLXNC10.834
OLFM30.83
NDST30.83
TRUB10.826
CDH80.82
B4GALT60.819
ADAMTS30.818
WDR170.818
PRKAA20.817
RAB27B0.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CSAG1-0.545
TNFRSF10D-0.514
SPINK8-0.498
CST7-0.495
ROM1-0.491
RAB13-0.49
CNN2-0.488
NFE2-0.481
CPM-0.481
CDA-0.479

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of DCDC2 mRNA25088246
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl affects the expression of DCDC2 mRNA"20638727
C0179063-dinitrobenzene3-dinitrobenzene results in decreased expression of DCDC2 mRNA21983209
D000082AcetaminophenAcetaminophen results in decreased expression of DCDC2 mRNA26690555
C464485acetamipridacetamiprid results in decreased expression of DCDC2 mRNA27782041
C464485acetamipridacetamiprid results in increased expression of DCDC2 mRNA27782041
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCDC2 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of DCDC2 mRNA23630614
D000393Air PollutantsAir Pollutants analog results in decreased expression of DCDC2 mRNA21757418
D001280AtrazineAtrazine results in decreased expression of DCDC2 mRNA25929836
D001379AzathioprineAzathioprine results in decreased expression of DCDC2 mRNA22623647
C487081belinostatbelinostat results in decreased expression of DCDC2 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of DCDC2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DCDC2 mRNA26238291
C006780bisphenol Abisphenol A results in decreased expression of DCDC2 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of DCDC2 gene28505145
C018475butyraldehydebutyraldehyde results in decreased expression of DCDC2 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of DCDC2 mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of DCDC2 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of DCDC2 mRNA26577399
D016572CyclosporineCyclosporine results in decreased expression of DCDC2 mRNA25562108|2798913
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of DCDC2 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of DCDC2 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of DCDC2 mRNA28302478
C039281furanfuran results in increased expression of DCDC2 mRNA26194646|2738771
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of DCDC2 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of DCDC2 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of DCDC2 mRNA27259270
D007854LeadLead results in decreased expression of DCDC2 mRNA19921347
C045463leflunomideleflunomide affects the expression of DCDC2 mRNA28988120
D011441PropylthiouracilPropylthiouracil results in increased expression of DCDC2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of DCDC2 mRNA21632981
D012999SomanSoman results in decreased expression of DCDC2 mRNA19281266
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DCDC2 mRNA21632981
D013853ThioacetamideThioacetamide results in increased expression of DCDC2 mRNA23411599
D014212TretinoinTretinoin results in increased expression of DCDC2 mRNA21934132
D014212TretinoinTretinoin results in increased expression of DCDC2 mRNA20488242
D014520UrethaneUrethane results in decreased expression of DCDC2 mRNA28818685
D014635Valproic AcidValproic Acid results in decreased expression of DCDC2 mRNA29154799
D014638VanadatesVanadates results in decreased expression of DCDC2 mRNA22714537
C088658zoledronic acidzoledronic acid results in decreased expression of DCDC2 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI21698230  25416956  25557784  
GO:0019894kinesin binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001764neuron migration-IBA21873635  
GO:0001764neuron migration-ISS-  
GO:0001764neuron migration-NAS16278297  
GO:0006968cellular defense response-TAS10601354  
GO:0007165signal transduction-IBA21873635  
GO:0007605sensory perception of sound-IMP25601850  
GO:0030111regulation of Wnt signaling pathway-IMP25557784  
GO:0032502developmental process-IBA21873635  
GO:0035556intracellular signal transduction-IEA-  
GO:0045880positive regulation of smoothened signaling pathway-IMP21698230  
GO:0048813dendrite morphogenesis-IBA21873635  
GO:0060271cilium assembly-IBA21873635  
GO:0060271cilium assembly-IMP27319779  
GO:1902017regulation of cilium assembly-IBA21873635  
GO:1902017regulation of cilium assembly-IMP25601850  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005737cytoplasm-IDA21698230  27319779  
GO:0005815microtubule organizing center-IBA21873635  
GO:0005815microtubule organizing center-IDA-  
GO:0005829cytosol-IDA-  
GO:0005874microtubule-IBA21873635  
GO:0005929cilium-IBA21873635  
GO:0005929cilium-IDA21698230  25601850  27319779  
GO:0005930axoneme-IBA21873635  
GO:0005930axoneme-IDA25557784  27319779  
GO:0015630microtubule cytoskeleton-IDA-  
GO:0030864cortical actin cytoskeletonCOLOCALIZES_WITHIBA21873635  
GO:0060091kinocilium-IBA21873635  
GO:0060091kinocilium-ISS-  
GO:0072686mitotic spindle-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24268366Comparison of genome-wide DNA methylation in urothelial carcinomas of patients with and without arsenic exposure. (2014 Jan)Yang TYEnviron Res