Gene: ANKFY1

51479
ANKHZN|BTBD23|ZFYVE14
ankyrin repeat and FYVE domain containing 1
protein-coding
17p13.2
Ensembl:ENSG00000185722 MIM:607927 Vega:OTTHUMG00000177727 UniprotKB:Q9P2R3
NC_000017.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.534e-1 (AD)  4.330e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs1982176chr17:4171101 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg24276841chr17:4125562ANKFY1Gene body6.525e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SPG110.94
CNOT10.908
KDM3B0.907
SNRNP2000.907
SON0.905
EP3000.903
SYNRG0.901
UBR50.898
ZFYVE260.895
ANKHD10.894

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.564
OR4F29-0.524
KLRC2-0.294
NANOGNB-0.291
C17orf112-0.274
MTRNR2L6-0.226
OR6C74-0.225
HMHB1-0.225
CD8B-0.218
OR4F16-0.217

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ANKFY1 mRNA"19162173
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ANKFY1 mRNA"21346803
C0127962-butenal2-butenal results in decreased expression of ANKFY1 mRNA20471460
D000082AcetaminophenAcetaminophen results in decreased expression of ANKFY1 mRNA21420995
D000082AcetaminophenAcetaminophen results in increased expression of ANKFY1 mRNA22230336
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of ANKFY1 mRNA19770486
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of ANKFY1 mRNA21298039
D001152ArsenicalsArsenicals results in increased methylation of ANKFY1 promoter26039340
D001280AtrazineAtrazine results in decreased expression of ANKFY1 mRNA22378314
C547126AZM551248AZM551248 results in increased expression of ANKFY1 mRNA22323515
D001554BenzeneBenzene results in decreased expression of ANKFY1 mRNA21843810
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ANKFY1 mRNA"19150397
C044887beta-methylcholinebeta-methylcholine affects the expression of ANKFY1 mRNA21179406
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKFY1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ANKFY1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ANKFY1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKFY1 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ANKFY1 mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of ANKFY1 mRNA26982218
D002220CarbamazepineCarbamazepine affects the expression of ANKFY1 mRNA25979313
D019327Copper SulfateCopper Sulfate results in decreased expression of ANKFY1 mRNA19549813
D003471CuprizoneCuprizone results in increased expression of ANKFY1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ANKFY1 mRNA25562108
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKFY1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKFY1 mRNA28628672
C000944dicrotophosdicrotophos results in increased expression of ANKFY1 mRNA28302478
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ANKFY1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of ANKFY1 mRNA21525395
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKFY1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKFY1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKFY1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of ANKFY1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ANKFY1 mRNA28628672
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of ANKFY1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of ANKFY1 mRNA"25554681
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKFY1 mRNA25729387
D010416PentachlorophenolPentachlorophenol results in increased expression of ANKFY1 mRNA23892564
D010936Plant ExtractsPlant Extracts results in increased expression of ANKFY1 mRNA23557933
D012822Silicon DioxideSilicon Dioxide analog results in increased expression of ANKFY1 mRNA25895662
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANKFY1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ANKFY1 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of ANKFY1 mRNA25613284
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ANKFY1 mRNA25729387
C012589trichostatin Atrichostatin A results in increased expression of ANKFY1 mRNA15901671
D014635Valproic AcidValproic Acid results in increased expression of ANKFY1 mRNA15901671
D014635Valproic AcidValproic Acid affects the expression of ANKFY1 mRNA17292431
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of ANKFY1 gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15328530  20562859  22284051  27189942  
GO:0017137Rab GTPase binding-IDA15328530  
GO:0046872metal ion binding-IEA-  
GO:1901981phosphatidylinositol phosphate binding-IDA15328530  
GO ID GO Term Qualifier Evidence PubMed
GO:0006897endocytosis-IEA-  
GO:0016197endosomal transport-IMP24102721  
GO:0034058endosomal vesicle fusion-IDA15328530  
GO:0042147retrograde transport, endosome to Golgi-IMP22284051  
GO:0048549positive regulation of pinocytosis-IDA15328530  
GO:0090160Golgi to lysosome transport-IMP22284051  
GO ID GO Term Qualifier Evidence PubMed
GO:0005765lysosomal membrane-HDA17897319  
GO:0005768endosome-IDA-  
GO:0005769early endosome-IDA15328530  
GO:0005829cytosol-IEA-  
GO:0010008endosome membrane-ISS-  
GO:0016020membrane-IDA10940552  
GO:0030904retromer complexcolocalizes_withIDA22284051  
GO:0043231intracellular membrane-bounded organelle-IDA-  
GO:0044354macropinosome-IDA15328530  
GO:0070062extracellular exosome-HDA18570454  19056867  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal