Gene info: ID 51520

Gene: LARS

GENE ID: 51520

Description: leucyl-tRNA synthetase

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000133706 MIM:151350 Vega:OTTHUMG00000163429 UniprotKB:Q9P2J5

RefSeq: NG_042294.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND|AD

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.687e-1 (AD) 3.744e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
DHX9	0.953
EPRS	0.949
KPNB1	0.947
RBBP4	0.939
SLC39A9	0.939
ZNF512	0.936
XRCC5	0.935
TFCP2	0.934
CSNK2A1	0.934
GDI2	0.934

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
OR4F5	-0.793
OR4F29	-0.758
MTRNR2L6	-0.215
C8orf74	-0.208
MTRNR2L9	-0.198
HMHB1	-0.195
KLRB1	-0.194
NKX6-1	-0.191
OR6C74	-0.191
MTRNR2L10	-0.187

There is no DrugBank record for this gene !

ID	Drug Name	Action	PubMed
C511295	2,2',4,4'-tetrabromodiphenyl ether	"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of LARS mRNA"	25614096
C111118	2',3,3',4',5-pentachloro-4-hydroxybiphenyl	"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of LARS mRNA"	19114083
C023514	2,6-dinitrotoluene	"2,6-dinitrotoluene affects the expression of LARS mRNA"	21346803
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
C459179	4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
C516138	(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
D000082	Acetaminophen	Acetaminophen affects the expression of LARS mRNA	17562736
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of LARS mRNA	22228805
D015123	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of LARS mRNA"	20018196
D001622	Betaine	Betaine results in decreased expression of LARS mRNA	26391144
C006780	bisphenol A	bisphenol A results in increased expression of LARS mRNA	25181051
D019256	Cadmium Chloride	Cadmium Chloride results in increased expression of LARS mRNA	25596134
D002220	Carbamazepine	Carbamazepine affects the expression of LARS mRNA	25979313
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of LARS mRNA	27339419
D002509	Cephaloridine	Cephaloridine results in decreased expression of LARS mRNA	18500788
C004656	chloroacetaldehyde	chloroacetaldehyde results in decreased expression of LARS mRNA	25596134
C074702	chromium hexavalent ion	chromium hexavalent ion affects the expression of LARS mRNA	28472532
C059262	cidofovir	cidofovir results in decreased expression of LARS mRNA	25596134
C029892	cupric chloride	cupric chloride results in increased expression of LARS mRNA	24650576
D016572	Cyclosporine	Cyclosporine results in increased expression of LARS mRNA	20106945\|2556210
D016572	Cyclosporine	Cyclosporine results in increased expression of LARS mRNA	25596134
C010902	decabromobiphenyl ether	decabromobiphenyl ether results in decreased expression of LARS mRNA	23914054
D013759	Dronabinol	Dronabinol results in increased expression of LARS mRNA	16616335
D003907	Dexamethasone	Dexamethasone results in decreased expression of LARS mRNA	22733784
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of LARS mRNA	24893172
D002945	Cisplatin	Cisplatin results in decreased expression of LARS mRNA	25596134
D004791	Enzyme Inhibitors	[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of LARS protein	23301498
D011345	Fenofibrate	Fenofibrate results in increased expression of LARS mRNA	25596134
D011345	Fenofibrate	Fenofibrate results in decreased expression of LARS mRNA	25596134
D005485	Flutamide	Flutamide results in decreased expression of LARS mRNA	24793618
D005485	Flutamide	Flutamide results in increased expression of LARS mRNA	24136188
C001277	geldanamycin	geldanamycin results in increased expression of LARS mRNA	26705709
D005839	Gentamicins	Gentamicins results in increased expression of LARS mRNA	22061828
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of LARS mRNA	21179406
D007052	Ibuprofen	Ibuprofen results in increased expression of LARS mRNA	25596134
C492448	ICG 001	ICG 001 results in increased expression of LARS mRNA	26191083
D008687	Metformin	Metformin results in increased expression of LARS mRNA	25596134
C004925	methylmercuric chloride	methylmercuric chloride results in decreased expression of LARS mRNA	28001369
D008741	Methyl Methanesulfonate	Methyl Methanesulfonate results in decreased expression of LARS mRNA	23649840
C583365	N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide	"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of LARS mRNA"	29244179
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in increased expression of LARS mRNA"	25620056
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of LARS mRNA"	25620056
C058305	phenethyl isothiocyanate	phenethyl isothiocyanate results in decreased expression of LARS mRNA	17616710
C006253	pirinixic acid	pirinixic acid results in increased expression of LARS mRNA	18301758
C006253	pirinixic acid	pirinixic acid results in decreased expression of LARS mRNA	16940010
D010936	Plant Extracts	Plant Extracts results in increased expression of LARS mRNA	23557933
D013605	T-2 Toxin	T-2 Toxin results in decreased expression of LARS mRNA	26141394
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of LARS mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of LARS mRNA	21570461
D013750	Tetrachloroethylene	Tetrachloroethylene results in increased expression of LARS mRNA	28973375
D013849	Thimerosal	Thimerosal results in decreased expression of LARS mRNA	27188386
C483909	torcetrapib	torcetrapib results in increased expression of LARS mRNA	23228038
D014212	Tretinoin	Tretinoin results in decreased expression of LARS mRNA	23724009
C012589	trichostatin A	"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
C012589	trichostatin A	trichostatin A results in decreased expression of LARS mRNA	26272509
D014635	Valproic Acid	"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LARS mRNA"	27188386
D014635	Valproic Acid	Valproic Acid affects the expression of LARS mRNA	25979313
D014635	Valproic Acid	Valproic Acid results in decreased expression of LARS mRNA	23179753\|2627250
D001335	Vehicle Emissions	Vehicle Emissions results in increased methylation of LARS gene	25560391
C025643	vinclozolin	vinclozolin affects the expression of LARS mRNA	23034163
C111237	vorinostat	vorinostat results in decreased expression of LARS mRNA	27188386

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0002161	aminoacyl-tRNA editing activity	-	IEA	-
GO:0004819	glutamine-tRNA ligase activity	-	IDA	26869582
GO:0004823	leucine-tRNA ligase activity	-	IBA	21873635
GO:0004823	leucine-tRNA ligase activity	-	TAS	-
GO:0005096	GTPase activator activity	-	IMP	22424946
GO:0005515	protein binding	-	IPI	16055448 22424946
GO:0005524	ATP binding	-	IEA	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0006418	tRNA aminoacylation for protein translation	-	TAS	-
GO:0006425	glutaminyl-tRNA aminoacylation	-	IDA	26869582
GO:0006429	leucyl-tRNA aminoacylation	-	IBA	21873635
GO:0006622	protein targeting to lysosome	-	IMP	22424946
GO:0008361	regulation of cell size	-	IMP	22424946
GO:0010507	negative regulation of autophagy	-	IMP	22424946
GO:0034198	cellular response to amino acid starvation	-	IMP	22424946
GO:0043547	positive regulation of GTPase activity	-	IMP	22424946
GO:0071230	cellular response to amino acid stimulus	-	IMP	22424946
GO:0071233	cellular response to leucine	-	IMP	22424946
GO:0106074	aminoacyl-tRNA metabolism involved in translational fidelity	-	IEA	-
GO:1904263	positive regulation of TORC1 signaling	-	IMP	22424946
GO:1990253	cellular response to leucine starvation	-	IMP	22424946

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005737	cytoplasm	-	IDA	22424946
GO:0005764	lysosome	-	IMP	22424946
GO:0005783	endoplasmic reticulum	-	IDA	22424946
GO:0005829	cytosol	-	IDA	19289464
GO:0005829	cytosol	-	TAS	-
GO:0012505	endomembrane system	-	IDA	22424946
GO:0016604	nuclear body	-	IDA	-
GO:0017101	aminoacyl-tRNA synthetase multienzyme complex	-	IDA	19131329

KEGG ID	KEGG Term
hsa00290	Valine, leucine and isoleucine biosynthesis
hsa00970	Aminoacyl-tRNA biosynthesis

Reactome ID	Reactome Term	Evidence
R-HSA-1430728	Metabolism	IEA
R-HSA-2408517	SeMet incorporation into proteins	IEA
R-HSA-2408522	Selenoamino acid metabolism	IEA
R-HSA-379716	Cytosolic tRNA aminoacylation	TAS
R-HSA-379724	tRNA Aminoacylation	TAS
R-HSA-392499	Metabolism of proteins	TAS
R-HSA-71291	Metabolism of amino acids and derivatives	IEA
R-HSA-72766	Translation	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
9551774	The effects of cigarette smoking on overnight performance. (1998 Mar)	Parkin C	Psychopharmacology (Berl)