Gene: ZC3HC1

51530
HSPC216|NIPA
zinc finger C3HC-type containing 1
protein-coding
7q32.2
Ensembl:ENSG00000091732 Vega:OTTHUMG00000157648 UniprotKB:Q86WB0
NC_000007.14
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.636e-2 (AD)  4.918e-2 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ERAL10.904
SMYD50.893
SLC25A380.892
PRR30.888
SPPL30.886
PRCC0.883
DMAP10.883
DRG10.883
RRAGA0.882
RNF250.881

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.643
OR4F29-0.582
TFPI2-0.305
MTRNR2L9-0.303
RAI14-0.29
TRPV5-0.286
KLRB1-0.284
IFNG-0.282
C9orf153-0.281
MTRNR2L6-0.262

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ZC3HC1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ZC3HC1 mRNA"21346803
D000082AcetaminophenAcetaminophen results in decreased expression of ZC3HC1 mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of ZC3HC1 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of ZC3HC1 mRNA28959563
D000535Aluminum[APP protein modified form binds to Aluminum] which results in increased expression of ZC3HC1 mRNA21298039
D001280AtrazineAtrazine results in increased expression of ZC3HC1 mRNA25929836
D001280AtrazineAtrazine results in decreased expression of ZC3HC1 mRNA22378314
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ZC3HC1 mRNA22316170
C006780bisphenol Abisphenol A affects the expression of ZC3HC1 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of ZC3HC1 mRNA25181051
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of ZC3HC1 promoter22457795
D002166CamptothecinZC3HC1 mRNA results in decreased susceptibility to Camptothecin25269479
C089595cylindrospermopsincylindrospermopsin results in increased expression of ZC3HC1 mRNA24921660
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of ZC3HC1 mRNA17361019|2126653
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of ZC3HC1 protein23301498
D005485FlutamideFlutamide results in decreased expression of ZC3HC1 mRNA21126777
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZC3HC1 mRNA25613284
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ZC3HC1 mRNA19710929
C009277sodium arsenatesodium arsenate results in increased expression of ZC3HC1 mRNA23922661
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ZC3HC1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ZC3HC1 mRNA21354282
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ZC3HC1 mRNA25613284

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI16105984  
GO:0008270zinc ion binding-IEA-  
GO:0019901protein kinase binding-IPI16105984  
GO ID GO Term Qualifier Evidence PubMed
GO:0007049cell cycle-IEA-  
GO:0016567protein ubiquitination-IEA-  
GO:0051301cell division-IEA-  
GO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0031965nuclear membrane-IDA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
26893834Association of genetic variants with atrial fibrillation. (2016 Feb)Yamase YBiomed Rep