Gene: PDGFA

5154
PDGF-A|PDGF1
platelet derived growth factor subunit A
protein-coding
7p22.3
Ensembl:ENSG00000197461 MIM:173430 Vega:OTTHUMG00000151412 UniprotKB:P04085
NG_029727.1
PubMed
ND
4   
NA (AD)  NA (ND)   (Frontal_Cortex)
9.092e-1 (AD)  NA (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg23112425chr7:547637PDGFAGene body4.477e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TMEM1890.852
RALY0.846
BIN10.837
SCNM10.831
PHC20.829
MAX0.825
SNX90.819
PTMA0.818
EIF2B40.815
STX40.815

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.64
OR4F29-0.634
SLC6A2-0.222
FAM216B-0.193
POU3F4-0.193
HES5-0.188
RGS8-0.163
SP8-0.156
NDNF-0.151
NPBWR1-0.149

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of PDGFA mRNA"22698814
C0005915411-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of PDGFA mRNA]"24403227
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in decreased expression of PDGFA mRNA19933214
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of PDGFA mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PDGFA mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA mRNA"12376462|1521517
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of PDGFA protein"12376462
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PDGFA mRNA"26644586
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of PDGFA mRNA]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFA mRNA]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of PDGFA protein]23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased expression of PDGFA mRNA23625689
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide results in decreased secretion of PDGFA protein23625689
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDGFA mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PDGFA mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C1068765,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone"5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]"19201774
C1068765,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone"5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]"19201774
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C1118556-formylindolo(3,2-b)carbazole"6-formylindolo(3,2-b)carbazole results in increased expression of PDGFA mRNA"23625689
D000082AcetaminophenAcetaminophen results in increased expression of PDGFA mRNA21420995
D000082AcetaminophenAcetaminophen affects the expression of PDGFA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDGFA mRNA27153756
D000537Aluminum OxideAluminum Oxide results in increased expression of PDGFA mRNA19464052
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDGFA mRNA16483693
D039741Antigens, Dermatophagoides"[Nanotubes, Carbon co-treated with Antigens, Dermatophagoides] results in increased expression of PDGFA mRNA"26091108
C006632arsenic trioxidearsenic trioxide results in decreased expression of PDGFA mRNA20458559
C006632arsenic trioxidearsenic trioxide results in increased expression of PDGFA mRNA27829220
D017639Asbestos, Amosite"2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
D017639Asbestos, Amosite"Asbestos, Amosite results in decreased expression of PDGFA mRNA"21797767
D017639Asbestos, Amosite"Asbestos, Amosite results in increased expression of PDGFA mRNA"11306436|1247580
D017639Asbestos, Amosite"Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
D017639Asbestos, Amosite"Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436|1247580
D017639Asbestos, Amosite"tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
D017636Asbestos, Amphibole"Asbestos, Amphibole results in decreased expression of PDGFA mRNA"21797767
D001379AzathioprineAzathioprine results in increased expression of PDGFA mRNA22623647
C487081belinostatbelinostat results in decreased expression of PDGFA mRNA27188386
C487081belinostatbelinostat results in increased expression of PDGFA mRNA26272509
C487081belinostat"[NOG protein co-treated with belinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
D019324beta-Naphthoflavone[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PDGFA mRNA18164116
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFA mRNA23625689
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFA mRNA20713471|2156981
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFA mRNA22228805|2261060
D004958Estradiol[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]15866426
D004958EstradiolEstradiol results in decreased expression of PDGFA mRNA10731640
D004958EstradiolEstradiol results in increased expression of PDGFA mRNA20106945
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PDGFA mRNA17404688
D001663BilirubinBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
D001663BilirubinBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
D001663BilirubinBilirubin results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PDGFA mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of PDGFA mRNA23798566|2606340
C006780bisphenol Abisphenol A results in increased expression of PDGFA mRNA21932408
C006780bisphenol Abisphenol A results in increased expression of PDGFA mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFA mRNA28628672
C025703bleomycetinbleomycetin results in decreased expression of PDGFA mRNA21040473
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in increased expression of PDGFA mRNA15336504
D002104CadmiumCadmium results in increased expression of PDGFA mRNA17125913
D002104Cadmiumfulvestrant inhibits the reaction [Cadmium results in increased expression of PDGFA mRNA]17125913
D019256Cadmium ChlorideCadmium Chloride results in increased expression of PDGFA mRNA17125913|2647268
D019256Cadmium Chloridefulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PDGFA mRNA]17125913
C037123cadmium sulfatecadmium sulfate affects the reaction [MTF1 affects the expression of PDGFA mRNA]16221973
D002211CapsaicinCapsaicin results in increased expression of PDGFA protein22150557
D002211Capsaicin[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D002211CapsaicinNaproxen inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D002211CapsaicinSumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D002220CarbamazepineCarbamazepine affects the expression of PDGFA mRNA25979313
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PDGFA mRNA25827057
D002273CarcinogensCarcinogens results in increased expression of PDGFA mRNA16316942
D000068579CelecoxibCelecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
D000068579CelecoxibCelecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
D000068579CelecoxibCelecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]19201774
D000068579CelecoxibCelecoxib inhibits the reaction [PDGFA results in increased phosphorylation of and results in increased activity of AKT1 protein]19201774
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDGFA gene20938992
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of and results in increased activity of HMOX1 protein]12690112
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin results in increased activity of HMOX1 protein] results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
C018021cobaltous chloridecobaltous chloride results in increased expression of PDGFA mRNA26800359
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDGFA mRNA24386269
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of PDGFA mRNA20971185
D019327Copper SulfateCopper Sulfate results in increased expression of PDGFA mRNA19549813
D003314Corn OilCorn Oil affects the expression of PDGFA mRNA16360708
C030973cupric oxidecupric oxide results in decreased expression of PDGFA mRNA22077320
C017154cyanidincyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C017154cyanidincyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]16921400
D016572CyclosporineCyclosporine results in increased expression of PDGFA mRNA20106945|2163298
C017160cypermethrincypermethrin results in increased expression of PDGFA mRNA22528246
C014347decitabinedecitabine results in increased expression of PDGFA mRNA15251184
C014347decitabine[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFA mRNA15251184
D003676Deferoxamine"Deferoxamine inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
C017185delphinidindelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C017185delphinidindelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]16921400
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PDGFA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFA mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of PDGFA mRNA21041162
D003907DexamethasoneDexamethasone inhibits the reaction [nitrofen results in decreased expression of PDGFA mRNA]10646786
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDGFA mRNA21266533
D003994BucladesineBucladesine results in decreased expression of PDGFA mRNA1650039
D003999Dichloroacetic AcidDichloroacetic Acid results in increased expression of PDGFA mRNA28962523
D004026DieldrinDieldrin affects the expression of PDGFA mRNA22546817
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with beta-Naphthoflavone] results in decreased expression of PDGFA mRNA18164116
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of PDGFA mRNA15171707
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PDGFA mRNA"12376462
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of PDGFA protein"12376462
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PDGFA mRNA25380136
C118739entinostatentinostat results in increased expression of PDGFA mRNA26272509
C118739entinostat"[NOG protein co-treated with entinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
D004964EstriolEstriol results in decreased expression of PDGFA mRNA10731640
D004970EstroneEstrone results in decreased expression of PDGFA mRNA10731640
C017296estrone sulfateestrone sulfate results in decreased expression of PDGFA mRNA10731640
D000431EthanolEthanol results in decreased expression of PDGFA mRNA28789864
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PDGFA mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PDGFA mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDGFA mRNA17942748
D005419FlavonoidsFlavonoids results in increased expression of PDGFA mRNA18035473
D005492Folic AcidFolic Acid affects the expression of PDGFA mRNA16361273
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDGFA gene20938992
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium Chloride results in increased expression of PDGFA mRNA]17125913
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium results in increased expression of PDGFA mRNA]17125913
C056933fumonisin B1fumonisin B1 results in increased expression of PDGFA mRNA16221962
C039281furanfuran results in increased expression of PDGFA mRNA24183702
C038958gadolinium chloridegadolinium chloride results in decreased expression of PDGFA mRNA14578756
C001277geldanamycingeldanamycin results in increased expression of PDGFA mRNA26705709
D019833Genistein[Genistein co-treated with Methoxychlor] results in decreased expression of PDGFA mRNA21782745
D005944GlucosamineGlucosamine affects the expression of PDGFA mRNA17109745
D005944GlucosamineGlucosamine inhibits the reaction [IL1B results in increased expression of PDGFA mRNA]17109745
D005944GlucosamineIL1B affects the reaction [Glucosamine affects the expression of PDGFA mRNA]17109745
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PDGFA mRNA22634610
D006072Gossypol[zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA19825521
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PDGFA mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of PDGFA mRNA26644586
D006427Hemin[Hemin results in increased activity of HMOX1 protein] results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
D006861Hydrogen PeroxideHydrogen Peroxide affects the expression of PDGFA mRNA20044591
D006861Hydrogen Peroxide[nitrofen results in increased expression of [PDGFA protein co-treated with PDGFRA protein]] which results in increased abundance of Hydrogen Peroxide20920717
D003900Desoxycorticosterone[PDGFA protein binds to PDGFB protein] which results in increased susceptibility to Desoxycorticosterone11751714
D007052IbuprofenIbuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
D007052IbuprofenIbuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
C016517indole-3-carbinolindole-3-carbinol affects the expression of PDGFA mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PDGFA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFA mRNA28628672
D007501Iron"Iron promotes the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436|1247580
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of PDGFA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFA mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PDGFA mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFA mRNA26644586
C045463leflunomideleflunomide results in increased expression of PDGFA mRNA28988120
C482199lipopolysaccharide, E coli O55-B5"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PDGFA mRNA"20371263
D019808LosartanLosartan inhibits the reaction [AGT protein alternative form results in increased expression of PDGFA mRNA alternative form]12431451
C065861malvidinmalvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]15866426
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of PDGFA gene20938992
D008727MethotrexateMethotrexate results in increased expression of PDGFA mRNA21678067
D008731Methoxychlor[Genistein co-treated with Methoxychlor] results in decreased expression of PDGFA mRNA21782745
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PDGFA mRNA28001369
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of PDGFA mRNA21664453
D008767Methylmercury CompoundsMethylmercury Compounds affects the expression of PDGFA mRNA21664453
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDGFA mRNA"20188158
D008777MethyltestosteroneMethyltestosterone results in decreased expression of PDGFA mRNA29191790
D009151Mustard GasIL10 protein affects the reaction [Mustard Gas affects the expression of PDGFA mRNA]16173061
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of PDGFA mRNA"25461557
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased expression of PDGFA mRNA"25461557
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
C080955N-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamideN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDGFA mRNA"25554681
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Antigens, Dermatophagoides] results in increased expression of PDGFA mRNA"26091108
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDGFA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDGFA"25510677
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDGFA mRNA"26091108
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PDGFA mRNA25380136
D009288Naproxen[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D009288NaproxenNaproxen inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D000068577NebivololNebivolol results in decreased expression of PDGFA mRNA17467819
C029938nickel sulfatenickel sulfate results in increased expression of PDGFA mRNA16780908|2271453
D009538NicotineNicotine affects the expression of PDGFA mRNA20426880
D009538NicotineNicotine results in increased secretion of PDGFA protein17630920
C007350nitrofenDexamethasone inhibits the reaction [nitrofen results in decreased expression of PDGFA mRNA]10646786
C007350nitrofennitrofen results in decreased expression of PDGFA mRNA10646786|1089822
C007350nitrofennitrofen results in increased expression of PDGFA mRNA20920717
C007350nitrofennitrofen results in increased expression of PDGFA protein20920717
C007350nitrofen[nitrofen results in increased expression of [PDGFA protein co-treated with PDGFRA protein]] which results in increased abundance of Hydrogen Peroxide20920717
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of PDGFA mRNA20971185
C000592118ONO-8430506ONO-8430506 results in decreased expression of [PDGFA protein binds to PDGFA protein]26037280
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFA mRNA25729387
C030110oxaliplatinoxaliplatin results in increased expression of PDGFA mRNA25729387
D010100Oxygen"1-cyclopropyl-4-(4-((5-methyl-3-(3-(4-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-5-yl)-1H-pyrazol-1-yl)methyl)pyridin-2-yl)piperazine inhibits the reaction [Oxygen deficiency results in increased expression of PDGFA mRNA]"24403227
D010100OxygenOxygen deficiency results in increased expression of PDGFA mRNA24403227
D010126OzoneOzone results in decreased expression of PDGFA mRNA17095637
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PDGFA mRNA26272509
D010269ParaquatParaquat results in increased expression of PDGFA mRNA16324872
D010269ParaquatParaquat results in increased expression of PDGFA mRNA20498031
C473205peonidinpeonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of PDGFA mRNA19162173
D015232Dinoprostone"5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]"19201774
D015232DinoprostoneCelecoxib inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
D015232DinoprostoneIbuprofen inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
D015232DinoprostoneN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Dinoprostone]19201774
D015232DinoprostonePDGFA results in increased abundance of Dinoprostone19201774
D010634PhenobarbitalNR1I3 protein affects the reaction [Phenobarbital results in increased expression of PDGFA mRNA]19482888
D010634PhenobarbitalNR1I3 protein promotes the reaction [Phenobarbital results in increased expression of PDGFA mRNA]19482888
D010634PhenobarbitalPhenobarbital results in increased expression of PDGFA mRNA19482888
D010672PhenytoinPhenytoin results in increased expression of PDGFA mRNA14741686
D010795Phthalic AcidsPhthalic Acids results in increased expression of PDGFA mRNA22112501
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDGFA mRNA22714537
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PDGFA mRNA17404688
D011374ProgesteroneProgesterone results in increased expression of PDGFA mRNA16888808
D011464Epoprostenol"5,5-dimethyl-3-(3-fluorophenyl)-4-(4-methylsulfonyl)phenyl-2(5H)-furanone inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]"19201774
D011464EpoprostenolCelecoxib inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
D011464EpoprostenolIbuprofen inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
D011464EpoprostenolN-(2-cyclohexyloxy-4-nitrophenyl)methanesulfonamide inhibits the reaction [PDGFA results in increased abundance of Epoprostenol]19201774
D011464EpoprostenolPDGFA results in increased abundance of Epoprostenol19201774
D017257RamiprilRamipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]10352363
D017257RamiprilRamipril results in decreased expression of PDGFA mRNA10352363
D017382Reactive Oxygen Speciescyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciesdelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciesmalvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciespeonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Species[PDGFA protein binds to PDGFB protein] which results in increased chemical synthesis of Reactive Oxygen Species12690112
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of PDGFA mRNA19244175
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PDGFA mRNA"18039278
D019821SimvastatinSimvastatin results in decreased expression of PDGFA mRNA16414398
D012906SmokeSmoke results in decreased nitrosation of PDGFA protein21652289
D012906SmokeSmoke results in increased expression of PDGFA mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of PDGFA mRNA16882884
C009277sodium arsenatesodium arsenate results in increased expression of PDGFA mRNA12727804
C017947sodium arsenitesodium arsenite results in increased expression of PDGFA mRNA12727804|1276083
C017947sodium arsenitesodium arsenite results in decreased expression of PDGFA mRNA16014739
C016104sodium bichromatesodium bichromate results in increased expression of PDGFA mRNA25993096
D018038Sodium SeleniteSodium Selenite results in increased expression of PDGFA mRNA24383545
D053260SootSoot results in decreased expression of PDGFA mRNA26551751
D013467Sulindac"[Sulindac co-treated with lipopolysaccharide, E coli O55-B5] affects the expression of PDGFA mRNA"20371263
D018170Sumatriptan[Naproxen co-treated with Sumatriptan] inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
D018170SumatriptanSumatriptan inhibits the reaction [Capsaicin results in increased expression of PDGFA protein]22150557
C446685systhane"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in increased expression of PDGFA mRNA"25461557
C061133tamibarotenetamibarotene inhibits the reaction [KLF5 protein binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene inhibits the reaction [[KLF5 protein binds to [RARA protein binds to RXRA protein]] which binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene inhibits the reaction [KLF5 results in increased expression of PDGFA mRNA]16224062
C061133tamibarotenetamibarotene inhibits the reaction [[RARA co-treated with RXRA] promotes the reaction [KLF5 results in increased expression of PDGFA mRNA]]16224062
C061133tamibarotenetamibarotene inhibits the reaction [RARA protein binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene inhibits the reaction [RXRA protein binds to PDGFA promoter]16224062
C061133tamibarotenetamibarotene results in decreased expression of PDGFA mRNA16224062
C061133tamibarotenetamibarotene results in decreased expression of PDGFA mRNA16224062
D013629TamoxifenTamoxifen affects the expression of PDGFA mRNA17555576
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of PDGFA mRNA]23625689
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFA mRNA]23625689
D013749Tetrachlorodibenzodioxin2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Tetrachlorodibenzodioxin results in increased secretion of PDGFA protein]23625689
D013749TetrachlorodibenzodioxinPDGFA mutant form inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]23625689
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with IL1B protein] results in increased expression of PDGFA mRNA23625689
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDGFA mRNA26238291
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDGFA mRNA23625689
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of PDGFA protein23625689
D013749TetrachlorodibenzodioxinSRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFA mRNA]14708085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDGFA mRNA21570461|2468072
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with decitabine] results in increased expression of PDGFA mRNA15251184
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDGFA mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDGFA mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDGFA mRNA12167310|1470808
D013755Tetradecanoylphorbol AcetateRamipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA]10352363
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PDGFA mRNA10352363|1042850
C019107tetramethylthiourea"tetramethylthiourea inhibits the reaction [Asbestos, Amosite results in increased expression of PDGFA mRNA]"11306436
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFA mRNA]28560358
D013853ThioacetamideThioacetamide results in increased expression of PDGFA mRNA28560358
D013853ThioacetamideThioacetamide results in increased expression of PDGFA mRNA23411599
C032628tin protoporphyrin IX2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C032628tin protoporphyrin IX2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C032628tin protoporphyrin IXBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C032628tin protoporphyrin IXBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of and results in increased activity of HMOX1 protein]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C032628tin protoporphyrin IX[tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in increased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
C009495titanium dioxidetitanium dioxide results in increased expression of PDGFA mRNA23409001
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFA mRNA25729387
D019772TopotecanTopotecan results in increased expression of PDGFA mRNA25729387
D014118Toxins, Biological"Toxins, Biological affects the expression of PDGFA mRNA"19682533
D014212TretinoinTretinoin results in decreased expression of PDGFA mRNA23830798
D014212TretinoinTretinoin results in decreased expression of PDGFA mRNA16604517
D014212TretinoinTretinoin results in decreased expression of PDGFA mRNA16224062
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFA mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of PDGFA mRNA24935251
C012589trichostatin Atrichostatin A results in increased expression of PDGFA mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of PDGFA mRNA15901671
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of EGR1 protein]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of SOD2 mRNA]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]11511524
D014520Urethane[Urethane co-treated with IFNG protein] results in increased expression of PDGFA mRNA12810352
D014635Valproic AcidValproic Acid affects the expression of PDGFA mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDGFA mRNA28001369|2915479
D014635Valproic AcidValproic Acid results in increased expression of PDGFA mRNA24935251
D014635Valproic AcidValproic Acid results in increased methylation of PDGFA gene29154799
D014635Valproic AcidValproic Acid results in decreased expression of PDGFA mRNA15901671
C066075vanadium pentoxidevanadium pentoxide results in increased expression of PDGFA mRNA17134509
D014640VancomycinVancomycin results in decreased expression of PDGFA mRNA18930951
C025643vinclozolinvinclozolin affects the expression of PDGFA mRNA19015723
D014800VitalliumVitallium analog results in increased expression of PDGFA mRNA23825117
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of PDGFA mRNA19244175
C111237vorinostatvorinostat results in decreased expression of PDGFA mRNA27188386
C088658zoledronic acid[zoledronic acid co-treated with Gossypol] results in decreased expression of PDGFA mRNA19825521

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005161platelet-derived growth factor receptor binding-IBA21873635  
GO:0005161platelet-derived growth factor receptor binding-IDA2439522  2836953  
GO:0005161platelet-derived growth factor receptor binding-IPI2536956  
GO:0005515protein binding-IPI7679113  25241761  
GO:0005518collagen binding-IDA8900172  
GO:0008083growth factor activity-IDA12070119  
GO:0042803protein homodimerization activity-IDA2836953  3754619  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0046982protein heterodimerization activity-IPI7073684  
GO:0048407platelet-derived growth factor binding-IPI7073684  
GO:0070851growth factor receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001525angiogenesis-ISS-  
GO:0001775cell activation-TAS10508235  
GO:0001942hair follicle development-ISS-  
GO:0002053positive regulation of mesenchymal cell proliferation-ISS-  
GO:0002576platelet degranulation-TAS-  
GO:0007267cell-cell signaling-TAS2842868  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA2439522  2836953  7073684  10806482  16462734  17470632  
GO:0009611response to wounding-IDA2538439  
GO:0009887animal organ morphogenesis-ISS-  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010512negative regulation of phosphatidylinositol biosynthetic process-IDA2538439  
GO:0010544negative regulation of platelet activation-IDA2538439  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA11788434  
GO:0014910regulation of smooth muscle cell migration-IDA9409235  
GO:0030031cell projection assembly-ISS-  
GO:0030036actin cytoskeleton organization-ISS-  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0030335positive regulation of cell migration-IDA11788434  17470632  
GO:0031954positive regulation of protein autophosphorylation-IBA21873635  
GO:0031954positive regulation of protein autophosphorylation-IDA12070119  
GO:0032956regulation of actin cytoskeleton organization-TAS10508235  
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway-IDA19019919  
GO:0042060wound healing-TAS10508235  
GO:0043406positive regulation of MAP kinase activity-IBA21873635  
GO:0043406positive regulation of MAP kinase activity-IDA11788434  
GO:0043410positive regulation of MAPK cascade-IMP11788434  
GO:0043588skin development-ISS-  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IDA2439522  2536956  2836953  
GO:0048146positive regulation of fibroblast proliferation-IDA2439522  10806482  
GO:0048286lung alveolus development-ISS-  
GO:0050730regulation of peptidyl-tyrosine phosphorylation-ISS-  
GO:0050919negative chemotaxis-IDA9409235  
GO:0051781positive regulation of cell division-IEA-  
GO:0051897positive regulation of protein kinase B signaling-IDA19019919  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060683regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA11788434  
GO:0072124regulation of glomerular mesangial cell proliferationNOTIDA11788434  
GO:1990401embryonic lung development-ISS-  
GO:2000278regulation of DNA biosynthetic processNOTIDA11788434  19019919  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005615extracellular space-IDA3754619  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0005902microvillus-ISS-  
GO:0009986cell surface-IDA291037  2538439  2836953  
GO:0031093platelet alpha granule lumen-TAS-  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
17295719Regulation of platelet-derived growth factor signaling pathway by ethanol, nicotine, or both in mouse cortical neurons. (2007 Mar)Wang JAlcohol Clin Exp Res
19396864CDKN2A, NF2, and JUN are dysregulated among other genes by miRNAs in malignant mesothelioma -A miRNA microarray analysis. (2009 Jul)Guled MGenes Chromosomes Cancer
29212247A six-mRNA signature model for the prognosis of head and neck squamous cell carcinoma. (2017 Nov 7)Guo WOncotarget
28342264PDGFRA mRNA is overexpressed in oral cancer patients as compared to normal subjects with a significant trend of overexpression among tobacco users. (2017 Sep)Ong HSJ Oral Pathol Med