Gene: SIRT6

51548
SIR2L6
sirtuin 6
protein-coding
19p13.3
Ensembl:ENSG00000077463 MIM:606211 Vega:OTTHUMG00000181847 UniprotKB:Q8N6T7
NG_047153.1
PubMed
0   ANCO-SNPs
ND
3   
2.413e-1 (AD)  5.416e-1 (ND)   (Frontal_Cortex)
5.327e-1 (AD)  3.201e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NELFA0.898
MRPS20.888
MRPL380.883
TMEM161A0.879
UBE2J20.878
RHBDD30.878
LIN370.873
TIMM440.872
ELOF10.871
RFNG0.871

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.662
OR4F29-0.621
DNASE1L3-0.322
ARHGEF35-0.293
KLRB1-0.281
FER1L6-0.277
PDE5A-0.275
TFPI2-0.271
COL14A1-0.269
GADL1-0.265

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SIRT6 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of SIRT6 mRNA]"22698814
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of SIRT6 mRNA"21346803
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]27094368
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in increased expression of SIRT6 mRNA"20406850
D001194AsbestosAsbestos affects the expression of SIRT6 mRNA17297452
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of SIRT6 mRNA22228805
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [SIRT6 protein results in decreased expression of EP300 protein]27094368
C006780bisphenol Abisphenol A affects the expression of SIRT6 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of SIRT6 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of SIRT6 mRNA25181051
D003300Copper[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA24690739
D019327Copper SulfateCopper Sulfate results in increased expression of SIRT6 mRNA19549813
C030973cupric oxidecupric oxide results in increased expression of SIRT6 mRNA22077320
D019314Dehydroepiandrosterone SulfateDehydroepiandrosterone Sulfate results in increased expression of SIRT6 protein25786523
D004221Disulfiram[Disulfiram binds to Copper] which results in decreased expression of SIRT6 mRNA24690739
C069837fullerene C60fullerene C60 results in increased expression of SIRT6 mRNA19167457
D008694MethamphetamineMethamphetamine results in decreased expression of SIRT6 mRNA25452209
C028007nickel monoxidenickel monoxide results in increased expression of SIRT6 mRNA19167457
D010656PhenylephrinePhenylephrine results in decreased expression of and results in decreased activity of SIRT6 protein27094368
D010656PhenylephrineSIRT6 protein affects the reaction [Phenylephrine results in increased expression of MYH7 mRNA]27094368
D010656Phenylephrine[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPA mRNA]27094368
D010656Phenylephrine[SIRT6 protein co-treated with EP300 protein] affects the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of EP300 protein]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of MYH7 mRNA]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPA mRNA]27094368
D010656PhenylephrineSIRT6 protein inhibits the reaction [Phenylephrine results in increased expression of NPPB mRNA]27094368
D011794QuercetinQuercetin results in increased expression of SIRT6 mRNA25862958
C059514resveratrolPARP1 protein affects the reaction [resveratrol results in increased expression of SIRT6 protein]25533949
C059514resveratrolresveratrol results in increased expression of SIRT6 protein25533949
C059514resveratrolSTF-118804 inhibits the reaction [resveratrol results in increased expression of SIRT6 protein]25533949
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased expression of FOXO1 mRNA]21373642
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased expression of PPARGC1A mRNA]21373642
C089730rosiglitazoneSIRT6 affects the reaction [rosiglitazone results in increased phosphorylation of STK11 protein]21373642
C000593977STF-118804STF-118804 inhibits the reaction [resveratrol results in increased expression of SIRT6 protein]25533949
D013501Surface-Active AgentsSurface-Active Agents results in increased expression of SIRT6 mRNA22467014
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of SIRT6 mRNA21570461

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003682chromatin binding-IEA-  
GO:0003714transcription corepressor activity-IEA-  
GO:0003950NAD+ ADP-ribosyltransferase activity-TAS17456799  
GO:0003956NAD(P)+-protein-arginine ADP-ribosyltransferase activity-ISS-  
GO:0005515protein binding-IPI19135889  20829486  23217706  
GO:0008270zinc ion binding-ISS-  
GO:0017136NAD-dependent histone deacetylase activity-ISS-  
GO:0034979NAD-dependent protein deacetylase activity-TAS-  
GO:0046969NAD-dependent histone deacetylase activity (H3-K9 specific)-IDA18337721  
GO:0070403NAD+ binding-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0003247post-embryonic cardiac muscle cell growth involved in heart morphogenesis-IEA-  
GO:0006284base-excision repair-IEA-  
GO:0006471protein ADP-ribosylation-ISS-  
GO:0006471protein ADP-ribosylation-TAS17456799  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0010569regulation of double-strand break repair via homologous recombination-IDA19135889  
GO:0031648protein destabilization-IEA-  
GO:0031667response to nutrient levels-IEA-  
GO:0031940positive regulation of chromatin silencing at telomere-IMP21847107  
GO:0032206positive regulation of telomere maintenance-IMP23201774  25819580  
GO:0042593glucose homeostasis-IEA-  
GO:0045820negative regulation of glycolytic process-IEA-  
GO:0045892negative regulation of transcription, DNA-templated-IEA-  
GO:0046325negative regulation of glucose import-IEA-  
GO:0048146positive regulation of fibroblast proliferation-IEA-  
GO:0061647histone H3-K9 modification-IEA-  
GO:1902732positive regulation of chondrocyte proliferation-IMP25819580  
GO:1905549positive regulation of telomeric heterochromatin assembly-IMP21847107  
GO:1905555positive regulation blood vessel branching-IMP23201774  
GO:1905564positive regulation of vascular endothelial cell proliferation-IMP23201774  
GO:1990619histone H3-K9 deacetylation-IEA-  
GO:2000648positive regulation of stem cell proliferation-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA25819580  
GO:0005634nucleus-ISS-  
GO:0005654nucleoplasm-IDA16079181  
GO:0005654nucleoplasm-TAS-  
GO:0005724nuclear telomeric heterochromatin-IDA18337721  
GO:0005730nucleolusNOTIDA16079181  
GO:0005737cytoplasm-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-5693532DNA Double-Strand Break RepairTAS
R-HSA-5693538Homology Directed RepairTAS
R-HSA-5693567HDR through Homologous Recombination (HR) or Single Strand Annealing (SSA)TAS
R-HSA-5693607Processing of DNA double-strand break endsTAS
R-HSA-73894DNA RepairTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25541994SIRT6 minor allele genotype is associated with >5-year decrease in lifespan in an aged cohort. (2014)TenNapel MJPLoS One
22087257Association of the sirtuin and mitochondrial uncoupling protein genes with carotid plaque. (2011)Dong CPLoS One
24638860SIRT6 regulates the cigarette smoke-induced signalling in rheumatoid arthritis synovial fibroblasts. (2014 Jul)Engler AJ Mol Med (Berl)