Gene: PDGFB

5155
IBGC5|PDGF-2|PDGF2|SIS|SSV|c-sis
platelet derived growth factor subunit B
protein-coding
22q13.1
Ensembl:ENSG00000100311 MIM:190040 Vega:OTTHUMG00000151029 UniprotKB:P01127
NG_012111.1
PubMed
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.466e-1 (AD)  3.891e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
FHOD10.677
ACVR10.673
TSPAN90.665
STAT60.662
ETS20.659
ESYT20.656
JAG20.655
SLC5A60.65
NRROS0.649
PCSK70.647

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
DIAPH3-0.372
OR4F29-0.365
OR4F5-0.363
GLIPR1L2-0.346
GABRG1-0.342
RFTN2-0.321
BMPR1B-0.309
NXNL1-0.303
SLC14A1-0.3
MEGF10-0.286

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB06325PegpleranibSmall Molecule1618657-13-8InvestigationalTarget
ID Drug Name Action PubMed
C0256031,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid"1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]"9650640
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]15728660
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 mRNA]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 mRNA]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 protein]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]22700867
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C0939732-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]15919668
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]15919668
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]15919668
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]15919668
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]23457620
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-oneU 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]15919668
C0859112-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ACTA2 mRNA]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of ACTA2 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of CCND1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of CDK4 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of COL1A1 mRNA]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of COL1A1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of PCNA protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of RPS6KB1 protein]23958495
C1099862-aminoethoxydiphenyl borate2-aminoethoxydiphenyl borate results in decreased activity of [PDGFB protein binds to PDGFB protein]23958495
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of PDGFB mRNA]"26644586
C5779422-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PDGFB mRNA"26644586
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]"11348869
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]"11348869
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCND1 protein]"11348869
C0388644-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid"4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]"11348869
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal results in increased expression of PDGFB mRNA19191707
C0275764-hydroxy-2-nonenal4-hydroxy-2-nonenal inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]16527993
C4998235S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid"PDGFB protein promotes the reaction [5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid results in decreased phosphorylation of PDGFRB protein]"20709806
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]"16149045
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein]"16149045
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]"25896968
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]"25896968
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]"25896968
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]"25896968
C4076896,7-dimethoxy-2-phenylquinoxaline"6,7-dimethoxy-2-phenylquinoxaline results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]"23457620
C5188497-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one"7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one metabolite inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]"17268099
C5188497-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one"7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]"17268099
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PDGFB protein]26138014
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]22700867
D000111AcetylcysteineAcetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]22700867
D000111AcetylcysteineAcetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]22700867
D000111AcetylcysteineAcetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]22700867
D020106AcrylamideAcrylamide affects the expression of PDGFB mRNA28959563
D000244Adenosine DiphosphateAdenosine Diphosphate results in increased secretion of PDGFB protein17303692
D000244Adenosine DiphosphateAspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]17303692
D016604Aflatoxin B1Aflatoxin B1 results in increased methylation of PDGFB gene27153756
C430898AGN 194204AGN 194204 inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
C430898AGN 194204AGN 194204 inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]11348869
C430898AGN 194204AGN 194204 inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCND1 protein]11348869
C430898AGN 194204AGN 194204 inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]11348869
C103303alitretinoinalitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
C103303alitretinoinalitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]11348869
C103303alitretinoinalitretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]11348869
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDGFB mRNA16483693
C106407ampelopsinampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]21871475
C106407ampelopsinampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]21871475
C106407ampelopsinampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]21871475
C106407ampelopsinampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475
C021139anagrelideanagrelide results in increased expression of PDGFB mRNA15682418
D039741Antigens, Dermatophagoides"[Nanotubes, Carbon co-treated with Antigens, Dermatophagoides] results in increased expression of PDGFB mRNA"26091108
D018501Antirheumatic AgentsAntirheumatic Agents results in increased expression of PDGFB mRNA24449571
C015001arsenitearsenite results in decreased methylation of PDGFB promoter23974009
D001241AspirinAspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein]17303692
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFB mRNA20064835
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased secretion of PDGFB protein25896968
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFB mRNA21569818
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDGFB mRNA22610609
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]15728660
C072553benzyloxycarbonylleucyl-leucyl-leucine aldehydebenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in decreased expression of PDGFB mRNA25566086
D004958Estradiol[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]15866426
D004958Estradiol[Estradiol co-treated with Progesterone] results in decreased expression of PDGFB mRNA20660070
D004958Estradiol[Progesterone co-treated with Estradiol] results in decreased expression of PDGFB mRNA17404688
D004958EstradiolEstradiol affects the secretion of [PDGFB protein binds to PDGFB protein]15653758
D001663BilirubinBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
D001663BilirubinBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
D001663BilirubinBilirubin results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
C006780bisphenol Abisphenol A results in decreased expression of PDGFB mRNA25181051
C074619bivalirudinbivalirudin affects the expression of PDGFB protein10754393|1131695
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in decreased expression of CCND3 protein]15919668
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]15919668
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]15919668
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]15919668
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein]15919668
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]12782152
D0200011-Butanol1-Butanol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]12782152
D019256Cadmium ChlorideAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PDGFB protein]26138014
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of PDGFB protein26138014
D002118CalciumPDGFB protein results in increased import of Calcium19576918
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PDGFB mRNA17341687
D002251Carbon TetrachlorideS1PR2 protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFB mRNA]17341687
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of PDGFB protein12930639|1476128
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]16097048
D002251Carbon TetrachlorideCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]18006644
D002251Carbon TetrachlorideLosartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]12930639
D002251Carbon TetrachloridePerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]12930639|1476128
D002251Carbon TetrachloridePerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]16097048
D002330CarmustineCarmustine results in increased expression of PDGFB protein15286697
C043211carvedilolcarvedilol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]11904532
D002737ChloropreneChloroprene results in decreased expression of PDGFB mRNA23125180
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFB gene20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFB mRNA20938992
D002794Choline[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PDGFB mRNA22915297
D002794CholineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PDGFB mRNA]22915297
D002809Chondroitin SulfatesChondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]16945567
D002809Chondroitin SulfatesGenistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]16945567
C055162clopidogrelclopidogrel results in decreased expression of PDGFB mRNA19155974
C055162clopidogrelclopidogrel results in decreased expression of PDGFB protein19155974
D060729Coal AshCoal Ash results in increased expression of PDGFB mRNA19000753
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein20961405
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C007095cobaltiprotoporphyrincobaltiprotoporphyrin inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C007095cobaltiprotoporphyrincobaltiprotoporphyrin promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of and results in increased activity of HMOX1 protein]12690112
C007095cobaltiprotoporphyrin[cobaltiprotoporphyrin results in increased activity of HMOX1 protein] results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
C497448CP-673,451"CP-673,451 inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]"15705896
C461979CT52923CT52923 inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]17268099
C007164cumene hydroperoxidecumene hydroperoxide inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]16527993
D003474CurcuminCurcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]18006644
D003474CurcuminCurcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]18784349
D003474CurcuminCurcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]18784349
D003474Curcumintin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]18784349
D003474Curcumintin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]18784349
C017154cyanidincyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C017154cyanidincyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]16921400
D016572CyclosporineCyclosporine results in increased expression of PDGFB mRNA25562108|8708960
D003545CysteineCysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]15158331
D003545CysteineCysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]15158331
C014347decitabinedecitabine results in decreased activity of [PDGFB protein binds to PDGFB protein]23423710
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in decreased expression of RASAL1 mRNA]22056649
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in decreased expression of RASAL1 protein]22056649
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in increased expression of MECP2 mRNA]22056649
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]22056649
C014347decitabinedecitabine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]22056649
D003676DeferoxamineDeferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]18032466
D003676DeferoxamineDeferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]18032466
D003676DeferoxamineDeferoxamine inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]18032466
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]23298457
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]23298457
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]23298457
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]23298457
C548688dehydroglyasperin Cdehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of PLCG1 protein]23298457
C017185delphinidindelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C017185delphinidindelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased secretion of VEGFA protein]16921400
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDGFB mRNA17361019|2126653
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of PDGFB mRNA27392435
C058705diethyl malatediethyl malate affects the expression of PDGFB mRNA24814887
C058705diethyl malateS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]24814887
C015144dihydrolipoic aciddihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]21251946
C015144dihydrolipoic aciddihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]21251946
C015144dihydrolipoic aciddihydrolipoic acid inhibits the reaction [PDGFB protein results in increased phosphorylation of RPS6KB1 protein]21251946
C015144dihydrolipoic aciddihydrolipoic acid results in decreased activity of PDGFB protein21251946
D000069462Dimethyl Fumarate[Dimethyl Fumarate results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein20961405
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of PDGFB mRNA17036385
D004128Dimethylnitrosamine"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of PDGFB mRNA]"17036385
D004365Drugs, Chinese Herbal"Drugs, Chinese Herbal inhibits the reaction [Dimethylnitrosamine results in increased expression of PDGFB mRNA]"17036385
D004533Egtazic AcidEgtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]19576918
D004533Egtazic AcidEgtazic Acid inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]19576918
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]15288473
D004642EmodinEmodin inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]15288473
D004966Estrogens, Conjugated (USP)"Estrogens, Conjugated (USP) affects the secretion of [PDGFB protein binds to PDGFB protein]"15653758
C018541falcarinolfalcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of CREB1 protein]18199429
C018541falcarinolfalcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]18199429
C018541falcarinolfalcarinol inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]18199429
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFB gene20938992
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFB mRNA20938992
C069837fullerene C60fullerene C60 results in increased expression of PDGFB mRNA19167457
C038958gadolinium chloridegadolinium chloride results in decreased expression of PDGFB mRNA14578756
D019833GenisteinGenistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]16945567
D019833GenisteinGenistein results in increased expression of PDGFB mRNA22553218
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]15728660
C002963geranylgeranyl pyrophosphategeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]15728660
C568713GSK1210151AGSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PDGFB mRNA]26644586
C568713GSK1210151AGSK1210151A results in decreased expression of PDGFB mRNA26644586
D006418HemeHeme metabolite results in decreased expression of PDGFB mRNA19191707
D006427Hemin[Hemin results in increased expression of HMOX1 protein] which results in decreased susceptibility to PDGFB protein20961405
D006427Hemin[Hemin results in increased activity of HMOX1 protein] results in decreased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
D006493HeparinHeparin affects the expression of PDGFB protein8441232
C479171hirulog-like peptidehirulog-like peptide affects the expression of PDGFB protein11316950
D017313FenretinideFenretinide results in increased expression of PDGFB mRNA28973697
D006861Hydrogen PeroxidePDGFB protein results in increased abundance of Hydrogen Peroxide19822164
D006861Hydrogen Peroxidesalvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]19822164
D006861Hydrogen Peroxidesalvianolic acid B inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]19822164
D003900Desoxycorticosterone[PDGFA protein binds to PDGFB protein] which results in increased susceptibility to Desoxycorticosterone11751714
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PDGFB protein15786421
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [nitrofen results in increased expression of PDGFB protein]22447953
D000068877Imatinib MesylateImatinib Mesylate inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]17268099
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K1 protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAP2K2 protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]15288473
C078038inchinko-toinchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of RAF1 protein]15288473
D007295Inositol Phosphates[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates9581680
D007295Inositol PhosphatesQuercetin inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates]9581680
D007295Inositol Phosphatesresveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates]9581680
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of PDGFB mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PDGFB mRNA]26644586
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFB mRNA26644586
C561695(+)-JQ1 compound(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of PDGFB mRNA]25890327
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFB mRNA26644586
C523615levistolide A[levistolide A co-treated with PDGFB protein] results in decreased expression of BCL2 protein17520522
C523615levistolide A[levistolide A co-treated with PDGFB protein] results in decreased phosphorylation of AKT1 protein17520522
C523615levistolide A[levistolide A co-treated with PDGFB protein] results in increased phosphorylation of MAPK8 protein17520522
C523615levistolide Alevistolide A inhibits the reaction [PDGFB protein results in increased expression of CCNB1 protein]17520522
C523615levistolide Alevistolide A inhibits the reaction [PDGFB protein results in increased expression of CCND1 protein]17520522
C523615levistolide Alevistolide A inhibits the reaction [PDGFB protein results in increased expression of CCND2 protein]17520522
C523615levistolide Alevistolide A results in decreased susceptibility to PDGFB protein17520522
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in increased expression of PDGFB mRNA"11578593
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]22004089
D008070LipopolysaccharidesLipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB protein]22004089
D008070LipopolysaccharidesMAPK9 gene mutant form inhibits the reaction [Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]]22004089
D008070LipopolysaccharidesNFKBIA protein mutant form inhibits the reaction [Lipopolysaccharides promotes the reaction [TGFB1 results in increased expression of PDGFB mRNA]]22004089
D008070Lipopolysaccharides[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of PDGFB protein18437699
D008070Lipopolysaccharides(+)-JQ1 compound inhibits the reaction [Lipopolysaccharides results in increased expression of PDGFB mRNA]25890327
D008070LipopolysaccharidesLipopolysaccharides results in increased expression of PDGFB mRNA25890327
C040527lipoxin A4lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]12223454
C040527lipoxin A4PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein]20709806
D019808LosartanLosartan inhibits the reaction [AGT protein results in increased expression of PDGFB mRNA]17043664
D019808LosartanLosartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]12930639
C065861malvidinmalvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]21871475
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]21871475
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]21871475
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]21871475
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475
C480486malvidin-3-O-glucoside-4 vinylmalvidin-3-O-glucoside-4 vinyl results in decreased activity of [PDGFB protein binds to PDGFB protein]21871475
D017258Medroxyprogesterone Acetate[Estradiol co-treated with Medroxyprogesterone Acetate] results in decreased secretion of [PDGFA protein binds to PDGFB protein]15866426
C042720mercuric bromidemercuric bromide results in increased expression of PDGFB mRNA26272509
C042720mercuric bromide"[NOG protein co-treated with mercuric bromide co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
D008694MethamphetamineMethamphetamine results in increased expression of PDGFB mRNA26307267
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of and results in increased expression of PDGFB20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of PDGFB gene20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFB mRNA20938992
D008715Methionine[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PDGFB mRNA22915297
D008715MethionineQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PDGFB mRNA]22915297
D008715MethionineMethionine inhibits the reaction [PDGFB protein results in increased phosphorylation of AKT1 protein]15158331
D008715MethionineMethionine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]15158331
D008727MethotrexateMethotrexate results in decreased expression of PDGFB mRNA17400583
D008731MethoxychlorMethoxychlor results in decreased expression of PDGFB mRNA24806340
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of PDGFB mRNA28001369
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of PDGFB mRNA12634122
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]15728660
D008798Mevalonic AcidMevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein]8231022
D009020MorphinePDGFB protein inhibits the reaction [Morphine results in decreased expression of BCL2 protein]21483469
D009020MorphinePDGFB protein inhibits the reaction [Morphine results in increased activity of CASP3 protein]21483469
D009020MorphinePDGFB protein inhibits the reaction [Morphine results in increased expression of BAX protein]21483469
D009020MorphinePDGFB protein results in decreased susceptibility to Morphine21483469
C451426N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of PDGFB mRNA"25461557
D037742Nanotubes, Carbon"[Nanotubes, Carbon co-treated with Antigens, Dermatophagoides] results in increased expression of PDGFB mRNA"26091108
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of PDGFB mRNA"26091108
D000068577NebivololNebivolol results in decreased expression of PDGFB mRNA17310107
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 mRNA]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 mRNA]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 protein]]22700867
D009532Nickel2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]22700867
D009532NickelAcetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]22700867
D009532NickelAcetylcysteine inhibits the reaction [Nickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]22700867
D009532NickelAcetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]]22700867
D009532NickelAcetylcysteine inhibits the reaction [PDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]]22700867
D009532NickelNickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]22700867
D009532NickelNickel analog promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]22700867
D009532NickelPDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 mRNA]22700867
D009532NickelPDGFB protein promotes the reaction [Nickel analog results in increased expression of CCL2 protein]22700867
D009532NickelPDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 mRNA]22700867
D009532NickelPDGFB protein promotes the reaction [Nickel analog results in increased expression of CXCL10 protein]22700867
D009532NickelPDGFB protein promotes the reaction [Nickel analog results in increased expression of HIF1A protein]22700867
C022838nickel chloride[nickel chloride co-treated with Lipopolysaccharides] results in increased secretion of PDGFB protein18437699
D009538Nicotine"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFB mRNA]"16149045
D009538Nicotine"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased secretion of PDGFB protein]"16149045
D009538NicotineNicotine results in increased expression of PDGFB mRNA16149045
D009538NicotineNicotine results in increased secretion of PDGFB protein16149045
D009538NicotineNicotine results in increased expression of PDGFB mRNA16254210
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased activity of PTK2B protein]19556728
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased activity of SRC protein]19556728
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of AKT1 protein modified form]20530298
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of SRC protein modified form]19556728
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of CSE1L protein]19556728
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of CTTN protein]19556728
D009543NifedipineNifedipine inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PXN protein]19556728
C007350nitrofenImatinib Mesylate inhibits the reaction [nitrofen results in increased expression of PDGFB protein]22447953
C007350nitrofennitrofen results in increased expression of PDGFB protein22447953
C000594117ON123300ON123300 affects the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]24568969
C000594117ON123300ON123300 affects the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]24568969
C000594117ON123300ON123300 inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]24568969
C412603orantiniborantinib inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]17268099
D010100OxygenOxygen deficiency results in increased expression of PDGFB mRNA22711276
D010100OxygenValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]22711276
D010100Oxygenvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]22711276
D010100OxygenOxygen deficiency results in increased expression of PDGFB mRNA24236059
D010100OxygenARNT gene mutant form inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]20412331
D010100OxygenOxygen deficiency results in increased expression of PDGFB mRNA16373842|2041233
D010100OxygenSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]16373842
C500026palbociclibpalbociclib inhibits the reaction [[PDGFB protein binds to PDGFB protein] inhibits the reaction [RB1 protein binds to SP1 protein]]21880723
D010269ParaquatParaquat results in increased expression of PDGFB mRNA16328009
D052638Particulate MatterParticulate Matter inhibits the reaction [PDGFB protein binds to PDGFB protein]28189646
D052638Particulate MatterParticulate Matter results in decreased expression of PDGFB mRNA17450221
C473205peonidinpeonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in increased expression of PDGFB mRNA23602845
D020913PerindoprilPerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFB protein]12930639|1476128
D020913PerindoprilPerindopril inhibits the reaction [Carbon Tetrachloride results in increased expression of [PDGFB protein binds to PDGFB protein]]16097048
D010634PhenobarbitalPhenobarbital results in increased expression of PDGFB mRNA19162173
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFB mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PDGFB mRNA26272509
D010672PhenytoinPhenytoin results in increased expression of PDGFB mRNA14741686|8463938
D010672PhenytoinPhenytoin results in increased expression of PDGFB mRNA8463938
D010672PhenytoinPhenytoin results in increased expression of PDGFB protein8463938
D010705PhosgenePhosgene affects the expression of PDGFB mRNA16300373
C068564phosphatidylbutanolEWSR1 protein affects the reaction [PLD2 protein promotes the reaction [PDGFB protein results in increased abundance of phosphatidylbutanol]]15919668
C068564phosphatidylbutanolPLD2 protein promotes the reaction [PDGFB protein results in increased abundance of phosphatidylbutanol]15919668
C060836pioglitazone[PDGFB protein binds to PDGFB protein] inhibits the reaction [pioglitazone results in decreased phosphorylation of MAPK1 protein]26643070
C060836pioglitazone[PDGFB protein binds to PDGFB protein] inhibits the reaction [pioglitazone results in decreased phosphorylation of MAPK3 protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased degradation of CDKN1B protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of CCND1 protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of CDKN1A protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of EIF4EBP1 protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6KB1 protein]26643070
C060836pioglitazonepioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6 protein]26643070
C060836pioglitazonePRKAA1 protein affects the reaction [pioglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of RPS6 protein]]26643070
D010936Plant ExtractsPlant Extracts results in decreased expression of PDGFB mRNA23557933
D010936Plant ExtractsPlant Extracts results in decreased susceptibility to PDGFB protein17520522
C060540polyhexamethyleneguanidinepolyhexamethyleneguanidine results in increased expression of [PDGFB protein binds to PDGFB protein]29175452
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDGFB mRNA22714537
D011374Progesterone[Estradiol co-treated with Progesterone] results in decreased expression of PDGFB mRNA20660070
D011374Progesterone[Progesterone co-treated with Estradiol] results in decreased expression of PDGFB mRNA17404688
D011374ProgesteroneProgesterone results in decreased expression of PDGFB mRNA17404688
C005556propionaldehydepropionaldehyde results in increased expression of PDGFB mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PDGFB mRNA24780913
D011794QuercetinQuercetin inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates]9581680
D011794QuercetinQuercetin results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]9581680
D011794QuercetinQuercetin inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of PDGFB mRNA]22915297
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the secretion of [PDGFB protein binds to PDGFB protein]15653758
D017257RamiprilRamipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]10352363
D017257RamiprilRamipril results in decreased expression of PDGFB mRNA10352363
D017382Reactive Oxygen Speciescyanidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciesdelphinidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciesmalvidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen SpeciesPDGFB protein results in increased abundance of Reactive Oxygen Species11710721
D017382Reactive Oxygen Speciespeonidin inhibits the reaction [[PDGFA protein co-treated with PDGFB protein] results in increased abundance of Reactive Oxygen Species]16921400
D017382Reactive Oxygen Speciesdihydrolipoic acid affects the reaction [PDGFB protein results in increased abundance of Reactive Oxygen Species]21251946
D017382Reactive Oxygen SpeciesPDGFB protein results in increased abundance of Reactive Oxygen Species21251946
D017382Reactive Oxygen Species[PDGFA protein binds to PDGFB protein] which results in increased chemical synthesis of Reactive Oxygen Species12690112
C059514resveratrolresveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased chemical synthesis of Inositol Phosphates]9581680
C059514resveratrolresveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]23457620
C059514resveratrolresveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]16343977
C059514resveratrolresveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]16343977
C059514resveratrolresveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]16343977
C059514resveratrolresveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]16343977
C059514resveratrolresveratrol results in decreased activity of PDGFB protein16343977
C059514resveratrolresveratrol results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]23457620|9581680
C059514resveratrolresveratrol results in increased expression of PDGFB mRNA12002526
C089730rosiglitazonerosiglitazone affects the reaction [PDGFB protein results in increased phosphorylation of GSK3B protein]19201691
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of PDGFB mRNA"16678137
C066201salvianolic acid Asalvianolic acid A inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]19822164
C066201salvianolic acid Asalvianolic acid A inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]19822164
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]19822164
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]19822164
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]19822164
C076944salvianolic acid Bsalvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of NCF1 protein]19822164
C093642SB 203580SB 203580 inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]15728660
C093642SB 203580SB 203580 results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]23457620
C093642SB 203580SB 203580 promotes the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]9671412
D017632Asbestos, Serpentine"Asbestos, Serpentine results in increased expression of PDGFB mRNA"18039278
D017632Asbestos, Serpentine"PDGFB protein results in increased susceptibility to Asbestos, Serpentine"15511213
C042431S-ethyl glutathioneS-ethyl glutathione inhibits the reaction [diethyl malate affects the expression of PDGFB mRNA]24814887
D012822Silicon DioxideSilicon Dioxide results in increased secretion of [PDGFB protein binds to PDGFB protein]22300531
D012822Silicon DioxideSilicon Dioxide results in increased expression of PDGFB mRNA19073995
D012834SilverSilver results in decreased expression of PDGFB mRNA27131904
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]]15728660
D019821Simvastatingeranylgeranyl pyrophosphate inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]15728660
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]]15728660
D019821SimvastatinMevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein]8231022
D019821SimvastatinSimvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased expression of MMP9 mRNA]15728660
D019821SimvastatinSimvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]15728660
D019821SimvastatinSimvastatin results in decreased activity of PDGFB protein8231022
D019821SimvastatinSimvastatin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]16373842
D019821SimvastatinSimvastatin results in decreased expression of PDGFB mRNA10412775
D019821SimvastatinSimvastatin results in decreased expression of PDGFB protein10412745
D020123SirolimusSirolimus inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]15919668
D020123Sirolimus[Sirolimus results in decreased activity of MTOR protein] inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]15919668
C017947sodium arsenitesodium arsenite results in increased expression of [PDGFB protein binds to PDGFB protein]26135927
C446685systhane"[systhane co-treated with N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide] results in decreased expression of PDGFB mRNA"25461557
C003377taxifolintaxifolin results in decreased expression of PDGFB mRNA17541156
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PDGFB mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased secretion of PDGFB protein25896968
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDGFB mRNA21570461|2468072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDGFB mRNA22666406
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDGFB mRNA22666406
D013755Tetradecanoylphorbol AcetateRamipril inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA]10352363
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate results in increased expression of PDGFB mRNA10352363|1042850
D013755Tetradecanoylphorbol AcetateTetradecanoylphorbol Acetate inhibits the reaction [PDGFB protein results in increased expression of FOS mRNA]9650640
D013853ThioacetamideTGFBR1 protein promotes the reaction [Thioacetamide results in increased expression of PDGFB mRNA]28560358
D013853ThioacetamideThioacetamide results in increased expression of PDGFB mRNA28560358
C096900thrombin receptor-activating peptide SFLLRNPNDKYthrombin receptor-activating peptide SFLLRNPNDKY analog results in increased secretion of PDGFB protein17303692
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK1 protein]]18784349
C032628tin protoporphyrin IXtin protoporphyrin IX inhibits the reaction [Curcumin inhibits the reaction [PDGFB protein results in increased phosphorylation of MAPK3 protein]]18784349
C032628tin protoporphyrin IX2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C032628tin protoporphyrin IX2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C032628tin protoporphyrin IXBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]]12690112
C032628tin protoporphyrin IXBilirubin inhibits the reaction [tin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of and results in increased activity of HMOX1 protein]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]12690112
C032628tin protoporphyrin IXtin protoporphyrin IX promotes the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]12690112
C032628tin protoporphyrin IX[tin protoporphyrin IX results in decreased activity of HMOX1 protein] results in increased susceptibility to [PDGFA protein binds to PDGFB protein]12690112
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDGFB mRNA28065790
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDGFB mRNA28111298
D014118Toxins, Biological"Toxins, Biological affects the expression of PDGFB mRNA"19682533
D014212TretinoinTretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in decreased expression of CDKN1B protein]11348869
D014212TretinoinTretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCNA2 protein]11348869
D014212TretinoinTretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased expression of CCND1 protein]11348869
D014212TretinoinTretinoin inhibits the reaction [[[PDGFB protein binds to PDGFB protein] which co-treated with INS protein] results in increased phosphorylation of RB1 protein]11348869
D014212TretinoinTretinoin results in decreased expression of PDGFB mRNA12969142
D014241TrichloroethylenePPARA protein inhibits the reaction [Trichloroethylene results in increased expression of PDGFB protein]15363585
D014241TrichloroethyleneTrichloroethylene results in increased expression of PDGFB mRNA15363585
C013320tris(2-butoxyethyl) phosphatetris(2-butoxyethyl) phosphate affects the expression of PDGFB mRNA29024780
C057693troglitazonetroglitazone results in decreased expression of PDGFB mRNA28973697
C057693troglitazonePPARG protein affects the reaction [troglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of FOS mRNA]]10678274
C057693troglitazonetroglitazone inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased expression of FOS mRNA]10678274
C057693troglitazonetroglitazone results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]10678274|8878442
C113580U 0126U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]15919668
C113580U 0126U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]15919668
C113580U 0126U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]15919668
C113580U 0126U 0126 inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]15919668
C113580U 0126U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]15919668
C113580U 0126U 0126 results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]23457620
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of EGR1 protein]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased expression of SOD2 mRNA]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]11511524
C113580U 0126[U 0126 results in decreased activity of MAP2K1 protein] inhibits the reaction [[PDGFA protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]11511524
C113580U 0126U 0126 inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]23958495
C113580U 0126U 0126 inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]23958495
D014520UrethaneUrethane results in decreased expression of PDGFB mRNA28818685
D014520UrethaneIFNG protein inhibits the reaction [Urethane results in decreased expression of PDGFB mRNA]12810352
D014635Valproic AcidValproic Acid inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]22711276
D014635Valproic AcidValproic Acid results in increased methylation of PDGFB gene29154799
C066075vanadium pentoxidevanadium pentoxide results in increased expression of PDGFB mRNA17134509
D014640VancomycinVancomycin results in decreased expression of PDGFB mRNA18930951
D001335Vehicle EmissionsAHR mutant form inhibits the reaction [Vehicle Emissions analog results in increased secretion of PDGFB protein]25896968
D001335Vehicle EmissionsVehicle Emissions analog results in increased secretion of PDGFB protein25896968
D001335Vehicle EmissionsVehicle Emissions inhibits the reaction [PDGFB protein binds to PDGFB protein]28189646
C412469vitisin Avitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK1 protein]21871475
C412469vitisin Avitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of MAPK3 protein]21871475
C412469vitisin Avitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]21871475
C412469vitisin Avitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PLCG1 protein]21871475
C111237vorinostatvorinostat inhibits the reaction [Oxygen deficiency results in increased expression of PDGFB mRNA]22711276
D014859WarfarinWarfarin results in decreased expression of PDGFB mRNA11290560
D014859WarfarinWarfarin results in decreased expression of PDGFB protein11290560

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005161platelet-derived growth factor receptor binding-IBA21873635  
GO:0005161platelet-derived growth factor receptor binding-IDA2439522  2836953  
GO:0005161platelet-derived growth factor receptor binding-IPI2536956  
GO:0005161platelet-derived growth factor receptor binding-NAS1661670  
GO:0005515protein binding-IPI2536956  7679113  10806482  11297552  12070119  17981115  
20534510  
GO:0005518collagen binding-IDA8900172  
GO:0008083growth factor activity-IDA12070119  
GO:0016176superoxide-generating NADPH oxidase activator activity-IDA17942966  
GO:0042056chemoattractant activity-IDA21245381  
GO:0042802identical protein binding-IPI1396586  7679113  23139410  
GO:0042803protein homodimerization activity-IDA2836953  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0046982protein heterodimerization activity-IPI7073684  
GO:0048407platelet-derived growth factor binding-IPI7073684  
GO:0070851growth factor receptor binding-IBA21873635  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001892embryonic placenta development-ISS-  
GO:0001938positive regulation of endothelial cell proliferation-IDA9685360  
GO:0002548monocyte chemotaxis-IDA17991872  
GO:0002576platelet degranulation-TAS-  
GO:0003104positive regulation of glomerular filtration-ISS-  
GO:0006468protein phosphorylation-IDA17942966  
GO:0007507heart development-ISS-  
GO:0008284positive regulation of cell proliferation-IBA21873635  
GO:0008284positive regulation of cell proliferation-IDA2439522  2836953  7073684  
GO:0009611response to wounding-IDA2538439  
GO:0009611response to wounding-NAS1661670  
GO:0010469regulation of signaling receptor activity-IEA-  
GO:0010512negative regulation of phosphatidylinositol biosynthetic process-IDA2538439  
GO:0010544negative regulation of platelet activation-IDA2538439  
GO:0010628positive regulation of gene expression-IDA23554459  24008408  
GO:0010629negative regulation of gene expression-IDA23554459  25089138  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IBA21873635  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-IDA10734101  11788434  17942966  
GO:0014911positive regulation of smooth muscle cell migration-IDA9409235  
GO:0018105peptidyl-serine phosphorylation-IDA16530387  
GO:0018108peptidyl-tyrosine phosphorylation-IDA10734101  16530387  
GO:0030097hemopoiesisNOTIMP11264163  
GO:0030198extracellular matrix organization-TAS-  
GO:0030335positive regulation of cell migration-IBA21873635  
GO:0030335positive regulation of cell migration-IDA11788434  21245381  
GO:0031954positive regulation of protein autophosphorylation-IBA21873635  
GO:0031954positive regulation of protein autophosphorylation-IDA12070119  16530387  
GO:0032091negative regulation of protein binding-IDA22619279  
GO:0032147activation of protein kinase activity-IDA16530387  
GO:0032148activation of protein kinase B activity-IDA16530387  
GO:0035655interleukin-18-mediated signaling pathway-IDA21321938  
GO:0035793positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway-IDA19019919  
GO:0038001paracrine signaling-ISS-  
GO:0043406positive regulation of MAP kinase activity-IBA21873635  
GO:0043406positive regulation of MAP kinase activity-IDA9685360  11788434  16530387  17942966  
GO:0043410positive regulation of MAPK cascade-IMP11788434  
GO:0043536positive regulation of blood vessel endothelial cell migration-IDA9685360  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IDA16530387  
GO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activity-IDA16530387  
GO:0045840positive regulation of mitotic nuclear division-IDA10644978  10734101  17942966  
GO:0045892negative regulation of transcription, DNA-templated-IDA16530387  25089138  
GO:0045893positive regulation of transcription, DNA-templated-IDA16530387  17324121  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IBA21873635  
GO:0048008platelet-derived growth factor receptor signaling pathway-IDA2439522  2536956  2836953  19088079  21245381  23554459  
GO:0048146positive regulation of fibroblast proliferation-IDA2439522  10644978  17324121  
GO:0048661positive regulation of smooth muscle cell proliferation-IDA21321938  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA21245381  
GO:0050918positive chemotaxis-IEA-  
GO:0050921positive regulation of chemotaxis-IDA9409235  19019919  
GO:0051781positive regulation of cell division-IEA-  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0060326cell chemotaxis-IDA16014047  17991872  21245381  
GO:0061098positive regulation of protein tyrosine kinase activity-IDA16530387  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IDA11788434  16530387  17942966  
GO:0070528protein kinase C signaling-IMP24008408  
GO:0071363cellular response to growth factor stimulus-IDA21245381  
GO:0071506cellular response to mycophenolic acid-ISS-  
GO:0072126positive regulation of glomerular mesangial cell proliferation-IDA11788434  16014047  
GO:0072255metanephric glomerular mesangial cell development-ISS-  
GO:0072593reactive oxygen species metabolic process-IMP17942966  
GO:0090280positive regulation of calcium ion import-IDA19019919  
GO:1900127positive regulation of hyaluronan biosynthetic process-IDA17324121  
GO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II-IDA26493107  
GO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II-IDA19088079  
GO:1904707positive regulation of vascular smooth muscle cell proliferation-IDA12070119  19088079  23554459  
GO:1904754positive regulation of vascular associated smooth muscle cell migration-IDA12070119  19088079  23554459  
GO:1905064negative regulation of vascular smooth muscle cell differentiation-IDA19088079  
GO:1905176positive regulation of vascular smooth muscle cell dedifferentiation-IDA19088079  
GO:2000379positive regulation of reactive oxygen species metabolic process-IDA19019919  
GO:2000573positive regulation of DNA biosynthetic process-IDA10644978  10734101  11788434  12070119  16530387  17942966  19019919  
GO:2000591positive regulation of metanephric mesenchymal cell migration-IDA10734101  
GO ID GO Term Qualifier Evidence PubMed
GO:0000139Golgi membrane-TAS-  
GO:0005576extracellular region-NAS1661670  
GO:0005576extracellular region-TAS-  
GO:0005615extracellular space-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0005796Golgi lumen-TAS-  
GO:0009986cell surface-IDA291037  2538439  2836953  9685360  
GO:0016323basolateral plasma membrane-ISS-  
GO:0031093platelet alpha granule lumen-TAS-  
GO:0062023collagen-containing extracellular matrix-HDA23979707  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05211Renal cell carcinoma
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-109582HemostasisTAS
R-HSA-114608Platelet degranulation TAS
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-1474244Extracellular matrix organizationTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-3000171Non-integrin membrane-ECM interactionsTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-76002Platelet activation, signaling and aggregationTAS
R-HSA-76005Response to elevated platelet cytosolic Ca2+TAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28956832Multiple Gene-Environment Interactions on the Angiogenesis Gene-Pathway Impact Rectal Cancer Risk and Survival. (2017 Sep 28)Sharafeldin NInt J Environ Res Public Health