Gene: PEX5L

51555
PEX5R|PEX5RP|PXR2|PXR2B|TRIP8b
peroxisomal biogenesis factor 5 like
protein-coding
3q26.33
Ensembl:ENSG00000114757 MIM:611058 Vega:OTTHUMG00000157363 UniprotKB:Q8IYB4
NC_000003.12
SNP Mapped
3   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.861e-2 (AD)  9.622e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs9823402chr3:179851760 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs7640024chr3:179851152 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6443673chr3:179848495 (GRCh38.p7)C>Talcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PTPRD0.945
SLC24A20.933
MFSD60.932
HECW20.932
DIRAS20.93
ANK30.928
SLITRK10.928
CLASP20.919
CLCN40.919
DNAJC60.918

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RNF135-0.536
TFPI2-0.501
ARHGEF5-0.501
CSAG1-0.496
EMP3-0.49
PDZK1IP1-0.48
MDFI-0.476
GJB2-0.476
TEAD3-0.475
RAB13-0.473

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
D020106AcrylamideAcrylamide results in increased expression of PEX5L mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PEX5L gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PEX5L mRNA16483693
D001280AtrazineAtrazine results in decreased expression of PEX5L mRNA25929836
C006780bisphenol Abisphenol A results in decreased expression of PEX5L mRNA25181051
D003042CocaineCocaine results in increased expression of PEX5L mRNA17898221
D003471CuprizoneCuprizone results in decreased expression of PEX5L mRNA26577399
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of PEX5L mRNA28962523
D004041Dietary FatsDietary Fats results in increased expression of PEX5L mRNA25016146
C118739entinostatentinostat results in decreased expression of PEX5L mRNA27188386
D000431EthanolEthanol results in increased expression of PEX5L mRNA19167417
D005557FormaldehydeFormaldehyde results in decreased expression of PEX5L mRNA23649840
C011890kojic acidkojic acid results in decreased expression of PEX5L mRNA16595896
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PEX5L mRNA23649840
C025256nonylphenolnonylphenol results in increased expression of PEX5L mRNA22982499
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of PEX5L mRNA"25510870
D010936Plant ExtractsPlant Extracts results in decreased expression of PEX5L mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of PEX5L mRNA21334430
D011441PropylthiouracilPropylthiouracil results in decreased expression of PEX5L mRNA24780913
D001335Vehicle EmissionsVehicle Emissions affects the methylation of PEX5L gene25560391

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000268peroxisome targeting sequence binding-IDA18346465  
GO:0005052peroxisome matrix targeting signal-1 binding-IBA21873635  
GO:0031267small GTPase binding-IPI18346465  
GO ID GO Term Qualifier Evidence PubMed
GO:0016560protein import into peroxisome matrix, docking-IBA21873635  
GO:0043949regulation of cAMP-mediated signaling-ISS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005778peroxisomal membrane-IBA21873635  
GO:0005829cytosol-IBA21873635  
GO:0043235receptor complex-IDA23382219  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal