Gene: PDGFRA

5156
CD140A|PDGFR-2|PDGFR2
platelet derived growth factor receptor alpha
protein-coding
4q12
Ensembl:ENSG00000134853 MIM:173490 Vega:OTTHUMG00000128699 UniprotKB:P16234
NG_009250.1
PubMed
ND
9   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.235e-1 (AD)  6.572e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PCDH150.853
LHFPL30.805
BCHE0.774
MYT10.763
VCAN0.753
FERMT10.75
SEMA5A0.735
STK32A0.707
LUZP20.707
TNR0.703

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.39
OR4F29-0.342
FAM83D-0.336
TMEM95-0.336
GCM1-0.332
KRTAP5-5-0.329
STC2-0.308
ALPI-0.297
FAM170B-0.297
SLC25A47-0.296

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00102BecaplerminBiotechDrug165101-51-9Approved|InvestigationalTarget
DB00619ImatinibSmall Molecule152459-95-5ApprovedTarget
DB01268SunitinibSmall Molecule557795-19-4Approved|InvestigationalTarget
DB05146XL820Small Molecule-InvestigationalTarget
DB06043OlaratumabBiotechDrug1024603-93-7Approved|InvestigationalTarget
DB06589PazopanibSmall Molecule444731-52-6ApprovedTarget
DB06595MidostaurinSmall Molecule120685-11-2Approved|InvestigationalTarget
DB08896RegorafenibSmall Molecule755037-03-7ApprovedTarget
DB08901PonatinibSmall Molecule943319-70-8Approved|InvestigationalTarget
DB12742AmuvatinibSmall Molecule850879-09-3InvestigationalTarget
ID Drug Name Action PubMed
C0549192,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA"19422813
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in decreased expression of PDGFRA mRNA"25614096
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C0235142,6-dinitrotoluene"2,6-dinitrotoluene results in decreased expression of PDGFRA mRNA"20406850
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDGFRA mRNA"28973690
C5830744,4'-hexafluorisopropylidene diphenol"4,4'-hexafluorisopropylidene diphenol results in decreased expression of PDGFRA mRNA"25912373
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C0293704-toluidine4-toluidine results in decreased expression of PDGFRA mRNA27638505
C0126064-vinyl-1-cyclohexene dioxide4-vinyl-1-cyclohexene dioxide affects the expression of PDGFRA mRNA20829426
C5610525H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one"5H-benzo(4,5)cyclohepta(1,2-b)pyridin-5-one results in decreased activity of PDGFRA protein"21608528
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C1062506,7-dimethoxy-3-phenylquinoxaline"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PDGFRA protein]"26385185
D000082AcetaminophenAcetaminophen affects the expression of PDGFRA mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDGFRA mRNA28943387
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of PDGFRA gene27153756
D000452Aldrin"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA"19422813
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PDGFRA mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDGFRA mRNA16483693
D001151ArsenicArsenic results in increased methylation of PDGFRA promoter21291286
C015001arsenitearsenite results in increased methylation of PDGFRA promoter23974009
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased methylation of PDGFRA promoter28329817
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFRA mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of PDGFRA mRNA22610609
D004958EstradiolEstradiol affects the expression of PDGFRA mRNA15598610
D004958Estradiol[Estradiol co-treated with Progesterone co-treated with Cuprizone] results in increased expression of PDGFRA mRNA19031445
D004958EstradiolEstradiol results in increased expression of PDGFRA mRNA19484750
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in decreased expression of PDGFRA mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of PDGFRA mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDGFRA mRNA28628672
C006780bisphenol Abisphenol A affects the expression of PDGFRA mRNA25181051
C006780bisphenol Abisphenol A results in decreased expression of PDGFRA mRNA25084756
C006780bisphenol Abisphenol A results in decreased expression of PDGFRA protein25084756
C006780bisphenol Abisphenol A results in increased expression of PDGFRA mRNA12604637
C006780bisphenol Abisphenol A results in increased expression of PDGFRA protein12604637
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFRA mRNA28628672
D002104CadmiumCadmium results in increased phosphorylation of PDGFRA protein17125913
D002104Cadmiumfulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of PDGFRA protein]17125913
D019256Cadmium ChlorideCadmium Chloride results in increased phosphorylation of PDGFRA protein17125913
D019256Cadmium Chloridefulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of PDGFRA protein]17125913
D019256Cadmium Chloride[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PDGFRA mRNA19840844
D002251Carbon TetrachlorideCarbon Tetrachloride affects the expression of PDGFRA mRNA17484886
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PDGFRA mRNA16239168
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRA mRNA20548288|2093899
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PDGFRA mRNA28472532
D003300Copper[NSC 689534 binds to Copper] which results in decreased expression of PDGFRA mRNA20971185
D003375CoumestrolCoumestrol results in increased expression of PDGFRA mRNA12604637
D003375CoumestrolCoumestrol results in increased expression of PDGFRA protein12604637
C461979CT52923CT52923 binds to and results in decreased activity of PDGFRA protein15994924
D003471Cuprizone[Estradiol co-treated with Progesterone co-treated with Cuprizone] results in increased expression of PDGFRA mRNA19031445
C057862cyanoginosin LRcyanoginosin LR results in increased expression of PDGFRA mRNA17654400
D016572CyclosporineCyclosporine results in decreased expression of PDGFRA mRNA27989131
C515055darinaparsindarinaparsin results in increased expression of PDGFRA mRNA22535156
D000069439DasatinibDasatinib results in decreased phosphorylation of PDGFRA protein mutant form18619723
C014347decitabinedecitabine affects the expression of PDGFRA mRNA23300844
D003871Dermatan SulfateDermatan Sulfate results in decreased expression of PDGFRA mRNA16945567
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDGFRA mRNA]27941970
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDGFRA mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFRA mRNA28628672
D003907DexamethasoneDexamethasone results in increased expression of PDGFRA mRNA22733784
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDGFRA mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of PDGFRA mRNA24893172
D002945CisplatinCisplatin affects the expression of PDGFRA mRNA23300844
D002945CisplatinCisplatin results in decreased expression of PDGFRA mRNA21151649
D003632Dichlorodiphenyldichloroethane"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA"19422813
D003633Dichlorodiphenyl Dichloroethylene"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA"19422813
D004026Dieldrin"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRA mRNA"19422813
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PDGFRA mRNA27070252
D004041Dietary Fatsresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PDGFRA mRNA]27070252
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PDGFRA mRNA27070252
D019422Dietary Sucroseresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PDGFRA mRNA]27070252
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of PDGFRA mRNA25031359
D004051Diethylhexyl Phthalate[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of PDGFRA protein25031359
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PDGFRA mRNA25031359
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of PDGFRA protein25031359
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PDGFRA mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of PDGFRA mRNA24535843
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PDGFRA mRNA12604637
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of PDGFRA protein12604637
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of PDGFRA mRNA25380136
D004147DioxinsDioxins affects the expression of PDGFRA mRNA20463971
D004221DisulfiramDisulfiram results in decreased expression of PDGFRA mRNA20530235
D004237DiuronDiuron results in decreased expression of PDGFRA mRNA25152437
D004237DiuronDiuron results in increased expression of PDGFRA mRNA21551480
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PDGFRA mRNA17557909
C024565ethylene dichlorideethylene dichloride results in increased expression of PDGFRA mRNA28189721
D005485FlutamideFlutamide results in decreased expression of PDGFRA mRNA21126777
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRA mRNA20548288|2093899
D005557FormaldehydeFormaldehyde results in increased expression of PDGFRA mRNA18045764
D005557FormaldehydeFormaldehyde results in increased expression of PDGFRA mRNA18045764
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium Chloride results in increased phosphorylation of PDGFRA protein]17125913
C070081fulvestrantfulvestrant inhibits the reaction [Cadmium results in increased phosphorylation of PDGFRA protein]17125913
C039281furanfuran results in decreased methylation of PDGFRA gene27387713
C039281furanfuran results in increased expression of PDGFRA mRNA27387713
D005665FurosemideFurosemide affects the expression of PDGFRA mRNA16526316
D019833GenisteinGenistein results in decreased expression of PDGFRA mRNA22228119
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of PDGFRA mRNA25031359
D019833Genistein[Diethylhexyl Phthalate co-treated with Genistein] results in decreased expression of PDGFRA protein25031359
D019833GenisteinGenistein results in decreased expression of PDGFRA mRNA25031359
D019833GenisteinGenistein results in decreased expression of PDGFRA protein25031359
D019833GenisteinGenistein results in increased expression of PDGFRA mRNA12604637
D019833GenisteinGenistein results in increased expression of PDGFRA protein12604637
D005947Glucose[INS protein co-treated with Glucose] results in increased expression of PDGFRA mRNA22634610
C010176halofuginonehalofuginone results in increased expression of PDGFRA mRNA17180598
D006493HeparinHeparin results in decreased expression of PDGFRA mRNA16945567
C538724HhAntag691[GLI1 mRNA co-treated with GLI2 mRNA] affects the reaction [HhAntag691 results in decreased expression of PDGFRA protein]22087285
C538724HhAntag691HhAntag691 results in decreased expression of PDGFRA protein22087285
D006861Hydrogen PeroxideHydrogen Peroxide results in decreased expression of PDGFRA mRNA17997286
D006861Hydrogen PeroxideSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDGFRA mRNA]17997286
D006861Hydrogen Peroxide[nitrofen results in increased expression of [PDGFA protein co-treated with PDGFRA protein]] which results in increased abundance of Hydrogen Peroxide20920717
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PDGFRA protein15786421|1761435
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PDGFRA protein modified form17614352
D000068877Imatinib MesylateProgesterone promotes the reaction [Imatinib Mesylate results in decreased expression of PDGFRA protein]17614352
D000068877Imatinib MesylateProgesterone promotes the reaction [Imatinib Mesylate results in decreased expression of PDGFRA protein modified form]17614352
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PDGFRA protein22447953
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDGFRA mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFRA mRNA28628672
D007213IndomethacinIndomethacin results in increased expression of PDGFRA mRNA17440234
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of PDGFRA mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of PDGFRA mRNA28628672
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDGFRA mRNA25961927
D007854LeadCBL protein affects the reaction [Lead results in decreased expression of PDGFRA protein]17298174
D007854LeadFYN protein affects the reaction [Lead results in decreased expression of PDGFRA protein]17298174
D007854LeadLead results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA protein17298174
C008261lead acetateCBL protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]17298174
C008261lead acetateFYN protein affects the reaction [lead acetate results in decreased expression of PDGFRA protein]17298174
C008261lead acetatelead acetate results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA protein17298174
C045463leflunomideleflunomide results in increased expression of PDGFRA mRNA24136188
D008148LovastatinLovastatin results in decreased expression of PDGFRA mRNA20578043
D008344Maneb[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA23963992
D008344ManebMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA]23963992
D008550MelatoninMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA]23963992
D008694MethamphetamineMethamphetamine results in decreased expression of PDGFRA mRNA28619521
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRA mRNA20548288|2093899
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of PDGFRA protein17298174
D008767Methylmercury CompoundsCBL protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]17298174
D008767Methylmercury CompoundsFYN protein affects the reaction [Methylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein]17298174
D008767Methylmercury CompoundsMethylmercury Compounds results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA protein17298174
D008767Methylmercury CompoundsMethylmercury Compounds results in increased ubiquitination of and results in increased degradation of PDGFRA protein17298174
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PDGFRA mRNA26011545
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of PDGFRA mRNA"26251327
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Cadmium Chloride] results in decreased expression of PDGFRA mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PDGFRA mRNA19840844
D008769Methylnitronitrosoguanidine[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PDGFRA mRNA19840844
D015735MifepristoneMifepristone results in decreased expression of PDGFRA mRNA25972201
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of PDGFRA mRNA22108045|2517754
C523799MRK 003MRK 003 results in decreased expression of PDGFRA mRNA21169257
D009151Mustard GasMustard Gas results in increased expression of PDGFRA mRNA18988085
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PDGFRA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDGFRA mRNA"25554681
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in increased expression of PDGFRA mRNA25380136
C017096n-butoxyethanoln-butoxyethanol results in decreased expression of PDGFRA mRNA19812364
C007350nitrofen[nitrofen results in increased expression of [PDGFA protein co-treated with PDGFRA protein]] which results in increased abundance of Hydrogen Peroxide20920717
C007350nitrofennitrofen results in increased expression of PDGFRA mRNA20920717
C007350nitrofennitrofen results in increased expression of PDGFRA protein20920717
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PDGFRA mRNA27935865
C558013NSC 689534[NSC 689534 binds to Copper] which results in decreased expression of PDGFRA mRNA20971185
C025589ochratoxin Aochratoxin A results in decreased expression of PDGFRA mRNA21703336
C025589ochratoxin ASHH protein modified form inhibits the reaction [ochratoxin A results in decreased expression of PDGFRA mRNA]21703336
D019319Okadaic Acid[Methylnitronitrosoguanidine co-treated with Okadaic Acid] results in decreased expression of PDGFRA mRNA19840844
D010098OxycodoneOxycodone results in increased expression of PDGFRA protein26377394
D010100OxygenOxygen deficiency results in increased expression of PDGFRA mRNA24205000
D010100OxygenOxygen deficiency results in increased expression of PDGFRA mRNA26476374
D010100OxygenQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFRA mRNA]26476374
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of PDGFRA mRNA26272509
D010269Paraquat[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA23963992
D010269ParaquatMelatonin inhibits the reaction [[Maneb co-treated with Paraquat] results in increased expression of PDGFRA mRNA]23963992
D010269ParaquatParaquat results in increased expression of PDGFRA mRNA21371552
D010269ParaquatParaquat results in increased expression of PDGFRA mRNA alternative form17215068
D010269ParaquatCBL protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]17298174
D010269ParaquatFYN protein affects the reaction [Paraquat results in decreased expression of PDGFRA protein]17298174
D010269ParaquatParaquat affects the expression of PDGFRA mRNA16854511
D010269ParaquatParaquat results in decreased expression of and results in decreased phosphorylation of and results in decreased activity of PDGFRA protein17298174
D052638Particulate MatterParticulate Matter results in increased expression of PDGFRA mRNA17987463
D052638Particulate Matter[PDGFRA gene mutant form affects the susceptibility to Particulate Matter] which results in decreased expression of PDGFRA mRNA21222557|2122255
C516667pazopanibpazopanib results in decreased activity of PDGFRA protein19956806|2061637
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in increased expression of PDGFRA mRNA"25510870
C046012pentanalpentanal results in increased expression of PDGFRA mRNA26079696
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDGFRA mRNA19162173
D010634Phenobarbital[Diethylnitrosamine co-treated with Phenobarbital] results in decreased expression of PDGFRA mRNA24535843
D010634PhenobarbitalPhenobarbital affects the expression of PDGFRA mRNA23091169
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of PDGFRA mRNA26272509
D010671Phenylurea CompoundsPhenylurea Compounds results in decreased activity of PDGFRA protein18343900
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of PDGFRA mRNA27935865
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of PDGFRA mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of PDGFRA mRNA12832660
C545373ponatinibponatinib analog results in decreased activity of PDGFRA protein21561767
C545373ponatinibponatinib results in decreased activity of PDGFRA protein19878872
C545373ponatinibponatinib results in decreased activity of PDGFRA protein mutant form19878872
C545373ponatinibponatinib results in decreased phosphorylation of PDGFRA protein mutant form21482694
C545373ponatinibponatinib affects the activity of PDGFRA protein mutant form22301675
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDGFRA mRNA23608068
D011374ProgesteroneProgesterone promotes the reaction [Imatinib Mesylate results in decreased expression of PDGFRA protein]17614352
D011374ProgesteroneProgesterone promotes the reaction [Imatinib Mesylate results in decreased expression of PDGFRA protein modified form]17614352
D011374Progesterone[Progesterone results in increased secretion of [VEGFA protein binds to VEGFA protein]] which results in increased phosphorylation of PDGFRA protein16888808
D011374Progesterone[Estradiol co-treated with Progesterone co-treated with Cuprizone] results in increased expression of PDGFRA mRNA19031445
D011374ProgesteroneProgesterone results in increased expression of PDGFRA mRNA22238285
C005556propionaldehydepropionaldehyde results in increased expression of PDGFRA mRNA26079696
D011441PropylthiouracilPropylthiouracil results in increased expression of PDGFRA mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PDGFRA protein]26385185
D011794QuercetinQuercetin inhibits the reaction [Oxygen deficiency results in increased expression of PDGFRA mRNA]26476374
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of PDGFRA mRNA14699072
C059514resveratrolresveratrol inhibits the reaction [[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of PDGFRA mRNA]27070252
D017632Asbestos, Serpentine"Asbestos, Serpentine results in decreased expression of PDGFRA mRNA"16251409
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDGFRA mRNA25895662
D012834SilverSilver results in decreased expression of PDGFRA mRNA27131904
D019821SimvastatinSimvastatin results in decreased expression of PDGFRA mRNA16414398
C009277sodium arsenatesodium arsenate results in increased expression of PDGFRA mRNA21795629
D012965Sodium ChlorideSodium Chloride results in increased expression of PDGFRA mRNA23634900
D018038Sodium SeleniteSodium Selenite inhibits the reaction [Hydrogen Peroxide results in decreased expression of PDGFRA mRNA]17997286
D018038Sodium SeleniteSodium Selenite results in decreased expression of PDGFRA mRNA18209489
C471405sorafenibsorafenib results in decreased phosphorylation of PDGFRA protein mutant form21482694
D013311StreptozocinStreptozocin results in decreased expression of PDGFRA mRNA26073000
C473478sunitinibsunitinib results in decreased phosphorylation of PDGFRA protein mutant form21482694
C473478sunitinibsunitinib results in decreased activity of PDGFRA protein20616376
D013629TamoxifenTamoxifen results in increased expression of PDGFRA mRNA24769059
D013749TetrachlorodibenzodioxinSRC protein promotes the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFRA mRNA]14708085
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDGFRA mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDGFRA mRNA14708085|1758670
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDGFRA mRNA22298810
D013755Tetradecanoylphorbol Acetate[Methylnitronitrosoguanidine co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of PDGFRA mRNA19840844
D019284ThapsigarginThapsigargin results in decreased expression of PDGFRA mRNA22378314
D013893ThiramThiram results in decreased expression of PDGFRA mRNA20530235
C009495titanium dioxidetitanium dioxide results in decreased expression of PDGFRA mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution affects the expression of PDGFRA mRNA20133372
D014118Toxins, Biological"Toxins, Biological affects the expression of PDGFRA mRNA"19682533
C496197trans-10,cis-12-conjugated linoleic acid"trans-10,cis-12-conjugated linoleic acid results in decreased expression of PDGFRA mRNA"17951470
D014212TretinoinTretinoin results in increased expression of PDGFRA mRNA21934132|2372400
D014212TretinoinTretinoin results in decreased expression of PDGFRA protein16956736
D014212TretinoinTretinoin results in increased expression of PDGFRA mRNA16604517
C447082tricarbonyldichlororuthenium (II) dimer"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PDGFRA protein]"26385185
C447082tricarbonyldichlororuthenium (II) dimerProtein Kinase Inhibitors inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PDGFRA protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer inhibits the reaction [F2 protein results in increased phosphorylation of PDGFRA protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer promotes the reaction [PDGFRA protein binds to PTK2B protein]26385185
C447082tricarbonyldichlororuthenium (II) dimertricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of PDGFRA protein26385185
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of PDGFRA mRNA24935251|2627250
C012589trichostatin Atrichostatin A results in decreased expression of PDGFRA mRNA15901671
D014415TunicamycinTunicamycin results in decreased expression of PDGFRA mRNA22378314
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of PDGFRA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of PDGFRA mRNA23179753|2438349
D014635Valproic AcidValproic Acid results in increased expression of PDGFRA mRNA19136453|2489608
D014635Valproic AcidValproic Acid results in decreased expression of PDGFRA mRNA15901671
C066075vanadium pentoxidevanadium pentoxide results in increased expression of PDGFRA mRNA17134509
D001335Vehicle EmissionsVehicle Emissions results in increased expression of PDGFRA mRNA17987463
D001335Vehicle Emissions[PDGFRA gene mutant form affects the susceptibility to Vehicle Emissions] which results in decreased expression of PDGFRA mRNA21222557|2122255
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of PDGFRA gene25560391
C025643vinclozolinvinclozolin results in increased expression of PDGFRA mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of PDGFRA mRNA26682919
D014810Vitamin EVitamin E results in increased expression of PDGFRA mRNA19244175
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of PDGFRA mRNA"27188386
C111237vorinostatvorinostat results in increased expression of PDGFRA mRNA26272509
C088658zoledronic acidzoledronic acid results in increased expression of PDGFRA mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-IDA24190966  
GO:0004709MAP kinase kinase kinase activity-IBA21873635  
GO:0004713protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IBA21873635  
GO:0004714transmembrane receptor protein tyrosine kinase activity-IDA1646396  
GO:0004888transmembrane signaling receptor activity-IBA21873635  
GO:0005018platelet-derived growth factor alpha-receptor activity-IBA21873635  
GO:0005018platelet-derived growth factor alpha-receptor activity-IDA2536956  8188664  10806482  
GO:0005018platelet-derived growth factor alpha-receptor activity-IMP2554309  
GO:0005021vascular endothelial growth factor-activated receptor activity-IDA17470632  
GO:0005088Ras guanyl-nucleotide exchange factor activity-TAS-  
GO:0005161platelet-derived growth factor receptor binding-IPI2542288  
GO:0005515protein binding-IPI7679113  9546424  10733900  10806482  17470632  24658140  
25241761  25416956  
GO:0005524ATP binding-IEA-  
GO:0019838growth factor binding-IBA21873635  
GO:0031434mitogen-activated protein kinase kinase binding-IBA21873635  
GO:0038085vascular endothelial growth factor binding-IPI17470632  
GO:0042803protein homodimerization activity-IDA2542288  
GO:0044877protein-containing complex binding-IEA-  
GO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity-TAS-  
GO:0048407platelet-derived growth factor binding-IBA21873635  
GO:0048407platelet-derived growth factor binding-IDA2554309  8188664  
GO:0048407platelet-derived growth factor binding-IPI2536956  10806482  
GO ID GO Term Qualifier Evidence PubMed
GO:0000165MAPK cascade-TAS-  
GO:0001553luteinization-ISS-  
GO:0001701in utero embryonic development-IEA-  
GO:0001775cell activation-TAS10508235  
GO:0002244hematopoietic progenitor cell differentiation-IEA-  
GO:0007204positive regulation of cytosolic calcium ion concentration-IMP2554309  
GO:0007275multicellular organism development-IBA21873635  
GO:0008210estrogen metabolic process-IEA-  
GO:0008284positive regulation of cell proliferation-IDA10806482  
GO:0008284positive regulation of cell proliferation-IMP2554309  
GO:0009968negative regulation of signal transduction-IBA21873635  
GO:0010544negative regulation of platelet activation-IDA8188664  
GO:0010863positive regulation of phospholipase C activity-IMP1646396  
GO:0014068positive regulation of phosphatidylinositol 3-kinase signaling-TAS10734113  
GO:0016032viral process-IEA-  
GO:0018108peptidyl-tyrosine phosphorylation-IDA1646396  2536956  8188664  
GO:0023019signal transduction involved in regulation of gene expression-IEA-  
GO:0030154cell differentiation-IBA21873635  
GO:0030198extracellular matrix organization-IEA-  
GO:0030324lung development-IEA-  
GO:0030325adrenal gland development-IEA-  
GO:0030335positive regulation of cell migration-IDA17470632  
GO:0030335positive regulation of cell migration-IMP1646396  
GO:0030539male genitalia development-IEA-  
GO:0033327Leydig cell differentiation-IEA-  
GO:0033674positive regulation of kinase activity-IBA21873635  
GO:0034614cellular response to reactive oxygen species-IDA24190966  
GO:0035790platelet-derived growth factor receptor-alpha signaling pathway-IMP2554309  
GO:0038091positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway-IDA17470632  
GO:0042060wound healing-ISS-  
GO:0042475odontogenesis of dentin-containing tooth-IEA-  
GO:0043066negative regulation of apoptotic process-IBA21873635  
GO:0043410positive regulation of MAPK cascade-IBA21873635  
GO:0043552positive regulation of phosphatidylinositol 3-kinase activity-IMP1646396  
GO:0046777protein autophosphorylation-IDA1646396  2536956  8188664  
GO:0046854phosphatidylinositol phosphorylation-IEA-  
GO:0048008platelet-derived growth factor receptor signaling pathway-IDA2536956  10806482  
GO:0048015phosphatidylinositol-mediated signaling-IMP2554309  
GO:0048146positive regulation of fibroblast proliferation-IDA10806482  
GO:0048557embryonic digestive tract morphogenesis-ISS-  
GO:0048701embryonic cranial skeleton morphogenesis-IBA21873635  
GO:0048701embryonic cranial skeleton morphogenesis-ISS-  
GO:0048704embryonic skeletal system morphogenesis-ISS-  
GO:0050920regulation of chemotaxis-IMP2554309  
GO:0051897positive regulation of protein kinase B signaling-TAS-  
GO:0055003cardiac myofibril assembly-ISS-  
GO:0060021roof of mouth development-IEA-  
GO:0060325face morphogenesis-IEA-  
GO:0060326cell chemotaxis-IMP1646396  
GO:0061298retina vasculature development in camera-type eye-ISS-  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IBA21873635  
GO:0070374positive regulation of ERK1 and ERK2 cascade-IMP10734113  
GO:0070527platelet aggregation-IMP8188664  
GO:0071230cellular response to amino acid stimulus-IEA-  
GO:0072277metanephric glomerular capillary formation-ISS-  
GO:2000249regulation of actin cytoskeleton reorganization-TAS10734113  
GO:2000739regulation of mesenchymal stem cell differentiation-IMP21596750  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-ISS-  
GO:0005886plasma membrane-IDA-  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-IBA21873635  
GO:0005887integral component of plasma membrane-IDA2536956  
GO:0005902microvillus-IEA-  
GO:0009897external side of plasma membrane-IEA-  
GO:0016020membrane-HDA19946888  
GO:0030054cell junction-IDA-  
GO:0031226intrinsic component of plasma membrane-IDA2554309  
GO:0032991protein-containing complex-IDA24190966  
GO:0043235receptor complex-IBA21873635  
KEGG ID KEGG Term
hsa04010MAPK signaling pathway
hsa04020Calcium signaling pathway
hsa04060Cytokine-cytokine receptor interaction
hsa04144Endocytosis
hsa04510Focal adhesion
hsa04540Gap junction
hsa04810Regulation of actin cytoskeleton
hsa05200Pathways in cancer
hsa05214Glioma
hsa05215Prostate cancer
hsa05218Melanoma
Reactome ID Reactome Term Evidence
R-HSA-1257604PIP3 activates AKT signalingTAS
R-HSA-162582Signal TransductionTAS
R-HSA-1643685DiseaseTAS
R-HSA-186763Downstream signal transductionTAS
R-HSA-186797Signaling by PDGFTAS
R-HSA-199418Negative regulation of the PI3K/AKT networkTAS
R-HSA-2219528PI3K/AKT Signaling in CancerTAS
R-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerTAS
R-HSA-5663202Diseases of signal transductionTAS
R-HSA-5673001RAF/MAP kinase cascadeTAS
R-HSA-5683057MAPK family signaling cascadesTAS
R-HSA-5684996MAPK1/MAPK3 signalingTAS
R-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingTAS
R-HSA-9006925Intracellular signaling by second messengersTAS
R-HSA-9006934Signaling by Receptor Tyrosine KinasesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23599765Abnormal methylation of seven genes and their associations with clinical characteristics in early stage non-small cell lung cancer. (2013 Apr)Zhao YOncol Lett
29796116Genome-wide analysis of DNA methylation in bronchial washings. (2018)Um SWClin Epigenetics
22670177An immunohistochemical and molecular genetic analysis of KIT and PDGFRA in small cell lung carcinoma in Japanese. (2012)Terada TInt J Clin Exp Pathol
29133146Association of genetic polymorphisms with erythrocyte traits: Verification of SNPs reported in a previous GWAS in a Japanese population. (2018 Feb 5)Seiki TGene
19968631Gene-gene and gene-environment interactions on IgE production in prenatal stage. (2010 Jun 1)Yang KDAllergy
28342264PDGFRA mRNA is overexpressed in oral cancer patients as compared to normal subjects with a significant trend of overexpression among tobacco users. (2017 Sep)Ong HSJ Oral Pathol Med
27542180A Graphical Model of Smoking-Induced Global Instability in Lung Cancer. (2018 Jan-Feb)Wang YIEEE/ACM Trans Comput Biol Bioinform
22975805The transcriptional landscape and mutational profile of lung adenocarcinoma. (2012 Nov)Seo JSGenome Res
26923333Screening for major driver oncogene alterations in adenosquamous lung carcinoma using PCR coupled with next-generation and Sanger sequencing methods. (2016 Feb 29)Shi XSci Rep