Gene: UFM1

51569
BM-002|C13orf20|HLD14
ubiquitin fold modifier 1
protein-coding
13q13.3
Ensembl:ENSG00000120686 MIM:610553 Vega:OTTHUMG00000017409 UniprotKB:P61960
NC_000013.11
PubMed
0   ANCO-SNPs
ND|AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.553e-2 (AD)  7.295e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CMPK10.925
PCNP0.922
NAP1L10.907
CSDE10.905
RAD210.903
HMGB10.903
HNRNPR0.902
SET0.899
HINT30.897
DIMT10.896

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.787
OR4F5-0.753
MMP23B-0.156
RNF223-0.145
MOGAT2-0.143
MTRNR2L10-0.141
KCNK5-0.14
EPPIN-0.136
MTRNR2L6-0.131
ADAMTSL5-0.127

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether analog results in increased expression of UFM1 mRNA"19095052
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UFM1 mRNA"27188386
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of UFM1 mRNA"19561079
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UFM1 mRNA"27188386
D000082AcetaminophenAcetaminophen affects the expression of UFM1 mRNA17562736
D000111AcetylcysteineAcetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA]18723479
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of UFM1 gene27153756
D013196DihydrotestosteroneDihydrotestosterone results in increased expression of UFM1 mRNA16631469
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of UFM1 mRNA"20018196
C006780bisphenol Abisphenol A results in increased expression of UFM1 mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of UFM1 mRNA26191083
D002220CarbamazepineCarbamazepine affects the expression of UFM1 mRNA25979313
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of UFM1 mRNA23650126
C018021cobaltous chloridecobaltous chloride results in increased expression of UFM1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of UFM1 mRNA19549813
C029892cupric chloridecupric chloride results in increased expression of UFM1 mRNA24650576
D016572CyclosporineCyclosporine results in increased expression of UFM1 mRNA20106945|2163298
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of UFM1 mRNA]27941970
C000944dicrotophosdicrotophos results in decreased expression of UFM1 mRNA28302478
C512195elesclomolAcetylcysteine inhibits the reaction [elesclomol results in increased expression of UFM1 mRNA]18723479
C512195elesclomolelesclomol results in increased expression of UFM1 mRNA18723479
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of UFM1 mRNA23649840
D005485FlutamideFlutamide results in increased expression of UFM1 mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of UFM1 mRNA23649840
D005897GlafenineGlafenine results in increased expression of UFM1 mRNA24136188
D006861Hydrogen Peroxide[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UFM1 protein18951874
C492448ICG 001ICG 001 results in increased expression of UFM1 mRNA26191083
C016517indole-3-carbinolindole-3-carbinol affects the expression of UFM1 mRNA21396975
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UFM1 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of UFM1 mRNA27392435
C410337K 7174K 7174 results in increased expression of UFM1 mRNA24086573
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of UFM1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of UFM1 mRNA23649840
D008777MethyltestosteroneMethyltestosterone results in increased expression of UFM1 mRNA29191790
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of UFM1 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of UFM1 mRNA"25554681|2562005
D009538NicotineNicotine results in increased expression of UFM1 mRNA16949557
C012655nimesulidenimesulide results in increased expression of UFM1 mRNA24136188
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in increased expression of UFM1 mRNA19095052
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of UFM1 mRNA27153767
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of UFM1 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of UFM1 mRNA26272509
D010936Plant ExtractsPlant Extracts results in increased expression of UFM1 mRNA23557933
D011078Polychlorinated BiphenylsPolychlorinated Biphenyls affects the expression of UFM1 mRNA21334430
C045950propiconazolepropiconazole results in increased expression of UFM1 mRNA21278054
C031280pyrazolepyrazole results in increased expression of UFM1 mRNA17945193
D011794QuercetinQuercetin results in increased expression of UFM1 mRNA21632981
D012834SilverSilver results in decreased expression of UFM1 mRNA27131904
D012969Sodium FluorideSodium Fluoride results in decreased expression of UFM1 protein28918527
D013749TetrachlorodibenzodioxinAHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of UFM1 mRNA]16891777
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of UFM1 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of UFM1 mRNA16891777
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of UFM1 mRNA25613284
D019284ThapsigarginThapsigargin results in increased expression of UFM1 mRNA22378314
D013806Theophylline[Hydrogen Peroxide co-treated with Theophylline] results in increased expression of UFM1 protein18951874
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in increased expression of UFM1 mRNA28065790
C012589trichostatin Atrichostatin A results in increased expression of UFM1 mRNA24935251
D014415TunicamycinTunicamycin results in increased expression of UFM1 mRNA22378314
D014635Valproic AcidValproic Acid results in decreased expression of UFM1 mRNA23179753|2718838
D014635Valproic AcidValproic Acid results in increased expression of UFM1 mRNA29154799
D014635Valproic AcidValproic Acid affects the expression of UFM1 mRNA17292431

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI26872069  
GO ID GO Term Qualifier Evidence PubMed
GO:0033146regulation of intracellular estrogen receptor signaling pathway-IDA25219498  
GO:0034976response to endoplasmic reticulum stress-IDA23152784  
GO:0043066negative regulation of apoptotic process-ISS-  
GO:0071569protein ufmylation-IDA15071506  
GO:1990592protein K69-linked ufmylation-IBA21873635  
GO:1990592protein K69-linked ufmylation-IDA25219498  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA15071506  
GO:0005737cytoplasm-IBA21873635  
GO:0005737cytoplasm-IDA15071506  
GO:0005783endoplasmic reticulum-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28139377CPT1A methylation is associated with plasma adiponectin. (2017 Mar)Aslibekyan SNutr Metab Cardiovasc Dis
28104585RCAD/BiP pathway is necessary for the proper synthesis of digestive enzymes and secretory function of the exocrine pancreas. (2017 Mar 1)Miller CAm J Physiol Gastrointest Liver Physiol