Gene: AZIN1

51582
AZI|AZI1|AZIA1|OAZI|OAZIN|ODC1L
antizyme inhibitor 1
protein-coding
8q22.3
Ensembl:ENSG00000155096 MIM:607909 Vega:OTTHUMG00000164766 UniprotKB:O14977
NC_000008.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.251e-1 (AD)  2.061e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2304348chr8:102833298 (GRCh38.p7)A>Calcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
NUDT210.953
CAPRIN10.945
EIF1AX0.942
BTBD10.942
ACTR20.941
EIF2S10.937
CNOT70.937
TAX1BP10.936
UBE3A0.934
RAD23B0.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.694
OR4F29-0.673
CSAG1-0.301
ANPEP-0.268
MTRNR2L10-0.248
OLAH-0.241
MTRNR2L6-0.233
VNN3-0.228
KLRK1-0.224
NFE2-0.212

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of AZIN1 mRNA"19162173
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of AZIN1 mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of AZIN1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of AZIN1 mRNA"21346803
C0303702-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone"2-methoxy-5-(2',3',4'-trimethoxyphenyl)tropone results in decreased expression of AZIN1 mRNA"20206263
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of AZIN1 mRNA"19561079
D000082AcetaminophenAcetaminophen affects the expression of AZIN1 mRNA17562736
D000082AcetaminophenAcetaminophen results in decreased expression of AZIN1 mRNA11264010
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AZIN1 mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of AZIN1 mRNA19770486
D000643Ammonium ChlorideAmmonium Chloride affects the expression of AZIN1 mRNA16483693
C030935benz(a)anthracenebenz(a)anthracene affects the expression of AZIN1 mRNA26377693
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of AZIN1 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of AZIN1 mRNA18007998
C006780bisphenol Abisphenol A results in increased expression of AZIN1 mRNA25181051
D002065BuspironeBuspirone results in decreased expression of AZIN1 mRNA24136188
D019328Buthionine SulfoximineButhionine Sulfoximine results in decreased expression of AZIN1 mRNA15878706
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of AZIN1 mRNA15336504
C037123cadmium sulfatecadmium sulfate results in decreased expression of AZIN1 mRNA19274763
D002220CarbamazepineCarbamazepine affects the expression of AZIN1 mRNA24752500|2597931
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AZIN1 gene20938992
C018021cobaltous chloridecobaltous chloride results in increased expression of AZIN1 mRNA19376846
D019327Copper SulfateCopper Sulfate results in increased expression of AZIN1 mRNA19549813
D016572CyclosporineCyclosporine results in increased expression of AZIN1 mRNA20106945|2556210
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AZIN1 mRNA17361019|2126653
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of AZIN1 mRNA21266533
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of AZIN1 mRNA27392435
D004008DiclofenacDiclofenac affects the expression of AZIN1 mRNA24752500
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of AZIN1 mRNA27638505
D004137DinitrochlorobenzeneDinitrochlorobenzene results in decreased expression of AZIN1 mRNA17374397
D004147DioxinsDioxins affects the expression of AZIN1 mRNA20463971
D004317DoxorubicinDoxorubicin results in increased expression of AZIN1 mRNA22016648
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AZIN1 mRNA22079256
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of AZIN1 mRNA17942748
D005485FlutamideFlutamide results in increased expression of AZIN1 mRNA24136188
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AZIN1 gene20938992
D005944GlucosamineGlucosamine results in decreased expression of AZIN1 mRNA17109745
D005944GlucosamineIL1B promotes the reaction [Glucosamine results in increased expression of AZIN1 mRNA]17109745
D017313FenretinideFenretinide results in increased expression of AZIN1 mRNA28973697
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AZIN1 mRNA25613284
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of AZIN1 mRNA27392435
C544151jinfukangjinfukang results in decreased expression of AZIN1 mRNA27392435
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of AZIN1 mRNA26254443
C410337K 7174K 7174 results in increased expression of AZIN1 mRNA24086573
D008627Mercuric ChlorideMercuric Chloride affects the expression of AZIN1 mRNA20353558
D008701MethapyrileneMethapyrilene results in increased expression of AZIN1 mRNA16393664
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation of AZIN1 gene20938992
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of AZIN1 mRNA"20188158
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of AZIN1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of AZIN1 mRNA"25554681
C017096n-butoxyethanoln-butoxyethanol results in increased expression of AZIN1 mRNA19812364
C051752nefazodonenefazodone results in increased expression of AZIN1 mRNA24136188
C017557nickel subsulfidenickel subsulfide results in increased expression of AZIN1 mRNA21086188
C029938nickel sulfatenickel sulfate results in decreased expression of AZIN1 mRNA17374397
C044387N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine"N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in increased expression of AZIN1 mRNA"12756304
C018620oleoresinsoleoresins results in increased expression of AZIN1 mRNA20008804
D010081OxazoloneOxazolone results in decreased expression of AZIN1 mRNA17374397
D010100OxygenOxygen deficiency results in increased expression of AZIN1 mRNA22629407
D010100OxygenOxygen inhibits the reaction [Oxygen deficiency results in increased expression of AZIN1 mRNA]22629407
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of AZIN1 mRNA18593933
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of AZIN1 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of AZIN1 mRNA19159669
D010634PhenobarbitalPhenobarbital results in increased expression of AZIN1 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of AZIN1 mRNA19162173
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of AZIN1 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of AZIN1 mRNA18445702|2381119
C006253pirinixic acidpirinixic acid results in increased expression of AZIN1 mRNA18301758
D010936Plant ExtractsPlant Extracts results in increased expression of AZIN1 mRNA23557933
D010938Plant OilsPlant Oils results in increased expression of AZIN1 mRNA23370395
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of AZIN1 mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of AZIN1 mRNA22079256
D011192Potassium DichromatePotassium Dichromate results in decreased expression of AZIN1 mRNA23608068
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of AZIN1 mRNA21427059
D012822Silicon DioxideSilicon Dioxide results in decreased expression of AZIN1 mRNA25351596
D012834SilverSilver results in increased expression of AZIN1 mRNA26014281
D012460SulfasalazineSulfasalazine results in increased expression of AZIN1 mRNA22016648
C061133tamibarotenetamibarotene affects the expression of AZIN1 mRNA15498508
D013629TamoxifenTamoxifen affects the expression of AZIN1 mRNA14699072
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of AZIN1 mRNA21570461|2892240
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with TIPARP gene mutant form] results in decreased expression of AZIN1 mRNA25975270
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of AZIN1 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of AZIN1 mRNA25613284
C009495titanium dioxidetitanium dioxide affects the expression of AZIN1 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of AZIN1 mRNA15498508
D014635Valproic AcidValproic Acid affects the expression of AZIN1 mRNA25979313
D014635Valproic AcidValproic Acid analog results in decreased expression of AZIN1 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of AZIN1 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of AZIN1 mRNA21427059
D014635Valproic AcidValproic Acid results in decreased expression of AZIN1 mRNA23665938
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of AZIN1 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003824catalytic activity-IEA-  
GO:0004586ornithine decarboxylase activity-IBA21873635  
GO:0005515protein binding-IPI25416956  
GO:0042978ornithine decarboxylase activator activity-IBA21873635  
GO:0042978ornithine decarboxylase activator activity-IDA17900240  
GO ID GO Term Qualifier Evidence PubMed
GO:0006521regulation of cellular amino acid metabolic process-TAS-  
GO:0033387putrescine biosynthetic process from ornithine-IBA21873635  
GO:0042177negative regulation of protein catabolic process-IDA17900240  
GO:0043085positive regulation of catalytic activity-IEA-  
GO:1902269positive regulation of polyamine transmembrane transport-IDA18508777  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-ISS-  
GO:0005737cytoplasm-IBA21873635  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-350562Regulation of ornithine decarboxylase (ODC)TAS
R-HSA-351202Metabolism of polyaminesTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal