Gene: MED15

51586
ARC105|CAG7A|CTG7A|PCQAP|TIG-1|TIG1|TNRC7
mediator complex subunit 15
protein-coding
22q11.21
Ensembl:ENSG00000099917 MIM:607372 Vega:OTTHUMG00000150810 UniprotKB:Q96RN5
NC_000022.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.003e-1 (AD)  7.886e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg06861736chr22:20918809MED158.100e-9Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HGS0.953
ATG4B0.949
GAK0.949
POLRMT0.942
SCAF10.937
DBN10.936
TMEM2140.935
EDC40.935
SYMPK0.935
CARM10.934

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.741
OR4F29-0.697
MTRNR2L6-0.282
MTRNR2L9-0.268
MTRNR2L10-0.253
KLRB1-0.245
KCNJ15-0.239
ASB4-0.238
C9orf153-0.233
PROK2-0.233

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of MED15 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of MED15 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of MED15 mRNA17562736
D000535Aluminum[APP protein modified form binds to Aluminum] which results in decreased expression of MED15 mRNA21298039
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of MED15 mRNA22228805
C006780bisphenol Abisphenol A results in increased expression of MED15 mRNA25181051
C018021cobaltous chloridecobaltous chloride results in increased expression of MED15 mRNA19320972|1937684
C029892cupric chloridecupric chloride results in increased expression of MED15 mRNA17211630
D016572CyclosporineCyclosporine results in increased expression of MED15 mRNA25562108
D002945Cisplatin[Cisplatin co-treated with jinfukang] results in decreased expression of MED15 mRNA27392435
D002945CisplatinCisplatin results in decreased expression of MED15 mRNA27392435|2759478
C000944dicrotophosdicrotophos results in increased expression of MED15 mRNA28302478
D0198131,2-Dimethylhydrazine"1,2-Dimethylhydrazine results in increased expression of MED15 mRNA"27840820
D004147DioxinsDioxins affects the expression of MED15 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of MED15 protein23301498
D005485FlutamideFlutamide results in increased expression of MED15 mRNA24136188
D005897GlafenineGlafenine results in increased expression of MED15 mRNA24136188
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of MED15 mRNA26846883
C544151jinfukang[Cisplatin co-treated with jinfukang] results in decreased expression of MED15 mRNA27392435
D008727MethotrexateMED15 protein affects the susceptibility to Methotrexate16217747
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of MED15 mRNA26011545
C028007nickel monoxidenickel monoxide results in increased expression of MED15 mRNA19167457
D012643Selenium[Selenium co-treated with Vitamin E] results in increased expression of MED15 mRNA19244175
D012643SeleniumSelenium results in increased expression of MED15 mRNA19244175
D013467SulindacSulindac results in increased expression of MED15 mRNA11906190
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of MED15 mRNA21570461
D014241TrichloroethyleneTrichloroethylene results in increased methylation of MED15 gene27618143
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of MED15 mRNA"26179874
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of MED15 gene25560391
D014810Vitamin E[Selenium co-treated with Vitamin E] results in increased expression of MED15 mRNA19244175
D014810Vitamin EVitamin E results in increased expression of MED15 mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI12167862  16799563  16904669  17500595  18385733  18568018  
24882805  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IEA-  
GO:0006367transcription initiation from RNA polymerase II promoter-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
GO:0005634nucleus-IDA-  
GO:0005654nucleoplasm-TAS-  
GO:0005737cytoplasm-IEA-  
GO:0016020membrane-HDA19946888  
GO:0016592mediator complex-IEA-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1266738Developmental BiologyTAS
R-HSA-1266738Developmental BiologyIEA
R-HSA-1430728MetabolismTAS
R-HSA-1989781PPARA activates gene expressionTAS
R-HSA-212436Generic Transcription PathwayTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationTAS
R-HSA-381340Transcriptional regulation of white adipocyte differentiationIEA
R-HSA-400206Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)TAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-73857RNA Polymerase II TranscriptionTAS
R-HSA-74160Gene expression (Transcription)TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25057238DNA Methylation at the Novel CpG Sites in the Promoter of MED15/PCQAP Gene as a Biomarker for Head and Neck Cancers. (2014)Ovchinnikov DABiomark Insights