Gene info: ID 5159

Gene: PDGFRB

GENE ID: 5159

Description: platelet derived growth factor receptor beta

Gene type: protein-coding

Location: 5q32

dbXrefs: Ensembl:ENSG00000113721 MIM:173410 Vega:OTTHUMG00000130053 UniprotKB:P09619

RefSeq: NG_023367.1

Retrived from: PubMed

SNPs: 0 ANCO-SNPs

Phenotype: ND

# Publications: 1

Sherlock p-value : NA (AD) NA (ND) (Frontal_Cortex)

Pascal p-value : 2.132e-1 (AD) 8.962e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
LAMB2	0.875
RHOJ	0.822
PEAR1	0.819
DOCK6	0.808
SOX13	0.801
RGL3	0.794
NFATC4	0.793
INPPL1	0.787
TLN1	0.781
BCAM	0.781

Top 10 negatively co-expressed genes

Gene Symbol	Pearson Correlation Coefficient
SMIM18	-0.503
GLRA2	-0.467
PPP1R17	-0.462
CRH	-0.439
FSTL5	-0.437
PTPRR	-0.436
IL13RA2	-0.433
HAS1	-0.42
PPEF1	-0.417
CBLN1	-0.412

ID	Drug Name	Drug Type	CAS Num	Status	Role
DB00102	Becaplermin	BiotechDrug	165101-51-9	Approved\|Investigational	Target
DB00398	Sorafenib	Small Molecule	284461-73-0	Approved\|Investigational	Target
DB00619	Imatinib	Small Molecule	152459-95-5	Approved	Target
DB01254	Dasatinib	Small Molecule	302962-49-8	Approved\|Investigational	Target
DB01268	Sunitinib	Small Molecule	557795-19-4	Approved\|Investigational	Target
DB05014	XL999	Small Molecule	921206-68-0	Investigational	Target
DB05146	XL820	Small Molecule	-	Investigational	Target
DB06589	Pazopanib	Small Molecule	444731-52-6	Approved	Target
DB06595	Midostaurin	Small Molecule	120685-11-2	Approved\|Investigational	Target
DB08896	Regorafenib	Small Molecule	755037-03-7	Approved	Target
DB09221	Polaprezinc	Small Molecule	107667-60-7	Approved\|Investigational	Target

ID	Drug Name	Action	PubMed
C032668	1-nitropyrene	1-nitropyrene results in decreased expression of PDGFRB mRNA	19041380
C054919	2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene	"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA"	19422813
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of PDGFRB mRNA	18332871
C093973	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one	2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one results in decreased expression of PDGFRB protein	18332871
C013186	2,3-pentanedione	"2,3-pentanedione results in increased expression of PDGFRB mRNA"	25710175
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide inhibits the reaction [TGFB1 protein results in increased expression of PDGFRB mRNA]"	26644586
C577942	2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide	"2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide results in decreased expression of PDGFRB mRNA"	26644586
C117011	3-(4-dimethylamino-benzylidenyl)-2-indolinone	3-(4-dimethylamino-benzylidenyl)-2-indolinone results in decreased activity of PDGFRB protein	15728459
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal binds to PDGFRB protein	16527993
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	16527993
C027576	4-hydroxy-2-nonenal	dinitrophenylhydrazine inhibits the reaction [4-hydroxy-2-nonenal binds to PDGFRB protein]	16527993
C027576	4-hydroxy-2-nonenal	Hydralazine inhibits the reaction [4-hydroxy-2-nonenal binds to PDGFRB protein]	16527993
C027576	4-hydroxy-2-nonenal	4-hydroxy-2-nonenal affects the activity of PDGFRB protein	17263919
C499823	5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid	"5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid results in decreased phosphorylation of PDGFRB protein"	20709806
C499823	5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid	"PDGFB protein promotes the reaction [5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-eicosapentaenoic acid results in decreased phosphorylation of PDGFRB protein]"	20709806
C407689	6,7-dimethoxy-2-phenylquinoxaline	"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]"	16149045
C407689	6,7-dimethoxy-2-phenylquinoxaline	"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]"	25896968
C106250	6,7-dimethoxy-3-phenylquinoxaline	"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]"	12223454
C518849	7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one	"7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one metabolite inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]"	17268099
C518849	7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one	"7-(3-(cyclohexylmethyl)ureido)-3-(1-methyl-1H-pyrrolo(2,3-b)pyridin-3-yl)quinoxalin-2(1H)-one inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]"	17268099
D000082	Acetaminophen	Acetaminophen results in increased expression of PDGFRB mRNA	29067470
D000082	Acetaminophen	Acetaminophen affects the expression of PDGFRB mRNA	17562736
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]	23392711
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]	23392711
D000111	Acetylcysteine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]	23392711
D000111	Acetylcysteine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]	23392711
D000111	Acetylcysteine	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PDGFRB mRNA]	21134390
D000171	Acrolein	Acrolein binds to PDGFRB protein	16527993
D000452	Aldrin	"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA"	19422813
D000452	Aldrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
C004471	allyl isothiocyanate	allyl isothiocyanate results in decreased expression of PDGFRB mRNA	24036144
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA	23859036
D024502	alpha-Tocopherol	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein	23859036
D000643	Ammonium Chloride	Ammonium Chloride affects the expression of PDGFRB mRNA	16483693
C106407	ampelopsin	ampelopsin analog inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]	21871475
D000880	Anthraquinones	Anthraquinones analog results in decreased activity of PDGFRB protein	27473261
D018501	Antirheumatic Agents	Antirheumatic Agents results in increased expression of PDGFRB mRNA	24449571
D001205	Ascorbic Acid	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA	23859036
D001205	Ascorbic Acid	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein	23859036
D001280	Atrazine	Atrazine results in increased expression of PDGFRB mRNA	22378314
C030935	benz(a)anthracene	benz(a)anthracene results in increased expression of PDGFRB mRNA	26377693
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDGFRB mRNA	26001963
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDGFRB mRNA	22316170\|2623829
D001564	Benzo(a)pyrene	AHR protein inhibits the reaction [Benzo(a)pyrene results in increased expression of PDGFRB mRNA]	15034205
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in decreased expression of PDGFRB mRNA	21569818
D001564	Benzo(a)pyrene	Benzo(a)pyrene results in increased expression of PDGFRB mRNA	15034205\|2222880
D019207	beta Carotene	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA	23859036
D019207	beta Carotene	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein	23859036
D004958	Estradiol	[Progesterone co-treated with Estradiol] results in increased expression of PDGFRB mRNA	18692832
C023888	beta-hexachlorocyclohexane	beta-hexachlorocyclohexane results in decreased expression of PDGFRB mRNA	25270620
C044887	beta-methylcholine	beta-methylcholine affects the expression of PDGFRB mRNA	21179406
C070515	bisindolylmaleimide I	bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]	12223454
C006780	bisphenol A	bisphenol A results in decreased expression of PDGFRB mRNA	26063408
C006780	bisphenol A	bisphenol A affects the expression of PDGFRB mRNA	21786754
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in decreased methylation of PDGFRB gene	28505145
C006780	bisphenol A	[bisphenol A co-treated with Genistein] results in increased methylation of PDGFRB gene	28505145
C006780	bisphenol A	bisphenol A results in decreased expression of PDGFRB mRNA	25181051
C006780	bisphenol A	bisphenol A results in increased expression of PDGFRB mRNA	12604637\|2909715
C006780	bisphenol A	bisphenol A results in increased expression of PDGFRB protein	12604637
C006780	bisphenol A	bisphenol A results in increased methylation of PDGFRB gene	28505145
D000069286	Bortezomib	[Bortezomib co-treated with sorafenib] results in decreased phosphorylation of PDGFRB protein	16985072
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]	23392711
D019328	Buthionine Sulfoximine	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]	23392711
C055494	caffeic acid phenethyl ester	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PDGFRB mRNA	20360939
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PDGFRB mRNA	17962354\|2733941
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PDGFRB protein	27477297
D002251	Carbon Tetrachloride	F2R protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	17962354
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]	27477297
D002251	Carbon Tetrachloride	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]	27477297
D002251	Carbon Tetrachloride	PPARD protein affects the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	18038451
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	27477297
D002251	Carbon Tetrachloride	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	27477297
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in decreased expression of PDGFRB protein	17069927
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PDGFRB mRNA	15623374\|1800664
D002251	Carbon Tetrachloride	Carbon Tetrachloride results in increased expression of PDGFRB protein	19646978\|2414477
D002251	Carbon Tetrachloride	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	18006644
D002251	Carbon Tetrachloride	epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	19646978
D002251	Carbon Tetrachloride	epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	19646978
D002251	Carbon Tetrachloride	Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	24144775
D002251	Carbon Tetrachloride	olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	24144775
D002251	Carbon Tetrachloride	olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]	24144775
D002713	Chlorine	[Ozone co-treated with Chlorine] affects the expression of PDGFRB mRNA	18636392
D002793	Cholic Acids	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PDGFRB mRNA	27344345
D002794	Choline	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRB mRNA	20938992
D002809	Chondroitin Sulfates	Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]	16945567
D002809	Chondroitin Sulfates	Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]	16945567
D003300	Copper	[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA	24690739
D019327	Copper Sulfate	Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]	23392711
D019327	Copper Sulfate	Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]	23392711
D019327	Copper Sulfate	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB mRNA]]	23392711
D019327	Copper Sulfate	Buthionine Sulfoximine inhibits the reaction [Acetylcysteine inhibits the reaction [Copper Sulfate results in increased expression of PDGFRB protein]]	23392711
D019327	Copper Sulfate	Copper Sulfate results in decreased expression of PDGFRB mRNA	19549813
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PDGFRB mRNA	23392711
D019327	Copper Sulfate	Copper Sulfate results in increased expression of PDGFRB protein	23392711
D003375	Coumestrol	Coumestrol results in increased expression of PDGFRB mRNA	12604637
D003375	Coumestrol	Coumestrol results in increased expression of PDGFRB protein	12604637
C497448	CP-673,451	"CP-673,451 inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]"	15705896
C497448	CP-673,451	"CP-673,451 results in decreased activity of PDGFRB protein"	15705896
C497448	CP-673,451	"CP-673,451 results in decreased phosphorylation of PDGFRB protein"	15705896
C461979	CT52923	CT52923 binds to and results in decreased activity of PDGFRB protein	15994924
C461979	CT52923	CT52923 inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]	17268099
C007164	cumene hydroperoxide	cumene hydroperoxide inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	16527993
D003474	Curcumin	Curcumin results in increased expression of PDGFRB mRNA	21594647
D003474	Curcumin	Curcumin inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	18006644
D003474	Curcumin	Curcumin results in decreased expression of PDGFRB mRNA	18332871
D003474	Curcumin	Curcumin results in decreased expression of PDGFRB protein	18332871
D003474	Curcumin	Curcumin results in decreased phosphorylation of PDGFRB protein	17372590\|1833287
D016572	Cyclosporine	Cyclosporine results in decreased expression of PDGFRB mRNA	25562108
D016572	Cyclosporine	Cyclosporine results in increased expression of PDGFRB mRNA	20106945
D003545	Cysteine	Cysteine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	15158331
D003545	Cysteine	Cysteine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15158331
D003545	Cysteine	Cysteine results in decreased expression of PDGFRB protein	15158331
D003561	Cytarabine	Cytarabine results in decreased expression of PDGFRB mRNA	21198554
D000069439	Dasatinib	Dasatinib results in decreased phosphorylation of PDGFRB protein	20664932
D000069439	Dasatinib	Dasatinib results in increased expression of PDGFRB mRNA	20579391
D000069439	Dasatinib	Dasatinib results in decreased activity of PDGFRB protein	21128601
D003634	DDT	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
C014347	decitabine	decitabine results in increased expression of PDGFRB mRNA	21856257
D003676	Deferoxamine	Deferoxamine results in decreased expression of PDGFRB protein	18032466
C548688	dehydroglyasperin C	dehydroglyasperin C inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	23298457
D003871	Dermatan Sulfate	Dermatan Sulfate results in decreased expression of PDGFRB mRNA	16945567
D003907	Dexamethasone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA	16054899
D003907	Dexamethasone	Dexamethasone results in decreased expression of PDGFRB mRNA	22733784
D003907	Dexamethasone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
D003907	Dexamethasone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
D003993	Dibutyl Phthalate	Dibutyl Phthalate results in increased expression of PDGFRB mRNA	21266533
D002945	Cisplatin	Cisplatin results in decreased expression of PDGFRB mRNA	21151649
D003632	Dichlorodiphenyldichloroethane	"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA"	19422813
D003632	Dichlorodiphenyldichloroethane	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
D003633	Dichlorodiphenyl Dichloroethylene	"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA"	19422813
D003633	Dichlorodiphenyl Dichloroethylene	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
D004008	Diclofenac	Diclofenac results in decreased expression of PDGFRB mRNA	26934552
C000944	dicrotophos	dicrotophos results in increased expression of PDGFRB mRNA	28302478
C036042	dicyclohexyl phthalate	dicyclohexyl phthalate affects the expression of PDGFRB mRNA	26924002
D004026	Dieldrin	"[Dichlorodiphenyldichloroethane co-treated with Dichlorodiphenyl Dichloroethylene co-treated with 2,2-(2-chlorophenyl-4'-chlorophenyl)-1,1-dichloroethene co-treated with Aldrin co-treated with Dieldrin] results in increased expression of PDGFRB mRNA"	19422813
D004026	Dieldrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
D004052	Diethylnitrosamine	[Diethylnitrosamine co-treated with caffeic acid phenethyl ester] results in increased expression of PDGFRB mRNA	20360939
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PDGFRB mRNA	19638242
D004052	Diethylnitrosamine	Diethylnitrosamine results in increased expression of PDGFRB protein	26589970
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PDGFRB mRNA	12604637
D004054	Diethylstilbestrol	Diethylstilbestrol results in increased expression of PDGFRB protein	12604637
C552122	dimerumic acid	dimerumic acid results in decreased expression of PDGFRB mRNA	24036144
C552122	dimerumic acid	NFE2L2 protein affects the reaction [dimerumic acid results in decreased expression of PDGFRB mRNA]	24036144
C015835	dimethyl-4-toluidine	dimethyl-4-toluidine results in decreased expression of PDGFRB mRNA	27638505
C024629	dimethyl phthalate	dimethyl phthalate affects the expression of PDGFRB mRNA	26924002
C446799	dinitrophenylhydrazine	dinitrophenylhydrazine inhibits the reaction [4-hydroxy-2-nonenal binds to PDGFRB protein]	16527993
D004221	Disulfiram	[Disulfiram binds to Copper] which results in increased expression of PDGFRB mRNA	24690739
D004642	Emodin	Emodin inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	15288473
D004642	Emodin	Emodin results in decreased expression of PDGFRB protein	15288473
D004732	Endrin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
C045651	epigallocatechin gallate	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDGFRB mRNA	22079256
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	19646978
C045651	epigallocatechin gallate	epigallocatechin gallate inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	19646978
D000431	Ethanol	Ethanol results in increased expression of PDGFRB mRNA	20116195
D000431	Ethanol	fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA]	20116195
D004997	Ethinyl Estradiol	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDGFRB mRNA	17942748
D004997	Ethinyl Estradiol	Ethinyl Estradiol results in decreased expression of PDGFRB mRNA	17557909
C540355	fenamidone	fenamidone results in increased expression of PDGFRB mRNA	27029645
D005395	Fish Oils	Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	24144775
D005395	Fish Oils	olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]	24144775
D005485	Flutamide	Flutamide results in increased expression of PDGFRB mRNA	20566332
D005492	Folic Acid	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRB mRNA	20938992
C010238	fomepizole	fomepizole inhibits the reaction [Ethanol results in increased expression of PDGFRB mRNA]	20116195
C069837	fullerene C60	fullerene C60 results in decreased expression of PDGFRB mRNA	19167457
C039281	furan	furan results in increased expression of PDGFRB mRNA	27387713
D005665	Furosemide	Furosemide results in increased expression of PDGFRB mRNA	16526316
D019833	Genistein	Genistein inhibits the reaction [Chondroitin Sulfates promotes the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of PDGFRB protein]]	16945567
D019833	Genistein	Genistein results in decreased expression of PDGFRB mRNA	22228119
D019833	Genistein	[bisphenol A co-treated with Genistein] results in decreased methylation of PDGFRB gene	28505145
D019833	Genistein	[bisphenol A co-treated with Genistein] results in increased methylation of PDGFRB gene	28505145
D019833	Genistein	Genistein results in increased expression of PDGFRB mRNA	12604637
D019833	Genistein	Genistein results in increased expression of PDGFRB protein	12604637
C568713	GSK1210151A	GSK1210151A inhibits the reaction [TGFB1 protein results in increased expression of PDGFRB mRNA]	26644586
C568713	GSK1210151A	GSK1210151A results in decreased expression of PDGFRB mRNA	26644586
C412815	GW 4064	GW 4064 promotes the reaction [NR1H4 protein binds to PDGFRB gene]	20091679
D006830	Hydralazine	Hydralazine inhibits the reaction [4-hydroxy-2-nonenal binds to PDGFRB protein]	16527993
D006861	Hydrogen Peroxide	Hydrogen Peroxide affects the expression of PDGFRB mRNA	20044591
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK1 protein]	14975446
D006861	Hydrogen Peroxide	HSPB1 protein inhibits the reaction [[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK3 protein]	14975446
D006861	Hydrogen Peroxide	[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK1 protein	14975446
D006861	Hydrogen Peroxide	[Hydrogen Peroxide affects the activity of PDGFRB protein] which results in increased activity of MAPK3 protein	14975446
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PDGFRB mRNA	23022513
D006861	Hydrogen Peroxide	Hydrogen Peroxide results in increased expression of PDGFRB protein	23022513
D006861	Hydrogen Peroxide	tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]	23022513
D006861	Hydrogen Peroxide	tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]	23022513
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of PDGFRB protein	15786421
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased phosphorylation of PDGFRB protein	15786421
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased phosphorylation of PDGFRB protein	15867366
D000068877	Imatinib Mesylate	Imatinib Mesylate inhibits the reaction [nitrofen results in increased expression of PDGFRB protein]	22447953
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased expression of PDGFRB mRNA	19242505
D000068877	Imatinib Mesylate	Imatinib Mesylate inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]	17268099
D000068877	Imatinib Mesylate	Imatinib Mesylate results in decreased activity of PDGFRB protein	17377918\|2399474
C078038	inchinko-to	inchinko-to inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	15288473
C078038	inchinko-to	inchinko-to inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15288473
D007213	Indomethacin	Indomethacin results in increased expression of PDGFRB mRNA	17440234
D019266	Iron, Dietary	"Iron, Dietary affects the reaction [Thioacetamide affects the expression of PDGFRB mRNA]"	18032466
D015056	1-Methyl-3-isobutylxanthine	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA	16054899
D015056	1-Methyl-3-isobutylxanthine	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
D015056	1-Methyl-3-isobutylxanthine	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
C561695	(+)-JQ1 compound	(+)-JQ1 compound inhibits the reaction [TGFB1 protein results in increased expression of PDGFRB mRNA]	26644586
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PDGFRB mRNA	23430699\|2479639
C561695	(+)-JQ1 compound	(+)-JQ1 compound results in decreased expression of PDGFRB mRNA	26644586
C060343	lercanidipine	lercanidipine results in decreased phosphorylation of PDGFRB protein	18973813
D001556	Lindane	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
D008070	Lipopolysaccharides	Lipopolysaccharides results in decreased expression of PDGFRB mRNA	12057914
D008070	Lipopolysaccharides	Lipopolysaccharides results in increased expression of PDGFRB mRNA	27339419
C040527	lipoxin A4	lipoxin A4 affects the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	12223454
C040527	lipoxin A4	lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]	12223454
C040527	lipoxin A4	lipoxin A4 results in decreased phosphorylation of PDGFRB protein	20709806
C040527	lipoxin A4	PDGFB protein promotes the reaction [lipoxin A4 results in decreased phosphorylation of PDGFRB protein]	20709806
D019808	Losartan	Losartan inhibits the reaction [AGT protein results in increased expression of PDGFRB mRNA]	17043664
D017998	Leukotriene D4	"6,7-dimethoxy-3-phenylquinoxaline inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]"	12223454
D017998	Leukotriene D4	bisindolylmaleimide I inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]	12223454
D017998	Leukotriene D4	Leukotriene D4 promotes the reaction [SRC protein binds to PDGFRB protein]	12223454
D017998	Leukotriene D4	Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein	12223454
D017998	Leukotriene D4	lipoxin A4 inhibits the reaction [Leukotriene D4 results in increased activity of PDGFRB protein]	12223454
D017998	Leukotriene D4	pobilukast inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]	12223454
C480486	malvidin-3-O-glucoside-4 vinyl	malvidin-3-O-glucoside-4 vinyl inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]	21871475
D008555	Melitten	Melitten results in decreased phosphorylation of and results in decreased activity of PDGFRB protein	17654254
D008715	Methionine	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of PDGFRB mRNA	20938992
D008715	Methionine	Methionine inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	15158331
D008715	Methionine	Methionine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15158331
D008715	Methionine	Methionine results in decreased expression of PDGFRB protein	15158331
C004925	methylmercuric chloride	methylmercuric chloride results in increased expression of PDGFRB mRNA	28001369
D018817	N-Methyl-3,4-methylenedioxyamphetamine	"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of PDGFRB mRNA"	20188158
D015735	Mifepristone	Mifepristone results in decreased expression of PDGFRB mRNA	25972201
C517284	monomethyl phthalate	monomethyl phthalate affects the expression of PDGFRB mRNA	26924002
C500085	muraglitazar	muraglitazar results in increased expression of PDGFRB mRNA	21515302
D009151	Mustard Gas	IL10 protein affects the reaction [Mustard Gas affects the expression of PDGFRB mRNA]	16173061
D037742	Nanotubes, Carbon	"Nanotubes, Carbon analog results in decreased expression of PDGFRB mRNA"	25554681
D037742	Nanotubes, Carbon	"Nanotubes, Carbon results in increased expression of PDGFRB mRNA"	25926378
D015058	1-Naphthylisothiocyanate	[1-Naphthylisothiocyanate co-treated with Cholic Acids] affects the expression of PDGFRB mRNA	27344345
D009538	Nicotine	"6,7-dimethoxy-2-phenylquinoxaline inhibits the reaction [Nicotine results in increased expression of PDGFRB protein]"	16149045
D009538	Nicotine	Nicotine results in increased expression of PDGFRB protein	16149045
D009538	Nicotine	Nicotine results in decreased phosphorylation of and results in decreased activity of PDGFRB protein	20447445
C007350	nitrofen	Imatinib Mesylate inhibits the reaction [nitrofen results in increased expression of PDGFRB protein]	22447953
C007350	nitrofen	nitrofen results in increased expression of PDGFRB protein	22447953
C025256	nonylphenol	nonylphenol results in decreased expression of PDGFRB mRNA	15518916
C501177	NVP-AEW541	NVP-AEW541 results in decreased phosphorylation of PDGFRB protein	20664932
D016627	Oxidopamine	Oxidopamine results in decreased expression of PDGFRB mRNA	15518916
C437965	olmesartan	olmesartan inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	24144775
C437965	olmesartan	olmesartan inhibits the reaction [Fish Oils inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]	24144775
C507134	ON 01910	ON 01910 results in increased phosphorylation of PDGFRB protein	25472472
C412603	orantinib	orantinib results in decreased phosphorylation of and results in decreased activity of PDGFRB protein	16144927
C412603	orantinib	orantinib inhibits the reaction [PDGFB protein results in increased activity of PDGFRB protein]	17268099
C412603	orantinib	orantinib results in decreased activity of PDGFRB protein	14760097\|1555134
C030110	oxaliplatin	[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFRB mRNA	25729387
C030110	oxaliplatin	oxaliplatin results in increased expression of PDGFRB mRNA	25729387
D010100	Oxygen	Oxygen deficiency results in increased expression of and results in increased activity of PDGFRB protein	19520921
D010100	Oxygen	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of PDGFRB protein]	19520921
D010126	Ozone	[Ozone co-treated with Chlorine] affects the expression of PDGFRB mRNA	18636392
D052638	Particulate Matter	Particulate Matter results in decreased expression of PDGFRB mRNA	23085030
C516667	pazopanib	pazopanib results in decreased activity of PDGFRB protein	19956806\|2061637
C023036	perfluorooctanoic acid	perfluorooctanoic acid results in increased expression of PDGFRB mRNA	28511854
D010634	Phenobarbital	Phenobarbital affects the expression of PDGFRB mRNA	23091169
D010795	Phthalic Acids	Phthalic Acids results in decreased expression of PDGFRB mRNA	15518916
C006253	pirinixic acid	pirinixic acid results in decreased expression of PDGFRB mRNA	18445702
C006253	pirinixic acid	pirinixic acid results in increased expression of PDGFRB mRNA	17426115
C052393	pobilukast	pobilukast inhibits the reaction [Leukotriene D4 results in increased phosphorylation of and results in increased activity of PDGFRB protein]	12223454
D059808	Polyphenols	Polyphenols results in decreased expression of PDGFRB mRNA	16293270
C545373	ponatinib	ponatinib analog results in decreased activity of PDGFRB protein	21561767
C545373	ponatinib	ponatinib results in decreased activity of PDGFRB protein	19878872
C027373	potassium chromate(VI)	[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDGFRB mRNA	22079256
C027373	potassium chromate(VI)	potassium chromate(VI) results in decreased expression of PDGFRB mRNA	22079256
D011374	Progesterone	[Progesterone co-treated with Estradiol] results in increased expression of PDGFRB mRNA	18692832
C513428	pyrachlostrobin	pyrachlostrobin results in increased expression of PDGFRB mRNA	27029645
C432165	pyrazolanthrone	pyrazolanthrone results in decreased expression of PDGFRB mRNA	18332871
C432165	pyrazolanthrone	pyrazolanthrone results in decreased expression of PDGFRB protein	18332871
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of PDGFRB mRNA"	21152443
C014175	pyrazolo(3,4-d)pyrimidine	"pyrazolo(3,4-d)pyrimidine analog affects the expression of PDGFRB mRNA"	21152443
D020849	Raloxifene Hydrochloride	Raloxifene Hydrochloride affects the expression of PDGFRB mRNA	14699072
C059514	resveratrol	resveratrol inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]	23457620
C059514	resveratrol	resveratrol inhibits the reaction [PDGFB protein results in increased phosphorylation of PDGFRB protein]	16343977
C059514	resveratrol	resveratrol results in decreased phosphorylation of PDGFRB protein	18567737
C059514	resveratrol	[resveratrol results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK1 protein	18567737
C059514	resveratrol	[resveratrol results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK3 protein	18567737
C059514	resveratrol	[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein	18567737
C059514	resveratrol	[[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK1 protein	18567737
C059514	resveratrol	[[resveratrol results in increased activity of PTPN1 protein] which results in decreased phosphorylation of PDGFRB protein] which results in decreased phosphorylation of MAPK3 protein	18567737
D015474	Isotretinoin	Isotretinoin results in increased expression of PDGFRB mRNA	20436886
C089730	rosiglitazone	[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA	16054899
C089730	rosiglitazone	EGF protein inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
C089730	rosiglitazone	rosiglitazone inhibits the reaction [Oxygen deficiency results in increased expression of and results in increased activity of PDGFRB protein]	19520921
C089730	rosiglitazone	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
C089730	rosiglitazone	rosiglitazone results in decreased expression of PDGFRB mRNA	17713437
C089730	rosiglitazone	rosiglitazone results in increased expression of PDGFRB mRNA	21515302
C010327	salinomycin	salinomycin results in decreased expression of PDGFRB mRNA	19682730
D019821	Simvastatin	[Lindane co-treated with Aldrin co-treated with Dieldrin co-treated with Endrin co-treated with Dichlorodiphenyl Dichloroethylene co-treated with Dichlorodiphenyldichloroethane co-treated with DDT co-treated with Simvastatin] results in increased expression of PDGFRB mRNA	28263720
D019821	Simvastatin	Simvastatin results in decreased expression of PDGFRB mRNA	10412775
C017947	sodium arsenite	Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of PDGFRB mRNA]	21134390
C017947	sodium arsenite	sodium arsenite results in decreased expression of PDGFRB mRNA	16014739
C017947	sodium arsenite	sodium arsenite results in increased expression of PDGFRB mRNA	21134390
D012965	Sodium Chloride	Sodium Chloride results in increased expression of PDGFRB mRNA	23634900
D018038	Sodium Selenite	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA	23859036
D018038	Sodium Selenite	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein	23859036
D053260	Soot	Soot results in decreased expression of PDGFRB mRNA	26551751
C471405	sorafenib	[Bortezomib co-treated with sorafenib] results in decreased phosphorylation of PDGFRB protein	16985072
C471405	sorafenib	sorafenib results in decreased activity of PDGFRB protein mutant form	17229632
C471405	sorafenib	sorafenib results in decreased phosphorylation of PDGFRB protein	19139124
C471405	sorafenib	sorafenib results in decreased expression of PDGFRB mRNA	19338580
C471405	sorafenib	sorafenib results in decreased phosphorylation of and results in decreased activity of PDGFRB protein	19338580
C471405	sorafenib	sorafenib affects the activity of PDGFRB protein	18808443
C471405	sorafenib	sorafenib results in decreased activity of PDGFRB protein	20616376
C473478	sunitinib	sunitinib results in decreased activity of PDGFRB protein	20616376
C501413	tesaglitazar	tesaglitazar results in increased expression of PDGFRB mRNA	21515302
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PDGFRB mRNA	22298810
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDGFRB mRNA	20106945\|2163298
D013749	Tetrachlorodibenzodioxin	AHR protein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PDGFRB mRNA]	15034205
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin affects the expression of PDGFRB mRNA	21570461\|2637764
D013749	Tetrachlorodibenzodioxin	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDGFRB mRNA	17942748
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in decreased expression of PDGFRB mRNA]	16054899
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PDGFRB gene]	20819909
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in decreased expression of PDGFRB mRNA	18691609\|2081990
D013749	Tetrachlorodibenzodioxin	Tetrachlorodibenzodioxin results in increased expression of PDGFRB mRNA	15034205\|2081990
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]]	27477297
C017953	tetramethylpyrazine	NFE2L2 protein promotes the reaction [tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB mRNA]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Carbon Tetrachloride results in increased expression of PDGFRB protein]	27477297
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB mRNA]	23022513
C017953	tetramethylpyrazine	tetramethylpyrazine inhibits the reaction [Hydrogen Peroxide results in increased expression of PDGFRB protein]	23022513
C020809	tetrathiomolybdate	tetrathiomolybdate results in decreased expression of PDGFRB protein	18480265
D013792	Thalidomide	Thalidomide results in increased expression of PDGFRB mRNA	19751816
D013853	Thioacetamide	Cysteine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15158331
D013853	Thioacetamide	inchinko-to inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15288473
D013853	Thioacetamide	"Iron, Dietary affects the reaction [Thioacetamide affects the expression of PDGFRB mRNA]"	18032466
D013853	Thioacetamide	Methionine inhibits the reaction [Thioacetamide results in increased expression of PDGFRB protein]	15158331
D013853	Thioacetamide	Thioacetamide results in increased expression of PDGFRB protein	15158331\|1528847
D014050	Toluene	Toluene results in increased expression of PDGFRB mRNA	22967744
D019772	Topotecan	[oxaliplatin co-treated with Topotecan] results in increased expression of PDGFRB mRNA	25729387
D019772	Topotecan	Topotecan results in increased expression of PDGFRB mRNA	25729387
D014118	Toxins, Biological	"Toxins, Biological affects the expression of PDGFRB mRNA"	19682533
D014212	Tretinoin	Tretinoin results in increased expression of PDGFRB mRNA	23724009
D014212	Tretinoin	Tretinoin results in increased expression of PDGFRB mRNA	21295132
D014212	Tretinoin	Tretinoin results in increased expression of PDGFRB protein	21295132
D014212	Tretinoin	Tretinoin results in increased expression of PDGFRB mRNA alternative form	17303670
C013320	tris(2-butoxyethyl) phosphate	tris(2-butoxyethyl) phosphate affects the expression of PDGFRB mRNA	29024780
C057693	troglitazone	troglitazone results in decreased expression of PDGFRB mRNA	28973697
D014415	Tunicamycin	Tunicamycin results in decreased expression of PDGFRB mRNA	22378314
D014635	Valproic Acid	Valproic Acid results in decreased expression of PDGFRB mRNA	29154799
D014635	Valproic Acid	Valproic Acid results in increased methylation of PDGFRB gene	29154799
D014635	Valproic Acid	Valproic Acid results in increased expression of PDGFRB mRNA	24896083
D014640	Vancomycin	Vancomycin results in decreased expression of PDGFRB mRNA	18930951
C025643	vinclozolin	vinclozolin results in increased expression of PDGFRB mRNA	20566332
D002762	Cholecalciferol	Cholecalciferol results in increased expression of PDGFRB mRNA	17170073
D014810	Vitamin E	Vitamin E results in increased expression of PDGFRB mRNA	19244175
C412469	vitisin A	vitisin A inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of PDGFRB protein]	21871475
D015032	Zinc	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB mRNA	23859036
D015032	Zinc	[alpha-Tocopherol co-treated with beta Carotene co-treated with Ascorbic Acid co-treated with Zinc co-treated with Sodium Selenite] results in decreased expression of PDGFRB protein	23859036

GO/Pathway

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0004709	MAP kinase kinase kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IBA	21873635
GO:0004713	protein tyrosine kinase activity	-	IDA	1653029
GO:0004714	transmembrane receptor protein tyrosine kinase activity	-	IBA	21873635
GO:0004888	transmembrane signaling receptor activity	-	IBA	21873635
GO:0004992	platelet activating factor receptor activity	-	TAS	2536956
GO:0005017	platelet-derived growth factor-activated receptor activity	-	IBA	21873635
GO:0005017	platelet-derived growth factor-activated receptor activity	-	TAS	2536956
GO:0005019	platelet-derived growth factor beta-receptor activity	-	IBA	21873635
GO:0005019	platelet-derived growth factor beta-receptor activity	-	IDA	1314164 2536956 2850496
GO:0005019	platelet-derived growth factor beta-receptor activity	-	IMP	2554309 26599395
GO:0005088	Ras guanyl-nucleotide exchange factor activity	-	TAS	-
GO:0005102	signaling receptor binding	-	IPI	10821867
GO:0005161	platelet-derived growth factor receptor binding	-	IPI	2542288
GO:0005515	protein binding	-	IPI	1314164 1330535 1334459 1375321 1396585 1661130 2157284 7530043 7536927 7679113 7680644 7683666 7685273 7687537 7688466 7692233 7876130 8119896 8181064 8183548 8382612 8382774 8538796 8555205 8564419 8670861 8940081 9153411 9355745 9512716 9742401 10336465 10752619 10806482 10821867 11046132 11297552 11710529 11896612 12614164 12706723 15641795 16456542 16477012 17242191 17470632 17981115 18997771 19167335 19864249 20534510 21245321 21376233 23063561 23397142 24012959 25241761 25416956
GO:0005524	ATP binding	-	IEA	-
GO:0019838	growth factor binding	-	IBA	21873635
GO:0019899	enzyme binding	-	IPI	26315405
GO:0019901	protein kinase binding	-	IPI	16479011
GO:0031434	mitogen-activated protein kinase kinase binding	-	IBA	21873635
GO:0038085	vascular endothelial growth factor binding	-	IPI	17470632
GO:0043548	phosphatidylinositol 3-kinase binding	-	IEA	-
GO:0046934	phosphatidylinositol-4,5-bisphosphate 3-kinase activity	-	TAS	-
GO:0048407	platelet-derived growth factor binding	-	IBA	21873635
GO:0048407	platelet-derived growth factor binding	-	IDA	2554309 2850496
GO:0048407	platelet-derived growth factor binding	-	IPI	2536956

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0000165	MAPK cascade	-	TAS	-
GO:0006024	glycosaminoglycan biosynthetic process	-	IEA	-
GO:0007165	signal transduction	-	IDA	10821867
GO:0007186	G-protein coupled receptor signaling pathway	-	IEA	-
GO:0007275	multicellular organism development	-	IBA	21873635
GO:0007568	aging	-	IEA	-
GO:0008284	positive regulation of cell proliferation	-	IMP	2554309
GO:0008584	male gonad development	-	IEA	-
GO:0009968	negative regulation of signal transduction	-	IBA	21873635
GO:0010863	positive regulation of phospholipase C activity	-	IDA	1653029
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling	-	ISS	-
GO:0014911	positive regulation of smooth muscle cell migration	-	IMP	21679854
GO:0014911	positive regulation of smooth muscle cell migration	-	ISS	-
GO:0016477	cell migration	-	IMP	2554309
GO:0018108	peptidyl-tyrosine phosphorylation	-	IDA	1653029 2536956 2850496
GO:0030154	cell differentiation	-	IBA	21873635
GO:0030335	positive regulation of cell migration	-	IDA	17470632
GO:0032355	response to estradiol	-	IEA	-
GO:0032516	positive regulation of phosphoprotein phosphatase activity	-	IDA	7691811
GO:0032526	response to retinoic acid	-	IEA	-
GO:0032956	regulation of actin cytoskeleton organization	-	ISS	-
GO:0032967	positive regulation of collagen biosynthetic process	-	IEA	-
GO:0033674	positive regulation of kinase activity	-	IBA	21873635
GO:0034405	response to fluid shear stress	-	IEA	-
GO:0035025	positive regulation of Rho protein signal transduction	-	IEA	-
GO:0035441	cell migration involved in vasculogenesis	-	ISS	-
GO:0035789	metanephric mesenchymal cell migration	-	IEA	-
GO:0035791	platelet-derived growth factor receptor-beta signaling pathway	-	IMP	2554309 26599395
GO:0035793	positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway	-	ISS	-
GO:0035909	aorta morphogenesis	-	ISS	-
GO:0036120	cellular response to platelet-derived growth factor stimulus	-	IEA	-
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	-	IBA	21873635
GO:0038091	positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway	-	IDA	17470632
GO:0042060	wound healing	-	IEA	-
GO:0042542	response to hydrogen peroxide	-	IEA	-
GO:0043065	positive regulation of apoptotic process	-	IEA	-
GO:0043066	negative regulation of apoptotic process	-	IBA	21873635
GO:0043066	negative regulation of apoptotic process	-	IEA	-
GO:0043406	positive regulation of MAP kinase activity	-	ISS	-
GO:0043410	positive regulation of MAPK cascade	-	IBA	21873635
GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity	-	IDA	1314164
GO:0043627	response to estrogen	-	IEA	-
GO:0045840	positive regulation of mitotic nuclear division	-	ISS	-
GO:0046488	phosphatidylinositol metabolic process	-	IMP	1653029
GO:0046777	protein autophosphorylation	-	IDA	1314164 2536956 2850496
GO:0046854	phosphatidylinositol phosphorylation	-	IEA	-
GO:0048008	platelet-derived growth factor receptor signaling pathway	-	IDA	1314164 2536956
GO:0048015	phosphatidylinositol-mediated signaling	-	IMP	2554309
GO:0048146	positive regulation of fibroblast proliferation	-	IEA	-
GO:0048661	positive regulation of smooth muscle cell proliferation	-	IMP	21679854
GO:0048661	positive regulation of smooth muscle cell proliferation	-	ISS	-
GO:0048839	inner ear development	-	IEA	-
GO:0050921	positive regulation of chemotaxis	-	ISS	-
GO:0051897	positive regulation of protein kinase B signaling	-	TAS	-
GO:0055003	cardiac myofibril assembly	-	ISS	-
GO:0055093	response to hyperoxia	-	IEA	-
GO:0060326	cell chemotaxis	-	IDA	2554309 17991872
GO:0060437	lung growth	-	IEA	-
GO:0060981	cell migration involved in coronary angiogenesis	-	ISS	-
GO:0061298	retina vasculature development in camera-type eye	-	ISS	-
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IBA	21873635
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	IMP	21679854
GO:0070374	positive regulation of ERK1 and ERK2 cascade	-	ISS	-
GO:0071670	smooth muscle cell chemotaxis	-	ISS	-
GO:0072075	metanephric mesenchyme development	-	IEA	-
GO:0072262	metanephric glomerular mesangial cell proliferation involved in metanephros development	-	ISS	-
GO:0072277	metanephric glomerular capillary formation	-	ISS	-
GO:0072278	metanephric comma-shaped body morphogenesis	-	IEA	-
GO:0072284	metanephric S-shaped body morphogenesis	-	IEA	-
GO:0090280	positive regulation of calcium ion import	-	ISS	-
GO:2000379	positive regulation of reactive oxygen species metabolic process	-	ISS	-
GO:2000491	positive regulation of hepatic stellate cell activation	-	IEA	-
GO:2000573	positive regulation of DNA biosynthetic process	-	ISS	-

GO ID	GO Term	Qualifier	Evidence	PubMed
GO:0005634	nucleus	-	ISS	-
GO:0005737	cytoplasm	-	IBA	21873635
GO:0005737	cytoplasm	-	ISS	-
GO:0005794	Golgi apparatus	-	IDA	-
GO:0005886	plasma membrane	-	TAS	-
GO:0005887	integral component of plasma membrane	-	IBA	21873635
GO:0005925	focal adhesion	-	HDA	21423176
GO:0009986	cell surface	-	IEA	-
GO:0016020	membrane	-	HDA	19946888
GO:0016020	membrane	-	IDA	16477012
GO:0016021	integral component of membrane	-	IEA	-
GO:0016324	apical plasma membrane	-	ISS	-
GO:0031226	intrinsic component of plasma membrane	-	IDA	2554309
GO:0031410	cytoplasmic vesicle	-	IEA	-
GO:0043202	lysosomal lumen	-	IEA	-
GO:0043231	intracellular membrane-bounded organelle	-	IDA	-
GO:0043235	receptor complex	-	IBA	21873635

KEGG ID	KEGG Term
hsa04010	MAPK signaling pathway
hsa04020	Calcium signaling pathway
hsa04060	Cytokine-cytokine receptor interaction
hsa04510	Focal adhesion
hsa04540	Gap junction
hsa04810	Regulation of actin cytoskeleton
hsa05200	Pathways in cancer
hsa05214	Glioma
hsa05215	Prostate cancer
hsa05218	Melanoma

Reactome ID	Reactome Term	Evidence
R-HSA-1257604	PIP3 activates AKT signaling	TAS
R-HSA-162582	Signal Transduction	TAS
R-HSA-1643685	Disease	TAS
R-HSA-186763	Downstream signal transduction	TAS
R-HSA-186797	Signaling by PDGF	TAS
R-HSA-199418	Negative regulation of the PI3K/AKT network	TAS
R-HSA-2219528	PI3K/AKT Signaling in Cancer	TAS
R-HSA-2219530	Constitutive Signaling by Aberrant PI3K in Cancer	TAS
R-HSA-5663202	Diseases of signal transduction	TAS
R-HSA-5673001	RAF/MAP kinase cascade	TAS
R-HSA-5683057	MAPK family signaling cascades	TAS
R-HSA-5684996	MAPK1/MAPK3 signaling	TAS
R-HSA-6811558	PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling	TAS
R-HSA-9006925	Intracellular signaling by second messengers	TAS
R-HSA-9006934	Signaling by Receptor Tyrosine Kinases	TAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID	Title (Year)	Author	Journal
21751195	Interactions between environmental factors and polymorphisms in angiogenesis pathway genes in esophageal adenocarcinoma risk: a case-only study. (2012 Feb 1)	Zhai R	Cancer