Gene: LSR

51599
ILDR3|LISCH7
lipolysis stimulated lipoprotein receptor
protein-coding
19q13.12
Ensembl:ENSG00000105699 MIM:616582 Vega:OTTHUMG00000183142 UniprotKB:Q86X29
NC_000019.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.932e-1 (AD)  4.406e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CLEC14A0.871
USHBP10.869
GATA20.829
ARHGEF150.826
ST6GALNAC10.818
PTPRB0.804
CYYR10.799
PAQR50.793
CD340.789
HSPA12B0.789

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CPLX3-0.269
OR4F29-0.265
KCNG1-0.263
CHRNA4-0.26
DRD5-0.256
HYAL3-0.254
WNT7B-0.254
ATP2C2-0.251
BCL11A-0.248
ASPDH-0.247

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C49562614-deoxy-11,12-didehydroandrographolide"14-deoxy-11,12-didehydroandrographolide results in decreased expression of LSR mRNA"22101062
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl affects the expression of LSR mRNA"19114083
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of LSR mRNA"21346803
C0495842-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine"2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine results in increased expression of LSR mRNA"12376462
C0179063-dinitrobenzene3-dinitrobenzene results in increased expression of LSR mRNA21983209
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of LSR mRNA"18648102
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSR mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSR mRNA"27188386
D020106AcrylamideAcrylamide results in decreased expression of LSR mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of LSR mRNA27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of LSR gene27153756
D000643Ammonium ChlorideAmmonium Chloride affects the expression of LSR mRNA16483693
C006632arsenic trioxidearsenic trioxide results in decreased expression of LSR mRNA22521957
C006632arsenic trioxideLSR protein results in decreased susceptibility to arsenic trioxide20707922
D001280AtrazineAtrazine results in increased expression of LSR mRNA25929836
D001554BenzeneBenzene affects the expression of LSR mRNA15878777
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of LSR mRNA19770486|2222880
D004958EstradiolEstradiol results in increased expression of LSR mRNA18556351
D004958Estradiol[Estradiol co-treated with Progesterone] results in increased expression of LSR mRNA18556351
D004958EstradiolEstradiol results in increased expression of LSR mRNA15289156|1948475
C006780bisphenol Abisphenol A results in decreased expression of LSR mRNA26063408
C006780bisphenol Abisphenol A affects the expression of LSR mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of LSR gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of LSR mRNA21297351
C010063carbonyl sulfidecarbonyl sulfide results in increased expression of LSR mRNA19395590
D002273CarcinogensCarcinogens results in increased expression of LSR mRNA16316942
D002994ClofibrateClofibrate results in decreased expression of LSR mRNA17585979
C018021cobaltous chloridecobaltous chloride results in increased expression of LSR mRNA19376846
D003471CuprizoneCuprizone results in increased expression of LSR mRNA26577399
C004742daidzein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
C013908daidzin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of LSR mRNA21266533
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of LSR mRNA15289156
D002117CalcitriolCalcitriol results in increased expression of LSR mRNA26485663
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of LSR mRNA27638505
D0151279,10-Dimethyl-1,2-benzanthracene"9,10-Dimethyl-1,2-benzanthracene results in increased expression of LSR mRNA"12376462
D004237DiuronDiuron results in increased expression of LSR mRNA21551480
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LSR mRNA22079256
D005485FlutamideFlutamide results in decreased expression of LSR mRNA24136188
D005557FormaldehydeFormaldehyde results in increased expression of LSR mRNA23649840
C056933fumonisin B1fumonisin B1 results in increased expression of LSR mRNA16221962
D019833Genistein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
D019833GenisteinGenistein results in increased expression of LSR mRNA15289156
C040641genistin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
D005947Glucose[INS protein co-treated with Glucose] results in decreased expression of LSR mRNA22634610
C086566glycitein[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
C433283glycitin[daidzein co-treated with daidzin co-treated with genistin co-treated with Genistein co-treated with glycitin co-treated with glycitein] affects the expression of LSR mRNA27424125
D017313FenretinideFenretinide results in increased expression of LSR mRNA28973697
C098607JP8 aviation fuelJP8 aviation fuel results in decreased expression of LSR protein17337753
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of LSR mRNA23458150
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of LSR mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of LSR mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of LSR mRNA"25620056
C029938nickel sulfatenickel sulfate results in increased expression of LSR mRNA18651567
D010416PentachlorophenolPentachlorophenol results in increased expression of LSR mRNA24642059
C006253pirinixic acidpirinixic acid results in decreased expression of LSR mRNA16221962
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of LSR mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of LSR mRNA22079256
D011374Progesterone[Estradiol co-treated with Progesterone] results in increased expression of LSR mRNA18556351
D011374ProgesteroneProgesterone results in decreased expression of LSR mRNA22238285
D011441PropylthiouracilPropylthiouracil results in increased expression of LSR mRNA24780913
D011794QuercetinQuercetin results in increased expression of LSR mRNA21632981
D012643SeleniumSelenium results in increased expression of LSR mRNA19244175
D012906SmokeSmoke results in decreased expression of LSR mRNA21095227
C017947sodium arsenitesodium arsenite results in decreased expression of LSR mRNA22714537
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of LSR mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of LSR mRNA21215274
D014050TolueneToluene results in increased expression of LSR mRNA22967744
D014241TrichloroethyleneTrichloroethylene results in increased expression of LSR mRNA19448997
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of LSR mRNA"27188386
C012589trichostatin Atrichostatin A results in decreased expression of LSR mRNA24935251|2627250
D014415TunicamycinTunicamycin results in decreased expression of LSR mRNA22414386
C022884undecaneundecane results in decreased expression of LSR protein17337753
D014520UrethaneUrethane results in increased expression of LSR mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of LSR mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of LSR mRNA23179753
D014635Valproic AcidValproic Acid results in increased methylation of LSR gene29154799
D014810Vitamin EVitamin E results in increased expression of LSR mRNA19244175

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI15324660  17353931  
GO ID GO Term Qualifier Evidence PubMed
GO:0001889liver development-ISS-  
GO:0019216regulation of lipid metabolic process-IEA-  
GO:0060856establishment of blood-brain barrier-IEA-  
GO:0061833protein localization to tricellular tight junction-IEA-  
GO:1904274tricellular tight junction assembly-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005886plasma membrane-ISS-  
GO:0016021integral component of membrane-IEA-  
GO:0034361very-low-density lipoprotein particle-IEA-  
GO:0034362low-density lipoprotein particle-IEA-  
GO:0042627chylomicron-IEA-  
GO:0061689tricellular tight junction-IEA-  
GO:0070062extracellular exosome-HDA19199708  20458337  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-174824Plasma lipoprotein assembly, remodeling, and clearanceIEA
R-HSA-382551Transport of small moleculesIEA
R-HSA-8964038LDL clearanceIEA
R-HSA-8964043Plasma lipoprotein clearanceIEA
R-HSA-8964046VLDL clearanceIEA

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
22274584A large-sample assessment of possible association between ischaemic stroke and rs12188950 in the PDE4D gene. (2012 Jul)Lovkvist HEur J Hum Genet
25622723Design of a multi-center immunophenotyping analysis of peripheral blood, sputum and bronchoalveolar lavage fluid in the Subpopulations and Intermediate Outcome Measures in COPD Study (SPIROMICS). (2015 Jan 27)Freeman CMJ Transl Med