Gene: PDHB

5162
PDHBD|PDHE1-B|PDHE1B|PHE1B
pyruvate dehydrogenase E1 beta subunit
protein-coding
3p14.3
Ensembl:ENSG00000168291 MIM:179060 Vega:OTTHUMG00000159157 UniprotKB:P11177
NG_016860.1
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
1.461e-1 (AD)  5.837e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HNRNPH20.948
OCIAD10.947
MTCH20.947
SLC25A30.942
OAT0.941
APEX10.94
FH0.939
TMEM30A0.939
UQCRC20.937
ATP6AP20.936

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.792
OR4F29-0.753
MTRNR2L6-0.342
MTRNR2L9-0.32
EVC2-0.306
MTRNR2L10-0.294
CSAG1-0.284
TNFRSF10D-0.279
SERPINH1-0.262
RUNX3-0.259

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of PDHB mRNA"19162173
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of PDHB mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of PDHB mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDHB mRNA19770486
D016604Aflatoxin B1[sulforafan co-treated with Aflatoxin B1] affects the expression of PDHB mRNA25450479
D001280AtrazineAtrazine results in decreased expression of PDHB mRNA25929836
C406592azaspiracidazaspiracid results in increased expression of PDHB mRNA28939011
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of PDHB mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDHB mRNA22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of PDHB mRNA21839799
D004958EstradiolEstradiol results in decreased expression of PDHB mRNA19484750
C006780bisphenol Abisphenol A affects the expression of PDHB mRNA21786754
C006780bisphenol Abisphenol A results in decreased expression of PDHB mRNA29275510
C006780bisphenol Abisphenol A results in increased expression of PDHB mRNA21932408|2379856
C006780bisphenol Abisphenol A results in increased expression of PDHB mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of PDHB gene28505145
D019256Cadmium ChlorideCadmium Chloride results in decreased methylation of PDHB promoter22457795
C041167chromium nitratechromium nitrate results in decreased expression of PDHB protein22144121
C018021cobaltous chloridecobaltous chloride results in decreased expression of PDHB mRNA19376846
D019327Copper SulfateCopper Sulfate results in decreased expression of PDHB mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of PDHB mRNA20106945|2556210
D003676DeferoxamineDeferoxamine results in increased expression of PDHB protein19515424
D003676Deferoxamineferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein]19515424
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of PDHB mRNA]27941970
D003907Dexamethasone[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PDHB mRNA23428407
C000944dicrotophosdicrotophos results in decreased expression of PDHB mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of PDHB mRNA19030233
D004147DioxinsDioxins affects the expression of PDHB mRNA20463971
D004317Doxorubicin[Doxorubicin co-treated with MT2A protein] results in decreased expression of PDHB protein16144979
D004317DoxorubicinDoxorubicin results in decreased expression of PDHB mRNA19915844
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDHB mRNA22079256
D000431EthanolEthanol results in increased expression of PDHB protein19609968
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of PDHB mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHB mRNA17942748
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in decreased expression of PDHB mRNA23649840
C013531ferric ammonium citrateferric ammonium citrate inhibits the reaction [Deferoxamine results in increased expression of PDHB protein]19515424
D005485FlutamideFlutamide results in increased expression of PDHB mRNA24136188
D005947GlucoseGlucose affects the expression of PDHB mRNA24349266
D006493HeparinHeparin results in decreased expression of PDHB protein17488504
C492448ICG 001ICG 001 results in increased expression of PDHB mRNA26191083
D000068877Imatinib Mesylate[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of PDHB mRNA19208803
D000068877Imatinib MesylateImatinib Mesylate results in decreased expression of PDHB mRNA19208803
D0150561-Methyl-3-isobutylxanthine[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS1 protein] results in increased expression of PDHB mRNA23428407
D008694MethamphetamineMethamphetamine results in increased expression of PDHB protein19826936
D008767Methylmercury CompoundsMethylmercury Compounds results in increased expression of PDHB mRNA20039754
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of PDHB mRNA23649840
D009020MorphineMorphine deficiency affects the reaction [Morphine results in increased expression of PDHB protein]23056601
D009020MorphineMorphine results in increased expression of PDHB protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of PDHB mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDHB mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDHB mRNA"25554681
C025589ochratoxin Aochratoxin A results in increased expression of PDHB protein19445961
D016627OxidopamineOxidopamine results in decreased expression of PDHB mRNA19763263
C086401pentabromodiphenyl etherpentabromodiphenyl ether results in increased expression of PDHB protein25616259
D010416PentachlorophenolPentachlorophenol results in decreased expression of PDHB mRNA24642059
C522391perfluorododecanoic acidperfluorododecanoic acid results in increased expression of PDHB protein26168851
C006253pirinixic acidpirinixic acid results in increased expression of PDHB mRNA16940010
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of PDHB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of PDHB mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of PDHB protein22144121
D011791QuartzQuartz results in decreased expression of PDHB mRNA27917503
D011791QuartzQuartz results in increased expression of PDHB protein27917503
C059514resveratrolresveratrol results in increased expression of PDHB protein25505154
D015474IsotretinoinIsotretinoin results in decreased expression of PDHB mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of PDHB mRNA22013433
C089730rosiglitazonerosiglitazone results in increased expression of PDHB mRNA17245590
D012402RotenoneRotenone results in increased expression of PDHB protein19763263
D012524SarinSarin results in increased expression of PDHB protein25842371
D012524SarinSarin results in decreased expression of PDHB mRNA19522546
D012524SarinSarin results in increased expression of PDHB mRNA19522546
D012524SarinSarin results in decreased expression of PDHB protein28973502
D012822Silicon DioxideSilicon Dioxide results in increased expression of PDHB protein27917503
C080703SK&F 83959SK&F 83959 affects the expression of PDHB protein25852303
C017947sodium arsenitesodium arsenite affects the expression of PDHB mRNA29319823
C017947sodium arsenitesodium arsenite results in increased expression of PDHB protein21925251
D012969Sodium FluorideSodium Fluoride results in increased expression of PDHB protein28918527
D012999SomanSoman results in decreased expression of PDHB mRNA19281266
C016766sulforafan[sulforafan co-treated with Aflatoxin B1] affects the expression of PDHB mRNA25450479
D013605T-2 ToxinT-2 Toxin affects the expression of PDHB protein26141394
C534735tetraarsenic tetrasulfide[Imatinib Mesylate co-treated with tetraarsenic tetrasulfide] results in decreased expression of PDHB mRNA19208803
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDHB mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of PDHB mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDHB mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDHB mRNA20959002|2121527
D0156472,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine"2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine results in decreased expression of PDHB protein"25852303
D019284ThapsigarginThapsigargin results in decreased expression of PDHB mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of PDHB mRNA23557971
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of PDHB protein22595367
C011559tributyltintributyltin results in increased expression of PDHB mRNA23428407
C501517UCF 101UCF 101 results in increased expression of PDHB protein19763263
D014635Valproic AcidValproic Acid affects the expression of PDHB mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of PDHB mRNA23179753
D014635Valproic AcidValproic Acid affects the expression of PDHB mRNA17963808
D014640VancomycinVancomycin results in increased expression of PDHB mRNA18930951
D014747VinblastinePDHB protein affects the susceptibility to Vinblastine16217747
C025643vinclozolinvinclozolin results in decreased expression of PDHB mRNA23034163|2355583
C088658zoledronic acidzoledronic acid results in increased expression of PDHB protein28871336

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004738pyruvate dehydrogenase activity-IDA19081061  
GO:0004739pyruvate dehydrogenase (acetyl-transferring) activity-IEA-  
GO:0005515protein binding-IPI12651851  18206651  19081061  
GO:0034604pyruvate dehydrogenase (NAD+) activitycontributes_toIDA18164639  
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-IEA-  
GO:0006086acetyl-CoA biosynthetic process from pyruvate-IDA19081061  
GO:0006099tricarboxylic acid cycle-IDA19081061  
GO:0061732mitochondrial acetyl-CoA biosynthetic process from pyruvate-IC18164639  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-HDA21630459  
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0045254pyruvate dehydrogenase complex-IDA19081061  
KEGG ID KEGG Term
hsa00010Glycolysis / Gluconeogenesis
hsa00020Citrate cycle (TCA cycle)
hsa00290Valine, leucine and isoleucine biosynthesis
hsa00620Pyruvate metabolism
hsa00650Butanoate metabolism
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complexTAS
R-HSA-389661Glyoxylate metabolism and glycine degradationTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71291Metabolism of amino acids and derivativesTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
28860800Effectiveness of a diabetes mellitus pictorial diary handbook program for middle-aged and elderly type 2 diabetes mellitus patients: a quasi-experimental study at Taladnoi Primary Care Unit, Saraburi, Thailand. (2017)Eknithiset RJ Multidiscip Healthc