Gene: KLF13

51621
BTEB3|FKLF2|NSLP1|RFLAT-1|RFLAT1
Kruppel like factor 13
protein-coding
15q13.3
Ensembl:ENSG00000169926 MIM:605328 Vega:OTTHUMG00000172224 UniprotKB:Q9Y2Y9
NC_000015.10
PubMed
0   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.294e-1 (AD)  2.008e-1 (ND)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg26146569chr15:31637592KLF134.850e-8Maternal smoking in pregnancy27040690
cg11739148chr15:31622112KLF132.500e-12Smoking27651444
cg26146569chr15:31637592KLF131.100e-8Smoking27651444

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TPPP0.922
WDTC10.919
SBF10.916
TATDN20.913
PIP4K2B0.912
CDC42BPB0.91
MECP20.904
ZC3H7B0.904
B3GAT10.903
ELAVL30.902

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.653
OR4F29-0.631
TFPI2-0.363
ZNF114-0.355
C9orf135-0.355
PDZK1IP1-0.354
PRRX2-0.348
CD8B-0.346
C1orf87-0.338
IL18RAP-0.334

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0264861,2,5,6-dibenzanthracene"1,2,5,6-dibenzanthracene results in increased expression of KLF13 mRNA"26377693
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KLF13 mRNA]"19467301
C4727913-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid3-(4'-hydroxy-3'-adamantylbiphenyl-4-yl)acrylic acid results in decreased expression of KLF13 mRNA16788091
D000082AcetaminophenAcetaminophen results in decreased expression of KLF13 mRNA21420995
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of KLF13 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF13 mRNA]17585979
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of KLF13 mRNA28522335
D001151ArsenicArsenic affects the methylation of KLF13 gene25304211
C006632arsenic trioxidearsenic trioxide results in decreased expression of KLF13 mRNA20458559
D001280AtrazineAtrazine results in decreased expression of KLF13 mRNA25929836
D001507BeclomethasoneBeclomethasone results in increased expression of KLF13 mRNA23656298
D001554BenzeneBenzene results in increased expression of KLF13 mRNA15929907|1916216
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in decreased expression of KLF13 mRNA26377693
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of KLF13 mRNA21569818
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of KLF13 mRNA"19150397|2001819
D004958EstradiolEstradiol results in increased expression of KLF13 mRNA23019147
C044887beta-methylcholinebeta-methylcholine affects the expression of KLF13 mRNA21179406
C006780bisphenol Abisphenol A affects the expression of KLF13 mRNA25181051
D002104CadmiumCadmium results in decreased expression of KLF13 mRNA24067728
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of KLF13 mRNA16934159
D004390ChlorpyrifosChlorpyrifos results in decreased expression of KLF13 mRNA18668222
D002794Choline[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF13 gene20938992
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of KLF13 mRNA17585979
D002994ClofibrateClofibrate results in decreased expression of KLF13 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of KLF13 mRNA]17585979
C018021cobaltous chloridecobaltous chloride results in decreased expression of KLF13 mRNA19320972
D003520CyclophosphamideCyclophosphamide results in decreased expression of KLF13 mRNA21041162
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of KLF13 mRNA]27941970
D003907DexamethasoneDexamethasone results in decreased expression of KLF13 mRNA21041162
D003907DexamethasoneDexamethasone results in increased expression of KLF13 mRNA22733784
D003999Dichloroacetic AcidDichloroacetic Acid results in decreased expression of KLF13 mRNA28962523
C000944dicrotophosdicrotophos results in increased expression of KLF13 mRNA28302478
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of KLF13 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of KLF13 mRNA19467301|2501614
D004054DiethylstilbestrolDiethylstilbestrol results in decreased expression of KLF13 mRNA21041162
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of KLF13 mRNA17942748
C024565ethylene dichlorideethylene dichloride results in decreased expression of KLF13 mRNA28189721
D005492Folic Acid[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF13 gene20938992
C492448ICG 001ICG 001 results in increased expression of KLF13 mRNA26191083
C544151jinfukangjinfukang results in increased expression of KLF13 mRNA27392435
D008715Methionine[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased methylation of KLF13 gene20938992
D008727MethotrexateMethotrexate affects the expression of KLF13 mRNA18502557
D008752Methylene ChlorideMethylene Chloride results in decreased expression of KLF13 mRNA28392392
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KLF13 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of KLF13 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of KLF13 mRNA"20188158
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of KLF13 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of KLF13 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of KLF13 mRNA"25554681
C022838nickel chloridenickel chloride results in decreased expression of KLF13 mRNA24612858
C568608PCI 5002[PCI 5002 co-treated with Zinc] results in increased expression of KLF13 mRNA18593933
D010416PentachlorophenolPentachlorophenol results in increased expression of KLF13 mRNA23892564
D010634PhenobarbitalPhenobarbital affects the expression of KLF13 mRNA23091169
D010634PhenobarbitalPhenobarbital results in decreased expression of KLF13 mRNA19270015
D010634PhenobarbitalPhenobarbital results in increased expression of KLF13 mRNA19270015
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of KLF13 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of KLF13 mRNA20813756|2381119
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in increased expression of KLF13 mRNA28903501
C059514resveratrolresveratrol results in increased expression of KLF13 mRNA25905778
C064116S-(1,1,2,2-tetrafluoroethyl)cysteine"S-(1,1,2,2-tetrafluoroethyl)cysteine results in decreased expression of KLF13 mRNA"16678137
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of KLF13 mRNA25895662
D053260SootSoot results in increased expression of KLF13 mRNA22461453|2655175
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of KLF13 mRNA21570461
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of KLF13 mRNA17035482
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of KLF13 mRNA28973375
D013849ThimerosalThimerosal results in decreased expression of KLF13 mRNA27188386
D013853ThioacetamideThioacetamide results in decreased expression of KLF13 mRNA23411599
C009495titanium dioxidetitanium dioxide results in decreased expression of KLF13 mRNA23557971
D014212TretinoinTretinoin results in decreased expression of KLF13 mRNA21934132
D014212TretinoinTretinoin results in increased expression of KLF13 mRNA23724009
D014212TretinoinTretinoin results in decreased expression of KLF13 mRNA16788091
D014241TrichloroethyleneTrichloroethylene results in increased expression of KLF13 mRNA25549359
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of KLF13 mRNA"26743178
D014520UrethaneUrethane results in decreased expression of KLF13 mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of KLF13 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased expression of KLF13 mRNA29154799
D014635Valproic AcidValproic Acid results in increased methylation of KLF13 gene29154799
D014635Valproic AcidValproic Acid affects the expression of KLF13 mRNA17963808
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of KLF13 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of KLF13 mRNA23034163
D015032Zinc[PCI 5002 co-treated with Zinc] results in increased expression of KLF13 mRNA18593933

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-IBA21873635  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-ISA-  
GO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding-NAS19274049  
GO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding-IEA-  
GO:0005515protein binding-IPI17053787  17513757  
GO:0046872metal ion binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006357regulation of transcription by RNA polymerase II-IBA21873635  
GO:0006366transcription by RNA polymerase II-TAS10023774  
GO:0008285negative regulation of cell proliferation-IEA-  
GO:0045647negative regulation of erythrocyte differentiation-IEA-  
GO:0045944positive regulation of transcription by RNA polymerase II-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IBA21873635  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25552657Prenatal exposure to maternal smoking and offspring DNA methylation across the lifecourse: findings from the Avon Longitudinal Study of Parents and Children (ALSPAC). (2015 Apr 15)Richmond RCHum Mol Genet
21970977Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. (2012 Feb)Stephens SHPsychiatr Genet