Gene: DHRS7

51635
CGI-86|SDR34C1|retDSR4|retSDR4
dehydrogenase/reductase 7
protein-coding
14q23.1
Ensembl:ENSG00000100612 MIM:612833 Vega:OTTHUMG00000140331 UniprotKB:Q9Y394
NC_000014.9
PubMed
0   ANCO-SNPs
ND
1   
5.944e-1 (AD)  7.745e-1 (ND)   (Frontal_Cortex)
1.466e-1 (AD)  8.462e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
TXNDC120.927
EMC70.911
CNBP0.902
USP390.901
TMEM590.901
ITM2B0.899
TSG1010.897
GLO10.895
ASAH10.895
ADIPOR10.893

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.787
OR4F29-0.739
OR6C74-0.2
TCL1A-0.195
TSPY2-0.191
HMHB1-0.173
TNFRSF13B-0.172
TRPV5-0.17
MTRNR2L6-0.166
MTRNR2L9-0.148

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0407561,2-naphthoquinone"DHRS7 protein results in increased reduction of 1,2-naphthoquinone"24246760
C5768821-(2-trifluoromethoxyphenyl)-2-nitroethanone1-(2-trifluoromethoxyphenyl)-2-nitroethanone results in decreased expression of DHRS7 protein22527513
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of DHRS7 mRNA19933214
C0291412,2,5,7,8-pentamethyl-1-hydroxychroman"2,2,5,7,8-pentamethyl-1-hydroxychroman results in decreased expression of DHRS7 mRNA"21920950
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DHRS7 mRNA"19114083
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane affects the expression of DHRS7 mRNA"18648102
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in decreased expression of DHRS7 mRNA"25380136
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
C0299154-nitrobenzaldehydeDHRS7 protein results in increased reduction of 4-nitrobenzaldehyde24246760
C0165834-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanoneDHRS7 protein results in increased reduction of 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone24246760
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
C0053999,10-phenanthrenequinone"DHRS7 protein results in increased reduction of 9,10-phenanthrenequinone"24246760
D000082AcetaminophenAcetaminophen affects the expression of DHRS7 mRNA17562736
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DHRS7 gene27153756
D000735AndrostenedioneDHRS7 protein results in increased reduction of Androstenedione24246760
C006632arsenic trioxidearsenic trioxide results in increased expression of DHRS7 mRNA27829220
C006697benzilDHRS7 protein results in increased reduction of benzil24246760
D001564Benzo(a)pyreneAHR protein affects the reaction [Benzo(a)pyrene affects the expression of DHRS7 mRNA]22228805
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of DHRS7 mRNA22228805
C543008bis(4-hydroxyphenyl)sulfone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DHRS7 mRNA28628672
C006780bisphenol Abisphenol A results in increased expression of DHRS7 mRNA28159858
C006780bisphenol Abisphenol A affects the expression of DHRS7 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of DHRS7 mRNA25181051
C006780bisphenol Abisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of DHRS7 mRNA]19228888
D002065BuspironeBuspirone results in increased expression of DHRS7 mRNA24136188
D019256Cadmium ChlorideCadmium Chloride affects the expression of DHRS7 mRNA22110744
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of DHRS7 mRNA25993096
C100187chloropicrinchloropicrin results in decreased expression of DHRS7 mRNA26352163
D002994ClofibrateClofibrate results in decreased expression of DHRS7 mRNA17585979
D009249NADPNADP binds to and results in increased activity of DHRS7 protein25526675
D019327Copper SulfateCopper Sulfate results in decreased expression of DHRS7 mRNA19549813
D003348CortisoneDHRS7 protein results in increased reduction of Cortisone24246760
D003375CoumestrolCoumestrol results in decreased expression of DHRS7 mRNA19167446
D016572CyclosporineCyclosporine results in increased expression of DHRS7 mRNA25562108
D016572CyclosporineCyclosporine results in decreased expression of DHRS7 mRNA21865292
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of DHRS7 mRNA23914054
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DHRS7 mRNA28628672
D002945CisplatinCisplatin results in increased expression of DHRS7 mRNA27392435
C000944dicrotophosdicrotophos results in decreased expression of DHRS7 mRNA28302478
D004041Dietary FatsDietary Fats results in decreased expression of DHRS7 mRNA18042831
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of DHRS7 mRNA19638242
D0198131,2-Dimethylhydrazine"[APC protein affects the susceptibility to 1,2-Dimethylhydrazine] which results in decreased expression of DHRS7 mRNA"27840820
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of DHRS7 mRNA25380136
D004785Environmental PollutantsEnvironmental Pollutants results in decreased expression of DHRS7 mRNA20064776
D004970EstroneDHRS7 protein results in increased reduction of Estrone24246760
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DHRS7 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHRS7 mRNA17942748
D018120FinasterideFinasteride results in increased expression of DHRS7 mRNA24136188
D005485FlutamideFlutamide results in decreased expression of DHRS7 mRNA24793618
D005620Freund's AdjuvantFreund's Adjuvant results in decreased expression of DHRS7 mRNA21149847
C039281furanfuran results in decreased expression of DHRS7 mRNA25539665|2619464
C016517indole-3-carbinolindole-3-carbinol affects the expression of DHRS7 mRNA21396975
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DHRS7 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHRS7 mRNA25613284
D007510IsatinDHRS7 protein results in increased reduction of Isatin24246760
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bis(4-hydroxyphenyl)sulfone] results in increased expression of DHRS7 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of DHRS7 mRNA20003209|2133504
D008797MetyraponeDHRS7 protein results in increased reduction of Metyrapone24246760
C406082monomethylarsonous acidmonomethylarsonous acid results in increased expression of DHRS7 protein24625837
C406082monomethylarsonous acidmonomethylarsonous acid results in decreased expression of DHRS7 mRNA20024957
C568376MT19c compoundMT19c compound results in increased expression of DHRS7 mRNA21781307
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of DHRS7 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of DHRS7 mRNA"25554681|2562005
D0150581-Naphthylisothiocyanate1-Naphthylisothiocyanate results in decreased expression of DHRS7 mRNA25380136
C012655nimesulidenimesulide results in increased expression of DHRS7 mRNA24136188
C036006oxcarbazepineDHRS7 protein results in increased reduction of oxcarbazepine24246760
D000073878Palm OilPalm Oil results in decreased expression of DHRS7 mRNA18042831
D052638Particulate MatterParticulate Matter results in decreased expression of DHRS7 mRNA17987463
D010634PhenobarbitalPhenobarbital results in increased expression of DHRS7 mRNA19270015
D010662Phenylmercuric Acetate"[NOG protein co-treated with Phenylmercuric Acetate co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
D010662Phenylmercuric AcetatePhenylmercuric Acetate results in increased expression of DHRS7 mRNA26272509
C006253pirinixic acidpirinixic acid results in increased expression of DHRS7 mRNA17426115
D011441PropylthiouracilPropylthiouracil results in decreased expression of DHRS7 mRNA24780913
D011794QuercetinQuercetin results in increased expression of DHRS7 mRNA21632981
C004532quinoneDHRS7 protein results in increased reduction of quinone24246760
C059514resveratrolresveratrol results in increased expression of DHRS7 protein25505154
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of DHRS7 mRNA25905778
D012402RotenoneRotenone results in increased expression of DHRS7 mRNA27979718
C016104sodium bichromatesodium bichromate results in decreased expression of DHRS7 mRNA25993096
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of DHRS7 mRNA25905778
D014284Triiodothyroninebisphenol A inhibits the reaction [Triiodothyronine results in decreased expression of DHRS7 mRNA]19228888
D014284TriiodothyronineTriiodothyronine results in decreased expression of DHRS7 mRNA19228888
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHRS7 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DHRS7 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of DHRS7 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DHRS7 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DHRS7 mRNA21215274
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of DHRS7 mRNA25613284
D013853ThioacetamideThioacetamide results in decreased expression of DHRS7 mRNA23411599
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of DHRS7 mRNA"26179874
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of DHRS7 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of DHRS7 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DHRS7 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DHRS7 mRNA23179753|2493525
D001335Vehicle EmissionsVehicle Emissions results in decreased expression of DHRS7 mRNA17987463
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of DHRS7 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of DHRS7 mRNA23034163
D014750VincristineVincristine results in increased expression of DHRS7 mRNA23649840

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0016491oxidoreductase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0055114oxidation-reduction process-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
29216386An exome-wide association study identifies new susceptibility loci for age of smoking initiation in African- and European-American populations. (2017 Dec 5)Jiang KNicotine Tob Res