Gene: PDK2

5164
PDHK2|PDKII
pyruvate dehydrogenase kinase 2
protein-coding
17q21.33
Ensembl:ENSG00000005882 MIM:602525 Vega:OTTHUMG00000161948 UniprotKB:Q15119
NC_000017.11
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
7.520e-1 (AD)  6.147e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
STIM10.941
ASTN10.94
PFKM0.939
ATG9A0.933
CYFIP20.928
KIAA0319L0.926
CTIF0.925
ABCA30.924
SPTAN10.924
DGCR20.923

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.61
OR4F29-0.559
TFPI2-0.495
KLRB1-0.453
SGMS2-0.45
TBX21-0.448
CD2-0.447
HAS2-0.447
CD48-0.447
SLAMF6-0.445

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C5112952,2',4,4'-tetrabromodiphenyl ether"2,2',4,4'-tetrabromodiphenyl ether results in increased expression of PDK2 mRNA"25614096
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of PDK2 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of PDK2 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of PDK2 mRNA"23196670
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of PDK2 mRNA"18648102
D000082AcetaminophenAcetaminophen results in decreased expression of PDK2 mRNA25704631|2906747
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of PDK2 mRNA19770486
D000393Air PollutantsAir Pollutants analog results in decreased expression of PDK2 mRNA21757418
C000188alachloralachlor results in increased expression of PDK2 mRNA12419858
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of PDK2 mRNA28522335
D000643Ammonium ChlorideAmmonium Chloride affects the expression of PDK2 mRNA16483693
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PDK2 protein24719335
D000643Ammonium ChlorideAmmonium Chloride results in increased expression of PDK2 protein mutant form24719335
D001280AtrazineAtrazine results in increased expression of PDK2 mRNA22378314
D001507BeclomethasoneBeclomethasone results in increased expression of PDK2 mRNA23656298
D004958EstradiolEstradiol affects the expression of PDK2 mRNA22574217
C095105bexarotenebexarotene results in increased expression of PDK2 mRNA16648578
D001629BezafibrateBezafibrate results in increased expression of PDK2 mRNA19124612
D001629BezafibratePPARA protein affects the susceptibility to [Bezafibrate results in increased expression of PDK2 mRNA]19124612
C006780bisphenol Abisphenol A affects the expression of PDK2 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of PDK2 mRNA29275510
C006780bisphenol Abisphenol A affects the expression of PDK2 mRNA21786754
C006780bisphenol Abisphenol A affects the expression of PDK2 mRNA25181051
D000069286BortezomibBortezomib results in decreased expression of PDK2 mRNA20977926
C013418bromfenacoumbromfenacoum results in increased expression of PDK2 protein28903499
D002251Carbon TetrachlorideCarbon Tetrachloride results in decreased expression of PDK2 mRNA27339419
C026690cerous chloridecerous chloride results in decreased expression of PDK2 mRNA23573234
D002738ChloroquineChloroquine results in increased expression of PDK2 protein mutant form24719335
D004390ChlorpyrifosChlorpyrifos results in decreased expression of PDK2 mRNA21356183
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in decreased expression of PDK2 mRNA21356183
C074702chromium hexavalent ionchromium hexavalent ion affects the expression of PDK2 mRNA28472532
C031180chrysenechrysene results in increased expression of PDK2 mRNA26377693
D002994ClofibrateClofibrate results in increased expression of PDK2 mRNA23811191
D003300Copper[Copper co-treated with Chlorpyrifos] results in decreased expression of PDK2 mRNA21356183
D003300CopperCopper results in decreased expression of PDK2 mRNA21356183
D003300CopperCopper results in decreased expression of PDK2 mRNA22465980
C030123coumarincoumarin results in decreased expression of PDK2 mRNA18480146
D003513CycloheximideCycloheximide results in decreased stability of PDK2 protein mutant form24719335
D016572CyclosporineCyclosporine results in decreased expression of PDK2 mRNA20106945
C010902decabromobiphenyl etherdecabromobiphenyl ether results in increased expression of PDK2 mRNA24317228
C014347decitabinedecitabine results in increased expression of PDK2 mRNA17908484
D003993Dibutyl PhthalateDibutyl Phthalate results in decreased expression of PDK2 mRNA21266533
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of PDK2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PDK2 mRNA17942748
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PDK2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of PDK2 mRNA17108234|1735126
D005419FlavonoidsFlavonoids results in decreased expression of PDK2 mRNA18035473
C408042fullerol C60(OH)24fullerol C60(OH)24 results in decreased expression of PDK2 mRNA21513982
D005897GlafenineGlafenine results in decreased expression of PDK2 mRNA24136188
D005947GlucoseGlucose affects the expression of PDK2 mRNA24349266
C508665gold (III) porphyrin 1agold (III) porphyrin 1a results in decreased expression of PDK2 mRNA16206274
D017313FenretinideFenretinide results in increased expression of PDK2 mRNA28973697
D006861Hydrogen PeroxideHydrogen Peroxide results in increased expression of PDK2 mRNA26846883
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of PDK2 mRNA23086925|2675264
D007649KetamineKetamine results in increased expression of PDK2 mRNA20080153
D048628KetolidesKetolides analog results in decreased expression of PDK2 mRNA24967691
D008627Mercuric ChlorideMercuric Chloride results in decreased expression of PDK2 mRNA16507785
C013598methoxyacetic acidmethoxyacetic acid affects the expression of PDK2 mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of PDK2 protein25809596
D009020MorphineMorphine results in decreased expression of PDK2 protein23056601
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of PDK2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of PDK2 mRNA"25554681|2562005
C051752nefazodonenefazodone results in decreased expression of PDK2 mRNA24136188
C012655nimesulidenimesulide results in decreased expression of PDK2 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in decreased expression of PDK2 mRNA17616710
C025589ochratoxin Aochratoxin A results in decreased expression of PDK2 mRNA22124623
D052638Particulate MatterParticulate Matter results in decreased expression of PDK2 mRNA28341207
C086401pentabromodiphenyl etherpentabromodiphenyl ether analog results in decreased expression of PDK2 mRNA19095052
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of PDK2 mRNA23427857
D010634PhenobarbitalPhenobarbital results in decreased expression of PDK2 mRNA19162173
D010656PhenylephrinePhenylephrine results in decreased expression of PDK2 mRNA18158353
D011192Potassium DichromatePotassium Dichromate results in increased expression of PDK2 mRNA11678601
D011374ProgesteroneProgesterone results in increased expression of PDK2 mRNA20726854
D011441PropylthiouracilPropylthiouracil results in decreased expression of PDK2 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of PDK2 mRNA15309432
C089730rosiglitazonerosiglitazone affects the expression of PDK2 mRNA22013433
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of PDK2 mRNA25895662
D019821SimvastatinSimvastatin results in increased expression of PDK2 mRNA19001041
C017947sodium arsenitesodium arsenite results in increased expression of PDK2 mRNA23648393
D013629TamoxifenTamoxifen affects the expression of PDK2 mRNA17555576
C020806tetrabromobisphenol Atetrabromobisphenol A results in decreased expression of PDK2 mRNA25172293
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDK2 mRNA21570461
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of PDK2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of PDK2 mRNA16267337
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of PDK2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of PDK2 mRNA16054898|2095900
D019284ThapsigarginThapsigargin results in increased expression of PDK2 mRNA22378314
C009495titanium dioxidetitanium dioxide results in decreased expression of PDK2 mRNA21513982
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of PDK2 mRNA"26179874
D014415TunicamycinTunicamycin results in increased expression of PDK2 mRNA22378314
D014520UrethaneUrethane results in decreased expression of PDK2 mRNA28818685
C406224valdecoxibvaldecoxib results in decreased expression of PDK2 mRNA24136188
D014635Valproic AcidValproic Acid affects the expression of PDK2 mRNA17292431
C034028vanadyl sulfatevanadyl sulfate results in increased expression of PDK2 mRNA16330358
D014640VancomycinVancomycin results in increased expression of PDK2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of PDK2 gene25560391
C000602510VER-246608VER-246608 binds to and results in decreased activity of PDK2 protein25404640
C025643vinclozolinvinclozolin results in increased expression of PDK2 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of PDK2 mRNA26682919
D015032ZincZinc results in increased expression of PDK2 mRNA17074742
D019287Zinc SulfateZinc Sulfate results in increased expression of PDK2 mRNA17074742

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004672protein kinase activity-TAS7499431  10748134  
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity-EXP11485553  
GO:0004740pyruvate dehydrogenase (acetyl-transferring) kinase activity-IDA19833728  
GO:0005524ATP binding-IDA16401071  
GO:0042803protein homodimerization activity-IPI19833728  
GO ID GO Term Qualifier Evidence PubMed
GO:0006006glucose metabolic process-IEA-  
GO:0006111regulation of gluconeogenesis-ISS-  
GO:0006468protein phosphorylation-IEA-  
GO:0006885regulation of pH-ISS-  
GO:0008286insulin receptor signaling pathway-ISS-  
GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate-ISS-  
GO:0010510regulation of acetyl-CoA biosynthetic process from pyruvate-TAS-  
GO:0010565regulation of cellular ketone metabolic process-ISS-  
GO:0010906regulation of glucose metabolic process-ISS-  
GO:0031670cellular response to nutrient-ISS-  
GO:0034614cellular response to reactive oxygen species-IMP21283817  
GO:0042593glucose homeostasis-ISS-  
GO:0050848regulation of calcium-mediated signaling-IEA-  
GO:0072332intrinsic apoptotic signaling pathway by p53 class mediator-IMP22123926  
GO ID GO Term Qualifier Evidence PubMed
GO:0005654nucleoplasm-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005759mitochondrial matrix-TAS-  
GO:0005829cytosol-IDA-  
GO:0005967mitochondrial pyruvate dehydrogenase complex-ISS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1428517The citric acid (TCA) cycle and respiratory electron transportTAS
R-HSA-1430728MetabolismTAS
R-HSA-162582Signal TransductionTAS
R-HSA-204174Regulation of pyruvate dehydrogenase (PDH) complexTAS
R-HSA-5362517Signaling by Retinoic AcidTAS
R-HSA-70268Pyruvate metabolismTAS
R-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycleTAS
R-HSA-9006931Signaling by Nuclear ReceptorsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
21283817Chronic CSE treatment induces the growth of normal oral keratinocytes via PDK2 upregulation, increased glycolysis and HIF1alpha stabilization. (2011 Jan 19)Sun WPLoS One