Gene: ENPP1

5167
ARHR2|COLED|M6S1|NPP1|NPPS|PC-1|PCA1|PDNP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
protein-coding
6q23.2
Ensembl:ENSG00000197594 MIM:173335 Vega:OTTHUMG00000015572 UniprotKB:P22413
NG_008206.1
PubMed|SNP Mapped
1   ANCO-SNPs
ND
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
6.655e-1 (AD)  7.186e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7768555chr6:131847222 (GRCh38.p7)G>Anicotine dependenceSNV(Single Nucleotide Variation)

DNA Methylation

Probe Locus(GRCh37) Gene Region p-val Trait PubMed ID
cg01554453chr6:132129103ENPP1Promoter6.129e-4Alcohol use disorders26763658

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
KDELR30.562
EXOG0.562
LIMA10.557
ZNF1400.549
TNFRSF190.543
PHLDA10.539
ZNF3000.539
FRMD30.539
OSBPL90.52
MEGF110.519

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
GALR3-0.264
RPS4Y1-0.259
KCNG1-0.256
DDX3Y-0.245
TMEM221-0.245
NLGN4Y-0.245
CCNO-0.241
EIF1AY-0.24
USP9Y-0.234
POU3F1-0.231

Drugs/Compounds

ID Drug Name Drug Type CAS Num Status Role
DB00811RibavirinSmall Molecule36791-04-5ApprovedTarget
DB01143AmifostineSmall Molecule20537-88-6Approved|InvestigationalTarget
DB06408TaribavirinSmall Molecule119567-79-2InvestigationalTarget
DB11077Polyethylene glycol 400Small Molecule25322-68-3ApprovedTarget
ID Drug Name Action PubMed
C0952841H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein]"21414308
C5486512-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester2-(1'H-indolo-3'-carbonyl)thiazole-4-carboxylic acid methyl ester results in increased expression of ENPP1 mRNA19933214
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ENPP1 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ENPP1 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ENPP1 mRNA"23196670
C4235823-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine"3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Nitroprusside results in decreased expression of ENPP1 protein]"21414308
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
D000082AcetaminophenAcetaminophen results in decreased expression of ENPP1 mRNA26690555
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENPP1 mRNA22100608
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of ENPP1 gene27153756
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENPP1 mRNA19770486
D000493AllopurinolAllopurinol results in decreased expression of ENPP1 mRNA26968635
D000638AmiodaroneAmiodarone affects the expression of ENPP1 mRNA19483382
D000643Ammonium ChlorideAmmonium Chloride affects the expression of ENPP1 mRNA16483693
D001104ArbutinArbutin results in decreased expression of ENPP1 mRNA17103032
D001553BenzbromaroneBenzbromarone affects the expression of ENPP1 mRNA19483382
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENPP1 mRNA26238291
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENPP1 mRNA22228805
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of ENPP1 mRNA"20382639
D004958EstradiolEGF protein inhibits the reaction [Estradiol results in decreased expression of ENPP1 mRNA]24758408
D004958EstradiolEstradiol results in decreased expression of ENPP1 mRNA24758408
D004958Estradiol[bisphenol A co-treated with Estradiol] results in increased expression of ENPP1 mRNA26496021
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in increased activity of ENPP1 protein18500657
C031463beta-glycerophosphoric acidbeta-glycerophosphoric acid results in increased expression of ENPP1 mRNA18500657
C031463beta-glycerophosphoric acidLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]18500657
C031463beta-glycerophosphoric acidLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA]18500657
C006780bisphenol Abisphenol A results in decreased expression of ENPP1 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ENPP1 mRNA28628672
C006780bisphenol Abisphenol A results in decreased expression of ENPP1 mRNA20739668
C006780bisphenol A[bisphenol A co-treated with Estradiol] results in increased expression of ENPP1 mRNA26496021
C006780bisphenol Abisphenol A results in increased expression of ENPP1 mRNA25181051
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ENPP1 mRNA28628672
C018475butyraldehydebutyraldehyde results in decreased expression of ENPP1 mRNA26079696
D002220CarbamazepineCarbamazepine affects the expression of ENPP1 mRNA24752500
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ENPP1 mRNA17484886
D004390Chlorpyrifos[Copper co-treated with Chlorpyrifos] results in increased expression of ENPP1 mRNA21356183
D002857ChromiumChromium results in increased expression of ENPP1 mRNA17547211
D002994ClofibrateClofibrate affects the expression of ENPP1 mRNA19483382
C018021cobaltous chloridecobaltous chloride results in decreased expression of ENPP1 mRNA24386269
D003300Copper[Copper co-treated with Chlorpyrifos] results in increased expression of ENPP1 mRNA21356183
D003300CopperCopper results in increased expression of ENPP1 mRNA21356183
D003300CopperCopper results in decreased expression of ENPP1 mRNA22465980
D003471CuprizoneCuprizone results in decreased expression of ENPP1 mRNA27523638
D016572CyclosporineCyclosporine results in decreased expression of ENPP1 mRNA20106945|2556210
D016572CyclosporineCyclosporine results in increased expression of ENPP1 mRNA21632981
D000069439DasatinibDasatinib results in decreased expression of ENPP1 mRNA20579391
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ENPP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ENPP1 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ENPP1 mRNA28628672
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of ENPP1 mRNA21266533
D004008DiclofenacDiclofenac affects the expression of ENPP1 mRNA24752500
D004041Dietary FatsDietary Fats results in increased expression of ENPP1 mRNA21852083
D004041Dietary Fatsresveratrol inhibits the reaction [Dietary Fats results in increased expression of ENPP1 mRNA]21852083
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ENPP1 mRNA24535843
D004052DiethylnitrosamineDiethylnitrosamine results in increased expression of ENPP1 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in increased expression of ENPP1 mRNA17547211
D011756DiphosphatesDiphosphates results in decreased expression of ENPP1 mRNA17383965
D004176DipyridamoleDipyridamole results in decreased expression of ENPP1 protein21414308
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ENPP1 mRNA17942748
D005001EthionineEthionine affects the expression of ENPP1 mRNA19483382
D005419FlavonoidsFlavonoids results in increased expression of ENPP1 mRNA18035473
D019833GenisteinGenistein results in increased expression of ENPP1 mRNA22228119
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ENPP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ENPP1 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ENPP1 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ENPP1 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of ENPP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in increased expression of ENPP1 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin] results in increased expression of ENPP1 mRNA28628672
D007545IsoproterenolIsoproterenol results in decreased expression of ENPP1 protein21414308
C561695(+)-JQ1 compound(+)-JQ1 compound results in increased expression of ENPP1 mRNA26752646
C410337K 7174K 7174 results in increased expression of ENPP1 mRNA24086573
C045463leflunomideleflunomide results in increased expression of ENPP1 mRNA28988120
C440499lipopolysaccharide, Escherichia coli O111 B4"lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of ENPP1 protein"17573159
D008628MercuryMercury results in increased expression of ENPP1 mRNA17547211
D008694MethamphetamineMethamphetamine results in decreased expression of ENPP1 mRNA26307267
D008727MethotrexateMethotrexate affects the expression of ENPP1 mRNA18502557
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ENPP1 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of ENPP1 mRNA26011545
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ENPP1 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ENPP1 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of ENPP1 mRNA24136188
D009532NickelNickel results in decreased expression of ENPP1 mRNA25583101
C029938nickel sulfatenickel sulfate results in increased expression of ENPP1 mRNA22714537
D009599Nitroprusside"1H-(1,2,4)oxadiazolo(4,3-a)quinoxalin-1-one inhibits the reaction [Nitroprusside results in decreased expression of ENPP1 protein]"21414308
D009599Nitroprusside"3-(4-Amino-5-cyclopropylpyrimidine-2-yl)-1-(2-fluorobenzyl)-1H-pyrazolo(3,4-b)pyridine promotes the reaction [Nitroprusside results in decreased expression of ENPP1 protein]"21414308
D009599NitroprussideNitroprusside results in decreased expression of ENPP1 protein21414308
D009853OmeprazoleOmeprazole affects the expression of ENPP1 mRNA19483382
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ENPP1 mRNA25729387
C030110oxaliplatinoxaliplatin results in decreased expression of ENPP1 mRNA25729387
D010117OxypurinolOxypurinol results in decreased expression of ENPP1 mRNA26968635
D010634PhenobarbitalPhenobarbital results in decreased expression of ENPP1 mRNA23091169
C006253pirinixic acidpirinixic acid results in decreased expression of ENPP1 mRNA23811191
C006253pirinixic acidpirinixic acid affects the expression of ENPP1 mRNA19483382
C006253pirinixic acidpirinixic acid results in decreased expression of ENPP1 mRNA22484513
D059808PolyphenolsPolyphenols results in decreased expression of ENPP1 mRNA16293270
D011192Potassium DichromatePotassium Dichromate results in increased expression of ENPP1 mRNA17547211
D011374ProgesteroneProgesterone results in decreased expression of ENPP1 mRNA23018184
D011374ProgesteroneProgesterone results in increased expression of ENPP1 mRNA20864642
D011374ProgesteroneProgesterone results in decreased expression of ENPP1 mRNA19690047
D011374ProgesteroneProgesterone results in decreased expression of ENPP117510236
D011441PropylthiouracilPropylthiouracil affects the expression of ENPP1 mRNA19483382
D011441PropylthiouracilPropylthiouracil results in decreased expression of ENPP1 mRNA24780913
D011794QuercetinQuercetin results in decreased expression of ENPP1 mRNA21632981
C059514resveratrolresveratrol inhibits the reaction [Dietary Fats results in increased expression of ENPP1 mRNA]21852083
D012402RotenoneRotenone results in increased expression of ENPP1 mRNA19013527
D012643SeleniumSelenium results in decreased expression of ENPP1 mRNA28810182
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of ENPP1 mRNA25895662
D012834SilverSilver results in decreased expression of ENPP1 mRNA27131904
C009277sodium arsenatesodium arsenate results in decreased expression of ENPP1 mRNA23922661
C017947sodium arsenitesodium arsenite results in increased expression of ENPP1 mRNA22714537
C031655tauroursodeoxycholic acidtauroursodeoxycholic acid results in decreased expression of ENPP1 mRNA15885361
C004648testosterone enanthatetestosterone enanthate affects the expression of ENPP1 mRNA17440010
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENPP1 mRNA19933214
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENPP1 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ENPP1 mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ENPP1 mRNA25613284
D007978LevamisoleLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased activity of ENPP1 protein]18500657
D007978LevamisoleLevamisole inhibits the reaction [beta-glycerophosphoric acid results in increased expression of ENPP1 mRNA]18500657
D013853ThioacetamideThioacetamide affects the expression of ENPP1 mRNA19483382
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ENPP1 mRNA25729387
D019772TopotecanTopotecan results in decreased expression of ENPP1 mRNA25729387
D014212TretinoinTretinoin results in increased expression of ENPP1 mRNA20488242
C012589trichostatin Atrichostatin A results in decreased expression of ENPP1 mRNA24935251
C015559trimellitic anhydridetrimellitic anhydride results in increased expression of ENPP1 mRNA19042947
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ENPP1 mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of ENPP1 mRNA28973697
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
D014635Valproic AcidValproic Acid affects the expression of ENPP1 mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of ENPP1 mRNA24383497|2627250
D000069470Venlafaxine HydrochlorideVenlafaxine Hydrochloride results in decreased expression of ENPP1 mRNA25423262
C025643vinclozolinvinclozolin results in increased expression of ENPP1 mRNA23034163
C029297vinylidene chloridevinylidene chloride results in decreased expression of ENPP1 mRNA26682919
C111237vorinostat"[NOG protein co-treated with vorinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP1 mRNA"27188386
D014859WarfarinWarfarin results in increased expression of ENPP1 mRNA22659116
D014859WarfarinWarfarin results in increased expression of ENPP1 protein22659116

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004527exonuclease activity-IDA22285541  
GO:0004528phosphodiesterase I activity-IDA27467858  
GO:0004528phosphodiesterase I activity-ISS-  
GO:0004551nucleotide diphosphatase activity-IDA12746903  
GO:0004551nucleotide diphosphatase activity-TAS-  
GO:0005044scavenger receptor activity-IEA-  
GO:0005158insulin receptor binding-IDA7830796  
GO:0005509calcium ion binding-ISS-  
GO:0005515protein binding-IPI11289049  
GO:0005524ATP binding-IDA7830796  
GO:0008270zinc ion binding-ISS-  
GO:0030247polysaccharide binding-IEA-  
GO:0035529NADH pyrophosphatase activity-IEA-  
GO:0042803protein homodimerization activity-IDA7830796  
GO:0047429nucleoside-triphosphate diphosphatase activity-IDA7830796  10513816  11159191  
GO:00506563'-phosphoadenosine 5'-phosphosulfate binding-IC7830796  
GO ID GO Term Qualifier Evidence PubMed
GO:0006091generation of precursor metabolites and energy-IDA12746903  
GO:0006771riboflavin metabolic process-TAS-  
GO:0006796phosphate-containing compound metabolic process-IDA10513816  11159191  
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006955immune response-IEA-  
GO:0009143nucleoside triphosphate catabolic process-IDA10513816  
GO:0030308negative regulation of cell growth-IDA17849011  
GO:0030500regulation of bone mineralization-IC10513816  
GO:0030505inorganic diphosphate transport-IDA10513816  
GO:0030643cellular phosphate ion homeostasis-IDA11159191  
GO:0030730sequestering of triglyceride-IDA17849011  
GO:0031214biomineral tissue development-IEA-  
GO:0031953negative regulation of protein autophosphorylation-IDA11289049  
GO:0032869cellular response to insulin stimulus-IDA7830796  17849011  
GO:0045599negative regulation of fat cell differentiation-IDA17849011  
GO:0045719negative regulation of glycogen biosynthetic process-IDA11289049  
GO:0046034ATP metabolic process-ISS-  
GO:0046325negative regulation of glucose import-IDA17849011  
GO:0046627negative regulation of insulin receptor signaling pathway-IDA7830796  17849011  
GO:00504273'-phosphoadenosine 5'-phosphosulfate metabolic process-IDA7830796  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IDA22285541  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA11159191  
GO:0005765lysosomal membrane-HDA17897319  
GO:0005886plasma membrane-IDA10513816  27467858  
GO:0005886plasma membrane-TAS-  
GO:0005887integral component of plasma membrane-ISS-  
GO:0009986cell surface-IDA10513816  
GO:0016021integral component of membrane-ISS-  
GO:0016323basolateral plasma membrane-NAS9553761  
KEGG ID KEGG Term
hsa00230Purine metabolism
hsa00500Starch and sucrose metabolism
hsa00740Riboflavin metabolism
hsa00760Nicotinate and nicotinamide metabolism
hsa00770Pantothenate and CoA biosynthesis
hsa01100Metabolic pathways
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196843Vitamin B2 (riboflavin) metabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-199220Vitamin B5 (pantothenate) metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
25383264PSEUDOXANTHOMA ELASTICUM: DIAGNOSTIC FEATURES, CLASSIFICATION, AND TREATMENT OPTIONS. (2014 Jun 1)Uitto JExpert Opin Orphan Drugs
26868433Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5. (2016 Mar)Trombetta MNutr Metab Cardiovasc Dis