Gene: ENPP2

5168
ATX|ATX-X|AUTOTAXIN|LysoPLD|NPP2|PD-IALPHA|PDNP2
ectonucleotide pyrophosphatase/phosphodiesterase 2
protein-coding
8q24.12
Ensembl:ENSG00000136960 MIM:601060 Vega:OTTHUMG00000164995 UniprotKB:Q13822
NG_029498.3
PubMed
AD
2   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.932e-1 (AD)  4.906e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
UGT80.964
TF0.963
MYRF0.949
MOG0.948
GPR370.944
MAG0.939
EVI2A0.935
FA2H0.935
SLC44A10.933
HHIP0.932

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
PAX2-0.326
NEUROD1-0.326
WTIP-0.309
LTK-0.304
CUX2-0.302
SHISA8-0.302
SLC29A4-0.3
GOLGA6L1-0.3
OR4F29-0.296
CHRNA2-0.291

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0095361,2,3-trichloropropane"1,2,3-trichloropropane results in increased secretion of ENPP2 protein"22952646
C0703791,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]"19014389
C0297902,2',3',4,4',5-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of ENPP2 mRNA"20702594
C0171992',3'-dialdehyde ATP"2',3'-dialdehyde ATP inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
C0817662,4,4'-trichlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C0098282,4,5,2',5'-pentachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ENPP2 mRNA"21346803
C0094072,5,2',5'-tetrachlorobiphenyl"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C0269422,6-diisocyanatotoluene"2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA"22952646
C0269422,6-diisocyanatotoluene"2,6-diisocyanatotoluene results in increased expression of ENPP2 protein"22952646
C0269422,6-diisocyanatotoluene"KN 62 inhibits the reaction [2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA]"22952646
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ENPP2 mRNA"21346803
C0065512-amino-2-methyl-1-propanol2-amino-2-methyl-1-propanol results in decreased expression of ENPP2 mRNA25088246
C0038982-anisidine2-anisidine results in decreased expression of ENPP2 mRNA28089782
C0807553-(2-methoxybenzylamino)-2-phenylpiperidine3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C0284513,4,3',4'-tetrachlorobiphenyl"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ENPP2 mRNA]"19467301
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in decreased expression of ENPP2 mRNA"23196670
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ENPP2 mRNA"20959002
C0339013'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate"3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C4591794-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C516138(6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
D000111Acetylcysteine"Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D000255Adenosine Triphosphate"Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ENPP2 protein20106945
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENPP2 mRNA21632981
D016604Aflatoxin B1Aflatoxin B1 results in decreased expression of ENPP2 mRNA19770486
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in increased expression of ENPP2 mRNA28522335
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]19028555
C011512alpha-naphthoflavonealpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]19028555
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ENPP2 mRNA24449571
C081565arachidonyltrifluoromethanearachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D001151ArsenicArsenic affects the expression of ENPP2 mRNA23866971
C006632arsenic trioxidearsenic trioxide results in increased expression of ENPP2 mRNA20458559
D001241AspirinAspirin results in decreased expression of ENPP2 mRNA12800193
D001280AtrazineAtrazine results in decreased expression of ENPP2 mRNA22378314
D001379AzathioprineAzathioprine results in increased expression of ENPP2 mRNA19192274
C547126AZM551248AZM551248 results in decreased expression of ENPP2 mRNA22323515
D001554BenzeneBenzene results in increased expression of ENPP2 mRNA19162166
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENPP2 mRNA20106945|2163298
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ENPP2 mRNA19770486|2071347
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of ENPP2 mRNA22228805|2719552
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ENPP2 mRNA25490995
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide affects the expression of ENPP2 mRNA"20382639
C046412benzyl acetatebenzyl acetate results in increased expression of ENPP2 mRNA22952646
C046412benzyl acetatebenzyl acetate results in increased expression of ENPP2 protein22952646
C475503benzylphosphonic acidbenzylphosphonic acid analog results in decreased activity of ENPP2 protein21465666
C475503benzylphosphonic acid[benzylphosphonic acid analog results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid21465666
D004958EstradiolEstradiol affects the expression of ENPP2 mRNA14699072
D004958Estradiol[Estradiol co-treated with Plant Preparations] results in decreased expression of ENPP2 mRNA26945725
C095105bexarotenebexarotene results in decreased expression of ENPP2 mRNA16648578
C070515bisindolylmaleimide Ibisindolylmaleimide I inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C006780bisphenol Abisphenol A results in decreased expression of ENPP2 mRNA26364221
C006780bisphenol Abisphenol A results in increased expression of ENPP2 mRNA29275510
C006780bisphenol A[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENPP2 mRNA28628672
C006780bisphenol Abisphenol A affects the expression of ENPP2 mRNA25181051
C006780bisphenol A[bisphenol A co-treated with Testosterone] results in decreased expression of ENPP2 mRNA26496021
C006780bisphenol Abisphenol A results in decreased expression of ENPP2 mRNA12075121
C000611646bisphenol F[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ENPP2 mRNA28628672
D020148Butyric AcidButyric Acid results in decreased expression of ENPP2 mRNA12800193
D002104CadmiumCadmium results in increased expression of ENPP2 mRNA21120746
D019256Cadmium ChlorideCadmium Chloride results in decreased expression of ENPP2 mRNA25993096
D002211Capsaicin"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]"19014389
D002211Capsaicin3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D002211Capsaicinarachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D002211Capsaicinbisindolylmaleimide I inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D002211Capsaicin[[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]19014389
D002211CapsaicinDizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D002211Capsaicin[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid19014389
D002211CapsaicinU 0126 inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D002211Capsaicinxestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C005563captaxcaptax results in increased expression of ENPP2 protein22952646
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased activity of ENPP2 protein17850827
C035377chlorendic acidchlorendic acid results in increased expression of ENPP2 mRNA22952646
C035377chlorendic acidchlorendic acid results in increased secretion of ENPP2 protein22952646
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in increased expression of ENPP2 mRNA18178546
D002922CiguatoxinsCiguatoxins affects the expression of ENPP2 mRNA18353800
C007068cinnamyl anthranilatecinnamyl anthranilate results in increased expression of and results in increased secretion of ENPP2 protein22952646
C007068cinnamyl anthranilateKN 62 inhibits the reaction [cinnamyl anthranilate results in increased expression of ENPP2 protein]22952646
C007068cinnamyl anthranilate[Testosterone co-treated with cinnamyl anthranilate] results in increased expression of ENPP2 protein22952646
D002994ClofibrateClofibrate results in increased expression of ENPP2 mRNA15585944
C004692coomassie Brilliant Blue"coomassie Brilliant Blue inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D003300Copper[NSC 689534 binds to Copper] which results in increased expression of ENPP2 mRNA20971185
C015763cumene[cumene co-treated with KRAS gene mutant form] results in decreased expression of ENPP2 mRNA18648096
D003471CuprizoneCuprizone results in decreased expression of ENPP2 mRNA26577399|2752363
D016572CyclosporineCyclosporine results in decreased expression of ENPP2 mRNA20106945|2163298
D003703DemecolcineDemecolcine results in increased expression of ENPP2 mRNA23649840
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENPP2 mRNA28628672
D003907Dexamethasone[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ENPP2 mRNA28628672
D003907Dexamethasone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA16054899
D003907DexamethasoneDexamethasone results in increased expression of ENPP2 mRNA22733784
D003907Dexamethasone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D003907DexamethasoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D002945CisplatinENPP2 protein affects the susceptibility to Cisplatin16217747
D004008DiclofenacDiclofenac results in increased expression of ENPP2 mRNA26934552
D004041Dietary Fats"3,4,3',4'-tetrachlorobiphenyl inhibits the reaction [Dietary Fats results in increased expression of ENPP2 mRNA]"19467301
D004041Dietary FatsDietary Fats results in increased expression of ENPP2 mRNA19467301
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ENPP2 mRNA19638242
D004128DimethylnitrosamineDimethylnitrosamine results in decreased expression of ENPP2 mRNA17072980
D004121Dimethyl SulfoxideDimethyl Sulfoxide results in decreased expression of ENPP2 protein22952646
D004237DiuronDiuron results in decreased expression of ENPP2 mRNA21551480|2515243
D016291Dizocilpine MaleateDizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
D000431EthanolEthanol affects the expression of ENPP2 mRNA11772933
D000431EthanolEthanol results in increased expression of ENPP2 mRNA15353170
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ENPP2 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ENPP2 mRNA16174780|1794274
D004997Ethinyl Estradiol[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ENPP2 mRNA17942748
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ENPP2 mRNA12075121|1557682
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of ENPP2 mRNA23550701
C024565ethylene dichlorideethylene dichloride results in decreased expression of ENPP2 mRNA28189721
D011345FenofibrateFenofibrate results in decreased expression of ENPP2 mRNA25572481
D005480FlurbiprofenFlurbiprofen results in decreased expression of ENPP2 mRNA16949054
C061365flusilazoleflusilazole results in decreased expression of ENPP2 mRNA22382673
C061365flusilazoleflusilazole results in decreased expression of ENPP2 mRNA28263823
D005557FormaldehydeFormaldehyde results in increased expression of ENPP2 mRNA23649840
C039281furanfuran results in decreased expression of ENPP2 mRNA27387713
C039281furanfuran results in increased methylation of ENPP2 gene22079235
C546771gardiquimodgardiquimod results in increased expression of ENPP2 mRNA28003376
C546771gardiquimodProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ENPP2 mRNA]28003376
D019833GenisteinGenistein results in decreased expression of ENPP2 mRNA15256057
D019833GenisteinGenistein results in decreased expression of ENPP2 mRNA12075121
D005897GlafenineGlafenine results in decreased expression of ENPP2 mRNA24136188
D006052Gold Sodium ThiomalateGold Sodium Thiomalate results in increased expression of ENPP2 mRNA19192274
C412815GW 4064GW 4064 results in decreased expression of ENPP2 mRNA26655953
D017313FenretinideFenretinide results in decreased expression of ENPP2 mRNA28973697
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENPP2 mRNA28628672
D007213Indomethacin[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ENPP2 mRNA28628672
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ENPP2 mRNA25613284
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in decreased expression of ENPP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of ENPP2 mRNA28628672
D0150561-Methyl-3-isobutylxanthine[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA16054899
D0150561-Methyl-3-isobutylxanthine[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D0150561-Methyl-3-isobutylxanthineTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
C098607JP8 aviation fuelJP8 aviation fuel results in increased expression of ENPP2 protein17337753
D007649KetamineKetamine results in increased expression of ENPP2 mRNA20080153
C063302KN 62"KN 62 inhibits the reaction [2,6-diisocyanatotoluene results in increased expression of ENPP2 mRNA]"22952646
C063302KN 62KN 62 inhibits the reaction [cinnamyl anthranilate results in increased expression of ENPP2 protein]22952646
C063302KN 62"KN 62 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
C008261lead acetatelead acetate results in decreased expression of ENPP2 mRNA21864555
C045463leflunomideleflunomide results in increased expression of ENPP2 mRNA24136188
C032881lysophosphatidic acid[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid24747415
C032881lysophosphatidic acid"1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]"19014389
C032881lysophosphatidic acid3-(2-methoxybenzylamino)-2-phenylpiperidine inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acidarachidonyltrifluoromethane inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acidbisindolylmaleimide I inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acid[[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]19014389
C032881lysophosphatidic acidDizocilpine Maleate inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acid[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid19014389
C032881lysophosphatidic acid[ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid19014389
C032881lysophosphatidic acidIL1B protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein]25896349
C032881lysophosphatidic acidlysophosphatidic acid results in decreased expression of ENPP2 protein25896349
C032881lysophosphatidic acid[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid24599971|2539876
C032881lysophosphatidic acid[[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid] which results in decreased expression of NFE2L225398768
C032881lysophosphatidic acid[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid25896349
C032881lysophosphatidic acid[[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid] which results in increased expression of ENPP2 mRNA25896349|2589634
C032881lysophosphatidic acidTNF protein inhibits the reaction [lysophosphatidic acid results in decreased expression of ENPP2 protein]25896349
C032881lysophosphatidic acidU 0126 inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acidxestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C032881lysophosphatidic acidlysophosphatidic acid inhibits the reaction [ENPP2 mutant form results in decreased expression of MBP mRNA]18594965
C032881lysophosphatidic acid[benzylphosphonic acid analog results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid21465666
C032881lysophosphatidic acidENPP2 protein results in increased chemical synthesis of lysophosphatidic acid19014389|2161507
C032881lysophosphatidic acid[ENPP2 protein results in increased metabolism of Lysophosphatidylcholines] which results in increased chemical synthesis of lysophosphatidic acid24747415|2603728
D008244Lysophosphatidylcholines[[Capsaicin results in increased chemical synthesis of Lysophosphatidylcholines] which results in increased secretion of Lysophosphatidylcholines] promotes the reaction [ENPP2 results in increased chemical synthesis of lysophosphatidic acid]19014389
D008244Lysophosphatidylcholines[ENPP2 protein co-treated with Lysophosphatidylcholines] results in increased chemical synthesis of lysophosphatidic acid19014389
D008244LysophosphatidylcholinesENPP2 protein results in increased hydrolysis of Lysophosphatidylcholines21615078
D008244LysophosphatidylcholinesENPP2 protein results in increased metabolism of Lysophosphatidylcholines19014389
D008244Lysophosphatidylcholines[ENPP2 protein results in increased metabolism of Lysophosphatidylcholines] which results in increased chemical synthesis of lysophosphatidic acid24747415|2603728
D058185Magnetite Nanoparticles[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ENPP2 mRNA26378955
D017258Medroxyprogesterone AcetateMedroxyprogesterone Acetate results in increased expression of ENPP2 mRNA20843944
D015122MercaptopurineMercaptopurine results in decreased expression of ENPP2 mRNA23358152
D008701MethapyrileneMethapyrilene results in decreased expression of ENPP2 mRNA16393664
D008727MethotrexateMethotrexate results in increased expression of ENPP2 mRNA19192274
D008748MethylcholanthreneMethylcholanthrene results in decreased expression of ENPP2 mRNA20713471
C004925methylmercuric chloridemethylmercuric chloride results in decreased expression of ENPP2 mRNA28001369
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ENPP2 mRNA26011545
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of ENPP2 mRNA23649840
D018817N-Methyl-3,4-methylenedioxyamphetamine"N-Methyl-3,4-methylenedioxyamphetamine results in decreased expression of ENPP2 mRNA"26251327
D008769MethylnitronitrosoguanidineMethylnitronitrosoguanidine results in increased expression of ENPP2 mRNA15120970
C028577monobutyl phthalatemonobutyl phthalate affects the expression of ENPP2 mRNA19162170
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in increased expression of ENPP2 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ENPP2 mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ENPP2 mRNA"25554681
C012655nimesulidenimesulide results in increased expression of ENPP2 mRNA24136188
C558013NSC 689534[NSC 689534 binds to Copper] which results in increased expression of ENPP2 mRNA20971185
C000592118ONO-8430506ONO-8430506 results in decreased activity of ENPP2 protein24747415
C000592118ONO-8430506[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid24747415
C000592118ONO-8430506ONO-8430506 results in decreased activity of ENPP2 protein24599971|2539876
C000592118ONO-8430506[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid24599971|2539876
C000592118ONO-8430506[[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased abundance of lysophosphatidic acid] which results in decreased expression of NFE2L225398768
C000592118ONO-8430506[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid25896349
C000592118ONO-8430506[[ONO-8430506 results in decreased activity of ENPP2 protein] which results in decreased chemical synthesis of and results in decreased abundance of lysophosphatidic acid] which results in increased expression of ENPP2 mRNA25896349|2589634
C000592118ONO-8430506ONO-8430506 results in decreased activity of ENPP2 protein24747415
D010100Oxygenalpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]19028555
D010100OxygenOxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]19028555
D010100OxygenOxygen deficiency results in increased activity of ENPP2 mRNA19028555
D010100OxygenOxygen deficiency results in increased expression of ENPP2 mRNA19028555
D017239PaclitaxelPaclitaxel results in increased expression of ENPP2 mRNA19682730
C496932panobinostat"[NOG protein co-treated with panobinostat co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C496932panobinostatpanobinostat results in increased expression of ENPP2 mRNA26272509
D052638Particulate MatterParticulate Matter results in increased expression of ENPP2 mRNA23085030
C410127PCB 180"[2,4,4'-trichlorobiphenyl co-treated with 2,5,2',5'-tetrachlorobiphenyl co-treated with 2,4,5,2',5'-pentachlorobiphenyl co-treated with 2,2',3',4,4',5-hexachlorobiphenyl co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with PCB 180] results in decreased expression of ENPP2 mRNA"25510870
C101814perfluoro-n-undecanoic acidperfluoro-n-undecanoic acid results in decreased expression of ENPP2 mRNA23602845
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ENPP2 mRNA19162173
D010634PhenobarbitalPhenobarbital affects the expression of ENPP2 mRNA23091169
D010634PhenobarbitalPhenobarbital results in increased expression of ENPP2 mRNA19162173
C006253pirinixic acidpirinixic acid results in decreased expression of ENPP2 mRNA23811191
D028321Plant Preparations[Estradiol co-treated with Plant Preparations] results in decreased expression of ENPP2 mRNA26945725
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ENPP2 mRNA22714537
D011192Potassium DichromatePotassium Dichromate results in increased expression of ENPP2 mRNA23608068
D011374ProgesteroneProgesterone results in decreased expression of ENPP2 mRNA23018184
D011374ProgesteroneProgesterone affects the expression of ENPP2 mRNA17251523
D011441PropylthiouracilPropylthiouracil results in decreased expression of ENPP2 mRNA24780913
D047428Protein Kinase InhibitorsProtein Kinase Inhibitors inhibits the reaction [gardiquimod results in increased expression of ENPP2 mRNA]28003376
C010313pseudocumenepseudocumene results in increased expression of ENPP2 protein17337753
D011794QuercetinQuercetin results in decreased expression of ENPP2 mRNA21632981
D020849Raloxifene HydrochlorideRaloxifene Hydrochloride affects the expression of ENPP2 mRNA14699072
D020849Raloxifene Hydrochloride[Raloxifene Hydrochloride co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA19059307
C059514resveratrol[resveratrol co-treated with Streptozocin] results in decreased expression of ENPP2 mRNA25905778
C013672riddelliineriddelliine results in decreased expression of ENPP2 mRNA18047727
C089730rosiglitazone[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA16054899
C089730rosiglitazone[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
C089730rosiglitazoneTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D012406RoxarsoneRoxarsone results in increased secretion of ENPP2 protein22952646
D012822Silicon DioxideSilicon Dioxide results in increased expression of ENPP2 mRNA22431001
C017947sodium arsenitesodium arsenite results in increased expression of ENPP2 mRNA22714537
D013311Streptozocin[resveratrol co-treated with Streptozocin] results in decreased expression of ENPP2 mRNA25905778
D004113Succimer[Succimer co-treated with Magnetite Nanoparticles] results in decreased expression of ENPP2 mRNA26378955
C016766sulforafansulforafan results in decreased expression of ENPP2 mRNA26833863
D013629Tamoxifen[Tamoxifen co-treated with ESR1 protein] results in increased expression of ENPP2 mRNA19059307
D013629TamoxifenTamoxifen affects the expression of ENPP2 mRNA17555576
D013629TamoxifenTamoxifen results in increased expression of ENPP2 mRNA25123088
D013739Testosterone[Testosterone co-treated with cinnamyl anthranilate] results in increased expression of ENPP2 protein22952646
D013739TestosteroneTestosterone results in increased expression of ENPP2 protein22952646
D013739Testosterone[bisphenol A co-treated with Testosterone] results in decreased expression of ENPP2 mRNA26496021
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Oxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]]19028555
D013749Tetrachlorodibenzodioxinalpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]19028555
D013749TetrachlorodibenzodioxinOxygen deficiency inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA]19028555
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENPP2 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ENPP2 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased activity of ENPP2 mRNA19028555
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENPP2 mRNA17555868|1902855
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ENPP2 mRNA20702594|2157046
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with EGF protein] inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D013749Tetrachlorodibenzodioxin[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ENPP2 mRNA17942748
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ENPP2 mRNA]16054899
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENPP2 mRNA16960034|1977048
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ENPP2 mRNA16054898|1696003
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ENPP2 mRNA25613284
D019284ThapsigarginThapsigargin results in decreased expression of ENPP2 mRNA22378314
D013853ThioacetamideThioacetamide results in increased activity of ENPP2 protein20957682
C009495titanium dioxidetitanium dioxide results in increased expression of ENPP2 mRNA23557971
D014051Toluene 2,4-Diisocyanate"2',3'-dialdehyde ATP inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"3'-O-(4-benzoyl)benzoyladenosine 5'-triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"Acetylcysteine inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"Adenosine Triphosphate promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"CCL2 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"coomassie Brilliant Blue inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"KN 62 inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"P2RX4 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"P2RX7 protein promotes the reaction [Toluene 2,4-Diisocyanate results in increased expression of ENPP2 protein]"26072274
D014051Toluene 2,4-Diisocyanate"Toluene 2,4-Diisocyanate results in increased secretion of and results in increased expression of ENPP2 protein"26072274
D014212TretinoinTretinoin results in decreased expression of ENPP2 mRNA20488242
D014241TrichloroethyleneTrichloroethylene results in increased expression of ENPP2 mRNA17905399
C012589trichostatin A"[NOG protein co-treated with trichostatin A co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
C012589trichostatin Atrichostatin A results in increased expression of ENPP2 mRNA24935251|2627250
C015559trimellitic anhydridetrimellitic anhydride results in decreased expression of ENPP2 mRNA19042947
D014415TunicamycinTunicamycin results in decreased expression of ENPP2 mRNA22378314
C113580U 0126U 0126 inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389
C022884undecaneundecane results in increased expression of ENPP2 protein17337753
D014635Valproic Acid"[NOG protein co-treated with Valproic Acid co-treated with (6-(4-(2-piperidin-1-ylethoxy)phenyl))-3-pyridin-4-ylpyrazolo(1,5-a)pyrimidine co-treated with 4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in increased expression of ENPP2 mRNA"27188386
D014635Valproic AcidValproic Acid results in increased expression of ENPP2 mRNA24383497|2627250
D014638VanadatesVanadates results in increased expression of ENPP2 mRNA22714537
D014640VancomycinVancomycin results in increased expression of ENPP2 mRNA18930951
D001335Vehicle EmissionsVehicle Emissions affects the methylation of ENPP2 gene25560391
C025643vinclozolinvinclozolin results in decreased expression of ENPP2 mRNA22615374
D014750VincristineVincristine results in increased expression of ENPP2 mRNA23649840
C511704xestospongin Cxestospongin C inhibits the reaction [[ENPP2 protein co-treated with Capsaicin] results in increased abundance of lysophosphatidic acid]19014389

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003676nucleic acid binding-IEA-  
GO:0004528phosphodiesterase I activity-IEA-  
GO:0004551nucleotide diphosphatase activity-IEA-  
GO:0004622lysophospholipase activity-IDA15280042  21240271  26371182  
GO:0005044scavenger receptor activity-IEA-  
GO:0005509calcium ion binding-IDA26371182  
GO:0005509calcium ion binding-ISS-  
GO:0008134transcription factor binding-TAS8586446  
GO:0008270zinc ion binding-IDA26371182  
GO:0008270zinc ion binding-ISS-  
GO:0016787hydrolase activity-TAS7982964  
GO:0030247polysaccharide binding-IEA-  
GO:0047391alkylglycerophosphoethanolamine phosphodiesterase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006898receptor-mediated endocytosis-IEA-  
GO:0006935chemotaxis-NAS7982964  
GO:0006955immune response-IEA-  
GO:0009395phospholipid catabolic process-IDA15280042  26371182  
GO:0010634positive regulation of epithelial cell migration-IGI18054784  
GO:0010634positive regulation of epithelial cell migration-IMP18054784  
GO:0030334regulation of cell migration-IDA1733949  
GO:0034638phosphatidylcholine catabolic process-IDA21240271  
GO:0045765regulation of angiogenesis-IEA-  
GO:0048870cell motility-TAS1733949  
GO:0050731positive regulation of peptidyl-tyrosine phosphorylation-IDA18054784  
GO:0090305nucleic acid phosphodiester bond hydrolysis-IEA-  
GO:2000394positive regulation of lamellipodium morphogenesis-IGI18054784  
GO ID GO Term Qualifier Evidence PubMed
GO:0005615extracellular space-IDA15280042  26371182  
GO:0005615extracellular space-ISS-  
GO:0005886plasma membrane-TAS8579579  
KEGG ID KEGG Term
hsa00565Ether lipid metabolism
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-196849Metabolism of water-soluble vitamins and cofactorsTAS
R-HSA-196854Metabolism of vitamins and cofactorsTAS
R-HSA-199220Vitamin B5 (pantothenate) metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
24890784Exon microarray analysis of human dorsolateral prefrontal cortex in alcoholism. (2014 Jun)Manzardo AMAlcohol Clin Exp Res
23747354Over-expression of the miRNA cluster at chromosome 14q32 in the alcoholic brain correlates with suppression of predicted target mRNA required for oligodendrocyte proliferation. (2013 Sep 10)Manzardo AMGene