Gene: HECA

51696
HDC|HDCL|HHDC|dJ225E12.1
hdc homolog, cell cycle regulator
protein-coding
6q24.1
Ensembl:ENSG00000112406 MIM:607977 Vega:OTTHUMG00000015686 UniprotKB:Q9UBI9
NC_000006.12
PubMed
0   ANCO-SNPs
ND|AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
2.501e-1 (AD)  1.501e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
WAC0.876
CDV30.856
CCNI0.85
GPBP10.846
TCP10.842
CTCF0.841
VPS26A0.836
TLK20.835
PAFAH1B20.833
ZRANB10.829

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F29-0.65
OR4F5-0.631
PON3-0.333
NXNL1-0.305
PON1-0.287
HOGA1-0.284
ALDH1L1-AS2-0.283
TPPP2-0.278
LFNG-0.274
NPFFR1-0.269

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in increased expression of HECA mRNA29067470
D016604Aflatoxin B1Aflatoxin B1 results in increased expression of HECA mRNA21641981
C006632arsenic trioxidearsenic trioxide results in increased expression of HECA mRNA20458559
C547126AZM551248AZM551248 results in decreased expression of HECA mRNA22323515
D001564Benzo(a)pyrene[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of HECA mRNA21632023
D001564Benzo(a)pyreneBenzo(a)pyrene results in increased expression of HECA mRNA21839799
C006780bisphenol Abisphenol A affects the expression of HECA mRNA21786754
C006780bisphenol Abisphenol A affects the expression of HECA mRNA21786754
C006780bisphenol Abisphenol A affects the expression of HECA mRNA25181051
C584509C646 compoundC646 compound results in decreased expression of HECA mRNA26191083
D019256Cadmium ChlorideCadmium Chloride results in increased expression of HECA mRNA20883709
D019256Cadmium ChlorideCadmium Chloride results in increased methylation of HECA promoter22457795
D002110CaffeineCaffeine results in increased expression of HECA mRNA20864626
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of HECA mRNA27339419
D019327Copper SulfateCopper Sulfate results in increased expression of HECA mRNA19549813
D003471CuprizoneCuprizone results in decreased expression of HECA mRNA26577399
D016572CyclosporineCyclosporine results in increased expression of HECA mRNA20106945
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HECA mRNA21266533
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of HECA mRNA21266533
C045651epigallocatechin gallate[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HECA mRNA22079256
D005020Ethyl MethanesulfonateEthyl Methanesulfonate results in increased expression of HECA mRNA23649840
D005557FormaldehydeFormaldehyde results in increased expression of HECA mRNA23649840
D005839GentamicinsGentamicins results in increased expression of HECA mRNA22061828
D005897GlafenineGlafenine results in decreased expression of HECA mRNA24136188
C492448ICG 001ICG 001 results in decreased expression of HECA mRNA26191083
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HECA mRNA25613284
D007545IsoproterenolIsoproterenol results in increased expression of HECA mRNA20003209
C482199lipopolysaccharide, E coli O55-B5"lipopolysaccharide, E coli O55-B5 results in decreased expression of HECA mRNA"24972896
C013598methoxyacetic acidmethoxyacetic acid results in increased expression of HECA mRNA20864626
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of HECA mRNA20864626
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in increased expression of HECA mRNA23649840
C028577monobutyl phthalatemonobutyl phthalate results in increased expression of HECA mRNA20864626
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of HECA mRNA"25554681
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of HECA mRNA"25554681
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in decreased expression of HECA mRNA27153767
D010634PhenobarbitalPhenobarbital affects the expression of HECA mRNA19159669
D010634PhenobarbitalPhenobarbital affects the expression of HECA mRNA23091169
D010795Phthalic AcidsPhthalic Acids results in increased expression of HECA mRNA21061450
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of HECA mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of HECA mRNA20813756
C027373potassium chromate(VI)[potassium chromate(VI) co-treated with epigallocatechin gallate] results in increased expression of HECA mRNA22079256
C027373potassium chromate(VI)potassium chromate(VI) results in increased expression of HECA mRNA22079256
C045950propiconazolepropiconazole results in decreased expression of HECA mRNA21278054
D011441PropylthiouracilPropylthiouracil results in increased expression of HECA mRNA24780913
D012822Silicon DioxideSilicon Dioxide analog results in decreased expression of HECA mRNA25895662
D012834SilverSilver results in decreased expression of HECA mRNA27131904
C017947sodium arsenitesodium arsenite results in increased expression of HECA mRNA20883709
C016104sodium bichromate[Benzo(a)pyrene co-treated with sodium bichromate] results in decreased expression of HECA mRNA21632023
D018038Sodium SeleniteSodium Selenite results in increased expression of HECA mRNA18175754
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of HECA mRNA21570461
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of HECA mRNA28973375
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in decreased expression of HECA mRNA25613284
D014212TretinoinTretinoin results in increased expression of HECA mRNA23724009
C012589trichostatin Atrichostatin A results in increased expression of HECA mRNA24935251
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of HECA mRNA"26179874
C057693troglitazonetroglitazone results in decreased expression of HECA mRNA28973697
D014520UrethaneUrethane results in increased expression of HECA mRNA28818685
D014635Valproic AcidValproic Acid affects the expression of HECA mRNA25979313
D014635Valproic AcidValproic Acid results in increased expression of HECA mRNA19101580|2317975
C025643vinclozolinvinclozolin affects the expression of HECA mRNA19015723
D024483Vitamin K 3Vitamin K 3 affects the expression of HECA mRNA20044591

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO ID GO Term Qualifier Evidence PubMed
GO:0030323respiratory tube development-NAS11696983  
GO:0045930negative regulation of mitotic cell cycle-IDA19643820  
GO:0045930negative regulation of mitotic cell cycle-IMP22100912  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA19643820  22100912  
GO:0005737cytoplasm-IDA19643820  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal