Gene: ACSL5

51703
ACS2|ACS5|FACL5
acyl-CoA synthetase long chain family member 5
protein-coding
10q25.2
Ensembl:ENSG00000197142 MIM:605677 Vega:OTTHUMG00000019060 UniprotKB:Q9ULC5
NC_000010.11
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  2.976e-2 (ND)   (Frontal_Cortex)
5.200e-1 (AD)  6.223e-2 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs7919710chr10:112409794 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
IL4R0.932
TGM20.915
F11R0.885
PLA1A0.882
PXN0.878
FGR0.874
CHSY10.873
IRAK30.873
SLCO4A10.864
ELOVL70.864

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
CRH-0.54
MARCH4-0.519
NEUROD6-0.512
CPLX3-0.504
SMIM18-0.502
ABCC12-0.493
KCNIP3-0.491
DLX1-0.485
SLC7A4-0.484
VWC2-0.483

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in decreased expression of ACSL5 mRNA"19162173
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACSL5 mRNA"22698814
C0284741,4-bis(2-(3,5-dichloropyridyloxy))benzene"NR1I3 protein promotes the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in decreased expression of ACSL5 mRNA]"22698814
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of ACSL5 mRNA"19114083
C0140242,4,5,2',4',5'-hexachlorobiphenyl"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSL5 mRNA"28433925
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of ACSL5 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of ACSL5 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ACSL5 mRNA"19692669
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of ACSL5 mRNA"23196670
C5756314-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile"4-(4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile affects the expression of ACSL5 mRNA"21218783
D000082AcetaminophenAcetaminophen results in decreased expression of ACSL5 mRNA21420995|2570463
D000082AcetaminophenAcetaminophen results in increased expression of ACSL5 mRNA26690555
D000082Acetaminophen[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL5 mRNA17585979
D000082AcetaminophenPPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL5 mRNA]17585979
D016604Aflatoxin B1Aflatoxin B1 affects the expression of ACSL5 protein20106945
D000517alpha-Chlorohydrinalpha-Chlorohydrin results in decreased expression of ACSL5 mRNA28522335
D018501Antirheumatic AgentsAntirheumatic Agents results in decreased expression of ACSL5 mRNA24449571
D001379AzathioprineAzathioprine results in increased expression of ACSL5 mRNA22623647
C547126AZM551248AZM551248 results in decreased expression of ACSL5 mRNA22323515
C487081belinostatbelinostat results in decreased expression of ACSL5 mRNA27188386
D001564Benzo(a)pyreneBenzo(a)pyrene affects the expression of ACSL5 mRNA20106945
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSL5 mRNA22316170
D001564Benzo(a)pyreneBenzo(a)pyrene results in decreased expression of ACSL5 mRNA19770486|2222880
D004958EstradiolEstradiol results in decreased expression of ACSL5 mRNA20106945
C095105bexarotenebexarotene results in increased expression of ACSL5 mRNA23292798
D001629BezafibrateBezafibrate results in increased expression of ACSL5 mRNA17118139
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ACSL5 mRNA25470364|2660616
C543008bis(4-hydroxyphenyl)sulfonebis(4-hydroxyphenyl)sulfone results in increased expression of ACSL5 mRNA27685785
C006780bisphenol Abisphenol A affects the methylation of ACSL5 promoter27334623
C006780bisphenol A"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSL5 mRNA"28433925
C006780bisphenol Abisphenol A affects the expression of ACSL5 mRNA25181051
C006780bisphenol Abisphenol A results in increased methylation of ACSL5 gene28505145
D002065BuspironeBuspirone results in decreased expression of ACSL5 mRNA24136188
D002104CadmiumCadmium results in increased oxidation of ACSL5 protein24496640
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of ACSL5 mRNA17484886
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of ACSL5 mRNA23650126
D004390ChlorpyrifosChlorpyrifos results in increased expression of ACSL5 mRNA18668222
D002994Clofibrate[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL5 mRNA17585979
D002994ClofibrateClofibrate results in increased expression of ACSL5 mRNA17585979
D002994ClofibratePPARA affects the reaction [[Clofibrate co-treated with Acetaminophen] affects the expression of ACSL5 mRNA]17585979
D002994ClofibrateClofibrate results in decreased expression of ACSL5 mRNA18670166
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACSL5 mRNA21139344
C018021cobaltous chloridecobaltous chloride results in decreased expression of ACSL5 mRNA24386269
D003042CocaineCocaine affects the expression of ACSL5 mRNA20187946
D019327Copper SulfateCopper Sulfate results in increased expression of ACSL5 mRNA19549813
D016572CyclosporineCyclosporine results in decreased expression of ACSL5 mRNA20106945
D016572CyclosporineCyclosporine results in increased expression of ACSL5 mRNA25562108|2798913
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of ACSL5 mRNA25222814|2689491
C010902decabromobiphenyl etherdecabromobiphenyl ether analog results in increased expression of ACSL5 mRNA26894911
D003907DexamethasoneDexamethasone inhibits the reaction [RX3 gene mutant form affects the expression of ACSL5 mRNA]27941970
D003907DexamethasoneDexamethasone results in increased expression of ACSL5 mRNA25047013
D002945CisplatinCisplatin results in decreased expression of ACSL5 mRNA22023808
D004026DieldrinDieldrin results in increased expression of ACSL5 mRNA20438755
D004041Dietary Fats[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ACSL5 mRNA28433925
D004041Dietary FatsDietary Fats results in decreased expression of ACSL5 mRNA18042831
D004041Dietary FatsDietary Fats results in increased expression of ACSL5 mRNA19030233
D019422Dietary Sucrose[Dietary Fats co-treated with Dietary Sucrose] results in decreased expression of ACSL5 mRNA28433925
D004051Diethylhexyl Phthalate"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSL5 mRNA"28433925
D004052Diethylnitrosamine[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ACSL5 mRNA28943392
D004052DiethylnitrosamineDiethylnitrosamine results in decreased expression of ACSL5 mRNA19638242
D004054DiethylstilbestrolDiethylstilbestrol results in increased expression of ACSL5 mRNA17005392
C019357dioscindioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]24146112
C019357dioscindioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]24146112
D000431Ethanoldioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]24146112
D000431EthanolEthanol results in decreased expression of ACSL5 protein24146112
D000431Ethanoldioscin inhibits the reaction [Ethanol results in decreased expression of ACSL5 protein]24146112
D000431EthanolEthanol results in decreased expression of ACSL5 protein24146112
D004997Ethinyl EstradiolEthinyl Estradiol results in decreased expression of ACSL5 mRNA17108234
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of ACSL5 mRNA16174780
D011345FenofibrateFenofibrate results in increased expression of ACSL5 mRNA17118139
D005411Flame RetardantsFlame Retardants results in decreased expression of ACSL5 mRNA18534652
D005485FlutamideFlutamide results in decreased expression of ACSL5 mRNA17702527
D005485FlutamideFlutamide results in decreased expression of ACSL5 mRNA24793618
D005839GentamicinsGentamicins results in increased expression of ACSL5 mRNA22061828
C089796hexabromocyclododecanehexabromocyclododecane analog results in decreased expression of ACSL5 mRNA27717803
C089796hexabromocyclododecanehexabromocyclododecane results in decreased expression of ACSL5 mRNA18534652
D017313FenretinideFenretinide results in increased expression of ACSL5 mRNA28973697
C011582IMOL S-140IMOL S-140 results in decreased expression of ACSL5 mRNA26894911
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACSL5 mRNA25613284
C561695(+)-JQ1 compound(+)-JQ1 compound results in decreased expression of ACSL5 mRNA21889194|2290429
D064704LevofloxacinLevofloxacin results in decreased expression of ACSL5 mRNA24136188
D001556LindaneLindane results in decreased expression of ACSL5 mRNA17785943
D008094LithiumLithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA]19149911
D008694MethamphetamineLithium inhibits the reaction [Methamphetamine results in increased expression of ACSL5 mRNA]19149911
D008694MethamphetamineMethamphetamine results in increased expression of ACSL5 mRNA19149911
C004925methylmercuric chloridemethylmercuric chloride results in increased expression of ACSL5 mRNA28001369
C583365N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide"N-(2-(1,1'-bicyclopropyl)-2-ylphenyl)-3-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxamide results in decreased expression of ACSL5 mRNA"29244179
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of ACSL5 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon results in decreased expression of ACSL5 mRNA"25620056
C051752nefazodonenefazodone results in decreased expression of ACSL5 mRNA24136188
C029938nickel sulfatenickel sulfate results in decreased expression of ACSL5 mRNA22714537
C012655nimesulidenimesulide results in decreased expression of ACSL5 mRNA24136188
C014707nitrosobenzylmethylaminenitrosobenzylmethylamine results in increased expression of ACSL5 mRNA17616710
C464660obeticholic acidobeticholic acid results in increased expression of ACSL5 mRNA27939613
D009966OrphenadrineOrphenadrine affects the expression of ACSL5 mRNA23665939
C030110oxaliplatin[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSL5 mRNA25729387
D000073878Palm OilPalm Oil results in decreased expression of ACSL5 mRNA18042831
C471071perfluorohexanesulfonic acidperfluorohexanesulfonic acid results in increased expression of ACSL5 mRNA21705711
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid affects the expression of ACSL5 mRNA19429403
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACSL5 mRNA20936131
C076994perfluorooctane sulfonic acidperfluorooctane sulfonic acid results in increased expression of ACSL5 mRNA18692542
C023036perfluorooctanoic acidperfluorooctanoic acid affects the expression of ACSL5 mRNA19429403
C023036perfluorooctanoic acidperfluorooctanoic acid results in increased expression of ACSL5 mRNA17681415|1846767
C023036perfluorooctanoic acidPPARA protein promotes the reaction [perfluorooctanoic acid results in increased expression of ACSL5 mRNA]18467677|2093613
C023036perfluorooctanoic acidperfluorooctanoic acid results in decreased expression of ACSL5 mRNA19162173
D010578PetroleumACSL5 gene SNP affects the susceptibility to Petroleum22919386
D010852PicrotoxinPicrotoxin results in decreased expression of ACSL5 mRNA15170462
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of ACSL5 mRNA19710929
C006253pirinixic acidpirinixic acid results in increased expression of ACSL5 mRNA15375163|1711813
C006253pirinixic acidPPARA protein promotes the reaction [pirinixic acid results in increased expression of ACSL5 mRNA]18467677|2005976
C027373potassium chromate(VI)potassium chromate(VI) results in decreased expression of ACSL5 mRNA22714537
D011285Pregnenolone CarbonitrilePregnenolone Carbonitrile results in decreased expression of ACSL5 mRNA28903501
C045950propiconazolepropiconazole results in decreased expression of ACSL5 mRNA19423681
D011794QuercetinQuercetin results in increased expression of ACSL5 mRNA21632981
C059514resveratrolresveratrol results in increased expression of ACSL5 mRNA22610192
D015474IsotretinoinIsotretinoin results in decreased expression of ACSL5 mRNA20436886
C089730rosiglitazonerosiglitazone affects the expression of ACSL5 mRNA22013433
C513635S-2-pentyl-4-pentynoic hydroxamic acidS-2-pentyl-4-pentynoic hydroxamic acid results in decreased expression of ACSL5 mRNA21427059
D012906SmokeSmoke results in decreased expression of ACSL5 mRNA21095227
C009277sodium arsenatesodium arsenate results in decreased expression of ACSL5 mRNA23922661
D014284TriiodothyronineTriiodothyronine results in increased expression of ACSL5 mRNA15953391
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACSL5 mRNA22298810
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSL5 mRNA20106945|2163298
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of ACSL5 mRNA19692669
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of ACSL5 mRNA21570461
D013749Tetrachlorodibenzodioxin"[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of ACSL5 mRNA"28433925
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACSL5 gene]28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSL5 mRNA28213091
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of ACSL5 mRNA21215274
D013750TetrachloroethyleneTetrachloroethylene results in increased expression of ACSL5 mRNA28973375
C582340tetradecabromodiphenoxybenzenetetradecabromodiphenoxybenzene analog results in increased expression of ACSL5 mRNA26894911
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of ACSL5 mRNA25613284
D013853Thioacetamide[Diethylnitrosamine co-treated with Thioacetamide] results in decreased expression of ACSL5 mRNA28943392
D014028Tobacco Smoke PollutionTobacco Smoke Pollution results in decreased expression of ACSL5 mRNA28065790
D019772Topotecan[oxaliplatin co-treated with Topotecan] results in decreased expression of ACSL5 mRNA25729387
C005445triphenyl phosphatetriphenyl phosphate metabolite results in decreased expression of ACSL5 mRNA25350880
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in decreased expression of ACSL5 mRNA"26743178
C016805tris(1,3-dichloro-2-propyl)phosphate"tris(1,3-dichloro-2-propyl)phosphate results in increased expression of ACSL5 mRNA"24273086|2689491
D014317Tritolyl PhosphatesTritolyl Phosphates results in increased expression of ACSL5 mRNA24273086
C057693troglitazonetroglitazone results in increased expression of ACSL5 protein21315101
D014415TunicamycinTunicamycin results in increased expression of ACSL5 mRNA17127020
C406224valdecoxibvaldecoxib results in decreased expression of ACSL5 mRNA24136188
D014635Valproic AcidValproic Acid results in increased expression of ACSL5 mRNA28001369
D014635Valproic AcidValproic Acid results in decreased expression of ACSL5 mRNA21427059
D014635Valproic AcidValproic Acid results in increased expression of ACSL5 mRNA24489787
D001335Vehicle EmissionsVehicle Emissions results in decreased methylation of ACSL5 gene25560391
C025643vinclozolinvinclozolin affects the expression of ACSL5 mRNA19015723
C025643vinclozolinvinclozolin results in increased expression of ACSL5 mRNA22570695
D015032ZincZinc deficiency results in increased expression of ACSL5 mRNA15671213
C088658zoledronic acidzoledronic acid results in increased expression of ACSL5 mRNA24714768

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004467long-chain fatty acid-CoA ligase activity-TAS-  
GO:0005524ATP binding-IEA-  
GO:0102391decanoate-CoA ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0001676long-chain fatty acid metabolic process-IEA-  
GO:0035338long-chain fatty-acyl-CoA biosynthetic process-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005634nucleus-IDA-  
GO:0005730nucleolus-IDA-  
GO:0005739mitochondrion-IDA-  
GO:0005741mitochondrial outer membrane-IEA-  
GO:0005789endoplasmic reticulum membrane-TAS-  
GO:0016020membrane-HDA19946888  
GO:0016021integral component of membrane-IEA-  
KEGG ID KEGG Term
hsa00071Fatty acid degradation
hsa01100Metabolic pathways
hsa03320PPAR signaling pathway
hsa04146Peroxisome
hsa04920Adipocytokine signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-1430728MetabolismTAS
R-HSA-556833Metabolism of lipidsTAS
R-HSA-75105Fatty acyl-CoA biosynthesisTAS
R-HSA-75876Synthesis of very long-chain fatty acyl-CoAsTAS
R-HSA-8978868Fatty acid metabolismTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal