Gene: CAB39

51719
CGI-66|MO25
calcium binding protein 39
protein-coding
2q37.1
Ensembl:ENSG00000135932 MIM:612174 Vega:OTTHUMG00000133220 UniprotKB:Q9Y376
NC_000002.12
SNP Mapped
6   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.949e-2 (AD)  7.047e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs3792068chr2:230808510 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs6717266chr2:230748426 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)
rs6711453chr2:230729374 (GRCh38.p7)A>Galcohol dependenceSNV(Single Nucleotide Variation)
rs13404879chr2:230723394 (GRCh38.p7)G>Talcohol dependenceSNV(Single Nucleotide Variation)
rs13411251chr2:230721625 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)
rs10933355chr2:230717481 (GRCh38.p7)G>Aalcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
SRPK20.966
GRSF10.964
PAFAH1B10.964
PJA20.963
NAPG0.962
UBQLN10.961
UBE2K0.958
AFTPH0.958
ZC3H150.958
CUL20.957

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.601
OR4F29-0.589
CSAG1-0.376
MTRNR2L10-0.359
PON3-0.349
MTRNR2L6-0.348
EYA2-0.334
STON2-0.334
ACOX2-0.331
C22orf31-0.33

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of CAB39 mRNA"21346803
C0235142,6-dinitrotoluene"2,6-dinitrotoluene affects the expression of CAB39 mRNA"21346803
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of CAB39 mRNA]28655636
C5116212-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of CAB39 mRNA]28655636
C0095054,4'-diaminodiphenylmethane"4,4'-diaminodiphenylmethane results in increased expression of CAB39 mRNA"18648102
D000082AcetaminophenAcetaminophen affects the expression of CAB39 mRNA17562736
C547126AZM551248AZM551248 results in decreased expression of CAB39 mRNA22323515
D0151237,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide"7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in decreased expression of CAB39 mRNA"19150397
C006780bisphenol Abisphenol A results in increased expression of CAB39 mRNA25181051
C013418bromfenacoumbromfenacoum results in increased expression of CAB39 protein28903499
D002166CamptothecinCamptothecin results in decreased expression of CAB39 mRNA17374387
D020111Chlorodiphenyl (54% Chlorine)Chlorodiphenyl (54% Chlorine) results in decreased expression of CAB39 mRNA23650126
D002994ClofibrateClofibrate results in decreased expression of CAB39 mRNA17585979
D019327Copper SulfateCopper Sulfate results in increased expression of CAB39 mRNA19549813
D003630DaunorubicinDaunorubicin results in decreased expression of CAB39 mRNA17374387
D003993Dibutyl PhthalateDibutyl Phthalate results in increased expression of CAB39 mRNA21266533
C000944dicrotophosdicrotophos results in decreased expression of CAB39 mRNA28302478
D002117CalcitriolCalcitriol results in increased expression of CAB39 mRNA16002434
D004147DioxinsDioxins affects the expression of CAB39 mRNA20463971
D005047EtoposideEtoposide results in decreased expression of CAB39 mRNA17374387
D005485FlutamideFlutamide results in decreased expression of CAB39 mRNA24793618
D005485FlutamideFlutamide results in increased expression of CAB39 mRNA24136188
C001277geldanamycingeldanamycin results in increased expression of CAB39 mRNA26705709
D005839GentamicinsGentamicins results in increased expression of CAB39 mRNA22061828
D006997Hypochlorous AcidHypochlorous Acid results in increased expression of CAB39 mRNA19376150
D015759Ionomycin[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAB39 mRNA25613284
C544151jinfukangjinfukang results in decreased expression of CAB39 mRNA27392435
C410337K 7174K 7174 results in increased expression of CAB39 mRNA24086573
D008070LipopolysaccharidesLipopolysaccharides results in decreased expression of CAB39 mRNA25613284
D008741Methyl MethanesulfonateMethyl Methanesulfonate results in decreased expression of CAB39 mRNA23649840
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in decreased expression of CAB39 mRNA"25554681
C051752nefazodonenefazodone results in increased expression of CAB39 mRNA24136188
C025256nonylphenolnonylphenol results in increased expression of CAB39 mRNA22982499
D010100OxygenOxygen deficiency affects the methylation of CAB39 promoter24205000
D010100OxygenOxygen deficiency results in increased expression of CAB39 mRNA24205000
D052638Particulate Matter2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Particulate Matter results in increased expression of CAB39 mRNA]28655636
D052638Particulate MatterParticulate Matter results in increased expression of CAB39 mRNA28655636
D010936Plant ExtractsPlant Extracts results in increased expression of CAB39 mRNA23557933
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of CAB39 mRNA22298810
D013755Tetradecanoylphorbol Acetate[Tetradecanoylphorbol Acetate co-treated with Ionomycin] results in increased expression of CAB39 mRNA25613284
D013853ThioacetamideThioacetamide results in increased expression of CAB39 mRNA23411599
D014241TrichloroethyleneTrichloroethylene results in increased methylation of CAB39 gene27618143
D014302Trinitrobenzenesulfonic AcidTrinitrobenzenesulfonic Acid results in decreased expression of CAB39 mRNA12163651
D001335Vehicle Emissions2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o-tolylazophenyl)amide inhibits the reaction [Vehicle Emissions results in increased expression of CAB39 mRNA]28655636
D001335Vehicle EmissionsVehicle Emissions results in increased expression of CAB39 mRNA28655636
D001335Vehicle EmissionsVehicle Emissions results in increased methylation of CAB39 gene25560391
D014801Vitamin AVitamin A deficiency results in decreased expression of CAB39 mRNA12163651

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0004674protein serine/threonine kinase activityCONTRIBUTES_TOIBA21873635  
GO:0004674protein serine/threonine kinase activitycontributes_toIDA24393035  
GO:0005515protein binding-IPI14676191  15733851  19513107  19892943  20562859  21423148  
23414517  23434407  25241761  25852190  26479318  
GO:0019900kinase binding-IPI19892943  
GO:0030295protein kinase activator activity-IDA19892943  
GO:0043539protein serine/threonine kinase activator activity-IDA19892943  24393035  
GO ID GO Term Qualifier Evidence PubMed
GO:0007050cell cycle arrest-TAS-  
GO:0010800positive regulation of peptidyl-threonine phosphorylation-IDA24393035  
GO:0018105peptidyl-serine phosphorylation-IDA24393035  
GO:0023014signal transduction by protein phosphorylation-IBA21873635  
GO:0023014signal transduction by protein phosphorylation-IDA24393035  
GO:0032147activation of protein kinase activity-IEA-  
GO:0035556intracellular signal transduction-IDA24393035  
GO:0043312neutrophil degranulation-TAS-  
GO:0051291protein heterooligomerization-IEA-  
GO:0071476cellular hypotonic response-IC24393035  
GO:0071902positive regulation of protein serine/threonine kinase activity-IDA19892943  24393035  
GO:1901017negative regulation of potassium ion transmembrane transporter activity-IC24393035  
GO:1901380negative regulation of potassium ion transmembrane transport-IC24393035  
GO ID GO Term Qualifier Evidence PubMed
GO:0005576extracellular region-TAS-  
GO:0005622intracellular-IBA21873635  
GO:0005829cytosol-TAS-  
GO:0034774secretory granule lumen-TAS-  
GO:0070062extracellular exosome-HDA19056867  19199708  23533145  
GO:1902554serine/threonine protein kinase complex-IC24393035  
GO:1904813ficolin-1-rich granule lumen-TAS-  
KEGG ID KEGG Term
hsa04150mTOR signaling pathway
Reactome ID Reactome Term Evidence
R-HSA-162582Signal TransductionTAS
R-HSA-165159mTOR signallingTAS
R-HSA-168249Innate Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-380972Energy dependent regulation of mTOR by LKB1-AMPKTAS
R-HSA-6798695Neutrophil degranulationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal