Gene: FBXO40

51725
FBX40
F-box protein 40
protein-coding
3q13.33
Ensembl:ENSG00000163833 MIM:609107 Vega:OTTHUMG00000159410 UniprotKB:Q9UH90
NC_000003.12
PubMed
0   ANCO-SNPs
ND
1   
NA (AD)  NA (ND)   (Frontal_Cortex)
4.650e-1 (AD)  6.495e-1 (ND)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
ZNF385B0.895
HECW10.888
FMN10.885
TBC1D300.882
LMTK20.882
GRM10.882
CHRM30.882
RSPO20.882
OPN30.882
SDR16C50.878

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
RAB13-0.608
HEY2-0.603
COPZ2-0.588
YES1-0.583
S100A16-0.58
MDFI-0.576
BCL7C-0.568
CHST14-0.548
MAPKAPK3-0.537
CMTM3-0.536

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
D000082AcetaminophenAcetaminophen results in decreased expression of FBXO40 mRNA26690555
D000393Air PollutantsAir Pollutants analog results in increased expression of FBXO40 mRNA21757418
C006780bisphenol Abisphenol A results in decreased expression of FBXO40 mRNA25181051
D003520CyclophosphamideCyclophosphamide results in increased expression of FBXO40 mRNA27281708
C412815GW 4064GW 4064 results in increased expression of FBXO40 mRNA26655953
C030272maleic acidmaleic acid results in increased expression of FBXO40 mRNA28392987
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FBXO40 mRNA27935865
C572573N-nitroso-tris-chloroethylurea[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FBXO40 mRNA27935865
C060836pioglitazone[N-nitroso-tris-chloroethylurea co-treated with pioglitazone] results in decreased expression of FBXO40 mRNA27935865
C004648testosterone enanthatetestosterone enanthate affects the expression of FBXO40 mRNA17440010
C581157XL147[N-nitroso-tris-chloroethylurea co-treated with XL147] results in decreased expression of FBXO40 mRNA27935865

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0003674molecular_function-ND-  
GO:0004842ubiquitin-protein transferase activity-EXP19028597  
GO:0004842ubiquitin-protein transferase activity-TAS-  
GO:0008270zinc ion binding-IEA-  
GO:0061630ubiquitin protein ligase activity-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0000209protein polyubiquitination-TAS-  
GO:0042692muscle cell differentiation-ISS17928169  
GO:0043687post-translational protein modification-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005737cytoplasm-ISS-  
GO:0005829cytosol-TAS-  
KEGG ID KEGG Term
Reactome ID Reactome Term Evidence
R-HSA-1280218Adaptive Immune SystemTAS
R-HSA-168256Immune SystemTAS
R-HSA-392499Metabolism of proteinsTAS
R-HSA-597592Post-translational protein modificationTAS
R-HSA-8951664NeddylationTAS
R-HSA-983168Antigen processing: Ubiquitination & Proteasome degradationTAS
R-HSA-983169Class I MHC mediated antigen processing & presentationTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal
23223146A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging. (2013 Apr)Le Clerc SJ Invest Dermatol