Gene: DNAJB11

51726
ABBP-2|ABBP2|DJ9|Dj-9|EDJ|ERdj3|ERj3|ERj3p|PRO1080|UNQ537
DnaJ heat shock protein family (Hsp40) member B11
protein-coding
3q27.3
Ensembl:ENSG00000090520 MIM:611341 Vega:OTTHUMG00000156614 UniprotKB:Q9UBS4
NG_034024.1
SNP Mapped
1   ANCO-SNPs
AD
0   
NA (AD)  NA (ND)   (Frontal_Cortex)
5.755e-1 (AD)  9.112e-1 (ND)

ANCO-SNPs

SNP ID Position Alleles Trait Variation Type
rs2280390chr3:186576031 (GRCh38.p7)T>Galcohol dependenceSNV(Single Nucleotide Variation)

DNA Methylation

There is no related methylation information for this gene.

Gene Expression in Different Tissues

Temporal and Spatial Expressions (BrainSpan)

Footnote:
SC: sub-cortical regions; SM: sensory-motor regions; FC: frontal cortex; and TP: temporal-parietal cortex
ST1: fetal (13 - 26 postconception weeks), ST2: early infancy to late childhood (4 months to 11 years), and ST3: adolescence to adulthood (13 - 23 years)
The bar shown representes average value of the expressions.

Top Co-expressed Genes in Brain-Frontal Cortex (BA9) (GTEx v7)

Top 10 positively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
HSPA50.905
HSP90B10.898
PDIA30.889
MANF0.889
XBP10.862
TARS0.853
VPS37C0.842
CALR0.842
PDIA60.841
PTGES30.841

Top 10 negatively co-expressed genes

Gene Symbol Pearson Correlation Coefficient
OR4F5-0.587
OR4F29-0.563
GLI1-0.222
HES5-0.218
ALDH1L1-AS2-0.209
NXNL1-0.2
C16orf96-0.199
GRIFIN-0.176
TCL1A-0.176
TTC16-0.175

Drugs/Compounds

    There is no DrugBank record for this gene !

ID Drug Name Action PubMed
C0493251,2-dithiol-3-thione"1,2-dithiol-3-thione results in increased expression of DNAJB11 mRNA"15375163
C0317631,3-butadiene"1,3-butadiene results in decreased expression of DNAJB11 mRNA"21147608
C1111182',3,3',4',5-pentachloro-4-hydroxybiphenyl"2',3,3',4',5-pentachloro-4-hydroxybiphenyl results in decreased expression of DNAJB11 mRNA"19114083
C0668412,3,7,8-tetrabromodibenzo-4-dioxin"2,3,7,8-tetrabromodibenzo-4-dioxin results in increased expression of DNAJB11 protein"27604104
C0142112,3,7,8-tetrachlorodibenzofuran"2,3,7,8-tetrachlorodibenzofuran affects the expression of DNAJB11 mRNA"18343893
C0164032,4-dinitrotoluene"2,4-dinitrotoluene affects the expression of DNAJB11 mRNA"21346803
C0230353,4,5,3',4'-pentachlorobiphenyl"3,4,5,3',4'-pentachlorobiphenyl results in increased expression of DNAJB11 mRNA"23994337
C517041(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)"(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II) results in increased expression of DNAJB11 mRNA"19561079
C0326424-aminophenylarsenoxide4-aminophenylarsenoxide binds to DNAJB11 protein26598702
C0326424-aminophenylarsenoxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DNAJB11 protein]26598702
C0821644-methoxycinnamate methyl ester4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]19442820
D000082AcetaminophenAcetaminophen affects the expression of DNAJB11 mRNA17562736
D020106AcrylamideAcrylamide results in increased expression of DNAJB11 mRNA28959563
D016604Aflatoxin B1Aflatoxin B1 results in decreased methylation of DNAJB11 gene27153756
D000638AmiodaroneAmiodarone results in decreased expression of DNAJB11 mRNA24535564
C006632arsenic trioxidearsenic trioxide inhibits the reaction [4-aminophenylarsenoxide binds to DNAJB11 protein]26598702
C006703benzo(b)fluoranthenebenzo(b)fluoranthene results in increased expression of DNAJB11 mRNA26377693
D019324beta-Naphthoflavonebeta-Naphthoflavone results in increased expression of DNAJB11 mRNA23994337
D004958EstradiolEstradiol promotes the reaction [DNAJB11 protein binds to ESR1 protein]27156127
C006780bisphenol Abisphenol A affects the expression of DNAJB11 mRNA21786754
C006780bisphenol Abisphenol A results in increased expression of DNAJB11 mRNA25912373
C006780bisphenol Abisphenol A results in increased expression of DNAJB11 mRNA25181051
C022777bufalinbufalin results in increased expression of DNAJB11 protein23091618
D020122tert-Butylhydroperoxidetert-Butylhydroperoxide results in decreased expression of DNAJB11 mRNA15003993
D019256Cadmium ChlorideCadmium Chloride results in increased expression of DNAJB11 mRNA25993096
C040048caffeic acidcaffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]19442820
D002118Calcium[DNAJB11 protein binds to HSPA5 protein] which results in decreased transport of Calcium26085089
D002118CalciumDNAJB11 protein inhibits the reaction [SEC61A1 protein results in increased transport of Calcium]26085089
D002118CalciumDNAJB11 protein results in decreased transport of Calcium26085089
D002118Calcium[DNAJB11 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin26085089
D002251Carbon TetrachlorideCarbon Tetrachloride results in increased expression of DNAJB11 mRNA27339419
D002793Cholic Acids[Cyclosporine co-treated with Cholic Acids] affects the expression of DNAJB11 mRNA27344345
C018021cobaltous chloridecobaltous chloride results in increased expression of DNAJB11 mRNA24612858
C030123coumarincoumarin results in increased expression of DNAJB11 mRNA18480146
D016572Cyclosporine[Cyclosporine co-treated with Cholic Acids] affects the expression of DNAJB11 mRNA27344345
D016572CyclosporineCyclosporine results in increased expression of DNAJB11 mRNA20106945|2163298
D002945CisplatinCisplatin results in increased expression of DNAJB11 mRNA19561079
D004051Diethylhexyl PhthalateDiethylhexyl Phthalate results in decreased expression of DNAJB11 mRNA21318169
C015835dimethyl-4-toluidinedimethyl-4-toluidine results in decreased expression of DNAJB11 mRNA27638505
D004147DioxinsDioxins affects the expression of DNAJB11 mRNA20463971
D004791Enzyme Inhibitors[Enzyme Inhibitors results in decreased activity of OGA protein] which results in increased O-linked glycosylation of DNAJB11 protein23301498
D004997Ethinyl EstradiolEthinyl Estradiol affects the expression of DNAJB11 mRNA17555576
D004997Ethinyl EstradiolEthinyl Estradiol results in increased expression of DNAJB11 mRNA17942748
C039281furanfuran results in decreased expression of DNAJB11 mRNA24183702
D005897GlafenineGlafenine results in increased expression of DNAJB11 mRNA24136188
D005944GlucosamineGlucosamine results in decreased expression of DNAJB11 mRNA17178593
D005947GlucoseGlucose results in decreased expression of DNAJB11 mRNA17178593
C010974glyphosateglyphosate results in increased expression of DNAJB11 mRNA25636363
C492448ICG 001ICG 001 results in increased expression of DNAJB11 mRNA26191083
C075954indolo(3,2-b)carbazole"indolo(3,2-b)carbazole results in increased expression of DNAJB11 mRNA"23994337
D007545IsoproterenolIsoproterenol results in increased expression of DNAJB11 mRNA21823215
D008627Mercuric ChlorideMercuric Chloride affects the expression of DNAJB11 mRNA20353558
D037742Nanotubes, Carbon"Nanotubes, Carbon affects the expression of DNAJB11 mRNA"25620056
D037742Nanotubes, Carbon"Nanotubes, Carbon analog results in increased expression of DNAJB11 mRNA"25554681|2562005
D037742Nanotubes, Carbon"Nanotubes, Carbon results in increased expression of DNAJB11 mRNA"25554681
D009532NickelNickel results in increased expression of DNAJB11 mRNA24768652|2558310
C022838nickel chloridenickel chloride results in increased expression of DNAJB11 mRNA24612858
C012655nimesulidenimesulide results in increased expression of DNAJB11 mRNA24136188
C464660obeticholic acidobeticholic acid results in increased expression of DNAJB11 mRNA27939613
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB11 mRNA17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJB11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJB11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB11 mRNA]17655762
C472349oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholineVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB11 mRNA]17655762
D052638Particulate Matteroxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Particulate Matter affects the expression of DNAJB11 mRNA]17655762
D052638Particulate MatterParticulate Matter affects the expression of DNAJB11 mRNA17655762
D052638Particulate MatterParticulate Matter promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB11 mRNA]17655762
C006253pirinixic acid[pirinixic acid binds to and results in increased activity of PPARA protein] which results in decreased expression of DNAJB11 mRNA19710929
C006253pirinixic acidpirinixic acid results in decreased expression of DNAJB11 mRNA21318169|2381119
C006253pirinixic acidPPARA protein affects the reaction [pirinixic acid results in decreased expression of DNAJB11 mRNA]21318169
D011374ProgesteroneProgesterone affects the expression of DNAJB11 mRNA17251523
C045950propiconazolepropiconazole results in increased expression of DNAJB11 mRNA21278054
C031280pyrazolepyrazole results in increased expression of DNAJB11 mRNA17945193
C059514resveratrolresveratrol results in increased expression of DNAJB11 protein25505154
C017947sodium arsenitesodium arsenite affects the methylation of DNAJB11 gene28589171
C017947sodium arsenitesodium arsenite results in decreased expression of DNAJB11 mRNA28595984
D013629TamoxifenTamoxifen affects the expression of DNAJB11 mRNA17555576
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin affects the expression of DNAJB11 mRNA18343893
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in decreased expression of DNAJB11 mRNA26290441
D013749TetrachlorodibenzodioxinTetrachlorodibenzodioxin results in increased expression of DNAJB11 mRNA15328365|1661135
D013750TetrachloroethyleneTetrachloroethylene results in decreased expression of DNAJB11 mRNA28973375
C014215tetrahydropalmatinetetrahydropalmatine results in decreased expression of DNAJB11 protein20109541
D019284Thapsigargin4-methoxycinnamate methyl ester promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]19442820
D019284Thapsigargincaffeic acid promotes the reaction [Thapsigargin results in decreased expression of DNAJB11 mRNA]19442820
D019284Thapsigargin[DNAJB11 protein results in decreased transport of Calcium] which results in increased susceptibility to Thapsigargin26085089
D019284ThapsigarginThapsigargin results in decreased expression of DNAJB11 mRNA19442820
D019284ThapsigarginThapsigargin results in increased expression of DNAJB11 mRNA22378314
C009495titanium dioxidetitanium dioxide results in increased expression of DNAJB11 mRNA23557971
D014241TrichloroethyleneTrichloroethylene results in decreased expression of DNAJB11 mRNA25549359
C012589trichostatin Atrichostatin A affects the expression of DNAJB11 mRNA28542535
D014415TunicamycinTunicamycin results in increased expression of DNAJB11 mRNA22378314
D014635Valproic AcidValproic Acid affects the expression of DNAJB11 mRNA25979313
D014635Valproic AcidValproic Acid results in decreased methylation of DNAJB11 gene29154799
D014635Valproic AcidValproic Acid results in increased expression of DNAJB11 mRNA23179753|2718838
D014635Valproic AcidValproic Acid affects the expression of DNAJB11 mRNA17292431
D014635Valproic AcidValproic Acid results in decreased expression of DNAJB11 mRNA24535564
D001335Vehicle Emissionsoxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine promotes the reaction [Vehicle Emissions affects the expression of DNAJB11 mRNA]17655762
D001335Vehicle EmissionsVehicle Emissions affects the expression of DNAJB11 mRNA17655762
D001335Vehicle EmissionsVehicle Emissions promotes the reaction [oxidized-L-alpha-1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine affects the expression of DNAJB11 mRNA]17655762
C025643vinclozolinvinclozolin results in decreased expression of DNAJB11 mRNA23034163
C111237vorinostatvorinostat results in increased expression of DNAJB11 protein20543569
D014874Water Pollutants, Chemical"Water Pollutants, Chemical results in increased expression of DNAJB11 mRNA"23246600

GO/Pathway

GO ID GO Term Qualifier Evidence PubMed
GO:0005515protein binding-IPI18923428  20335166  24189400  
GO:0051082unfolded protein binding-IEA-  
GO ID GO Term Qualifier Evidence PubMed
GO:0006457protein folding-IEA-  
GO:0032781positive regulation of ATPase activity-IDA20335166  
GO:0036498IRE1-mediated unfolded protein response-TAS-  
GO ID GO Term Qualifier Evidence PubMed
GO:0005783endoplasmic reticulum-IDA20335166  
GO:0005783endoplasmic reticulum-TAS16130169  
GO:0005788endoplasmic reticulum lumen-TAS-  
GO:0016020membrane-HDA19946888  
KEGG ID KEGG Term
hsa04141Protein processing in endoplasmic reticulum
Reactome ID Reactome Term Evidence
R-HSA-381038XBP1(S) activates chaperone genesTAS
R-HSA-381070IRE1alpha activates chaperonesTAS
R-HSA-381119Unfolded Protein Response (UPR)TAS
R-HSA-392499Metabolism of proteinsTAS

Interactions (STRING v10.5, Interaction Score >= 0.400)

Publications (Co-occurrence of gene symbol strings and ANCO-Dependence terms)

PMID Title (Year) Author Journal